Chicoric acid (BioDeep_00000017306)

 

Secondary id: BioDeep_00000002778, BioDeep_00000872095

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


Butanedioic acid, 2,3-bis[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-, (2R,3R)- (9CI)

化学式: C22H18O12 (474.0798228)
中文名称: L-菊苣酸, 菊苣酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 16.1%

分子结构信息

SMILES: c1(/C=C/C(=O)O[C@H]([C@@H](OC(=O)/C=C/c2ccc(c(c2)O)O)C(=O)O)C(=O)O)ccc(c(c1)O)O
InChI: InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3-,8-4-

描述信息

Chicoric acid (CAS: 6537-80-0) is found in the fresh aerial parts of different chicory varieties: green chicory (c.v. Catalogna), two red chicory varieties (radicchio rosso di Chioggia and radicchio rosso di Treviso), and Witloof or Belgian endive. Cichorium sp. L. is a member of the sunflower family (Asteraceae or Compositae), which also includes globe and Jerusalem artichokes, lettuce, and many ornamental plants. It is indigenous to Europe, western Asia, Egypt, and North America. In popular medicine, Cichorium intybus L. has been used to treat skin disorders, such as gout, because of its antihepatotoxic activity. Animal studies have revealed that preparations from chicory roots can lower serum and liver lipid concentration in rats. Cichorium aqueous extracts from roots and aerial parts have been reported for antibacterial activity. Chicory is used as a vegetable, fresh or cooked, while the ground and roasted roots are widely used for blending with coffee powder (PMID: 16076140). Chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro (PMID: 15302207).
D-chicoric acid, also known as D-chicate, belongs to tetracarboxylic acids and derivatives class of compounds. Those are carboxylic acids containing exactly four carboxyl groups. D-chicoric acid is practically insoluble (in water) and a moderately acidic compound (based on its pKa). D-chicoric acid can be found in green vegetables, which makes D-chicoric acid a potential biomarker for the consumption of this food product. Cichoric acid is a hydroxycinnamic acid, an organic compound of the phenylpropanoid class and occurs in a variety of plant species. It is a derivative of both caffeic acid and tartaric acid .
Chicoric acid is an organooxygen compound. It has a role as a HIV-1 integrase inhibitor and a geroprotector. It is functionally related to a tetracarboxylic acid.
Chicoric acid is a natural product found in Cichorium intybus, Cinnamomum camphora, and other organisms with data available.
D004791 - Enzyme Inhibitors > D019429 - Integrase Inhibitors > D019428 - HIV Integrase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3].
Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3].
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3].
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3].

同义名列表

63 个代谢物同义名

Butanedioic acid, 2,3-bis[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-, (2R,3R)- (9CI); Butanedioic acid, 2,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-, [R-[R*,R*-(E,E)]]-; Butanedioic acid, 2,3-bis((3-(3,4-dihydroxphenyl)-1-oxo-2-propenyl)oxy)-, (R-(R*,R*-(E,E)))-; butanedioic acid, 2,3-bis(((2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl)oxy)-, (2R,3R)-; Butanedioic acid, 2,3-bis[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-, (2R,3R)-; (2R,3R)-2,3-bis(((2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl)oxy)-butanedioic acid; (R-(R*,R*-(E,E)))-2,3-Bis((3-(3,4-dihydroxphenyl)-1-oxo-2-propenyl)oxy)butanedioic acid; Butanedioic acid, 2,3-bis((3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-, (R-(R*,R*))-; Butanedioic acid, 2,3-bis(((2E)-3-(3,4-dihydroxphenyl)-1-oxo-2-propenyl)oxy)-, (2R,3R)-; (2R,3R)-2,3-Bis[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]butanedioic acid; [S-(R*,R*)]-2,3-Bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]butanedioic acid; (2R,3R)-2,3-Bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]butanedioic acid; (2R,3R)-2,3-bis({[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy})butanedioic acid; (2R,3R)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid; (2R,3R)-2,3-Bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]butanedioic acid; (2R,3R)-2,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]butanedioic acid; (2R,3R)-2,3-Bis({[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy})butanedioate; (2R,3R)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}succinic acid; (2R,3R)-2,3-bis{[3-(3,4-Dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid; (2R,3R)-2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]-succinic acid; (2R,3R)-2,3-bis(((E)-3-(3,4-dihydroxyphenyl)acryloyl)oxy)succinic acid; 2,3-Bis((3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)butanedioic acid; (2R,3R)-2,3-Bis[[(E)-3-(3,4-dihydroxyphenyl)acryloyl]oxy]succinic Acid; (2R,3R)-2,3-bis((E)-3-(3,4-dihydroxyphenyl)acryloyloxy)succinic acid; (2R,3R)-2,3-Bis((3-(3,4-dihydroxyphenyl)acryloyl)oxy)succinic acid; Chicoric Acid, United States Pharmacopeia (USP) Reference Standard; 2,3-bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]butanedioic acid; (-)-Chicoric acid;trans-Caffeoyltartaric acid; TARTARIC ACID, BIS(3,4-DIHYDROXYCINNAMATE); ( -)-Chicoric acid, analytical standard; Cichoric acid;Dicaffeoyltartaric acid; Chicoric Acid, >=95\\% (HPLC); trans-Caffeoyltartaric acid; YDDGKXBLOXEEMN-IABMMNSOSA-N; Dicaffeoyl-L-tartaric acid; dicaffeoyltartaric acid; CHICORIC ACID [USP-RS]; Chicoric acid, (-)-; (-)-L-chicoric acid; cis-Linalool oxide; (-)-chicoric acid; L-chicoric acid; L-Cichoric acid; UNII-S4YY3V8YHD; l-Chicoric-acid; L-Chicoricacid; 1-chicoricacid; cichoric acid; Cichoric-Acid; L-Chicic acid; Chicoric acid; ChicoricAcid; Tox21_201055; CICHic acid; Chicic acid; S4YY3V8YHD; L-Chicate; Cichoric; CICHate; Chicate; L-DCTA; L-CA; GKP



