2-Hydroxy-1-naphthaldehyde (BioDeep_00000173291)

   

human metabolite blood metabolite Antitumor activity


代谢物信息卡片


2-Hydroxy-1-naphthalenecarboxaldehyde

化学式: C11H8O2 (172.0524)
中文名称: 2-羟基-1-萘甲醛, 2-羟基-1-萘醛
谱图信息: 最多检出来源 Homo sapiens(blood) 99.44%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=CC(=C2C=O)O
InChI: InChI=1S/C11H8O2/c12-7-10-9-4-2-1-3-8(9)5-6-11(10)13/h1-7,13H

描述信息

CFL-137 is a potent KRasG12C inhibitor. CFL-137 shows an antiproliferative effect. CFL-137 shows anticancer activity. CFL-137 has the potential for the research of lung cancer[1].

同义名列表

14 个代谢物同义名

2-Hydroxy-1-naphthalenecarboxaldehyde; 1-Hydroxy-2-naphthalenecarboxaldehyde; 2-hydroxynaphthalene-1-carbaldehyde; 2-Hydroxy-1-naphthylaldehyde; 2-Hydroxy-1-naphthalaldehyde; 2-Naphthol 1-carboxaldehyde; 2-Hydroxy-1-naphthaldehyde; beta-Hydroxynaphthaldehyde; 2-Hydroxy-naphthaldehyde; Β-hydroxynaphthaldehyde; b-Hydroxynaphthaldehyde; 1-Formyl-2-naphthol; CFL-137; 2-Hydroxy-1-naphthaldehyde



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Paramasivam Krishnamoorthy, Palanisamy Sathyadevi, Rachel R Butorac, Alan H Cowley, Nattamai S P Bhuvanesh, Nallasamy Dharmaraj. Variation in the biomolecular interactions of nickel(II) hydrazone complexes upon tuning the hydrazide fragment. Dalton transactions (Cambridge, England : 2003). 2012 Jun; 41(22):6842-54. doi: 10.1039/c2dt30121k. [PMID: 22506273]
  • Chien-Wei Hou. Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticus. Journal of biomedical science. 2011 Oct; 18(?):75. doi: 10.1186/1423-0127-18-75. [PMID: 22014163]
  • Palanisamy Sathyadevi, Paramasivam Krishnamoorthy, Rachel R Butorac, Alan H Cowley, Nattamai S P Bhuvanesh, Nallasamy Dharmaraj. Effect of substitution and planarity of the ligand on DNA/BSA interaction, free radical scavenging and cytotoxicity of diamagnetic Ni(II) complexes: a systematic investigation. Dalton transactions (Cambridge, England : 2003). 2011 Oct; 40(38):9690-702. doi: 10.1039/c1dt10767d. [PMID: 21858314]
  • Mary S Kalamaki, Dimitris Alexandrou, Diamanto Lazari, Georgios Merkouropoulos, Vasileios Fotopoulos, Irene Pateraki, Alexandros Aggelis, Armando Carrillo-López, Maria J Rubio-Cabetas, Angelos K Kanellis. Over-expression of a tomato N-acetyl-L-glutamate synthase gene (SlNAGS1) in Arabidopsis thaliana results in high ornithine levels and increased tolerance in salt and drought stresses. Journal of experimental botany. 2009; 60(6):1859-71. doi: 10.1093/jxb/erp072. [PMID: 19357433]
  • Ajay Singh, Maradumane L Mohan, Alfred Orina Isaac, Xiu Luo, Jiri Petrak, Daniel Vyoral, Neena Singh. Prion protein modulates cellular iron uptake: a novel function with implications for prion disease pathogenesis. PloS one. 2009; 4(2):e4468. doi: 10.1371/journal.pone.0004468. [PMID: 19212444]
  • Rupashree Balia Singh, Subrata Mahanta, Nikhil Guchhait. Study of interaction of proton transfer probe 1-hydroxy-2-naphthaldehyde with serum albumins: a spectroscopic study. Journal of photochemistry and photobiology. B, Biology. 2008 Apr; 91(1):1-8. doi: 10.1016/j.jphotobiol.2007.12.006. [PMID: 18296059]
  • P Neyroz, L Franzoni, A Spisni, L Masotti, L Brand. The chemical synthesis of N-[1-(2-naphthol)]-phosphatidylethanolamine, a fluorescent phospholipid for excited-state proton transfer studies. Chemistry and physics of lipids. 1992 May; 61(3):255-63. doi: 10.1016/0009-3084(92)90105-x. [PMID: 1326418]
  • G Nöhammer. The quantification of the histochemical protein staining with 2-hydroxy-1-naphthaldehyde (HNA) demonstrating primary amino groups of proteins. Acta histochemica. 1991; 90(1):5-10. doi: 10.1016/s0065-1281(11)80150-9. [PMID: 2048388]
  • J Mañes, J Mari, R Garcia, G Font. Liquid chromatographic determination of hydralazine in human plasma with 2-hydroxy-1-naphthaldehyde pre-column derivatization. Journal of pharmaceutical and biomedical analysis. 1990; 8(8-12):795-8. doi: 10.1016/0731-7085(90)80123-7. [PMID: 2100625]