N-Acetyl-L-tyrosine (BioDeep_00000405387)

Main id: BioDeep_00000017795

 

PANOMIX_OTCML-2023


代谢物信息卡片


N-Acetyl-L-tyrosine

化学式: C11H13NO4 (223.0844538)
中文名称: N-乙酰-L-酪氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)O
InChI: InChI=1S/C11H13NO4/c1-7(13)12-10(11(15)16)6-8-2-4-9(14)5-3-8/h2-5,10,14H,6H2,1H3,(H,12,13)(H,15,16)/t10-/m0/s1

描述信息

An N-acetyltyrosine in which the chiral centre has L configuration.
N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

同义名列表

2 个代谢物同义名

N-Acetyl-L-tyrosine; N-Acetyl-L-tyrosine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tomiko Kuhara, Morimasa Ohse, Yoshito Inoue, Arthur J L Cooper. A GC/MS-based metabolomic approach for diagnosing citrin deficiency. Analytical and bioanalytical chemistry. 2011 Jun; 400(7):1881-94. doi: 10.1007/s00216-011-4766-0. [PMID: 21365350]
  • Kiyoon Kang, Kyoungjin Kong, Sangkyu Park, Uyanga Natsagdorj, Young Soon Kim, Kyoungwhan Back. Molecular cloning of a plant N-acetylserotonin methyltransferase and its expression characteristics in rice. Journal of pineal research. 2011 Apr; 50(3):304-9. doi: 10.1111/j.1600-079x.2010.00841.x. [PMID: 21210840]
  • Chasity M Shelton, Amanda J Clark, Michael C Storm, Richard A Helms. Plasma amino Acid concentrations in 108 children receiving a pediatric amino Acid formulation as part of parenteral nutrition. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG. 2010 Apr; 15(2):110-8. doi: 10.5863/1551-6776-15.2.110. [PMID: 22477801]
  • Yoji Kato, Natsuko Dozaki, Toshiyuki Nakamura, Noritoshi Kitamoto, Akihiro Yoshida, Michitaka Naito, Masayasu Kitamura, Toshihiko Osawa. Quantification of Modified Tyrosines in Healthy and Diabetic Human Urine using Liquid Chromatography/Tandem Mass Spectrometry. Journal of clinical biochemistry and nutrition. 2009 Jan; 44(1):67-78. doi: 10.3164/jcbn.08-185. [PMID: 19177191]
  • Ming-Chou Chiang, Shiu-Feng Huang, Chuen Hsueh, Ming-Wei Lai, Jia-Woei Hou. Restrictive dermopathy: report of one case and the metabolic and post-mortem findings. The Turkish journal of pediatrics. 2008 Sep; 50(5):492-4. doi: NULL. [PMID: 19102058]
  • Rakesh Kumar, Uma Ramachandran, Suryaprakash Raichur, Ranjan Chakrabarti, Rahul Jain. Synthesis and evaluation of N-acetyl-L-tyrosine based compounds as PPARalpha selective activators. European journal of medicinal chemistry. 2007 Apr; 42(4):503-10. doi: 10.1016/j.ejmech.2006.11.005. [PMID: 17187904]
  • Jose E Abdenur, Nico Abeling, Norma Specola, Lia Jorge, Andrea B Schenone, Arno C van Cruchten, Nestor A Chamoles. Aromatic l-aminoacid decarboxylase deficiency: unusual neonatal presentation and additional findings in organic acid analysis. Molecular genetics and metabolism. 2006 Jan; 87(1):48-53. doi: 10.1016/j.ymgme.2005.09.007. [PMID: 16288991]
  • Stanley H Korman, Alisa Gutman. N-acetyl tyrosyluria caused by parenteral or enteral administration of N-acetyl-L-tyrosine: differentiation from hereditary and acquired tyrosinemias. Journal of pediatric gastroenterology and nutrition. 2004 Jul; 39(1):95-100. doi: 10.1097/00005176-200407000-00019. [PMID: 15187789]