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shijing Yang, Yaoxing Li, Xiaoman Zheng, Xirui Zheng, Yongshi Lin, Shining Guo, Cui Liu. Effects of folate-chicory acid liposome on macrophage polarization and TLR4/NF-κB signaling pathway in ulcerative colitis mouse. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155415. doi: 10.1016/j.phymed.2024.155415. [PMID: 38503151]
  • Yan Di, Yi Song, Kejia Xu, Qianxu Wang, Li Zhang, Qian Liu, Min Zhang, Xuebo Liu, Yutang Wang. Chicoric Acid Alleviates Colitis via Targeting the Gut Microbiota Accompanied by Maintaining Intestinal Barrier Integrity and Inhibiting Inflammatory Responses. Journal of agricultural and food chemistry. 2024 Mar; 72(12):6276-6288. doi: 10.1021/acs.jafc.3c08363. [PMID: 38485738]
  • Sheng Ma, Zaiyu Huang, Qifeng Chen, Xuewen Yin. Effect of Cichoric Acid on Colorectal Cancer: Impact on Migration, Epithelial-Mesenchymal Transition, and Proliferation via RhoA/ROCK Signaling Pathway Modulation. Discovery medicine. 2024 Jan; 36(180):190-198. doi: 10.24976/discov.med.202436180.18. [PMID: 38273759]
  • Heggar Venkataramana Sudeep, Kuluvar Gouthamchandra, Illuri Ramanaiah, Amritha Raj, Puttaswamy Naveen, Kodimule Shyamprasad. A standardized extract of Echinacea purpurea containing higher chicoric acid content enhances immune function in murine macrophages and cyclophosphamide-induced immunosuppression mice. Pharmaceutical biology. 2023 Dec; 61(1):1211-1221. doi: 10.1080/13880209.2023.2244000. [PMID: 37585723]
  • Miaomiao Wang, Mingxu Wang, Wei Li, Yameng Liu, Feng Qiu. Single-cell detection of DMSO promoted HL-60 differentiation towards granulocyte based on DC-iDEP for medicine screening. Biotechnology journal. 2023 Aug; ?(?):e2300073. doi: 10.1002/biot.202300073. [PMID: 37640006]
  • Tianyu Ma, Hongjing Dong, Yanling Geng, Lanping Guo, Xiao Wang. Preparative separation of eight phenolic acids from Echinacea purpurea L. Moench using pH-zone-refining counter-current chromatography and evaluation of their immunomodulatory effects and synergistic potential. Analytical methods : advancing methods and applications. 2023 02; 15(6):778-787. doi: 10.1039/d2ay01783k. [PMID: 36688325]
  • Mohammad Mohammadi, Roghayeh Abbasalipourkabir, Nasrin Ziamajidi. Fish oil and chicoric acid combination protects better against palmitate-induced lipid accumulation via regulating AMPK-mediated SREBP-1/FAS and PPARα/UCP2 pathways. Archives of physiology and biochemistry. 2023 Feb; 129(1):1-9. doi: 10.1080/13813455.2020.1789881. [PMID: 32654534]
  • Ran Huang, Meng-Hua Jiang, E Sun, Chao Li, Fa-Gen Zhu, Jian-Guo Shao, Liang Feng, Xiao-Bin Jia. [Effective delivery of quality markers in alcohol precipitation of Pudilan Xiaoyan Oral Liquid]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Nov; 47(21):5757-5764. doi: 10.19540/j.cnki.cjcmm.20220520.302. [PMID: 36471993]
  • Xuzhen Lv, Shuai Feng, Jiacheng Zhang, Sihai Sun, Yannan Geng, Min Yang, Yali Liu, Lu Qin, Tianlun Zhao, Chenxi Wang, Guangxu Liu, Feng Li. Application of HPLC Fingerprint Combined with Chemical Pattern Recognition and Multi-Component Determination in Quality Evaluation of Echinacea purpurea (L.) Moench. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196463. [PMID: 36235000]
