Desmosine (BioDeep_00000027611)

   

human metabolite Endogenous


代谢物信息卡片


3,5-bis[(3S)-3-amino-3-carboxypropyl]-4-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]pyridin-1-ium

化学式: C24H40N5O8+ (526.287674)
中文名称: ELA锁链素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC[n+]1cc(CC[C@@H](C(=O)O)N)c(CCC[C@@H](C(=O)O)N)c(CC[C@@H](C(=O)O)N)c1)CC(C(=O)O)N
InChI: InChI=1S/C24H39N5O8/c25-17(21(30)31)5-1-2-11-29-12-14(7-9-19(27)23(34)35)16(4-3-6-18(26)22(32)33)15(13-29)8-10-20(28)24(36)37/h12-13,17-20H,1-11,25-28H2,(H3-,30,31,32,33,34,35,36,37)/p+1/t17-,18-,19-,20-/m0/s1

描述信息

Desmosine is formed by condensation of four molecules of lysine into a pyridinium ring. Elastin molecules aggregate in the extracellular space where they are crosslinked by stable desmosine bridges. The resulting polymer is structurally organized as branched fibers and lamellae, which, in skin, are wider (a few microns) in the deep dermis and become progressively thinner (fraction of a micron) towards the papillary dermis. Several general and local factors seem to regulate elastin gene expression, deposition and degradation. (PMID: 9297692). Desmosines are crosslinking amino acids unique to mature elastin in humans. Owing to this unicity, they have been discussed as potentially indicators of connective tissue disorders whose clinical manifestations are mostly the result of elastin degradation. (PMID: 17390614). Emphysema (Pulmonary emphysema is a devastating disease for which there is no effective treatment) is associated with degradation of elastic fibers (PMID: 14704646). It has been shown that the urinary concentration of elastin specific crosslinks, desmosine correlates well with liver fibrosis score in biopsy specimens from patients with liver disease secondary to hepatitis C virus and alcohol. (PMID: 10996125).
Degradation production of Elastin

同义名列表

5 个代谢物同义名

3,5-bis[(3S)-3-amino-3-carboxypropyl]-4-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]pyridin-1-ium; 2-amino-6-[4-(4-amino-4-carboxy-butyl)-3,5-bis(3-amino-3-carboxy-propyl)pyridin-1-yl]hexanoic acid; 4-(4-Amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinium; Desmosine; Des



