norketamine (BioDeep_00000397497)
代谢物信息卡片
norketamine
化学式: C12H14ClNO (223.0763864)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC(C(=O)C1)(C2=CC=CC=C2Cl)N
InChI: InChI=1S/C12H14ClNO/c13-10-6-2-1-5-9(10)12(14)8-4-3-7-11(12)15/h1-2,5-6H,3-4,7-8,14H2
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:91519
- PubChem: 123767
- Metlin: METLIN882
- ChEMBL: CHEMBL1039
- CAS: 65329-10-4
- CAS: 35211-10-0
- MoNA: AU154606
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jhe-Wei Lin, Yi-Chun Lin, Jui-Ming Liu, Shing-Hwa Liu, Kai-Min Fang, Ren-Jun Hsu, Chun-Fa Huang, Kai-Yao Chang, Kuan-I Lee, Kai-Chih Chang, Chin-Chuan Su, Ya-Wen Chen. Norketamine, the Main Metabolite of Ketamine, Induces Mitochondria-Dependent and ER Stress-Triggered Apoptotic Death in Urothelial Cells via a Ca2+-Regulated ERK1/2-Activating Pathway.
International journal of molecular sciences.
2022 Apr; 23(9):. doi:
10.3390/ijms23094666. [PMID: 35563057] - Jaclyn N Highland, Cristan A Farmer, Panos Zanos, Jacqueline Lovett, Carlos A Zarate, Ruin Moaddel, Todd D Gould. Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans.
Journal of psychopharmacology (Oxford, England).
2022 02; 36(2):170-182. doi:
10.1177/02698811211064922. [PMID: 34971525] - Lili Ying, Yuyan Chen, Zuoquan Zhong, Yajin Wu, Lufeng Hu, Congcong Wen. Effects of long-term alcohol exposure on the pharmacokinetic profiles of ketamine and norketamine in rats.
Alcohol (Fayetteville, N.Y.).
2021 11; 96(?):55-61. doi:
10.1016/j.alcohol.2021.01.008. [PMID: 33549609] - Andrea Barbarossa, Anisa Bardhi, Teresa Gazzotti, Giampiero Pagliuca. A critical point in chiral chromatography-mass spectrometry analysis of ketamine metabolites.
Drug testing and analysis.
2021 Sep; 13(9):1689-1692. doi:
10.1002/dta.3112. [PMID: 34121336] - Jo-Chuan Liu, Yi-Ting Chen, Ya-Ju Hsieh, Chia-Chun Wu, Ming-Chyi Huang, Yu-Chao Hsu, Chun-Te Wu, Chih-Ken Chen, Srinivas Dash, Jau-Song Yu. Association of urinary ketamine and APOA1 levels with bladder dysfunction in ketamine abusers revealed via proteomics and targeted metabolite analyses.
Scientific reports.
2021 05; 11(1):9583. doi:
10.1038/s41598-021-89089-4. [PMID: 33953300] - Jasper Kamp, Kelly Jonkman, Monique van Velzen, Leon Aarts, Marieke Niesters, Albert Dahan, Erik Olofsen. Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis.
British journal of anaesthesia.
2020 11; 125(5):750-761. doi:
10.1016/j.bja.2020.06.067. [PMID: 32838982] - Beauty Arora, Sanjeev Lalwani, Rohit Saxena, Supriyo Ghose, Thirumurthy Velpandian. Postmortem redistribution of ketamine in ocular matrices: A study of forensic relevance.
Legal medicine (Tokyo, Japan).
2020 Nov; 47(?):101777. doi:
10.1016/j.legalmed.2020.101777. [PMID: 32858459] - Genevieve C Luca, Linda S Barter, Bruno H Pypendop. Pharmacokinetics of ketamine following a short intravenous infusion to isoflurane-anesthetized New Zealand White rabbits (Oryctolagus cuniculus).
Veterinary anaesthesia and analgesia.
2020 May; 47(3):334-340. doi:
10.1016/j.vaa.2020.02.002. [PMID: 32222343] - Lutea A A de Jong, Rouhollah Qurishi, Marieke P J Stams, Michael Böttcher, Cornelis A J de Jong. Prolonged Ketamine and Norketamine Excretion Profiles in Urine After Chronic Use: A Case Series.
Journal of clinical psychopharmacology.
2020 May; 40(3):300-304. doi:
10.1097/jcp.0000000000001191. [PMID: 32332467] - Samir M Ahmad, Mariana N Oliveira, Nuno R Neng, J M F Nogueira. A Fast and Validated High Throughput Bar Adsorptive Microextraction (HT-BAµE) Method for the Determination of Ketamine and Norketamine in Urine Samples.
Molecules (Basel, Switzerland).
