Classification Term: 2277
Tetracarboxylic acids and derivatives (ontology term: CHEMONTID:0002966)
Carboxylic acids containing exactly four carboxyl groups." []
found 73 associated metabolites at sub_class
metabolite taxonomy ontology rank level.
Ancestor: Carboxylic acids and derivatives
Child Taxonomies: There is no child term of current ontology term.
Edetic Acid
Edetic Acid is only found in individuals that have used or taken this drug. It is a chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive. [PubChem]The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are not significant. Copper is not mobilized and mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments. The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased. D064449 - Sequestering Agents > D002614 - Chelating Agents > D065096 - Calcium Chelating Agents C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent D000074385 - Food Ingredients > D005503 - Food Additives D006401 - Hematologic Agents > D000925 - Anticoagulants
D-Chicoric acid
D-Chicoric acid is found in green vegetables. D-Chicoric acid is isolated from chicory (Cichorium intybus) and Cichorium endivia (endive). Isolated from chicory (Cichorium intybus) and Cichorium endivia (endive). D-Chicoric acid is found in green vegetables. Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3]. Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3]. L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3]. L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3].
Acevaltrate
Production by Valeriana subspecies Acevaltrate is found in tea, fats and oils, and herbs and spices. Acevaltrate is found in fats and oils. Acevaltrate is produced by Valeriana specie C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively[1]. Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively[1].
Chicoric acid
Chicoric acid (CAS: 6537-80-0) is found in the fresh aerial parts of different chicory varieties: green chicory (c.v. Catalogna), two red chicory varieties (radicchio rosso di Chioggia and radicchio rosso di Treviso), and Witloof or Belgian endive. Cichorium sp. L. is a member of the sunflower family (Asteraceae or Compositae), which also includes globe and Jerusalem artichokes, lettuce, and many ornamental plants. It is indigenous to Europe, western Asia, Egypt, and North America. In popular medicine, Cichorium intybus L. has been used to treat skin disorders, such as gout, because of its antihepatotoxic activity. Animal studies have revealed that preparations from chicory roots can lower serum and liver lipid concentration in rats. Cichorium aqueous extracts from roots and aerial parts have been reported for antibacterial activity. Chicory is used as a vegetable, fresh or cooked, while the ground and roasted roots are widely used for blending with coffee powder (PMID: 16076140). Chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro (PMID: 15302207). D-chicoric acid, also known as D-chicate, belongs to tetracarboxylic acids and derivatives class of compounds. Those are carboxylic acids containing exactly four carboxyl groups. D-chicoric acid is practically insoluble (in water) and a moderately acidic compound (based on its pKa). D-chicoric acid can be found in green vegetables, which makes D-chicoric acid a potential biomarker for the consumption of this food product. Cichoric acid is a hydroxycinnamic acid, an organic compound of the phenylpropanoid class and occurs in a variety of plant species. It is a derivative of both caffeic acid and tartaric acid . Chicoric acid is an organooxygen compound. It has a role as a HIV-1 integrase inhibitor and a geroprotector. It is functionally related to a tetracarboxylic acid. Chicoric acid is a natural product found in Cichorium intybus, Cinnamomum camphora, and other organisms with data available. D004791 - Enzyme Inhibitors > D019429 - Integrase Inhibitors > D019428 - HIV Integrase Inhibitors D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3]. Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3]. L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3]. L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3].
Austin
Austin is a mycotoxin produced by the food storage mould (Aspergillus ustus). These are sesquiterpenes containing a lactone ring. Mycotoxin production by the food storage mould (Aspergillus ustus).
(+)-Chebulic acid
(+)-Chebulic acid is found in fruits. (+)-Chebulic acid is isolated from Phyllanthus emblica (emblic). Isolated from Phyllanthus emblica (emblic). (+)-Chebulic acid is found in fruits.
2-O-Feruloylhydroxycitric acid
2-O-Feruloylhydroxycitric acid is found in cereals and cereal products. 2-O-Feruloylhydroxycitric acid is a constituent of Zea mays (sweet corn). Constituent of Zea mays (sweet corn). 2-O-Feruloylhydroxycitric acid is found in cereals and cereal products, fats and oils, and corn.
1,2',3,5-Tetra-O-galloylhamamelofuranose
1,2,3,5-Tetra-O-galloylhamamelofuranose is found in nuts. 1,2,3,5-Tetra-O-galloylhamamelofuranose is isolated from the bark of Castanea crenata (Japanese chestnut). Isolated from the bark of Castanea crenata (Japanese chestnut). 1,2,3,5-Tetra-O-galloylhamamelofuranose is found in nuts.