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jerome O Cantor, Shuren Ma, Xingjian Liu, Michael A Campos, Charlton Strange, James M Stocks, Megan S Devine, Sherif G El Bayadi, Randolph J Lipchik, Robert A Sandhaus, Gerard M Turino. A 28-day clinical trial of aerosolized hyaluronan in alpha-1 antiprotease deficiency COPD using desmosine as a surrogate marker for drug efficacy. Respiratory medicine. 2021 06; 182(?):106402. doi: 10.1016/j.rmed.2021.106402. [PMID: 33906126]
  • Ify R Mordi, Rachael O Forsythe, Corry Gellatly, Zaid Iskandar, Olivia M McBride, Athanasios Saratzis, Rod Chalmers, Calvin Chin, Matthew J Bown, David E Newby, Chim C Lang, Jeffrey T J Huang, Anna-Maria Choy. Plasma Desmosine and Abdominal Aortic Aneurysm Disease. Journal of the American Heart Association. 2019 10; 8(20):e013743. doi: 10.1161/jaha.119.013743. [PMID: 31595818]
  • Tobias Hedtke, Christoph U Schräder, Andrea Heinz, Wolfgang Hoehenwarter, Jürgen Brinckmann, Thomas Groth, Christian E H Schmelzer. A comprehensive map of human elastin cross-linking during elastogenesis. The FEBS journal. 2019 09; 286(18):3594-3610. doi: 10.1111/febs.14929. [PMID: 31102572]
  • Jerome Cantor, Arnulfo Ochoa, Shuren Ma, Xingjian Liu, Gerard Turino. Free Desmosine is a Sensitive Marker of Smoke-Induced Emphysema. Lung. 2018 12; 196(6):659-663. doi: 10.1007/s00408-018-0163-1. [PMID: 30218154]
  • Pratikkumar Rathod, Manjeet Kaur, Hsin-Pin Ho, Marissa E Louis, Basant Dhital, Philip Durlik, Gregory S Boutis, Kevin J Mark, Jong I Lee, Emmanuel J Chang. Quantification of desmosine and isodesmosine using MALDI-ion trap tandem mass spectrometry. Analytical and bioanalytical chemistry. 2018 Oct; 410(26):6881-6889. doi: 10.1007/s00216-018-1288-z. [PMID: 30062515]
  • Christoph U Schräder, Andrea Heinz, Petra Majovsky, Berin Karaman Mayack, Jürgen Brinckmann, Wolfgang Sippl, Christian E H Schmelzer. Elastin is heterogeneously cross-linked. The Journal of biological chemistry. 2018 09; 293(39):15107-15119. doi: 10.1074/jbc.ra118.004322. [PMID: 30108173]
  • Gerard M Turino. Chronic Obstructive Pulmonary Disease. A Biomarker and a Potential Therapy. Annals of the American Thoracic Society. 2018 02; 15(Suppl 1):S15-S17. doi: 10.1513/annalsats.201707-568kv. [PMID: 29461896]
  • Changhwan Kim, Yousang Ko, Su Hee Kim, Hyun Ju Yoo, Jae Seung Lee, Chin Kook Rhee, Jin Hwa Lee, Ji-Hyun Lee, Tae-Hyung Kim, Seong Yong Lim, Kwang Ha Yoo, Joon Beom Seo, Yeon-Mok Oh, Sang-Do Lee, Yong Bum Park. Urinary desmosine is associated with emphysema severity and frequent exacerbation in patients with COPD. Respirology (Carlton, Vic.). 2018 02; 23(2):176-181. doi: 10.1111/resp.13170. [PMID: 28905464]
  • Rob Janssen, Cees Vermeer. Vitamin K deficit and elastolysis theory in pulmonary elasto-degenerative diseases. Medical hypotheses. 2017 Oct; 108(?):38-41. doi: 10.1016/j.mehy.2017.07.029. [PMID: 29055397]
  • Ruth Minkin, Gagangeet Sandhu, Horiana Grosu, Lori Tartell, Shuren Ma, Yong Y Lin, Edward Eden, Gerard M Turino. Desmosine and Isodesmosine as a Novel Biomarker for Pulmonary Arterial Hypertension: A Pilot Study. American journal of therapeutics. 2017 Jul; 24(4):e399-e404. doi: 10.1097/mjt.0000000000000260. [PMID: 26237301]
  • James D Chalmers, Kelly L Moffitt, Guillermo Suarez-Cuartin, Oriol Sibila, Simon Finch, Elizabeth Furrie, Alison Dicker, Karolina Wrobel, J Stuart Elborn, Brian Walker, S Lorraine Martin, Sara E Marshall, Jeffrey T-J Huang, Thomas C Fardon. Neutrophil Elastase Activity Is Associated with Exacerbations and Lung Function Decline in Bronchiectasis. American journal of respiratory and critical care medicine. 2017 05; 195(10):1384-1393. doi: 10.1164/rccm.201605-1027oc. [PMID: 27911604]
  • Ilaria Ferrarotti, Angelo Guido Corsico, Jan Stolk, Stefania Ottaviani, Marco Fumagalli, Sabina Janciauskiene, Paolo Iadarola. Advances in Identifying Urine/Serum Biomarkers in Alpha-1 Antitrypsin Deficiency for More Personalized Future Treatment Strategies. COPD. 2017 02; 14(1):56-65. doi: 10.1080/15412555.2016.1241760. [PMID: 27827549]