  • Laura Ravazzolo, Benedetto Ruperti, Marco Frigo, Oriana Bertaiola, Giovanna Pressi, Mario Malagoli, Silvia Quaggiotti. C3H Expression Is Crucial for Methyl Jasmonate Induction of Chicoric Acid Production by Echinacea purpurea (L.) Moench Cell Suspension Cultures. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911179. [PMID: 36232482]
  • Xiao-Qin Ding, Tun-Yu Jian, Ya-Nan Gai, Guan-Ting Niu, Yan Liu, Xiu-Hua Meng, Jing Li, Han Lyu, Bing-Ru Ren, Jian Chen. Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway. Journal of agricultural and food chemistry. 2022 Mar; 70(9):2923-2935. doi: 10.1021/acs.jafc.1c07795. [PMID: 35195395]
  • Tianxi Zhang, Jian Li, Lei Shi, Shuai Feng, Feng Li. Anti-RSV activities of chicoric acid from Echinacea purpurea in vitro. Minerva surgery. 2022 02; 77(1):78-80. doi: 10.23736/s2724-5691.21.08925-5. [PMID: 34047537]
  • Rao Fu, Pingyu Zhang, Ge Jin, Lianglei Wang, Shiqian Qi, Yang Cao, Cathie Martin, Yang Zhang. Versatility in acyltransferase activity completes chicoric acid biosynthesis in purple coneflower. Nature communications. 2021 03; 12(1):1563. doi: 10.1038/s41467-021-21853-6. [PMID: 33692355]
  • Fábio F Cardoso, Maximilia F de Souza, Cristiano L P Oliveira, Marcos R M Fontes. In-solution structural studies involving a phospholipase A2-like myotoxin and a natural inhibitor: Plasticity of oligomeric assembly affects mechanisms of inhibition. Biochimie. 2021 Feb; 181(?):145-153. doi: 10.1016/j.biochi.2020.12.008. [PMID: 33333169]
  • Plamen Momchev, Petar Ciganović, Mario Jug, Eva Marguí, Jasna Jablan, Marijana Zovko Končić. Comparison of Maceration and Ultrasonication for Green Extraction of Phenolic Acids from Echinacea purpurea Aerial Parts. Molecules (Basel, Switzerland). 2020 Nov; 25(21):. doi: 10.3390/molecules25215142. [PMID: 33167320]
  • Agata Jabłońska-Trypuć, Rafał Krętowski, Grzegorz Świderski, Marzanna Cechowska-Pasko, Włodzimierz Lewandowski. Cichoric acid attenuates the toxicity of mesotrione. Effect on in vitro skin cell model. Environmental toxicology and pharmacology. 2020 Jul; 77(?):103375. doi: 10.1016/j.etap.2020.103375. [PMID: 32279013]
  • Omnia E Hussein, Walaa G Hozayen, May N Bin-Jumah, Mousa O Germoush, Sanaa M Abd El-Twab, Ayman M Mahmoud. Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling. Environmental science and pollution research international. 2020 Jun; 27(17):20725-20735. doi: 10.1007/s11356-020-08557-y. [PMID: 32246423]
  • Izabela Szymborska-Sandhu, Jarosław L Przybył, Olga Kosakowska, Katarzyna Bączek, Zenon Węglarz. Chemical Diversity of Bastard Balm (Melittis melisophyllum L.) as Affected by Plant Development. Molecules (Basel, Switzerland). 2020 May; 25(10):. doi: 10.3390/molecules25102421. [PMID: 32455929]
  • Zheng Li, Haihua Feng, Lu Han, Lu Ding, Bingyu Shen, Ye Tian, Lilei Zhao, Meiyu Jin, Qi Wang, Haiyan Qin, Jiaqi Cheng, Guowen Liu. Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d-galactosamine induced acute liver injury. Journal of cellular and molecular medicine. 2020 03; 24(5):3022-3033. doi: 10.1111/jcmm.14935. [PMID: 31989756]
