Famotidine (BioDeep_00000017989)
human metabolite blood metabolite
代谢物信息卡片
3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N-sulfamoylpropanimidamide
化学式: C8H15N7O2S3 (337.044933)
中文名称: 法莫替丁
谱图信息:
最多检出来源 Homo sapiens(blood) 0.58%
分子结构信息
SMILES: C(CSCc1csc(n1)N=C(N)N)/C(=N/S(=O)(=O)N)/N
InChI: InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
描述信息
Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD). It is commonly marketed by Merck under the trade names Pepcidine and Pepcid. [HMDB]
Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD). It is commonly marketed by Merck under the trade names Pepcidine and Pepcid.
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BA - H2-receptor antagonists
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
同义名列表
93 个代谢物同义名
3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N-sulfamoylpropanimidamide; 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulphonyl)propanimidamide; 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide; (1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulphamide; (1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamide; N-Sulphamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamide; N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamide; Famotidine hydrochloride; Pepcidin pepcidine; Novo-famotidine; Apo-famotidine; Gastrodomina; Gastrosidin; Famotidinum; Apogastine; Mylanta ar; famotidine; Famotidina; Gastrofam; Gastridan; Neocidine; Gastropen; Renapepsa; Bestidine; Gastridin; Huberdina; Famodine; Vagostal; Famopsin; Rubacina; Ulceprax; Nulcerin; Confobos; Gastrion; Pepcidin; Peptidin; Pepfamin; Nulceran; Famogard; Blocacid; Ingastri; Quamatel; Ulgarine; Restadin; Antodine; Famovane; Ulfinol; Pepdine; Nevofam; Lecedil; Midefam; Ulfagel; Invigan; Famowal; Cuantin; Mensoma; Tipodex; Famotep; Ulcofam; Purifam; Famotin; Famodin; Famodil; Quamtel; Amfamox; Famodar; Famotal; Famonit; Rogasti; Famosan; Ulfamid; Panalba; Famocid; Notidin; Ulcatif; Cronol; Gastro; Motiax; Topcid; Brolin; Muclox; Peptan; Fluxid; Pepdul; Pepcid; Hacip; Cepal; Tamin; Logos; Ulfam; Mosul; Famos; MK-208
数据库引用编号
11 个数据库交叉引用编号
- PubChem: 3325
- HMDB: HMDB0001919
- DrugBank: DB00927
- Wikipedia: Famotidine
- MeSH: Famotidine
- foodb: FDB022737
- chemspider: 3208
- CAS: 76824-35-6
- PMhub: MS000001561
- RefMet: Famotidine
- medchemexpress: HY-B0377
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rajalakshmi Munusamy, Sangeetha Shanmugasundharam. Improved gastric residence time of famotidine by raft-forming drug delivery system using DOE.
International journal of immunopathology and pharmacology.
2024 Jan; 38(?):3946320241249429. doi:
10.1177/03946320241249429. [PMID: 38721971] - Juan C Durán-Álvarez, Blanca Prado, Rodolfo Zanella, Mario Rodríguez, Suhaila Díaz. Wastewater surveillance of pharmaceuticals during the COVID-19 pandemic in Mexico City and the Mezquital Valley: A comprehensive environmental risk assessment.
The Science of the total environment.
2023 Nov; 900(?):165886. doi:
10.1016/j.scitotenv.2023.165886. [PMID: 37524191] - Mona F Mahmoud, Walied Abdo, Mohamed Nabil, Badreddine Drissi, Assem M El-Shazly, Mohamed A O Abdelfattah, Mansour Sobeh. Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Feb; 160(?):114331. doi:
10.1016/j.biopha.2023.114331. [PMID: 36736281] - Ahmed A Ishola, Tanuja Joshi, Suliat I Abdulai, Habibu Tijjani, Hemlata Pundir, Subhash Chandra. Molecular basis for the repurposing of histamine H2-receptor antagonist to treat COVID-19.
Journal of biomolecular structure & dynamics.
2022 08; 40(13):5785-5802. doi:
10.1080/07391102.2021.1873191. [PMID: 33491579] - Huan Yang, Sam J George, Dane A Thompson, Harold A Silverman, Téa Tsaava, Aisling Tynan, Valentin A Pavlov, Eric H Chang, Ulf Andersson, Michael Brines, Sangeeta S Chavan, Kevin J Tracey. Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm.
Molecular medicine (Cambridge, Mass.).