  • Yoshiyuki Oyama, Noriyuki Enomoto, Yuzo Suzuki, Masato Kono, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Shigeki Kuroishi, Koshi Yokomura, Mikio Toyoshima, Shiro Imokawa, Keiji Oishi, Satoshi Watanabe, Kazuo Kasahara, Tomohisa Baba, Takashi Ogura, Hiroshi Ishii, Kentaro Watanabe, Yasuhiko Nishioka, Takafumi Suda. Evaluation of urinary desmosines as a noninvasive diagnostic biomarker in patients with idiopathic pleuroparenchymal fibroelastosis (PPFE). Respiratory medicine. 2017 02; 123(?):63-70. doi: 10.1016/j.rmed.2016.12.013. [PMID: 28137498]
  • Jerome Cantor, Shuren Ma, Gerard Turino. A pilot clinical trial to determine the safety and efficacy of aerosolized hyaluronan as a treatment for COPD. International journal of chronic obstructive pulmonary disease. 2017; 12(?):2747-2752. doi: 10.2147/copd.s142156. [PMID: 29075107]
  • Roberto A Rabinovich, Bruce E Miller, Karolina Wrobel, Kareshma Ranjit, Michelle C Williams, Ellen Drost, Lisa D Edwards, David A Lomas, Stephen I Rennard, Alvar Agustí, Ruth Tal-Singer, Jørgen Vestbo, Emiel F M Wouters, Michelle John, Edwin J R van Beek, John T Murchison, Charlotte E Bolton, William MacNee, Jeffrey T J Huang. Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD. The European respiratory journal. 2016 05; 47(5):1365-73. doi: 10.1183/13993003.01824-2015. [PMID: 27009168]
  • Xingjian Liu, Shuren Ma, Sophie Liu, Ming Liu, Gerard Turino, Jerome Cantor. The Ratio of Free to Bound Desmosine and Isodesmosine May Reflect Emphysematous Changes in COPD. Lung. 2015 Jun; 193(3):329-34. doi: 10.1007/s00408-015-9712-z. [PMID: 25762453]
  • Yimeng Yang, Yanfei Guo, Hongsheng Zhang, Tieying Sun. [Desmosine plasma levels and exacerbation risk assessment of chronic obstructive pulmonary disease]. Zhonghua yi xue za zhi. 2015 Mar; 95(8):577-80. doi: NULL. [PMID: 25917031]
  • Sara Ongay, Gert Hendriks, Jos Hermans, Maarten van den Berge, Nick H T ten Hacken, Nico C van de Merbel, Rainer Bischoff. Quantification of free and total desmosine and isodesmosine in human urine by liquid chromatography tandem mass spectrometry: a comparison of the surrogate-analyte and the surrogate-matrix approach for quantitation. Journal of chromatography. A. 2014 Jan; 1326(?):13-9. doi: 10.1016/j.chroma.2013.12.035. [PMID: 24380655]
  • Simona Viglio, Jan Stolk, Maurizio Luisetti, Fabio Ferrari, Paolo Piccinini, Paolo Iadarola. From micellar electrokinetic chromatography to liquid chromatography-mass spectrometry: revisiting the way of analyzing human fluids for the search of desmosines, putative biomarkers of chronic obstructive pulmonary disease. Electrophoresis. 2014 Jan; 35(1):109-18. doi: 10.1002/elps.201300159. [PMID: 24395662]
  • Jo Seddon, Victoria Kasprowicz, Naomi F Walker, Ho Ming Yuen, Henry Sunpath, Liku Tezera, Graeme Meintjes, Robert J Wilkinson, William R Bishai, Jon S Friedland, Paul T Elkington. Procollagen III N-terminal propeptide and desmosine are released by matrix destruction in pulmonary tuberculosis. The Journal of infectious diseases. 2013 Nov; 208(10):1571-9. doi: 10.1093/infdis/jit343. [PMID: 23922364]
  • Tasso Miliotis, Claes Lindberg, Kristina Forsman Semb, Marleen van Geest, Sven Kjellström. Quantitative high-performance liquid chromatography-tandem mass spectrometry method for the analysis of free desmosines in plasma and urine. Journal of chromatography. A. 2013 Sep; 1308(?):73-8. doi: 10.1016/j.chroma.2013.06.063. [PMID: 23953714]
  • Osama Albarbarawi, Alun Barton, Douglas Miller, Charles McSharry, Rekha Chaudhuri, Neil C Thomson, Colin Na Palmer, Graham Devereux, Jeffrey T-J Huang. Characterization and validation of an isotope-dilution LC-MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum. Bioanalysis. 2013 Aug; 5(16):1991-2001. doi: 10.4155/bio.13.164. [PMID: 23937134]