Sandoricin
Sandoricin is found in fruits. Sandoricin is a constituent of Sandoricum koetjape (santol). Constituent of Sandoricum koetjape (santol). Sandoricin is found in fruits.
3,5-Di-O-galloyl-1,4-galactarolactone
3,5-Di-O-galloyl-1,4-galactarolactone is found in fruits. 3,5-Di-O-galloyl-1,4-galactarolactone is a constituent of the fruit of emblic (Phyllanthus emblica).
2-O-Caffeoylhydroxycitric acid
Constituent of Spondias mombin (yellow mombin) and Zea mays (sweet corn). 2-O-Caffeoylhydroxycitric acid is found in many foods, some of which are cereals and cereal products, fats and oils, corn, and fruits. 2-O-Caffeoylhydroxycitric acid is found in cereals and cereal products. 2-O-Caffeoylhydroxycitric acid is a constituent of Spondias mombin (yellow mombin) and Zea mays (sweet corn).
Desmosine
Desmosine is formed by condensation of four molecules of lysine into a pyridinium ring. Elastin molecules aggregate in the extracellular space where they are crosslinked by stable desmosine bridges. The resulting polymer is structurally organized as branched fibers and lamellae, which, in skin, are wider (a few microns) in the deep dermis and become progressively thinner (fraction of a micron) towards the papillary dermis. Several general and local factors seem to regulate elastin gene expression, deposition and degradation. (PMID: 9297692). Desmosines are crosslinking amino acids unique to mature elastin in humans. Owing to this unicity, they have been discussed as potentially indicators of connective tissue disorders whose clinical manifestations are mostly the result of elastin degradation. (PMID: 17390614). Emphysema (Pulmonary emphysema is a devastating disease for which there is no effective treatment) is associated with degradation of elastic fibers (PMID: 14704646). It has been shown that the urinary concentration of elastin specific crosslinks, desmosine correlates well with liver fibrosis score in biopsy specimens from patients with liver disease secondary to hepatitis C virus and alcohol. (PMID: 10996125). Degradation production of Elastin
Isodesmosine
2-(4-Amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinium. A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.
Degradation production of Elastin which, together with Desmosine
Auranofin
Auranofin is only found in individuals that have used or taken this drug. It is a organogold compound classified by the World Health Organization as an antirheumatic agent. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties.Exactly how auranofin works is not well understood. It may act as an inhibitor of kappab kinase and thioredoxin reductase which would lead to a decreased immune response and decreased free radical production, respectively. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis, gold salts can decrease the inflammation of the joint lining. This effect can prevent destruction of bone and cartilage.
1-alpha-Acevaltrate
Constituent of Valeriana species 1-alpha-Acevaltrate is found in tea, fats and oils, and herbs and spices. 1-alpha-Acevaltrate is found in fats and oils. 1-alpha-Acevaltrate is a constituent of Valeriana sp.
Menadiol disuccinate
Prothrombogenic vitamin. Prothrombogenic vitamin
Acetyl tributyl citrate
Acetyl tributyl citrate is a flavouring ingredient and plasticiser used in packaging films for food. Flavouring ingredient. Plasticiser used in packaging films for food [DFC].
Plantaricin BN
Plantaricin BN is produced by Lactobacillus plantarum BN. Production by Lactobacillus plantarum BN
3'-(2',3'-Digalloyl-4',6'-hexahydroxydiphenoylglucosyl)-phloroacetophenone
3-(2,3-Digalloyl-4,6-hexahydroxydiphenoylglucosyl)-phloroacetophenone is found in herbs and spices. 3-(2,3-Digalloyl-4,6-hexahydroxydiphenoylglucosyl)-phloroacetophenone is a constituent of Syzygium aromaticum (clove). Constituent of Syzygium aromaticum (clove). 3-(2,3-Digalloyl-4,6-hexahydroxydiphenoylglucosyl)-phloroacetophenone is found in herbs and spices.
Acetyl citrate
This compound belongs to the family of Beta Hydroxy Acids and Derivatives. These are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom
Gadoteric acid
Gadoteric acid, also known as gadoterate, belongs to the class of organic compounds known as tetracarboxylic acids and derivatives. These are carboxylic acids containing exactly four carboxyl groups. Gadoteric acid is considered to be a practically insoluble (in water) and relatively neutral molecule.
