1-(2-Chloroethyl)-1-nitrosourea (BioDeep_00000172103)

   

human metabolite blood metabolite


代谢物信息卡片


1-(2-Chloroethyl)-1-nitrosourea

化学式: C3H6ClN3O2 (151.0148526)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 75%

分子结构信息

SMILES: C(CCl)N(C(=O)N)N=O
InChI: InChI=1S/C3H6ClN3O2/c4-1-2-7(6-9)3(5)8/h1-2H2,(H2,5,8)

描述信息

同义名列表

3 个代谢物同义名

1-(2-Chloroethyl)-1-nitrosourea; N-2-Chloroethylnitrosourea; CNU



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • A Sen, K K Goswami, A Mallick, A K Saxena, U Sanyal, R Baral. In vitro and in vivo evaluation of 2-chloroethylnitrosourea derivatives as antitumor agents. Experimental oncology. 2015 Mar; 37(1):23-9. doi: 10.31768/2312-8852.2015.37(1):23-29. [PMID: 25804227]
  • Thomas Galbo, Grith Skytte Olsen, Bjørn Quistorff, Erica Nishimura. Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism. PloS one. 2011; 6(11):e27424. doi: 10.1371/journal.pone.0027424. [PMID: 22087313]
  • Jiye A, Sixuan Qian, Guangji Wang, Bei Yan, Sujiang Zhang, Qing Huang, Lingna Ni, Weibin Zha, Linsheng Liu, Bei Cao, Ming Hong, Hanxin Wu, Hua Lu, Jian Shi, Mengjie Li, Jianyong Li. Chronic myeloid leukemia patients sensitive and resistant to imatinib treatment show different metabolic responses. PloS one. 2010 Oct; 5(10):e13186. doi: 10.1371/journal.pone.0013186. [PMID: 20949032]
  • Xavier Durando, Emilie Thivat, Marie-Chantal Farges, Eric Cellarier, Michel D'Incan, Aïcha Demidem, Marie-Paule Vasson, Chantal Barthomeuf, Philippe Chollet. Optimal methionine-free diet duration for nitrourea treatment: a Phase I clinical trial. Nutrition and cancer. 2008; 60(1):23-30. doi: 10.1080/01635580701525877. [PMID: 18444132]
  • Aicha Demidem, Daniel Morvan, Jean Claude Madelmont. Bystander effects are induced by CENU treatment and associated with altered protein secretory activity of treated tumor cells: a relay for chemotherapy?. International journal of cancer. 2006 Sep; 119(5):992-1004. doi: 10.1002/ijc.21761. [PMID: 16557598]
  • Mepur H Ravindranath, Sakunthala Muthugounder, Naftali Presser, Subramanian Viswanathan. Anticancer therapeutic potential of soy isoflavone, genistein. Advances in experimental medicine and biology. 2004; 546(?):121-65. doi: 10.1007/978-1-4757-4820-8_11. [PMID: 15584372]
  • L Panasci, S F Stinson, D Melnychuk, V Sandor, W H Miller, G Batist, F Patenaude, N Bangash, L Panarello, M Alaoui-Jamali, E Sausville. SarCNU, a nitrosourea analog on a day 1, 5, and 9 oral schedule: a phase I and pharmacokinetic study in patients with advanced solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2003 Jan; 21(2):232-40. doi: 10.1200/jco.2003.03.047. [PMID: 12525514]
  • S Samanta, A Pain, S Dutta, U Sanyal. Evaluation of naphthal-NU, a 2-chloroethylnitrosourea derivative of naphthalimide, as a mixed-function anticancer agent. Journal of experimental & clinical cancer research : CR. 2002 Mar; 21(1):87-93. doi: NULL. [PMID: 12071535]
  • P E Kintzel. Anticancer drug-induced kidney disorders. Drug safety. 2001 Jan; 24(1):19-38. doi: 10.2165/00002018-200124010-00003. [PMID: 11219485]
  • P M Loadman, A M Matthew, J E McCormick, R S McElhinney, M C Bibby. Pharmacokinetics and anti-tumour activity of B.4152, a reactive molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, and its uracil analogue. Anti-cancer drug design. 1996 Mar; 11(2):117-28. doi: NULL. [PMID: 8630185]
  • M R Davis, K Kassahun, C M Jochheim, K M Brandt, T A Baillie. Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro. Chemical research in toxicology. 1993 May; 6(3):376-83. doi: 10.1021/tx00033a020. [PMID: 8318660]
  • J E McCormick, R S McElhinney. Nitrosoureas from chemist to physician: classification and recent approaches to drug design. European journal of cancer (Oxford, England : 1990). 1990 Mar; 26(3):207-21. doi: 10.1016/0277-5379(90)90214-e. [PMID: 2141478]
  • G Eisenbrand, N Müller, E Denkel, W Sterzel. DNA adducts and DNA damage by antineoplastic and carcinogenic N-nitrosocompounds. Journal of cancer research and clinical oncology. 1986; 112(3):196-204. doi: 10.1007/bf00395912. [PMID: 3536942]
  • T Galeotti, S Borrello, G Minotti, G Palombini, L Masotti, G Sartor, P Cavatorta, A Arcioni, C Zannoni. Lipid composition, physical state, and lipid peroxidation of tumor membranes. Toxicologic pathology. 1984; 12(4):324-30. doi: 10.1177/019262338401200404. [PMID: 6099910]
  • H E Kann. Comparison of biochemical and biological effects of four nitrosoureas with differing carbamoylating activities. Cancer research. 1978 Aug; 38(8):2363-6. doi: NULL. [PMID: 149589]