  • Jens Lamerz, Arno Friedlein, Nicole Soder, Paul Cutler, Heinz Döbeli. Determination of free desmosine in human plasma and its application in two experimental medicine studies. Analytical biochemistry. 2013 May; 436(2):127-36. doi: 10.1016/j.ab.2013.01.012. [PMID: 23399390]
  • William MacNee. Systemic inflammatory biomarkers and co-morbidities of chronic obstructive pulmonary disease. Annals of medicine. 2013 May; 45(3):291-300. doi: 10.3109/07853890.2012.732703. [PMID: 23110517]
  • Atsushi Miyajima, Masahiro Okamoto, Takafumi Muto, Takashi Hirota. Disruption of elastic lamellae in aorta and dysfunction of vaso-regulation by rofecoxib in rats. The Journal of toxicological sciences. 2013; 38(5):719-29. doi: 10.2131/jts.38.719. [PMID: 24025789]
  • Barry Starcher, Edward Sauter, Coty Ho. Elastin turnover in malignant solid tumors. Connective tissue research. 2013; 54(4-5):313-8. doi: 10.3109/03008207.2013.820723. [PMID: 23869612]
  • Fabio Ferrari, Marco Fumagalli, Paolo Piccinini, Jan Stolk, Maurizio Luisetti, Simona Viglio, Carmine Tinelli, Paolo Iadarola. Micellar electrokinetic chromatography with laser induced detection and liquid chromatography tandem mass-spectrometry-based desmosine assays in urine of patients with Chronic Obstructive Pulmonary Disease: a comparative analysis. Journal of chromatography. A. 2012 Nov; 1266(?):103-9. doi: 10.1016/j.chroma.2012.10.014. [PMID: 23116803]
  • J Stuart Elborn, John Perrett, Kristina Forsman-Semb, Joanna Marks-Konczalik, Kulasiri Gunawardena, Neil Entwistle. Efficacy, safety and effect on biomarkers of AZD9668 in cystic fibrosis. The European respiratory journal. 2012 Oct; 40(4):969-76. doi: 10.1183/09031936.00194611. [PMID: 22267768]
  • Theresa A Laguna, Brandie D Wagner, Barry Starcher, Heidi K Luckey Tarro, Shelley A Mann, Scott D Sagel, Frank J Accurso. Urinary desmosine: a biomarker of structural lung injury during CF pulmonary exacerbation. Pediatric pulmonology. 2012 Sep; 47(9):856-63. doi: 10.1002/ppul.22525. [PMID: 22431382]
  • Anne Hilgendorff, Kakoli Parai, Robert Ertsey, G Juliana Rey-Parra, Bernard Thébaud, Rasa Tamosiuniene, Noopur Jain, Edwin F Navarro, Barry C Starcher, Mark R Nicolls, Marlene Rabinovitch, Richard D Bland. Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth. American journal of physiology. Lung cellular and molecular physiology. 2012 Aug; 303(3):L215-27. doi: 10.1152/ajplung.00405.2011. [PMID: 22683569]
  • Stavros G Memtsoudis, Anna Maria Bombardieri, Yan Ma, Federico P Girardi. The effect of low versus high tidal volume ventilation on inflammatory markers in healthy individuals undergoing posterior spine fusion in the prone position: a randomized controlled trial. Journal of clinical anesthesia. 2012 Jun; 24(4):263-9. doi: 10.1016/j.jclinane.2011.08.003. [PMID: 22001758]
  • Jeffrey T J Huang, Rekha Chaudhuri, Osama Albarbarawi, Alun Barton, Christal Grierson, Petra Rauchhaus, Christopher J Weir, Martina Messow, Nicola Stevens, Charles McSharry, Giora Feuerstein, Somnath Mukhopadhyay, Jeffrey Brady, Colin N A Palmer, Douglas Miller, Neil C Thomson. Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Thorax. 2012 Jun; 67(6):502-8. doi: 10.1136/thoraxjnl-2011-200279. [PMID: 22250098]
  • Yoo Jin Hong, Jinhyun Kim, Bo Ram Oh, Yun Jong Lee, Eun Young Lee, Eun Bong Lee, Seung-Hyo Lee, Yeong Wook Song. Serum elastin-derived peptides and anti-elastin antibody in patients with systemic sclerosis. Journal of Korean medical science. 2012 May; 27(5):484-8. doi: 10.3346/jkms.2012.27.5.484. [PMID: 22563211]
  • C A Lindberg, G Engström, M Gerhardsson de Verdier, U Nihlén, M Anderson, K Forsman-Semb, M Svartengren. Total desmosines in plasma and urine correlate with lung function. The European respiratory journal. 2012 Apr; 39(4):839-45. doi: 10.1183/09031936.00064611. [PMID: 21965222]
