Trimethadione (BioDeep_00000033223)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
trimethyl-1,3-oxazolidine-2,4-dione
化学式: C6H9NO3 (143.0582404)
中文名称: 3,5,5,-三甲基恶唑烷-2,4-二酮, 甲氧苄啶
谱图信息:
最多检出来源 Homo sapiens(blood) 41.37%
分子结构信息
SMILES: CC1(C(=O)N(C(=O)O1)C)C
InChI: InChI=1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3
描述信息
Trimethadione is only found in individuals that have used or taken this drug. It is an anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)Trimethadione reduces T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AC - Oxazolidine derivatives
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:9727
- PubChem: 5576
- HMDB: HMDB0014491
- DrugBank: DB00347
- ChEMBL: CHEMBL695
- Wikipedia: Trimethadione
- MeSH: Trimethadione
- chemspider: 5374
- CAS: 127-48-0
- RefMet: Trimethadione
分类词条
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
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- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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