(-)-Catechin 3-O-gallate (BioDeep_00000017299)

 

Secondary id: BioDeep_00000269608, BioDeep_00000400547

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


Benzoic acid, 3,4,5-trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester, (2S-trans)-

化学式: C22H18O10 (442.0899928)
中文名称: 儿茶素没食子酸酯
谱图信息: 最多检出来源 Viridiplantae(plant) 1.5%

分子结构信息

SMILES: C1(O)C=C2O[C@@H](C3C=C(O)C(O)=CC=3)[C@H](OC(C3C=C(O)C(O)=C(O)C=3)=O)CC2=C(O)C=1
InChI: InChI=1S/C22H18O10/c23-11-6-14(25)12-8-19(32-22(30)10-4-16(27)20(29)17(28)5-10)21(31-18(12)7-11)9-1-2-13(24)15(26)3-9/h1-7,19,21,23-29H,8H2

描述信息

(-)-catechin-3-O-gallate is a gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of (-)-catechin. It has a role as a metabolite. It is a gallate ester, a polyphenol and a member of flavans. It is functionally related to a (-)-catechin and a gallic acid. It is an enantiomer of a (+)-catechin-3-O-gallate.
(-)-Catechin gallate is a natural product found in Rheum palmatum, Vitis vinifera, and other organisms with data available.
A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of (-)-catechin.
(-)-Catechin 3-O-gallate is a polyphenol compound found in foods of plant origin (PMID: 20428313)
(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.
(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.
(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.
(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.

同义名列表

30 个代谢物同义名

Benzoic acid, 3,4,5-trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester, (2S-trans)-; Benzoic acid, 3,4,5-trihydroxy-, (2S,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester; (2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate; (2S,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate); [(2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate; (2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate; 3,4,5-Trihydroxy-benzoic acid (2S,3R)-2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-chroman-3-yl ester; [(2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-3-yl] 3,4,5-trihydroxybenzoate; (2S,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate; (-)-Catechin gallate, >=98\\% (HPLC), from green tea; (-)-Catechin gallate; 3-(3,4,5-trihydroxybenzoate); ent-Catechin 3-O-gallic acid; (-)-Catechin 3-O-gallic acid; ent-Catechin 3-gallic acid; (-)-catechin 3-o-gallate; (-)-catechin-3-o-gallate; (-)-Catechin gallate(CG); ent-Catechin 3-O-gallate; (-)-Catechin 3-gallate; Catechin gallate, (-)-; (?)-Catechin gallate; (-)-Catechin gallate; BCatechin gallate; catechin gallate; UNII-0KT1FO6VO6; (-)-Catechin; 0KT1FO6VO6; C22H18O10; (-)-CG; (-)-epicatechingallate