  • Ronald Dahl, Ingrid Titlestad, Ari Lindqvist, Pascal Wielders, Heather Wray, Millie Wang, Viktoria Samuelsson, John Mo, Alison Holt. Effects of an oral MMP-9 and -12 inhibitor, AZD1236, on biomarkers in moderate/severe COPD: a randomised controlled trial. Pulmonary pharmacology & therapeutics. 2012 Apr; 25(2):169-77. doi: 10.1016/j.pupt.2011.12.011. [PMID: 22306193]
  • M Luisetti, J Stolk, P Iadarola. Desmosine, a biomarker for COPD: old and in the way. The European respiratory journal. 2012 Apr; 39(4):797-8. doi: 10.1183/09031936.00172911. [PMID: 22467719]
  • Magnus Korsgren, Margareta Linden, Neil Entwistle, Jason Cook, Per Wollmer, Morgan Andersson, Bengt Larsson, Lennart Greiff. Inhalation of LPS induces inflammatory airway responses mimicking characteristics of chronic obstructive pulmonary disease. Clinical physiology and functional imaging. 2012 Jan; 32(1):71-9. doi: 10.1111/j.1475-097x.2011.01058.x. [PMID: 22152082]
  • Stefan Röpcke, Olaf Holz, Gereon Lauer, Meike Müller, Susanne Rittinghausen, Peter Ernst, Gezim Lahu, Martin Elmlinger, Norbert Krug, Jens M Hohlfeld. Repeatability of and relationship between potential COPD biomarkers in bronchoalveolar lavage, bronchial biopsies, serum, and induced sputum. PloS one. 2012; 7(10):e46207. doi: 10.1371/journal.pone.0046207. [PMID: 23056262]
  • Neil A Devenport, James C Reynolds, Ved Parkash, Jason Cook, Daniel J Weston, Colin S Creaser. Determination of free desmosine and isodesmosine as urinary biomarkers of lung disorder using ultra performance liquid chromatography-ion mobility-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Dec; 879(32):3797-801. doi: 10.1016/j.jchromb.2011.10.016. [PMID: 22088351]
  • Jeroen J W Liesker, Erik Bathoorn, Dirkje S Postma, Judith M Vonk, Wim Timens, Huib A M Kerstjens. Sputum inflammation predicts exacerbations after cessation of inhaled corticosteroids in COPD. Respiratory medicine. 2011 Dec; 105(12):1853-60. doi: 10.1016/j.rmed.2011.07.002. [PMID: 21802933]
  • Lieke van den Hout, Dick Tibboel, Sanne Vijfhuize, Harma te Beest, Wim Hop, Irwin Reiss. The VICI-trial: high frequency oscillation versus conventional mechanical ventilation in newborns with congenital diaphragmatic hernia: an international multicentre randomized controlled trial. BMC pediatrics. 2011 Nov; 11(?):98. doi: 10.1186/1471-2431-11-98. [PMID: 22047542]
  • Laura Fregonese, Fabio Ferrari, Marco Fumagalli, Maurizio Luisetti, Jan Stolk, Paolo Iadarola. Long-term variability of desmosine/isodesmosine as biomarker in alpha-1-antritrypsin deficiency-related COPD. COPD. 2011 Oct; 8(5):329-33. doi: 10.3109/15412555.2011.589871. [PMID: 21793711]
  • Natalie Slowik, Shuren Ma, Jiangtao He, Yong Y Lin, Offie P Soldin, Richard A Robbins, Gerard M Turino. The effect of secondhand smoke exposure on markers of elastin degradation. Chest. 2011 Oct; 140(4):946-953. doi: 10.1378/chest.10-2298. [PMID: 21415130]
  • Gerard M Turino, Shuren Ma, Yong Y Lin, Jerome O Cantor, Maurizio Luisetti. Matrix elastin: a promising biomarker for chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine. 2011 Sep; 184(6):637-41. doi: 10.1164/rccm.201103-0450pp. [PMID: 21757624]
  • Anne Hilgendorff, Kakoli Parai, Robert Ertsey, Noopur Jain, Edwin F Navarro, Joanna L Peterson, Rasa Tamosiuniene, Mark R Nicolls, Barry C Starcher, Marlene Rabinovitch, Richard D Bland. Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice. American journal of respiratory and critical care medicine. 2011 Sep; 184(5):537-46. doi: 10.1164/rccm.201012-2010oc. [PMID: 21562133]
  • Shuren Ma, Gerard M Turino, Yong Y Lin. Quantitation of desmosine and isodesmosine in urine, plasma, and sputum by LC-MS/MS as biomarkers for elastin degradation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Jul; 879(21):1893-8. doi: 10.1016/j.jchromb.2011.05.011. [PMID: 21621489]