2022 05; 28(1):57. doi:
10.1186/s10020-022-00483-8. [PMID: 35578169] - Christina M Brennan, Sandeep Nadella, Xiang Zhao, Richard J Dima, Nicole Jordan-Martin, Breanna R Demestichas, Sam O Kleeman, Miriam Ferrer, Eva Carlotta von Gablenz, Nicholas Mourikis, Michael E Rubin, Harsha Adnani, Hassal Lee, Taehoon Ha, Soma Prum, Cheryl B Schleicher, Sharon S Fox, Michael G Ryan, Christina Pili, Gary Goldberg, James M Crawford, Sara Goodwin, Xiaoyue Zhang, Jonathan B Preall, Ana S H Costa, Joseph Conigliaro, Joseph R Masci, Jie Yang, David A Tuveson, Kevin J Tracey, Tobias Janowitz. Oral famotidine versus placebo in non-hospitalised patients with COVID-19: a randomised, double-blind, data-intense, phase 2 clinical trial.
Gut.
2022 05; 71(5):879-888. doi:
10.1136/gutjnl-2022-326952. [PMID: 35144974] - Toshiki Kuno, Matsuo So, Mai Takahashi, Natalia N Egorova. The association between famotidine and in-hospital mortality of patients with COVID-19.
Journal of medical virology.
2022 03; 94(3):1186-1189. doi:
10.1002/jmv.27375. [PMID: 34609001] - Foad Rommasi, Mohammad Javad Nasiri, Mehdi Mirsaeidi. Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology features.
Molecular and cellular biochemistry.
2022 Mar; 477(3):711-726. doi:
10.1007/s11010-021-04325-9. [PMID: 35013850] - Song Ren, Karthick Vishwanathan, Mireille Cantarini, Paul Frewer, Indira Hara, Graeme Scarfe, Wendy Burke, Stein Schalkwijk, Yan Li, David Han, Ronald Goldwater. Clinical evaluation of the potential drug-drug interactions of savolitinib: Interaction with rifampicin, itraconazole, famotidine or midazolam.
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2022 02; 88(2):655-668. doi:
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Journal of biomolecular structure & dynamics.
2021 Sep; 39(14):5327-5333. doi:
10.1080/07391102.2020.1784795. [PMID: 32579065] - Rukmini Mukherjee, Anshu Bhattacharya, Denisa Bojkova, Ahmad Reza Mehdipour, Donghyuk Shin, Khadija Shahed Khan, Hayley Hei-Yin Cheung, Kam-Bo Wong, Wai-Lung Ng, Jindrich Cinatl, Paul P Geurink, Gerbrand J van der Heden van Noort, Krishnaraj Rajalingam, Sandra Ciesek, Gerhard Hummer, Ivan Dikic. Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection.
The Journal of biological chemistry.
2021 08; 297(2):100925. doi:
10.1016/j.jbc.2021.100925. [PMID: 34214498] - Waseem Amjad, Adnan Malik. Famotidine and Hospitalized COVID-19 Patients: Are the Benefits True?.
The American journal of gastroenterology.
2021 07; 116(7):1561. doi:
10.14309/ajg.0000000000001217. [PMID: 34183586] - Santenna Chenchula, Avik Ray, Balakrishnan Sadasivam. Famotidine Repurposing for Novel Corona Virus Disease of 2019: A Systematic Review.
Drug research.
2021 Jul; 71(6):295-301. doi:
10.1055/a-1397-6763. [PMID: 33757133] - Daniel E Freedberg, Timothy C Wang, Julian A Abrams. Famotidine and Coronavirus Disease 2019.
Gastroenterology.
2021 07; 161(1):360-361. doi:
10.1053/j.gastro.2020.12.044. [PMID: 33387529] - Rahul Sethia, Manya Prasad, Pramod Kumar Garg. Famotidine and Mortality in Coronavirus Disease 2019.
Gastroenterology.
2021 07; 161(1):361-362. doi:
10.1053/j.gastro.2020.12.045. [PMID: 33388317] - Faisal Kamal, Muhammad Ali Khan, Sachit Sharma, Zaid Imam, Colin W Howden. Lack of Consistent Associations Between Pharmacologic Gastric Acid Suppression and Adverse Outcomes in Patients With Coronavirus Disease 2019: Meta-Analysis of Observational Studies.
Gastroenterology.
2021 06; 160(7):2588-2590.e7. doi:
10.1053/j.gastro.2021.02.028. [PMID: 33609504] - Carl J Lavie. In Reply-Use of Famotidine and Risk of Severe Course of Illness in Patients With COVID-19: A Meta-analysis.
Mayo Clinic proceedings.
2021 05; 96(5):1367-1368. doi:
10.1016/j.mayocp.2021.03.002. [PMID: 33958066] - Chia Siang Kow, Ismail Abdul Sattar Burud, Syed Shahzad Hasan. Use of Famotidine and Risk of Severe Course of Illness in Patients With COVID-19: A Meta-analysis.
Mayo Clinic proceedings.