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Leandro Rocha Silva, Paulo Fernando da Silva Santos-Júnior, Júlia de Andrade Brandão, Letícia Anderson, Ênio José Bassi, João Xavier de Araújo-Júnior, Sílvia Helena Cardoso, Edeildo Ferreira da Silva-Júnior. Druggable targets from coronaviruses for designing new antiviral drugs. Bioorganic & medicinal chemistry. 2020 11; 28(22):115745. doi: 10.1016/j.bmc.2020.115745. [PMID: 33007557]
  • Aleksandra Golonko, Tomasz Pienkowski, Renata Swislocka, Ryszard Lazny, Marek Roszko, Wlodzimierz Lewandowski. Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system. European journal of medicinal chemistry. 2019 Apr; 167(?):291-311. doi: 10.1016/j.ejmech.2019.01.044. [PMID: 30776692]
  • Lun K Tsou, Jacob S Yount, Howard C Hang. Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells. Bioorganic & medicinal chemistry. 2017 06; 25(11):2883-2887. doi: 10.1016/j.bmc.2017.03.023. [PMID: 28325635]
  • Patrick Müller, Kevin M Downard. Catechin inhibition of influenza neuraminidase and its molecular basis with mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2015; 111(?):222-30. doi: 10.1016/j.jpba.2015.03.014. [PMID: 25910046]
  • Mihaela Skrt, Evgen Benedik, Crtomir Podlipnik, Nataša Poklar Ulrih. Interactions of different polyphenols with bovine serum albumin using fluorescence quenching and molecular docking. Food chemistry. 2012 Dec; 135(4):2418-24. doi: 10.1016/j.foodchem.2012.06.114. [PMID: 22980822]
  • Kimberly A Grove, Sudathip Sae-tan, Mary J Kennett, Joshua D Lambert. (-)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice. Obesity (Silver Spring, Md.). 2012 Nov; 20(11):2311-3. doi: 10.1038/oby.2011.139. [PMID: 21633405]
  • M Colon, C Nerin. Role of catechins in the antioxidant capacity of an active film containing green tea, green coffee, and grapefruit extracts. Journal of agricultural and food chemistry. 2012 Oct; 60(39):9842-9. doi: 10.1021/jf302477y. [PMID: 22973940]
  • Angel L Alvarez, Kevin P Dalton, Inés Nicieza, Yolanda Diñeiro, Anna Picinelli, Santiago Melón, Annele Roque, Belén Suárez, Francisco Parra. Bioactivity-guided fractionation of Phyllanthus orbicularis and identification of the principal anti HSV-2 compounds. Phytotherapy research : PTR. 2012 Oct; 26(10):1513-20. doi: 10.1002/ptr.4608. [PMID: 22318977]
  • Danhui Li, Nataly Martini, Zimei Wu, Jingyuan Wen. Development of an isocratic HPLC method for catechin quantification and its application to formulation studies. Fitoterapia. 2012 Oct; 83(7):1267-74. doi: 10.1016/j.fitote.2012.06.006. [PMID: 22735602]
  • Hsu-Hung Tseng, Pei-Ni Chen, Wu-Hsien Kuo, Jhih-Wei Wang, Shu-Chen Chu, Yih-Shou Hsieh. Antimetastatic potentials of Phyllanthus urinaria L on A549 and Lewis lung carcinoma cells via repression of matrix-degrading proteases. Integrative cancer therapies. 2012 Sep; 11(3):267-78. doi: 10.1177/1534735411417128. [PMID: 22144737]
  • Fernando Sánchez-Patán, Raquel Tabasco, María Monagas, Teresa Requena, Carmen Peláez, M Victoria Moreno-Arribas, Begoña Bartolomé. Capability of Lactobacillus plantarum IFPL935 to catabolize flavan-3-ol compounds and complex phenolic extracts. Journal of agricultural and food chemistry. 2012 Jul; 60(29):7142-51. doi: 10.1021/jf3006867. [PMID: 22646528]
  • Shangwu Jin, Eerdunbayaer, Airi Doi, Teruo Kuroda, Guixia Zhang, Tsutomu Hatano, Guilin Chen. Polyphenolic constituents of Cynomorium songaricum Rupr. and antibacterial effect of polymeric proanthocyanidin on methicillin-resistant Staphylococcus aureus. Journal of agricultural and food chemistry. 2012 Jul; 60(29):7297-305. doi: 10.1021/jf301621e. [PMID: 22747497]