  • Agata Jabłońska-Trypuć, Urszula Wydro, Elżbieta Wołejko, Grzegorz Świderski, Włodzimierz Lewandowski. Biological Activity of New Cichoric Acid-Metal Complexes in Bacterial Strains, Yeast-Like Fungi, and Human Cell Cultures In Vitro. Nutrients. 2020 Jan; 12(1):. doi: 10.3390/nu12010154. [PMID: 31935840]
  • Xiaoqin Ding, Tunyu Jian, Jiawei Li, Han Lv, Bei Tong, Jing Li, Xiuhua Meng, Bingru Ren, Jian Chen. Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice. Oxidative medicine and cellular longevity. 2020; 2020(?):9734560. doi: 10.1155/2020/9734560. [PMID: 33204402]
  • Meisam Salmanzadeh, Mohammad Sadegh Sabet, Ahmad Moieni, Mehdi Homaee. Heterologous expression of an acid phosphatase gene and phosphate limitation leads to substantial production of chicoric acid in Echinacea purpurea transgenic hairy roots. Planta. 2019 Dec; 251(1):31. doi: 10.1007/s00425-019-03317-w. [PMID: 31823013]
  • Canan Sevimli-Gur, Ozlem Yesil-Celiktas. Cytotoxicity screening of supercritical fluid extracted seaweeds and phenylpropanoids. Molecular biology reports. 2019 Aug; 46(4):3691-3699. doi: 10.1007/s11033-019-04812-9. [PMID: 31004301]
  • Maria Giovanna Molinu, Giovanna Piluzza, Giuseppe Campesi, Leonardo Sulas, Giovanni Antonio Re. Antioxidant Sources from Leaves of Russian Dandelion. Chemistry & biodiversity. 2019 Aug; 16(8):e1900250. doi: 10.1002/cbdv.201900250. [PMID: 31250533]
  • Valentina Maggini, Marinella De Leo, Carlotta Granchi, Tiziano Tuccinardi, Alessio Mengoni, Eugenia Rosaria Gallo, Sauro Biffi, Renato Fani, Luisa Pistelli, Fabio Firenzuoli, Patrizia Bogani. The influence of Echinacea purpurea leaf microbiota on chicoric acid level. Scientific reports. 2019 07; 9(1):10897. doi: 10.1038/s41598-019-47329-8. [PMID: 31350520]
  • Sanaa M Abd El-Twab, Omnia E Hussein, Walaa G Hozayen, May Bin-Jumah, Ayman M Mahmoud. Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2019 Jun; 68(6):511-523. doi: 10.1007/s00011-019-01241-z. [PMID: 31037316]
  • Yidan Bai, Jian Ma, Wanfang Zhu, Lei Wang, Wei Qu, Shengzhi Su, Weiwei Zhai, Feng Feng, Wenyuan Liu, Jie Zhang. Highly selective separation and purification of chicoric acid from Echinacea purpurea by quality control methods in macroporous adsorption resin column chromatography. Journal of separation science. 2019 Mar; 42(5):1027-1036. doi: 10.1002/jssc.201800928. [PMID: 30575275]
  • Yipeng Ma, Wenjuan Cong, Hao Huang, Liang Sun, Anh Hung Mai, Kurt Boonen, Wahedi Maryam, Wim De Borggraeve, Guoan Luo, Qingfei Liu, Liliane Schoofs, Frank Van Kuppeveld, Johan Neyts, Carmen Mirabelli, Walter Luyten. Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection. International journal of antimicrobial agents. 2019 Feb; 53(2):128-136. doi: 10.1016/j.ijantimicag.2018.07.014. [PMID: 30063999]
  • Hui Ding, Xinxin Ci, Hang Cheng, Qinlei Yu, Dan Li. Chicoric acid alleviates lipopolysaccharide-induced acute lung injury in mice through anti-inflammatory and anti-oxidant activities. International immunopharmacology. 2019 Jan; 66(?):169-176. doi: 10.1016/j.intimp.2018.10.042. [PMID: 30466029]