  • Stavros G Memtsoudis, Barry Starcher, Yan Ma, Valeria Buschiazzo, Michael K Urban, Federico P Girardi. The utility of urine desmosine as a marker of lung injury in spine surgery. HSS journal : the musculoskeletal journal of Hospital for Special Surgery. 2010 Sep; 6(2):160-3. doi: 10.1007/s11420-010-9158-z. [PMID: 21886530]
  • Brandie D Wagner, Frank J Accurso, Theresa A Laguna. The applicability of urinary creatinine as a method of specimen normalization in the cystic fibrosis population. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2010 May; 9(3):212-6. doi: 10.1016/j.jcf.2010.02.004. [PMID: 20227353]
  • Martina Ulrich, Dieter Worlitzsch, Simona Viglio, Nanna Siegmann, Paolo Iadarola, Janis K Shute, Marianne Geiser, Gerald B Pier, Godehard Friedel, Mark L Barr, Antje Schuster, Keith C Meyer, Felix Ratjen, Thomas Bjarnsholt, Erich Gulbins, Gerd Döring. Alveolar inflammation in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2010 May; 9(3):217-27. doi: 10.1016/j.jcf.2010.03.001. [PMID: 20347403]
  • Osama Albarbarawi, Alun Barton, Zhaosheng Lin, Eddie Takahashi, Ajay Buddharaju, Jeffrey Brady, Douglas Miller, Colin N A Palmer, Jeffrey T-J Huang. Measurement of urinary total desmosine and isodesmosine using isotope-dilution liquid chromatography-tandem mass spectrometry. Analytical chemistry. 2010 May; 82(9):3745-50. doi: 10.1021/ac100152f. [PMID: 20361748]
  • Kohei Shiraishi, Kazue Matsuzaki, Akinori Matsumoto, Yuuki Hashimoto, Kazuhiko Iba. Development of a robust LC-MS/MS method for determination of desmosine and isodesmosine in human urine. Journal of oleo science. 2010; 59(8):431-9. doi: 10.5650/jos.59.431. [PMID: 20625235]
  • Theresa A Laguna, Brandie D Wagner, Heidi K Luckey, Shelley A Mann, Scott D Sagel, Warren Regelmann, Frank J Accurso. Sputum desmosine during hospital admission for pulmonary exacerbation in cystic fibrosis. Chest. 2009 Dec; 136(6):1561-1568. doi: 10.1378/chest.09-0217. [PMID: 19567495]
  • Michel Boutin, Imran Ahmad, Marjo Jauhiainen, Nathalie Lachapelle, Claude Rondeau, Jean Roy, Pierre Thibault. NanoLC-MS/MS analyses of urinary desmosine, hydroxylysylpyridinoline and lysylpyridinoline as biomarkers for chronic graft-versus-host disease. Analytical chemistry. 2009 Nov; 81(22):9454-61. doi: 10.1021/ac9018796. [PMID: 19848412]
  • Renbin Zhao, Elizabeth Bruning, Dianne Rossetti, Barry Starcher, Miri Seiberg, Violetta Iotsova-Stone. Extracts from Glycine max (soybean) induce elastin synthesis and inhibit elastase activity. Experimental dermatology. 2009 Oct; 18(10):883-6. doi: 10.1111/j.1600-0625.2009.00862.x. [PMID: 19469891]
  • Stavros G Memtsoudis, Barry Starcher, Alejandro González Della Valle, Yan Ma, Kethy Jules-Elysee, Thomas P Sculco. Urine desmosine as a marker of lung injury following total knee arthroplasty. A pilot study. HSS journal : the musculoskeletal journal of Hospital for Special Surgery. 2009 Sep; 5(2):154-8. doi: 10.1007/s11420-009-9116-9. [PMID: 19521737]
  • Andrew Churg, Steven Zhou, Xiaoshan Wang, Rona Wang, Joanne L Wright. The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling. American journal of respiratory cell and molecular biology. 2009 Apr; 40(4):482-90. doi: 10.1165/rcmb.2008-0038oc. [PMID: 18931327]
  • Michel Boutin, Carl Berthelette, François G Gervais, Mary-Beth Scholand, John Hoidal, Mark F Leppert, Kevin P Bateman, Pierre Thibault. High-sensitivity nanoLC-MS/MS analysis of urinary desmosine and isodesmosine. Analytical chemistry. 2009 Mar; 81(5):1881-7. doi: 10.1021/ac801745d. [PMID: 19178285]
  • Shuren Ma, Yong Y Lin, Lori Tartell, Gerard M Turino. The effect of tiotropium therapy on markers of elastin degradation in COPD. Respiratory research. 2009 Feb; 10(?):12. doi: 10.1186/1465-9921-10-12. [PMID: 19243601]
  • Irina Petrache, Joud Hajjar, Michael Campos. Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency. Biologics : targets & therapy. 2009; 3(?):193-204. doi: 10.2147/btt.2009.3088. [PMID: 19707408]
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