2021 05; 96(5):1365-1367. doi:
10.1016/j.mayocp.2021.03.001. [PMID: 33958065] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ka Shing Cheung, Ivan F N Hung, Wai K Leung. Association Between Famotidine Use and COVID-19 Severity in Hong Kong: A Territory-wide Study.
Gastroenterology.
2021 04; 160(5):1898-1899. doi:
10.1053/j.gastro.2020.05.098. [PMID: 32682763] - Tianyi Ma, Meng Wu. Association Between Famotidine Use and Clinical Outcomes in Patients With COVID-19: Assessment of Available Evidence.
The American journal of gastroenterology.
2021 04; 116(4):848-849. doi:
10.14309/ajg.0000000000001008. [PMID: 33982973] - Vijay P Singh, Bara El-Kurdi, Christopher Rood. What Underlies the Benefit of Famotidine Formulations Used During COVID-19?.
Gastroenterology.
2021 04; 160(5):1899-1900. doi:
10.1053/j.gastro.2020.07.051. [PMID: 32777281] - Azza Shoaibi, Stephen Patrick Fortin, Rachel Weinstein, Jesse A Berlin, Patrick Ryan. Comparative Effectiveness of Famotidine in Hospitalized COVID-19 Patients.
The American journal of gastroenterology.
2021 04; 116(4):692-699. doi:
10.14309/ajg.0000000000001153. [PMID: 33982938] - Jeffrey Mather. Response to Ma and Wu.
The American journal of gastroenterology.
2021 04; 116(4):849-850. doi:
10.14309/ajg.0000000000001068. [PMID: 33982974] - Madeline Loffredo, Hector Lucero, Da-Yuan Chen, Aoife O'Connell, Simon Bergqvist, Ahmad Munawar, Asanga Bandara, Steff De Graef, Stephen D Weeks, Florian Douam, Mohsan Saeed, Ali H Munawar. The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication.
Scientific reports.
2021 03; 11(1):5433. doi:
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Gastroenterology.
2021 02; 160(3):919-921.e3. doi:
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PloS one.
2021; 16(11):e0259514. doi:
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Clinical pharmacokinetics.
2016 06; 55(6):711-21. doi:
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Journal of chromatographic science.
2016 Mar; 54(3):419-28. doi:
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Molecular pharmaceutics.
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Journal of pharmacy practice.
2015 Dec; 28(6):529-34. doi:
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Journal of the American Animal Hospital Association.
2015 Nov; 51(6):407-12. doi:
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Bulletin of experimental biology and medicine.
2015 Sep; 159(5):638-41. doi:
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Nephrology (Carlton, Vic.).
2015 Jun; 20(6):438-9. doi:
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Investigational new drugs.
2015 Apr; 33(2):349-56. doi:
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Journal of veterinary internal medicine.
2015 Jan; 29(1):104-12. doi:
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Drug design, development and therapy.
2015; 9(?):2159-69. doi:
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Drug delivery.
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Molecules (Basel, Switzerland).
2014 Sep; 19(9):13909-31. doi:
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Drug delivery.
2014 Sep; 21(6):459-66. doi:
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Journal of veterinary internal medicine.
2014 Sep; 28(5):1465-70. doi:
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Pharmacological reports : PR.
2014 Aug; 66(4):594-9. doi:
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Pharmacological reports : PR.
2014 Jun; 66(3):485-91. doi:
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Cancer biotherapy & radiopharmaceuticals.
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The Cochrane database of systematic reviews.
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Current drug delivery.
2013 Aug; 10(4):444-52. doi:
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Biomedical chromatography : BMC.
2013 Jul; 27(7):866-73. doi:
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Comparative medicine.
2013 Feb; 63(1):71-5. doi:
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Current drug delivery.
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Cancer chemotherapy and pharmacology.
2012 Aug; 70(2):351-2. doi:
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Gut.
2012 Jun; 61(6):804-11. doi:
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Cancer chemotherapy and pharmacology.
2012 Apr; 69(4):999-1004. doi:
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Journal of experimental botany.
2012 Mar; 63(5):2089-103. doi:
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PloS one.
2012; 7(2):e30885. doi:
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Evidence-based complementary and alternative medicine : eCAM.
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International journal of pharmaceutics.
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Journal of veterinary internal medicine.
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AIDS patient care and STDs.
2011 Sep; 25(9):509-15. doi:
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Bulletin of environmental contamination and toxicology.
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Journal of clinical biochemistry and nutrition.
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Indian journal of pharmaceutical sciences.
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G3 (Bethesda, Md.).
2011 Jul; 1(2):151-9. doi:
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Digestive diseases and sciences.
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Cancer biotherapy & radiopharmaceuticals.
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Fundamental & clinical pharmacology.
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Advances in pharmacological sciences.
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PloS one.
2011; 6(5):e19897. doi:
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PloS one.
2011; 6(8):e21268. doi:
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