  • L John Hoffer, Khurram Sher, Farhad Saboohi, Paule Bernier, Elizabeth M MacNamara, David Rinzler. N-acetyl-L-tyrosine as a tyrosine source in adult parenteral nutrition. JPEN. Journal of parenteral and enteral nutrition. 2003 Nov; 27(6):419-22. doi: 10.1177/0148607103027006419. [PMID: 14621123]
  • T Shutova, A Villarejo, B Zietz, V Klimov, T Gillbro, G Samuelsson, G Renger. Comparative studies on the properties of the extrinsic manganese-stabilizing protein from higher plants and of a synthetic peptide of its C-terminus. Biochimica et biophysica acta. 2003 Jun; 1604(2):95-104. doi: 10.1016/s0005-2728(03)00025-2. [PMID: 12765766]
  • Do Kyung Kim, Yoshikatsu Kanai, Hirotaka Matsuo, Ju Young Kim, Arthit Chairoungdua, Yukari Kobayashi, Atsushi Enomoto, Seok Ho Cha, Tomoyuki Goya, Hitoshi Endou. The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics. 2002 Jan; 79(1):95-103. doi: 10.1006/geno.2001.6678. [PMID: 11827462]
  • M Lehnig. 15N chemically induced dynamic nuclear polarization during reaction of N-acetyl-L-tyrosine with the nitrating systems nitrite/hydrogen peroxide/horseradish peroxidase and nitrite/hypochloric acid. Archives of biochemistry and biophysics. 2001 Sep; 393(2):245-54. doi: 10.1006/abbi.2001.2494. [PMID: 11556811]
  • M Sharma, R Jain. Isolation and analysis of dityrosine from enzyme-catalyzed oxidation of tyrosine and X-irradiated peptide and proteins. Chemico-biological interactions. 1998 Jan; 108(3):171-85. doi: 10.1016/s0009-2797(97)00098-7. [PMID: 9528688]
  • J P Eiserich, C E Cross, A D Jones, B Halliwell, A van der Vliet. Formation of nitrating and chlorinating species by reaction of nitrite with hypochlorous acid. A novel mechanism for nitric oxide-mediated protein modification. The Journal of biological chemistry. 1996 Aug; 271(32):19199-208. doi: 10.1074/jbc.271.32.19199. [PMID: 8702599]
  • W Druml, W Hübl, E Roth, H Lochs. Utilization of tyrosine-containing dipeptides and N-acetyl-tyrosine in hepatic failure. Hepatology (Baltimore, Md.). 1995 Apr; 21(4):923-8. doi: NULL. [PMID: 7705801]
  • L J Wykes, J D House, R O Ball, P B Pencharz. Aromatic amino acid metabolism of neonatal piglets receiving TPN: effect of tyrosine precursors. The American journal of physiology. 1994 Nov; 267(5 Pt 1):E672-9. doi: 10.1152/ajpendo.1994.267.5.e672. [PMID: 7977717]
  • J B Van Goudoever, E J Sulkers, M Timmerman, J G Huijmans, K Langer, V P Carnielli, P J Sauer. Amino acid solutions for premature neonates during the first week of life: the role of N-acetyl-L-cysteine and N-acetyl-L-tyrosine. JPEN. Journal of parenteral and enteral nutrition. 1994 Sep; 18(5):404-8. doi: 10.1177/0148607194018005404. [PMID: 7815670]
  • W Druml, H Lochs, E Roth, W Hübl, P Balcke, K Lenz. Utilization of tyrosine dipeptides and acetyltyrosine in normal and uremic humans. The American journal of physiology. 1991 Feb; 260(2 Pt 1):E280-5. doi: 10.1152/ajpendo.1991.260.2.e280. [PMID: 1996632]