  • Mateja Senica, Gregor Mlinsek, Robert Veberic, Maja Mikulic-Petkovsek. Which Plant Part of Purple Coneflower (Echinacea purpurea (L.) Moench) Should be Used for Tea and Which for Tincture?. Journal of medicinal food. 2019 Jan; 22(1):102-108. doi: 10.1089/jmf.2018.0026. [PMID: 30222488]
  • Ofentse Nobela, Ryan S Renslow, Dennis G Thomas, Sean M Colby, Sanyasi Sitha, Patrick Berka Njobeh, Louis du Preez, Fidele Tugizimana, Ntakadzeni Edwin Madala. Efficient discrimination of natural stereoisomers of chicoric acid, an HIV-1 integrase inhibitor. Journal of photochemistry and photobiology. B, Biology. 2018 Dec; 189(?):258-266. doi: 10.1016/j.jphotobiol.2018.10.025. [PMID: 30419521]
  • Fábio F Cardoso, Rafael J Borges, Thiago R Dreyer, Guilherme H M Salvador, Walter L G Cavalcante, Maeli Dal Pai, Márcia Gallacci, Marcos R M Fontes. Structural basis of phospholipase A2-like myotoxin inhibition by chicoric acid, a novel potent inhibitor of ophidian toxins. Biochimica et biophysica acta. General subjects. 2018 12; 1862(12):2728-2737. doi: 10.1016/j.bbagen.2018.08.002. [PMID: 30251662]
  • Rui Guo, Beita Zhao, Yijie Wang, Dandan Wu, Yutang Wang, Yafan Yu, Yuchen Yan, Wentong Zhang, Zhigang Liu, Xuebo Liu. Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells. Journal of agricultural and food chemistry. 2018 Sep; 66(37):9667-9678. doi: 10.1021/acs.jafc.8b02147. [PMID: 30036051]
  • Ji Ma, Maoru Li, Praveen Kumar Kalavagunta, Jiajing Li, Qiangqiang He, Yifan Zhang, Owais Ahmad, Hongli Yin, Tao Wang, Jing Shang. Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Aug; 104(?):679-685. doi: 10.1016/j.biopha.2018.05.081. [PMID: 29803928]
  • Karine Ferrare, Luc P R Bidel, Abdulmomem Awwad, Patrick Poucheret, Guillaume Cazals, Françoise Lazennec, Jacqueline Azay-Milhau, Michel Tournier, Anne-Dominique Lajoix, Didier Tousch. Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect. Journal of ethnopharmacology. 2018 Apr; 215(?):241-248. doi: 10.1016/j.jep.2017.12.035. [PMID: 29325917]
  • Zhijun Diao, Jing Li, Qian Liu, Yutang Wang. In-vivo metabolite profiling of chicoric acid in rat plasma, urine and feces after oral administration using liquid chromatography quadrupole time of flight mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Apr; 1081-1082(?):8-14. doi: 10.1016/j.jchromb.2018.02.016. [PMID: 29494984]
  • Faridoon, Dumisani Mnkandhla, Michelle Isaacs, Heinrich C Hoppe, Perry T Kaye. Synthesis and evaluation of substituted 4-arylimino-3-hydroxybutanoic acids as potential HIV-1 integrase inhibitors. Bioorganic & medicinal chemistry letters. 2018 04; 28(6):1067-1070. doi: 10.1016/j.bmcl.2018.02.020. [PMID: 29482943]
  • Agata Jabłońska-Trypuć, Rafał Krętowski, Monika Kalinowska, Grzegorz Świderski, Marzanna Cechowska-Pasko, Włodzimierz Lewandowski. Possible Mechanisms of the Prevention of Doxorubicin Toxicity by Cichoric Acid-Antioxidant Nutrient. Nutrients. 2018 Jan; 10(1):. doi: 10.3390/nu10010044. [PMID: 29303987]
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