Exact Mass: 151.0036196
Exact Mass Matches: 151.0036196
Found 333 metabolites which its exact mass value is equals to given mass value 151.0036196,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Guanine
Guanine is one of the five main nucleobases found in the nucleic acids DNA and RNA. Guanine is a derivative of purine, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Being unsaturated, the bicyclic molecule is planar. The guanine nucleoside is called guanosine. The first isolation of guanine was reported in 1844 from the excreta of sea birds, known as guano, which was used as a source of fertilizer. High affinity binding of guanine nucleotides and the ability to hydrolyze bound GTP to GDP are characteristics of an extended family of intracellular proteins. Guanine nucleotide-binding regulatory proteins may be involved in the activation of phospholipases C and A2 by hormones and other ligands. The binding of hormones to receptors that activate phospholipase C is decreased by guanine nucleotides and these hormones also stimulate a high-affinity GTPase activity in cell membranes. Effects of hormones on phospholipase C activity in cell-free preparations are dependent on the presence of guanine nucleotides. Hypoxanthine-guanine phosphoribosyltransferase (HPRT, EC 2.4.2.8) is a purine salvage enzyme that catalyses the conversion of hypoxanthine and guanine to their respective mononucleotides. Partial deficiency of this enzyme can result in the overproduction of uric acid leading to a severe form of gout, whilst a virtual absence of HPRT activity causes the Lesch-Nyhan syndrome, an inborn error of metabolism, which is characterised by hyperuricaemia, mental retardation, choreoathetosis and compulsive self-mutilation. Peroxynitrite induces DNA base damage predominantly at guanine (G) and 8-oxoguanine (8-oxoG) nucleobases via oxidation reactions. G and 8-oxoG are the most reactive bases toward Peroxynitrite and possibly the major contributors to peroxynitrite-derived genotoxic and mutagenic lesions. The neutral G radical, reacts with NO2 to yield 8-nitroguanine and 5-nitro-4-guanidinohydantoin (PMID: 16352449, 2435586, 2838362, 1487231). Guanine is a 2-aminopurine carrying a 6-oxo substituent. It has a role as a human metabolite, an algal metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purine nucleobase, an oxopurine and a member of 2-aminopurines. It derives from a hydride of a 9H-purine. Guanine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). Guanine is a natural product found in Fritillaria thunbergii, Isatis tinctoria, and other organisms with data available. Guanine is a purine base that is a constituent of nucleotides occurring in nucleic acids. Guanine is a mineral with formula of C5H3(NH2)N4O. The corresponding IMA (International Mineralogical Association) number is IMA1973-056. The IMA symbol is Gni. Guanine is a metabolite found in or produced by Saccharomyces cerevisiae. Occurs widely in animals and plants. Component of nucleic acids (CCD) A 2-aminopurine carrying a 6-oxo substituent. COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS [Spectral] Guanine (exact mass = 151.04941) and 3,4-Dihydroxy-L-phenylalanine (exact mass = 197.06881) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions. [Spectral] Guanine (exact mass = 151.04941) and D-Gluconic acid (exact mass = 196.0583) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions. [Spectral] Guanine (exact mass = 151.04941) and L-Valine (exact mass = 117.07898) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions. Acquisition and generation of the data is financially supported in part by CREST/JST. CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 54 CONFIDENCE standard compound; ML_ID 43
2-Hydroxyadenine
2-Hydroxyadenine (2-OH-Ade) is formed by hydroxyl radical attack on DNA bases and shows a genotoxicity in human, being the source of the mutations induced by reactive oxygen species. 2-OH-Ade in DNA is miscoding and elicits various mutations, and is a mutagenic in bacterial and mammalian cells. (Recent Research Developments in Biochemistry (2000)2:41-50) [HMDB] 2-Hydroxyadenine (2-OH-Ade) is formed by hydroxyl radical attack on DNA bases and shows a genotoxicity in human, being the source of the mutations induced by reactive oxygen species. 2-OH-Ade in DNA is miscoding and elicits various mutations, and is a mutagenic in bacterial and mammalian cells. (Recent Research Developments in Biochemistry (2000)2:41-50). Isoguanine is an oxopurine that is 3,7-dihydro-purin-2-one in which the hydrogen at position 6 is substituted by an amino group.
1,2-Benzisothiazol-3(2H)-one
Industrial biocide. 1,2-Benzisothiazol-3(2H)-one is present in can-end cement D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors Industrial biocide. Present in can-end cements D000890 - Anti-Infective Agents D004202 - Disinfectants
S-methylcysteine sulfoxide
(s)c(s)s-s-methylcysteine sulfoxide, also known as methiin, (dl-ala)-isomer or kale anemia factor, is a member of the class of compounds known as alpha amino acids. Alpha amino acids are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon) (s)c(s)s-s-methylcysteine sulfoxide is soluble (in water) and a moderately acidic compound (based on its pKa). (s)c(s)s-s-methylcysteine sulfoxide can be found in brassicas, garden onion, and onion-family vegetables, which makes (s)c(s)s-s-methylcysteine sulfoxide a potential biomarker for the consumption of these food products. (S)C(S)S-S-Methylcysteine sulfoxide is found in brassicas. (S)C(S)S-S-Methylcysteine sulfoxide is a constituent of onion (Allium cepa), other Allium species and Brassica species. Potential nutriceutical
4-Thiocyanatophenol
4-Thiocyanatophenol is found in fruits. 4-Thiocyanatophenol is a constituent of cucumber root. Constituent of cucumber root. 4-Thiocyanatophenol is found in fruits.