  • Adéline Delcambre, Cédric Saucier. Identification of new flavan-3-ol monoglycosides by UHPLC-ESI-Q-TOF in grapes and wine. Journal of mass spectrometry : JMS. 2012 Jun; 47(6):727-36. doi: 10.1002/jms.3007. [PMID: 22707165]
  • Carl Jenkinson, Andrea Petroczi, James Barker, Declan P Naughton. Dietary green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation. Steroids. 2012 May; 77(6):691-5. doi: 10.1016/j.steroids.2012.02.023. [PMID: 22429924]
  • Diana M Castañeda, Luis Miguel Pombo, Claudia Patricia Urueña, John Fredy Hernandez, Susana Fiorentino. A gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze displays cytotoxic activity and raises sensitivity to doxorubicin in a leukemia cell line. BMC complementary and alternative medicine. 2012 Apr; 12(?):38. doi: 10.1186/1472-6882-12-38. [PMID: 22490328]
  • Jin Wang, Yong-Ming Zhao, Chun-Yan Guo, Shao-Meng Zhang, Chun-Lei Liu, Dan-Shen Zhang, Xue-Mei Bai. Ultrasound-assisted extraction of total flavonoids from Inula helenium. Pharmacognosy magazine. 2012 Apr; 8(30):166-70. doi: 10.4103/0973-1296.96581. [PMID: 22701292]
  • Rakesh Jaiswal, Lalith Jayasinghe, Nikolai Kuhnert. Identification and characterization of proanthocyanidins of 16 members of the Rhododendron genus (Ericaceae) by tandem LC-MS. Journal of mass spectrometry : JMS. 2012 Apr; 47(4):502-15. doi: 10.1002/jms.2954. [PMID: 22689627]
  • Reşat Apak, Sema Demirci Çekiç, Aydan Cetinkaya, Hayati Filik, Mustafa Hayvalı, Emine Kılıç. Selective determination of catechin among phenolic antioxidants with the use of a novel optical fiber reflectance sensor based on indophenol dye formation on nano-sized TiO₂. Journal of agricultural and food chemistry. 2012 Mar; 60(11):2769-77. doi: 10.1021/jf204061s. [PMID: 22339278]
  • Mari Maeda-Yamamoto, Kaori Ema, Mamami Monobe, Yoshiko Tokuda, Hirofumi Tachibana. Epicatechin-3-O-(3″-O-methyl)-gallate content in various tea cultivars (Camellia sinensis L.) and its in vitro inhibitory effect on histamine release. Journal of agricultural and food chemistry. 2012 Mar; 60(9):2165-70. doi: 10.1021/jf204497b. [PMID: 22339247]
  • Judith C W Mak. Potential role of green tea catechins in various disease therapies: progress and promise. Clinical and experimental pharmacology & physiology. 2012 Mar; 39(3):265-73. doi: 10.1111/j.1440-1681.2012.05673.x. [PMID: 22229384]
  • Suraj P Shrestha, John A Thompson, Michael F Wempe, Mallikarjuna Gu, Rajesh Agarwal, Chapla Agarwal. Glucuronidation and methylation of procyanidin dimers b2 and 3,3″-di-o-galloyl-b2 and corresponding monomers epicatechin and 3-o-galloyl-epicatechin in mouse liver. Pharmaceutical research. 2012 Mar; 29(3):856-65. doi: 10.1007/s11095-011-0614-3. [PMID: 22068277]
  • Victoria Samanidou, Anastasios Tsagiannidis, Ioannis Sarakatsianos. Simultaneous determination of polyphenols and major purine alkaloids in Greek Sideritis species, herbal extracts, green tea, black tea, and coffee by high-performance liquid chromatography-diode array detection. Journal of separation science. 2012 Feb; 35(4):608-15. doi: 10.1002/jssc.201100894. [PMID: 22282422]
  • Rosalind J Miller, Kim G Jackson, Tony Dadd, Beate Nicol, Joanne L Dick, Andrew E Mayes, A Louise Brown, Anne M Minihane. A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins. European journal of nutrition. 2012 Feb; 51(1):47-55. doi: 10.1007/s00394-011-0189-0. [PMID: 21445620]
  • Yea-Tzy Deng, Tsai-Wen Chang, Ming-Shyue Lee, Jen-Kun Lin. Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells. Journal of agricultural and food chemistry. 2012 Feb; 60(4):1059-66. doi: 10.1021/jf204496f. [PMID: 22191431]
