Exact Mass: 143.0521
Exact Mass Matches: 143.0521
Found 192 metabolites which its exact mass value is equals to given mass value 143.0521,
within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error
0.001 dalton.
Vinylacetylglycine
Vinylacetylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:. acyl-CoA + glycine < -- > CoA + N-acylglycine. Vinylacetylglycine is a human metabolite that had been identified in a GC/MS urine screen. Increased amounts of this metabolite in the urine has been linked to a metabolomic disorder termed Isovaleric acidemia. (Gas-Chromatographic Method of Analysis for Urinary Organic Acids. I. Retention indices of 155 metaboically Important Compounds; Kay Tanaka, David G. Hine, Agnes West-Dull, and Theodore B. Lynn.). Vinylacetylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:
Trimethadione
Trimethadione is only found in individuals that have used or taken this drug. It is an anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)Trimethadione reduces T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened. N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AC - Oxazolidine derivatives C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
5-ethyl-5-methyl-2,4-oxazolidinedione
5-ethyl-5-methyl-2,4-oxazolidinedione is a metabolite of paramethadione. Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome. (Wikipedia)
6-oxopiperidine-2-carboxylate
6-Oxopiperidine-2-carboxylic acid, also known as 6-Oxo-pipecolinic acid, or 6-Oxo-piperidine-2-carboxylic acid, is associated with penicillin V in the production on Penicillium chrysogenum fermentations. Analysis of a 13C NMR spectrum of a concentrated broth from Penicillium chrysogenum fermentation revealed the presence of penicillin V and 6-oxo-piperidine-2-carboxylic acid(1) as the principal constituents. The latter lactam, identical to an authentic sample prepared by the cyclization of alpha-aminoadipic acid was present to the extent of 28 mol\\% of penicillin V. The lactam isolated form the broth was nearly racemic, having a slight excess of the L-isomer. This isolation provides further evidence regarding the biosynthetic precursors of the hydrophobic penicillins. (PMID: 6788737
(1S,4R)-1,4-dihydroxy-2-cyclopentene-1-carboxamide|rel-(1S,4R)-1,4-dihdyroxy-2-cyclopentenecarboxamide
(2S,3R)-2-Amino-3-hydroxy-4-hexynoic acid|2-Amino-3-hydroxy-4-hexynoic acid|L-threo-2-Amino-3-hydroxyhex-4-insaeure
1,2,3,6-Tetrahydro-3-hydroxy-2-pyridinecarboxylic acid
Trimethadione
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AC - Oxazolidine derivatives C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
N-methyl-1-(4-methyl-1,2,3-thiadiazol-5-yl)methanamine
methyl 2-methyl-4,5-dihydro-1,3-oxazole-4-carboxylate
3H-1,2,4-Triazole-3-thione,1,2-dihydro-5-propyl-(9CI)
(3-OXO-2-PENTYL-CYCLOPENTYL)-ACETICACIDMETHYLESTER
Cyclopropanecarboxylic acid, 2-[(methylamino)carbonyl]- (9CI)
(S)-4-METHYL-2,2,2-TRIPHENYL-2LAMBDA5-[1,3,2]DIOXAPHOSPHOLANE
4-AMINO-N-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXIMIDAMIDE
4-Isothioureidobutyronitrile
C274 - Antineoplastic Agent > C129839 - Apoptotic Pathway-targeting Antineoplastic Agent
5-Ethyl-5-methyl-1,3-oxazolidine-2,4-dione
An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by a methyl and ethyl group at position 5. It is a metabolite of paramethadione.
6-ketopiperidine-2-carboxylic acid
A delta-lactam that is piperidine-2-carboxylic acid substituted at position 6 by an oxo group.