8-Hydroxyadenine
8-hydroxyadenine is an intermediate in the oxidation of adenine to 2,8-dihydroxyadenine by xanthine oxidase (EC 1.1.3.22). A controversy exists as to whether or not this metabolite is a marker of DNA damage. Several papers have reported an artifactual formation of a number of modified bases from intact DNA bases during derivatization of DNA hydrolysates to be analyzed by gas chromatography-mass spectrometry (GC/MS). These reports dealt with 8-hydroxyadenine (8-OH). It needs to be emphasized that the procedures for hydrolysis of DNA and derivatization of DNA hydrolysates used in these papers substantially differed from the established procedures previously described. Furthermore, a large number of relevant papers reporting the levels of these modified bases in DNA of various sources have been ignored. Interestingly, the levels of modified bases reported in the literature were not as high as those reported prior to prepurification. Levels of 8-OH-Ade were quite close to, or even the same as, or smaller than the level reported after prepurification. All these facts raise the question of the validity of the claims about the measurement of these modified DNA bases by GC/MS. Oxidative damage to DNA may play an important role in aging and neurodegenerative diseases such as Alzheimers disease (AD). Attack on DNA by reactive oxygen species, particularly hydroxyl radicals, can lead to strand breaks, DNA-DNA and DNA-protein cross-linking, sister chromatid exchange and translocation, and formation of at least 20 oxidized base adducts. Modification of DNA bases can lead to mutation and altered protein synthesis. In late-stage AD brain, several studies have shown an elevation of the base adducts 8-hydroxyadenine (8-OHA). Several studies have shown a decline in repair of 8-OHG in AD. Most recently studies have shown elevated 8-OHA in nuclear and mitochondrial DNA in mild cognitive impairment, the earliest detectable form of AD, suggesting that oxidative damage to DNA is an early event in AD and not a secondary phenomenon. (PMID: 10098459, 17034348) [HMDB] 8-hydroxyadenine is an intermediate in the oxidation of adenine to 2,8-dihydroxyadenine by xanthine oxidase (EC 1.1.3.22). A controversy exists as to whether or not this metabolite is a marker of DNA damage. Several papers have reported an artifactual formation of a number of modified bases from intact DNA bases during derivatization of DNA hydrolysates to be analyzed by gas chromatography-mass spectrometry (GC/MS). These reports dealt with 8-hydroxyadenine (8-OH). It needs to be emphasized that the procedures for hydrolysis of DNA and derivatization of DNA hydrolysates used in these papers substantially differed from the established procedures previously described. Furthermore, a large number of relevant papers reporting the levels of these modified bases in DNA of various sources have been ignored. Interestingly, the levels of modified bases reported in the literature were not as high as those reported prior to prepurification. Levels of 8-OH-Ade were quite close to, or even the same as, or smaller than the level reported after prepurification. All these facts raise the question of the validity of the claims about the measurement of these modified DNA bases by GC/MS. Oxidative damage to DNA may play an important role in aging and neurodegenerative diseases such as Alzheimers disease (AD). Attack on DNA by reactive oxygen species, particularly hydroxyl radicals, can lead to strand breaks, DNA-DNA and DNA-protein cross-linking, sister chromatid exchange and translocation, and formation of at least 20 oxidized base adducts. Modification of DNA bases can lead to mutation and altered protein synthesis. In late-stage AD brain, several studies have shown an elevation of the base adducts 8-hydroxyadenine (8-OHA). Several studies have shown a decline in repair of 8-OHG in AD. Most recently studies have shown elevated 8-OHA in nuclear and mitochondrial DNA in mild cognitive impairment, the earliest detectable form of AD, suggesting that oxidative damage to DNA is an early event in AD and not a secondary phenomenon. (PMID: 10098459, 17034348).