  • Soo-Kyong Choi, Xian-Hua Zhang, Jung-Sook Seo. Suppression of oxidative stress by grape seed supplementation in rats. Nutrition research and practice. 2012 Feb; 6(1):3-8. doi: 10.4162/nrp.2012.6.1.3. [PMID: 22413034]
  • Yixiang Wang, Qing Li, Qian Wang, Yujiao Li, Junhong Ling, Lili Liu, Xiaohui Chen, Kaishun Bi. Simultaneous determination of seven bioactive components in Oolong tea Camellia sinensis: quality control by chemical composition and HPLC fingerprints. Journal of agricultural and food chemistry. 2012 Jan; 60(1):256-60. doi: 10.1021/jf204312w. [PMID: 22098505]
  • Kabir Mustapha Umar, S M Abdulkarim, Son Radu, Azizah Abdul Hamid, Nazamid Saari. Engineering the production of major catechins by Escherichia coli carrying metabolite genes of Camellia sinensis. TheScientificWorldJournal. 2012; 2012(?):529031. doi: 10.1100/2012/529031. [PMID: 22645428]
  • George Binh Lenon, Kang Xiao Li, Yung-Hsien Chang, Angela Weihong Yang, Clifford Da Costa, Chun Guang Li, Marc Cohen, Neil Mann, Charlie C L Xue. Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):435702. doi: 10.1155/2012/435702. [PMID: 22550541]
  • Sabita N Saldanha, Trygve O Tollefsbol. The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes. Journal of oncology. 2012; 2012(?):192464. doi: 10.1155/2012/192464. [PMID: 22187555]
  • S Mohd Joffry, N J Yob, M S Rofiee, M M R Meor Mohd Affandi, Z Suhaili, F Othman, A Md Akim, M N M Desa, Z A Zakaria. Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):258434. doi: 10.1155/2012/258434. [PMID: 22242040]
  • Aristidis S Veskoukis, Antonios Kyparos, Michalis G Nikolaidis, Dimitrios Stagos, Nektarios Aligiannis, Maria Halabalaki, Konstantinos Chronis, Nikolaos Goutzourelas, Leandros Skaltsounis, Dimitrios Kouretas. The antioxidant effects of a polyphenol-rich grape pomace extract in vitro do not correspond in vivo using exercise as an oxidant stimulus. Oxidative medicine and cellular longevity. 2012; 2012(?):185867. doi: 10.1155/2012/185867. [PMID: 22693650]
  • Sandip Pal, Chabita Saha, Maidul Hossain, Subrata Kumar Dey, Gopinatha Suresh Kumar. Influence of galloyl moiety in interaction of epicatechin with bovine serum albumin: a spectroscopic and thermodynamic characterization. PloS one. 2012; 7(8):e43321. doi: 10.1371/journal.pone.0043321. [PMID: 22916242]
  • Hye Kyung Kim. Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):439294. doi: 10.1155/2012/439294. [PMID: 22645628]
  • Denisa Margina, Mihaela Ilie, Daniela Gradinaru. Quercetin and epigallocatechin gallate induce in vitro a dose-dependent stiffening and hyperpolarizing effect on the cell membrane of human mononuclear blood cells. International journal of molecular sciences. 2012; 13(4):4839-59. doi: 10.3390/ijms13044839. [PMID: 22606013]
  • Qiu-Hong Zhang, Wen-Biao Wang, Jin Li, Yan-Xu Chang, Yue-Fei Wang, Jishu Zhang, Bo-Li Zhang, Xiu-Mei Gao. Simultaneous determination of catechin, epicatechin and epicatechin gallate in rat plasma by LC-ESI-MS/MS for pharmacokinetic studies after oral administration of Cynomorium songaricum extract. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jan; 880(1):168-71. doi: 10.1016/j.jchromb.2011.11.021. [PMID: 22153330]
  • Hardeep Kataria, Renu Wadhwa, Sunil C Kaul, Gurcharan Kaur. Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity. PloS one. 2012; 7(5):e37080. doi: 10.1371/journal.pone.0037080. [PMID: 22606332]
  • Russell L Blaylock, Joseph Maroon. Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system. Surgical neurology international. 2012; 3(?):19. doi: 10.4103/2152-7806.92935. [PMID: 22439110]