2020 Mar; 25(6):. doi:
10.3390/molecules25061438. [PMID: 32235801] - Ankit Rochani, Edwin Lam, Julian Tanjuakio, Hitoshi Hirose, Walter K Kraft, Gagan Kaushal. Simultaneous quantitative LC-MS method of ketamine, midazolam and their metabolites (dehydronorketamine, norketamine and 1hydroxymidazolam) for its application in patients on extracorporeal membrane oxygenation (ECMO) therapy.
Journal of pharmaceutical and biomedical analysis.
2020 Jan; 178(?):112947. doi:
10.1016/j.jpba.2019.112947. [PMID: 31708269] - Atsuhiro Fujita, Yuko Fujita, Yaoyu Pu, Lijia Chang, Kenji Hashimoto. MPTP-induced dopaminergic neurotoxicity in mouse brain is attenuated after subsequent intranasal administration of (R)-ketamine: a role of TrkB signaling.
Psychopharmacology.
2020 Jan; 237(1):83-92. doi:
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BioMed research international.
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Journal of psychiatric research.
2019 10; 117(?):129-134. doi:
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Neuropharmacology.
2019 07; 153(?):73-81. doi:
10.1016/j.neuropharm.2019.04.019. [PMID: 31015046] - Petr Tůma, Blanka Sommerová, Šimon Vaculín. Rapid electrophoretic monitoring of the anaesthetic ketamine and its metabolite norketamine in rat blood using a contactless conductivity detector to study the pharmacokinetics.
Journal of separation science.
2019 Jun; 42(11):2062-2068. doi:
10.1002/jssc.201900116. [PMID: 30938060] - Patricia Steckeler, Daniela Fux, Moritz Metzner, Gabriela Knubben, Anna Rieger, Christine Baumgartner. The course of plasma cortisol concentration after three different doses of ketamine in xylazine-premedicated calves.
Veterinary anaesthesia and analgesia.
2019 May; 46(3):335-343. doi:
10.1016/j.vaa.2018.11.005. [PMID: 30956016] - Samantha K Saland, Mohamed Kabbaj. Sex Differences in the Pharmacokinetics of Low-dose Ketamine in Plasma and Brain of Male and Female Rats.
The Journal of pharmacology and experimental therapeutics.
2018 12; 367(3):393-404. doi:
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Psychopharmacology.
2018 Nov; 235(11):3177-3185. doi:
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Journal of psychopharmacology (Oxford, England).
2018 10; 32(10):1127-1132. doi:
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American journal of veterinary research.
2018 Sep; 79(9):921-932. doi:
10.2460/ajvr.79.9.921. [PMID: 30153057] - Jun-Ichi Yamaguchi, Hidetoh Toki, Youge Qu, Chun Yang, Hiroyuki Koike, Kenji Hashimoto, Akiko Mizuno-Yasuhira, Shigeyuki Chaki. (2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2018 08; 43(9):1900-1907. doi:
10.1038/s41386-018-0084-y. [PMID: 29802366] - Friederike A Sandbaumhüter, Wolfgang Thormann. Enantioselective capillary electrophoresis provides insight into the phase II metabolism of ketamine and its metabolites in vivo and in vitro.
Electrophoresis.
2018 06; 39(12):1478-1481. doi:
10.1002/elps.201800012. [PMID: 29572863] - T Lilius, E Kangas, M Niemi, P Rauhala, E Kalso. Ketamine and norketamine attenuate oxycodone tolerance markedly less than that of morphine: from behaviour to drug availability.
British journal of anaesthesia.
2018 Apr; 120(4):818-826. doi:
10.1016/j.bja.2017.11.081. [PMID: 29576122] - Verònica Gálvez, Adrienne Li, Christina Huggins, Paul Glue, Donel Martin, Andrew A Somogyi, Angelo Alonzo, Anthony Rodgers, Philip B Mitchell, Colleen K Loo. Repeated intranasal ketamine for treatment-resistant depression - the way to go? Results from a pilot randomised controlled trial.
Journal of psychopharmacology (Oxford, England).
2018 04; 32(4):397-407. doi:
10.1177/0269881118760660. [PMID: 29542371] - Benjamin Duy Tran, Ganesh S Moorthy, Athena F Zuppa. Ketamine and norketamine stability in whole blood at ambient and 4°C conditions.
Biomedical chromatography : BMC.
2018 Mar; 32(3):. doi:
10.1002/bmc.4104. [PMID: 28976571] - Hidetoh Toki, Takuya Ichikawa, Akiko Mizuno-Yasuhira, Jun-Ichi Yamaguchi. A rapid and sensitive chiral LC-MS/MS method for the determination of ketamine and norketamine in mouse plasma, brain and cerebrospinal fluid applicable to the stereoselective pharmacokinetic study of ketamine.
Journal of pharmaceutical and biomedical analysis.