benzothiazolinone
CONFIDENCE standard compound; INTERNAL_ID 4059 CONFIDENCE standard compound; EAWAG_UCHEM_ID 3375
Benzisothiazolone
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors D000890 - Anti-Infective Agents D004202 - Disinfectants CONFIDENCE standard compound; INTERNAL_ID 330; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3188; ORIGINAL_PRECURSOR_SCAN_NO 3185 CONFIDENCE standard compound; INTERNAL_ID 330; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3184; ORIGINAL_PRECURSOR_SCAN_NO 3180 CONFIDENCE standard compound; INTERNAL_ID 330; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3180; ORIGINAL_PRECURSOR_SCAN_NO 3177 CONFIDENCE standard compound; INTERNAL_ID 330; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3256; ORIGINAL_PRECURSOR_SCAN_NO 3253 CONFIDENCE standard compound; INTERNAL_ID 330; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3187; ORIGINAL_PRECURSOR_SCAN_NO 3183 CONFIDENCE standard compound; INTERNAL_ID 330; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6732; ORIGINAL_PRECURSOR_SCAN_NO 6728 CONFIDENCE standard compound; INTERNAL_ID 330; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6754; ORIGINAL_PRECURSOR_SCAN_NO 6749 CONFIDENCE standard compound; INTERNAL_ID 330; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6795; ORIGINAL_PRECURSOR_SCAN_NO 6792 CONFIDENCE standard compound; INTERNAL_ID 2862 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 1058 CONFIDENCE standard compound; EAWAG_UCHEM_ID 301
Guanine
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; UYTPUPDQBNUYGX_STSL_0161_Guanine_0125fmol_180430_S2_LC02_MS02_179; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I. MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
2-Hydroxybenzothiazole
Benzothiazole substituted with a hydroxy group at the 2-position. CONFIDENCE standard compound; INTERNAL_ID 8712
8-Hydroxyadenine
A nucleobase analogue that is adenine bearing a single hydroxy substituent at position 8.
Proxan
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors D000890 - Anti-Infective Agents D004202 - Disinfectants
1H-Imidazole-5-carboxylicacid,4-cyano-1-methyl-(9CI)
1H-Imidazole-4-carboxylicacid,5-cyano-1-methyl-(9CI)
1H-Imidazole-4-carboxylicacid,5-cyano-,methylester(9CI)
4-Thiazolamine,2,5-dihydro-2-imino-, hydrochloride (1:1)
Pyrimido[5,4-e]-1,2,4-triazin-5-ol, 1,5-dihydro- (9CI)
5,7A-DIHYDRO-3H-IMIDAZO[1,2-B]PYRAZOLE-2-CARBOXYLIC ACID
Cyanamide, (6-amino-1,4-dihydro-4-oxo-2-pyrimidinyl)-
Methylisothiazolinone hydrochloride
C4H6ClNOS (150.98586160000002)
1-aminocyclobutane-1-carboxylic acid hydrochloride
THIAZOL-2-YLMETHANOL HYDROCHLORIDE
C4H6ClNOS (150.98586160000002)
O-(2,2,2-Trifluoroethyl)hydroxylamine hydrochloride
C2H5ClF3NO (151.00117459999998)
6H-Pyrazolo[3,4-d]pyrimidin-6-one,4-amino-1,7-dihydro-
3-aminocyclobutane-1-carboxylic acid hydrochloride
6-METHYL[1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZIN-7(8H)-ONE
6-hydroxy-1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one
1,2-dihydropyridazine-3,6-dione, monopotassium salt
1,4-DIHYDRO-PYRROLO[3,2-C]PYRAZOLE-5-CARBOXYLIC ACID
1,4-Cyclohexadiene-1-carboxylicacid,3-imino-6-oxo-(9CI)
1,2,3-Thiadiazole-5-carboxaldehyde, oxime, sodium salt
C3H2N3NaOS (150.98162820000002)
Thieno[2,3-c]pyridine, 2,3-dihydro-7-methyl- (9CI)
2-Pyrrolidinone,3,3-difluoro-5-(hydroxymethyl)-,(5S)-(9CI)
1-Aminocyclopropane-1-carboxylic acid ethyl ester hydrochloride
(S)-AZETIDINE-2-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
(2-Amino-6-oxo-1,6-dihydropyrimidin-4-yl)cyanamide
1-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
[1,2,4]Triazolo[1,5-a]pyrimidin-5(1H)-one,7-amino-
2-Methoxybenzoate
D000893 - Anti-Inflammatory Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D012459 - Salicylates
4-Methoxybenzoate
A methoxybenzoate that is the conjugate base of 4-methoxybenzoic acid.
Phenoxyacetate
A monocarboxylic acid anion that is the conjugate base of phenoxyacetic acid.
4-hydroxyphenylacetate
A monocarboxylic acid anion that is obtained by removal of a proton from the carboxylic acid group of 4-hydroxyphenylacetic acid.
(2-Hydroxyphenyl)acetate
The monocarboxylic acid anion formed from (2-hydroxyphenyl)acetic acid by loss of a proton from the carboxy group; major microspecies at pH 7.3.
6-Methylsalicylate
A hydroxybenzoate that is obtained by removal of a proton from the carboxylic acid group of 6-methylsalicylic acid.
3-Methoxybenzoate
A methoxybenzoate that is the conjugate base of 3-methoxybenzoic acid resulting from the deprotonation of the carboxy group; major species at pH 7.3.
3-Hydroxyphenylacetate
A hydroxy monocarboxylic acid anion that is the conjugate base of 3-hydroxyphenylacetic acid; major species at pH 7.3.
3-sulfinato-L-alaninate(2-)
COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
2-{[Amino(iminio)methyl]amino}ethanesulfinate
C3H9N3O2S (151.04154540000002)
8-Oxoadenine
An oxopurine that is adenine bearing a single oxo substituent at position 8.
3-sulfinato-L-alaninate(2-)
Dianion of 3-sulfino-L-alanine arising from deprotonation of carboxy and sulfinate groups.