  • Santanu Sabhapondit, Tanmoy Karak, Lakshi Prasad Bhuyan, Bhabesh Chandra Goswami, Mridul Hazarika. Diversity of catechin in northeast Indian tea cultivars. TheScientificWorldJournal. 2012; 2012(?):485193. doi: 10.1100/2012/485193. [PMID: 22448135]
  • Sishuo Cao, Wentao Xu, Nan Zhang, Yan Wang, YunBo Luo, Xiaoyun He, Kunlun Huang. A mitochondria-dependent pathway mediates the apoptosis of GSE-induced yeast. PloS one. 2012; 7(3):e32943. doi: 10.1371/journal.pone.0032943. [PMID: 22403727]
  • Lin-Lin Song, Ran Liang, Dan-Dan Li, Ya-Dong Xing, Rui-Min Han, Jian-Ping Zhang, Leif H Skibsted. β-carotene radical cation addition to green tea polyphenols. Mechanism of antioxidant antagonism in peroxidizing liposomes. Journal of agricultural and food chemistry. 2011 Dec; 59(23):12643-51. doi: 10.1021/jf2030456. [PMID: 22023371]
  • Juqiang Feng, Zhixiong Huang, Lihua Mu, Haixia Zhao, Ping Liu. [Study on chemical constituents of rhizome of Ardisia gigantifolia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Dec; 36(24):3463-6. doi: . [PMID: 22368857]
  • W Wisuitiprot, A Somsiri, K Ingkaninan, N Waranuch. In vitro human skin permeation and cutaneous metabolism of catechins from green tea extract and green tea extract-loaded chitosan microparticles. International journal of cosmetic science. 2011 Dec; 33(6):572-9. doi: 10.1111/j.1468-2494.2011.00673.x. [PMID: 21790662]
  • Muhammad R Khan, Iram Badar, Aisha Siddiquah. Prevention of hepatorenal toxicity with Sonchus asper in gentamicin treated rats. BMC complementary and alternative medicine. 2011 Nov; 11(?):113. doi: 10.1186/1472-6882-11-113. [PMID: 22082144]
  • Tamsyn Sa Thring, Pauline Hili, Declan P Naughton. Antioxidant and potential anti-inflammatory activity of extracts and formulations of white tea, rose, and witch hazel on primary human dermal fibroblast cells. Journal of inflammation (London, England). 2011 Oct; 8(1):27. doi: 10.1186/1476-9255-8-27. [PMID: 21995704]
  • Jang-Eun Lee, Bum-Jin Lee, Jeong-Ah Hwang, Kwang-Sup Ko, Jin-Oh Chung, Eun-Hee Kim, Sang-Jun Lee, Young-Shick Hong. Metabolic dependence of green tea on plucking positions revisited: a metabolomic study. Journal of agricultural and food chemistry. 2011 Oct; 59(19):10579-85. doi: 10.1021/jf202304z. [PMID: 21899366]
  • Helgi I Ingólfsson, Roger E Koeppe, Olaf S Andersen. Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties. FEBS letters. 2011 Oct; 585(19):3101-5. doi: 10.1016/j.febslet.2011.08.040. [PMID: 21896274]
  • Seham A El-Hawary, Nadia M Sokkar, Zeinab Y Ali, Marwa M Yehia. A profile of bioactive compounds of Rumex vesicarius L. Journal of food science. 2011 Oct; 76(8):C1195-202. doi: 10.1111/j.1750-3841.2011.02370.x. [PMID: 22417584]
  • D Thakur, S C Das, S Sabhapondit, P Tamuly, D K Deka. Antimicrobial activities of tocklai vegetative tea clones. Indian journal of microbiology. 2011 Oct; 51(4):450-5. doi: 10.1007/s12088-011-0190-6. [PMID: 23024406]
  • K Satyavani, S Gurudeeban, T Ramanathan, T Balasubramanian. Biomedical potential of silver nanoparticles synthesized from calli cells of Citrullus colocynthis (L.) Schrad. Journal of nanobiotechnology. 2011 Sep; 9(?):43. doi: 10.1186/1477-3155-9-43. [PMID: 21943321]
  • Mariateresa Maldini, Paola Montoro, Cosimo Pizza. Phenolic compounds from Byrsonima crassifolia L. bark: phytochemical investigation and quantitative analysis by LC-ESI MS/MS. Journal of pharmaceutical and biomedical analysis. 2011 Aug; 56(1):1-6. doi: 10.1016/j.jpba.2011.03.032. [PMID: 21571480]
  • Julia C Stingl, Thomas Ettrich, Rainer Muche, Martina Wiedom, Jürgen Brockmöller, Angela Seeringer, Thomas Seufferlein. Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population. BMC cancer. 2011 Aug; 11(?):360. doi: 10.1186/1471-2407-11-360. [PMID: 21851602]
