Exact Mass: 153.96230979999999

Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Clelands reagent. DTTs formula is C4H10O2S2 and the molecular structure of its reduced form is shown at the right; its oxidized form is a disulfide-bonded 6-membered ring (shown below). Its name derives from the four-carbon sugar, threose. DTT has an epimeric (sister) compound, dithioerythritol. A common use of DTT is as a reducing or "deprotecting" agent for thiolated DNA. The terminal sulfur atoms of thiolated DNA have a tendency to form dimers in solution, especially in the presence of oxygen. Dimerization greatly lowers the efficiency of subsequent coupling reactions such as DNA immobilization on gold in biosensors. Typically DTT is mixed with a DNA solution and allowed to react, and then is removed by filtration (for the solid catalyst) or by chromatography (for the liquid form). The DTT removal procedure is often called "desalting.". DTT is frequently used to reduce the disulfide bonds of proteins and, more generally, to prevent intramolecular and intermolecular disulfide bonds from forming between cysteine residues of proteins. However, even DTT cannot reduce buried (solvent-inaccessible) disulfide bonds, so reduction of disulfide bonds is sometimes carried out under denaturing conditions (e.g., at high temperatures, or in the presence of a strong denaturant such as 6 M guanidinium hydrochloride, 8 M urea, or 1\\% sodium dodecylsulfate). Conversely, the solvent exposure of different disulfide bonds can be assayed by their rate of reduction in the presence of DTT. DTT can also be used as an oxidizing agent. Its principal advantage is that effectively no mixed-disulfide species are populated, in contrast to other agents such as glutathione. In very rare cases, a DTT adduct may be formed, i.e., the two sulfur atoms of DTT may form disulfide bonds to different sulfur atoms; in such cases, DTT cannot cyclize since it has no remaining free thiols. Due to air oxidation, DTT is a relatively unstable compound whose useful life can be extended by refrigeration and handling in an inert atmosphere. Since protonated sulfurs have lowered nucleophilicities, DTT becomes less potent as the pH lowers. Tris(2-carboxyethyl)phosphine HCl (TCEP hydrochloride) is an alternative which is more stable and works even at low pH. Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Clelands reagent. DTT has an epimeric compound, dithioerythritol. COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

Propanoyl phosphate

The phosphate ester of propanoic acid.

Acetol phosphate

Hydroxyacetone phosphate

Glycerol 1,2-cyclic phosphate

1,3,2-Dioxaphospholane-4-methanol

3-sulfolactaldehyde

L-3-sulfolactaldehyde

C3H6O5S (153.9935946)

Dithioerythritol

erythro-1,4-Dimercapto-2,3-butanediol

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D013439 - Sulfhydryl Reagents

3-phosphonopropanoic acid

(E)-S-1-Propenyl thiosulfate

[(1E)-Prop-1-en-1-ylsulphanyl]sulphonic acid

C3H6O3S2 (153.9758366)

(Z)-S-1-Propenyl thiosulfate is found in onion-family vegetables. (Z)-S-1-Propenyl thiosulfate is a constituent of onion (Allium cepa). Constituent of Allium cepa (onion). (E)-S-1-Propenyl thiosulfate is found in garden onion and onion-family vegetables.

Methyl propyl trisulfide

1-Methyl-3-propyltrisulphane

Volatile flavouring component of onion oil, leeks and other Allium subspecies Also present in French fried potato and cocoa. Methyl propyl trisulfide is found in many foods, some of which are garden onion, potato, cocoa and cocoa products, and soft-necked garlic. Methyl propyl trisulfide is found in cocoa and cocoa products. Methyl propyl trisulfide is a volatile flavouring component of onion oil, leeks and other Allium species Also present in French fried potato and coco D000074385 - Food Ingredients > D005503 - Food Additives D010592 - Pharmaceutic Aids > D005421 - Flavoring Agents

Chloropentafluoroethane

1-Chloro-1,1,2,2,2-pentafluoro-ethane

C2ClF5 (153.960869)

Aerating agent for foamed or sprayed food products Chloropentafluoroethane is a chlorofluorocarbon once used as a refrigerant. Its production and consumption has been banned since 1 January 1996 under the Montreal Protocol because of its ozone-depleting potential

2,4,6-Trithiaheptane

(Methylsulphanyl)({[(methylsulphanyl)methyl]sulphanyl})methane

2,4,6-Trithiaheptane is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]")

Ethyl (methylthio)methyl disulfide

{[(methylsulphanyl)methyl]disulphanyl}ethane

Ethyl (methylthio)methyl disulfide is found in fruits. Ethyl (methylthio)methyl disulfide is a constituent of the fruit of Durio zibethinus (durian). Constituent of the fruit of Durio zibethinus (durian). Ethyl (methylthio)methyl disulfide is found in fruits.

Diethyl trisulfide

1,3-Diethyltrisulfane

Cystine thermal degradation product. Aroma constituent of salted pork, cooked beef and durian fruit (Durio zibethinus). Diethyl trisulfide is found in animal foods and fruits. Diethyl trisulfide is found in animal foods. Cystine thermal degradation product. Aroma constituent of salted pork, cooked beef and durian fruit (Durio zibethinus).

1-(2-Thienyl)-1,2-propanedione

1-(thiophen-2-yl)propane-1,2-dione

C7H6O2S (154.0088496)

1-(2-Thienyl)-1,2-propanedione is a flavouring ingredient. 1-(2-Thienyl)-1,2-propanedione is a component of flavourants produced by reaction of H2S and glucose. Flavouring ingredient. Component of flavourants produced by reaction of H2S and glucose

1,1'-Thiobisethanethiol

1-[(1-Sulphanylethyl)sulphanyl]ethane-1-thiol

1,1-Thiobisethanethiol is found in animal foods. 1,1-Thiobisethanethiol is a volatile constituent of cooked mutton. Volatile constituent of cooked mutton. 1,1-Thiobisethanethiol is found in animal foods.

(2R,3S)-3,4-DImercaptobutane-1,2-diol

2-Hydroxyethyl disulfide

2-[(2-hydroxyethyl)disulfanyl]ethan-1-ol

2-Phosphonopropionic acid

2-PHOSPHONOPROPIONIC ACID

3,3-Bis(chloromethyl)oxetane

C5H8Cl2O (153.99521779999998)

4-Mercaptobenzoic acid

4-Sulphanylbenzoic acid

C7H6O2S (154.0088496)

Dithioerythritol

DL-Threo-1,4-dimercapto-2,3-butanediol