  • I Magnusson, L Ekman, M Wångdahl, J Wahren. N-acetyl-L-tyrosine and N-acetyl-L-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans. Metabolism: clinical and experimental. 1989 Oct; 38(10):957-61. doi: 10.1016/0026-0495(89)90005-x. [PMID: 2507878]
  • W C Heird, W Hay, R A Helms, M C Storm, S Kashyap, R B Dell. Pediatric parenteral amino acid mixture in low birth weight infants. Pediatrics. 1988 Jan; 81(1):41-50. doi: NULL. [PMID: 3122162]
  • W C Heird, R B Dell, R A Helms, H L Greene, M E Ament, P Karna, M C Storm. Amino acid mixture designed to maintain normal plasma amino acid patterns in infants and children requiring parenteral nutrition. Pediatrics. 1987 Sep; 80(3):401-8. doi: NULL. [PMID: 3114709]
  • R J Ziccardi. Control of C1 activation by nascent C3b and C4b: a mechanism of feedback inhibition. Journal of immunology (Baltimore, Md. : 1950). 1986 May; 136(9):3378-83. doi: . [PMID: 3485688]
  • E Jellum, L Horn, O Thoresen, E A Kvittingen, O Stokke. Urinary excretion of N-acetyl amino acids in patients with some inborn errors of amino acid metabolism. Scandinavian journal of clinical and laboratory investigation. Supplementum. 1986; 184(?):21-6. doi: . [PMID: 3473611]
  • M Neuhäuser, J A Wandira, U Göttmann, K H Bässler, K Langer. Utilization of N-acetyl-L-tyrosine and glycyl-L-tyrosine during long-term parenteral nutrition in the growing rat. The American journal of clinical nutrition. 1985 Oct; 42(4):585-96. doi: 10.1093/ajcn/42.4.585. [PMID: 3931451]
  • H A Im, P D Meyer, L D Stegink. N-acetyl-L-tyrosine as a tyrosine source during total parenteral nutrition in adult rats. Pediatric research. 1985 Jun; 19(6):514-8. doi: 10.1203/00006450-198506000-00002. [PMID: 3925425]
  • P G Lankisch, S Ehrhardt-Schmelzer. [Chymotrypsin determination in feces: an indirect pancreatic function test]. Deutsche medizinische Wochenschrift (1946). 1984 Oct; 109(40):1527-9. doi: 10.1055/s-2008-1069407. [PMID: 6479053]
  • N Miyagawa, S Miyagawa, S Leskowitz. ABA-specific helper T cells in A/J mice bear the major cross-reactive idiotype. Cellular immunology. 1983 Apr; 77(1):120-31. doi: 10.1016/0008-8749(83)90012-6. [PMID: 6220814]
  • M Neuhäuser, B Welsch, B Bässler. [Utilization of N-acetylated amino acids in solutions for intravenous feeding. Cleavage of N-acetyltyrosine and N-acetylcysteine in rat tissues]. Zeitschrift fur Ernahrungswissenschaft. 1982 Mar; 21(1):21-6. doi: 10.1007/bf02023037. [PMID: 6803462]
  • A M DANNENBERG, W E BENNETT. HYDROLYTIC ENZYMES OF RABBIT MONONUCLEAR EXUDATE CELLS. I. QUANTITATIVE ASSAY AND PROPERTIES OF CERTAIN PROTEASES, NON-SPECIFIC ESTERASES, AND LIPASES OF MONONUCLEAR AND POLYMORPHONUCLEAR CELLS AND ERYTHROCYTES. The Journal of cell biology. 1964 Apr; 21(?):1-13. doi: 10.1083/jcb.21.1.1. [PMID: 14154492]
  • S LESKOWITZ. Immunochemical study of antigenic specificity in delayed hypersensitivity. II. Delayed hypersensitivity to polytyrosine-azobenzenearsonate and its suppression by haptens. The Journal of experimental medicine. 1963 Jun; 117(?):909-23. doi: 10.1084/jem.117.6.909. [PMID: 13929877]