2018 Jan; 148(?):288-297. doi:
10.1016/j.jpba.2017.09.033. [PMID: 29126076] - Tung-Ping Su, Mu-Hong Chen, Cheng-Ta Li, Wei-Chen Lin, Chen-Jee Hong, Ralitza Gueorguieva, Pei-Chi Tu, Ya-Mei Bai, Chih-Ming Cheng, John H Krystal. Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2017 Dec; 42(13):2482-2492. doi:
10.1038/npp.2017.94. [PMID: 28492279] - Cindy Ramiole, Benoit D'Hayer, Vincent Boudy, Josette Legagneux, Julien Fonsart, Pascal Houzé. Determination of ketamine and its main metabolites by liquid chromatography coupled to tandem mass spectrometry in pig plasma: Comparison of extraction methods.
Journal of pharmaceutical and biomedical analysis.
2017 Nov; 146(?):369-377. doi:
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Journal of pharmaceutical and biomedical analysis.
2017 Nov; 146(?):410-419. doi:
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Research in veterinary science.
2017 Jun; 112(?):208-213. doi:
10.1016/j.rvsc.2017.05.005. [PMID: 28521255] - Mahmoud Hasan, Robert Hofstetter, Georg M Fassauer, Andreas Link, Werner Siegmund, Stefan Oswald. Quantitative chiral and achiral determination of ketamine and its metabolites by LC-MS/MS in human serum, urine and fecal samples.
Journal of pharmaceutical and biomedical analysis.
2017 May; 139(?):87-97. doi:
10.1016/j.jpba.2017.02.035. [PMID: 28279931] - Friederike A Sandbaumhüter, Regula Theurillat, Rima N Bektas, Annette P N Kutter, Regula Bettschart-Wolfensberger, Wolfgang Thormann. Pharmacokinetics of ketamine and three metabolites in Beagle dogs under sevoflurane vs. medetomidine comedication assessed by enantioselective capillary electrophoresis.
Journal of chromatography. A.
2016 Oct; 1467(?):436-444. doi:
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Clinical pharmacokinetics.
2016 09; 55(9):1059-77. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Nov; 1004(?):67-78. doi:
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Anesthesia and analgesia.
2015 Oct; 121(4):925-933. doi:
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Neuropharmacology.
2014 Nov; 86(?):174-80. doi:
10.1016/j.neuropharm.2014.07.008. [PMID: 25063581] - Regula Theurillat, M Paula Larenza, Karsten Feige, Regula Bettschart-Wolfensberger, Wolfgang Thormann. Development of a method for analysis of ketamine and norketamine enantiomers in equine brain and cerebrospinal fluid by capillary electrophoresis.
Electrophoresis.
2014 Oct; 35(19):2863-9. doi:
10.1002/elps.201400093. [PMID: 24789372] - André Valle de Bairros, Rafael Lanaro, Rafael Menck de Almeida, Mauricio Yonamine. Determination of ketamine, norketamine and dehydronorketamine in urine by hollow-fiber liquid-phase microextraction using an essential oil as supported liquid membrane.
Forensic science international.
2014 Oct; 243(?):47-54. doi:
10.1016/j.forsciint.2014.04.016. [PMID: 24810678] - Angela Yu-Chen Lin, Wan-Ning Lee, Xiao-Huan Wang. Ketamine and the metabolite norketamine: persistence and phototransformation toxicity in hospital wastewater and surface water.
Water research.
2014 Apr; 53(?):351-60. doi:
10.1016/j.watres.2014.01.022. [PMID: 24531031] - Foon Yin Lai, Raimondo Bruno, Ho Wing Leung, Phong K Thai, Christoph Ort, Steve Carter, Kristie Thompson, Paul K S Lam, Jochen F Mueller. Estimating daily and diurnal variations of illicit drug use in Hong Kong: a pilot study of using wastewater analysis in an Asian metropolitan city.
Forensic science international.
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Pediatric emergency care.
2013 Nov; 29(11):1220-2. doi:
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The Analyst.
2013 Apr; 138(8):2239-43. doi:
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Fundamental & clinical pharmacology.
2012 Dec; 26(6):743-50. doi:
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Basic & clinical pharmacology & toxicology.
2012 Nov; 111(5):325-32. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2012 Nov; 42(11):1076-87. doi:
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Journal of analytical toxicology.
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British journal of clinical pharmacology.
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Anesthesiology.
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European journal of clinical pharmacology.
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Clinical pharmacology and therapeutics.
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Anesthesiology.
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Chirality.
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Fa yi xue za zhi.
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Pain physician.
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European journal of pain (London, England).
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Journal of analytical toxicology.
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Methods in molecular biology (Clifton, N.J.).
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Anesthesiology.
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Journal of the American Society of Nephrology : JASN.
2009 Sep; 20(9):1929-40. doi:
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Electrophoresis.
2009 Aug; 30(16):2912-21. doi:
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