(2R,3R)-2,3-Bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]butanedioic acid
(p-SCN-Bn)-dota
2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate
1-(4-(5-Maleimidopentyl)aminobenzyl)ethylenediaminetetraacetic acid
Propylenediamine tetra-acetic acid
ascorbic acid citrate
Bapta
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents D064449 - Sequestering Agents > D002614 - Chelating Agents BAPTA is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca2+ chelators[1][2].
Calixarene
Cbmida
2-[4,7,10-Tris(carboxymethyl)-6-[4-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]butyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
Diethylenetriaminetetraacetic acid
Tetraxetan
D064449 - Sequestering Agents > D002614 - Chelating Agents
2-Dichloromethylene-3a,7a-dichloro-3a,4,7,7a-tetrahydro-4,7-methanoindene-1,3-dione
Egtazic acid
D064449 - Sequestering Agents > D002614 - Chelating Agents > D065096 - Calcium Chelating Agents D020011 - Protective Agents > D000931 - Antidotes
Furaptra
3-[3-[4-[5-(2-Carboxyethyl)-2-hydroxyphenyl]-1,4-bis(carboxymethylamino)butyl]-4-hydroxyphenyl]propanoic acid
Glucose lactate pyruvate glutamate
Larotaxel
Methylthymol blue
Niceritrol
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AD - Nicotinic acid and derivatives C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98151 - Niacin-based Antilipidemic Agent D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents D009676 - Noxae > D000963 - Antimetabolites
Nicomol
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98151 - Niacin-based Antilipidemic Agent
Pyran-3,4-dicarboxylic anhydride, tetrahydro-2-methyl-6-(tetrahydro-2,5-dioxo-3-furyl)-, polymer
Phylanthoside
Quin 2
2-((2-((Dimethoxyphosphorothioyl)thio)-4-ethoxy-4-oxobutanoyl)oxy)-2-methylmalonic acid
Tetraazacyclododecanetetraacetic acid
3-[(2-Aminoethylamino)methyl]-3-[bis(carboxymethyl)amino]pentanedioic acid
3,4-Bis(carboxymethyl)-3,4-dihydroxyhexanedioic acid
triglyceride palmitate
Xylenol orange
Sodium calcium edetate
Preservative and sequestrant in foods. Ethylenediaminetetraacetic acid, widely abbreviated as EDTA, is a polyamino carboxylic acid and a colourless, water-soluble solid. Its conjugate base is named ethylenediaminetetraacetate. It is widely used to dissolve limescale. Its usefulness arises because of its role as a hexadentate (six-toothed") ligand and chelating agent Preservative and sequestrant in foods
Edetate disodium
Preservative and sequestrant in foods. Ethylenediaminetetraacetic acid, widely abbreviated as EDTA, is a polyamino carboxylic acid and a colourless, water-soluble solid. Its conjugate base is named ethylenediaminetetraacetate. It is widely used to dissolve limescale. Its usefulness arises because of its role as a hexadentate (six-toothed") ligand and chelating agent Preservative and sequestrant in foods
Edetate trisodium
Preservative. Ethylenediaminetetraacetic acid, widely abbreviated as EDTA, is a polyamino carboxylic acid and a colourless, water-soluble solid. Its conjugate base is named ethylenediaminetetraacetate. It is widely used to dissolve limescale. Its usefulness arises because of its role as a hexadentate (six-toothed") ligand and chelating agent Preservative
Sodium iron versenate
Listed in the EAFUS Food Additive Database (Jan 2001) but with no reported use
Disodium ethylenediaminetetraacetate
Sequestrant, preservative and discolouration inhibitor for foods. Ethylenediaminetetraacetic acid, widely abbreviated as EDTA, is a polyamino carboxylic acid and a colourless, water-soluble solid. Its conjugate base is named ethylenediaminetetraacetate. It is widely used to dissolve limescale. Its usefulness arises because of its role as a hexadentate ("six-toothed") ligand and chelating agent Sequestrant, preservative and discolouration inhibitor for foods
Edetate sodium
Chelating agent used in food processing. Ethylenediaminetetraacetic acid, widely abbreviated as EDTA, is a polyamino carboxylic acid and a colourless, water-soluble solid. Its conjugate base is named ethylenediaminetetraacetate. It is widely used to dissolve limescale. Its usefulness arises because of its role as a hexadentate ("six-toothed") ligand and chelating agent S - Sensory organs > S01 - Ophthalmologicals Chelating agent used in food processing