2-Methyl-4-(pyridin-3-ylethynyl)thiazole (BioDeep_00000181132)

   

human metabolite blood metabolite


代谢物信息卡片


3-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine

化学式: C11H8N2S (200.0408168)
中文名称: 3-[(2-甲基-1,3-噻唑-4-基)乙炔基]吡啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=NC(=CS1)C#CC1=CN=CC=C1
InChI: InChI=1S/C11H8N2S/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10/h2-3,6-8H,1H3

描述信息

同义名列表

5 个代谢物同义名

3-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine; 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine; 2-Methyl-4-(pyridin-3-ylethynyl)thiazole; MTEP compound; MTEP



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaotao Xu, Kaixuan Wu, Xiaqing Ma, Wenying Wang, Haiyan Wang, Min Huang, Limin Luo, Chen Su, Tifei Yuan, Haibo Shi, Ji Han, Aizhong Wang, Tao Xu. mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress. Molecular neurobiology. 2021 Oct; 58(10):4944-4958. doi: 10.1007/s12035-021-02469-9. [PMID: 34227060]
  • Carla L Busceti, Roxana P Ginerete, Luisa Di Menna, Giovanna D'Errico, Francesca Cisani, Paola Di Pietro, Tiziana Imbriglio, Valeria Bruno, Giuseppe Battaglia, Francesco Fornai, James A Monn, Anna Pittaluga, Ferdinando Nicoletti. Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice. Neuropharmacology. 2021 09; 196(?):108692. doi: 10.1016/j.neuropharm.2021.108692. [PMID: 34217776]
  • K Gawel, M Jenda-Wojtanowska, E Gibula-Bruzda, E Kedzierska, J Filarowska, M Marszalek-Grabska, K K Wojtanowski, L Komsta, S Talarek, J H Kotlinska. The influence of AMN082, metabotropic glutamate receptor 7 (mGlu7) allosteric agonist on the acute and chronic antinociceptive effects of morphine in the tail-immersion test in mice: Comparison with mGlu5 and mGlu2/3 ligands. Physiology & behavior. 2018 03; 185(?):112-120. doi: 10.1016/j.physbeh.2017.12.035. [PMID: 29294304]
  • Jens Nagel, Sergio Greco, Chris G Parsons, Gunnar Flik, Carsten Tober, Kai-Uwe Klein, Wojciech Danysz. Brain concentrations of mGluR5 negative allosteric modulator MTEP in relation to receptor occupancy--Comparison to MPEP. Pharmacological reports : PR. 2015 Jun; 67(3):624-30. doi: 10.1016/j.pharep.2015.01.004. [PMID: 25933979]
  • Milo Careaga, Tamanna Noyon, Kirin Basuta, Judy Van de Water, Flora Tassone, Randi J Hagerman, Paul Ashwood. Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome. Journal of neuroinflammation. 2014 Jun; 11(?):110. doi: 10.1186/1742-2094-11-110. [PMID: 24942544]
  • Fabiola M Ribeiro, Rebecca A Devries, Alison Hamilton, Isabella M Guimaraes, Sean P Cregan, Rita G W Pires, Stephen S G Ferguson. Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease. Human molecular genetics. 2014 Apr; 23(8):2030-42. doi: 10.1093/hmg/ddt598. [PMID: 24282028]
  • Tom H Johnston, Susan H Fox, Matthew J McIldowie, Matthew J Piggott, Jonathan M Brotchie. Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. The Journal of pharmacology and experimental therapeutics. 2010 Jun; 333(3):865-73. doi: 10.1124/jpet.110.166629. [PMID: 20231306]
  • Hwei-Hsien Chen, Astrid Stoker, Athina Markou. The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice. Psychopharmacology. 2010 May; 209(4):343-50. doi: 10.1007/s00213-010-1802-2. [PMID: 20217053]
  • Youmin Hu, Li Dong, Biying Sun, Marlene A Guillon, Leah R Burbach, Philip A Nunn, Xingrong Liu, Olga Vilenski, Anthony P D W Ford, Yu Zhong, Weifang Rong. The role of metabotropic glutamate receptor mGlu5 in control of micturition and bladder nociception. Neuroscience letters. 2009 Jan; 450(1):12-7. doi: 10.1016/j.neulet.2008.11.026. [PMID: 19027050]
  • Fabrice G Siméon, Amira K Brown, Sami S Zoghbi, Velvet M Patterson, Robert B Innis, Victor W Pike. Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography. Journal of medicinal chemistry. 2007 Jul; 50(14):3256-66. doi: 10.1021/jm0701268. [PMID: 17571866]
  • Margaret J Bradbury, Una Campbell, Darlene Giracello, Deborah Chapman, Chris King, Lida Tehrani, Nicholas D P Cosford, Jeff Anderson, Mark A Varney, Alison M Strack. Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. The Journal of pharmacology and experimental therapeutics. 2005 Apr; 313(1):395-402. doi: 10.1124/jpet.104.076406. [PMID: 15590770]
  • Jeffery J Anderson, Margaret J Bradbury, Darlene R Giracello, Deborah F Chapman, Greg Holtz, Jeffrey Roppe, Chris King, Nicholas D P Cosford, Mark A Varney. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). European journal of pharmacology. 2003 Jul; 473(1):35-40. doi: 10.1016/s0014-2999(03)01935-6. [PMID: 12877935]