  • Yuan Hu, Dai-Hong Guo, Ping Liu, Jing-Jing Cao, Ya-Ping Wang, Jian Yin, Ying Zhu, Khalid Rahman. Bioactive components from the tea polyphenols influence on endogenous antioxidant defense system and modulate inflammatory cytokines after total-body irradiation in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Aug; 18(11):970-5. doi: 10.1016/j.phymed.2011.02.012. [PMID: 21498061]
  • T P Tim Cushnie, Andrew J Lamb. Recent advances in understanding the antibacterial properties of flavonoids. International journal of antimicrobial agents. 2011 Aug; 38(2):99-107. doi: 10.1016/j.ijantimicag.2011.02.014. [PMID: 21514796]
  • Selim Erdogan, Burhan Ates, Gokhan Durmaz, Ismet Yilmaz, Turgay Seckin. Pressurized liquid extraction of phenolic compounds from Anatolia propolis and their radical scavenging capacities. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Jul; 49(7):1592-7. doi: 10.1016/j.fct.2011.04.006. [PMID: 21530603]
  • I-Hua Wei, Hui-Chin Tu, Chih-Chia Huang, Mang-Hung Tsai, Chi-Yu Tseng, Jeng-Yung Shieh. (-)-Epigallocatechin gallate attenuates NADPH-d/nNOS expression in motor neurons of rats following peripheral nerve injury. BMC neuroscience. 2011 Jun; 12(?):52. doi: 10.1186/1471-2202-12-52. [PMID: 21627848]
  • Yoshinori Uekusa, Miya Kamihira-Ishijima, Osamu Sugimoto, Takeshi Ishii, Shigenori Kumazawa, Kozo Nakamura, Ken-ichi Tanji, Akira Naito, Tsutomu Nakayama. Interaction of epicatechin gallate with phospholipid membranes as revealed by solid-state NMR spectroscopy. Biochimica et biophysica acta. 2011 Jun; 1808(6):1654-60. doi: 10.1016/j.bbamem.2011.02.014. [PMID: 21352801]
  • Ksenija Durgo, Sandra Kostić, Katarina Gradiški, Draženka Komes, Maja Osmak, Jasna Franekić. Genotoxic effects of green tea extract on human laryngeal carcinoma cells in vitro. Arhiv za higijenu rada i toksikologiju. 2011 Jun; 62(2):139-46. doi: 10.2478/10004-1254-62-2011-2105. [PMID: 21705301]
  • Yulong Chen, Yueming Jiang, John Shi, Xinlan Xu, Shaoyu Yang, Jun Duan. Effect of girdling at various positions of 'Huang Zhi Xiang' tea tree (Camellia sinensis) on the contents of catechins and starch in fresh leaf. Plant foods for human nutrition (Dordrecht, Netherlands). 2011 Jun; 66(2):169-74. doi: 10.1007/s11130-011-0222-8. [PMID: 21523413]
  • Pablo Gomes Ferreira, Maria Angélica Suedan Souza Lima, Robert Alvin Bernedo-Navarro, Rogério Arcuri Conceição, Edlaine Linhares, Alexandra Christine Helena Frankland Sawaya, Tomomasa Yano, Ione Salgado. Stimulation of acidic reduction of nitrite to nitric oxide by soybean phenolics: possible relevance to gastrointestinal host defense. Journal of agricultural and food chemistry. 2011 May; 59(10):5609-16. doi: 10.1021/jf201229x. [PMID: 21510708]
  • Youngmok Kim, Bruce A Welt, Stephen T Talcott. The impact of packaging materials on the antioxidant phytochemical stability of aqueous infusions of green tea (Camellia sinensis) and yaupon holly (Ilex vomitoria) during cold storage. Journal of agricultural and food chemistry. 2011 May; 59(9):4676-83. doi: 10.1021/jf104799y. [PMID: 21434687]
  • Jianghao Sun, Pei Chen, Long-Ze Lin, James M Harnly. A non-targeted approach to chemical discrimination between green tea dietary supplements and green tea leaves by HPLC/MS. Journal of AOAC International. 2011 Mar; 94(2):487-97. doi: 10.1093/jaoac/94.2.487. [PMID: 21563682]
  • Mari Maeda-Yamamoto, Kaori Ema, Yoshiko Tokuda, Manami Monobe, Hirofumi Tachibana, Yoichi Sameshima, Shinichi Kuriyama. Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study. Cytotechnology. 2011 Mar; 63(2):171-9. doi: 10.1007/s10616-010-9331-8. [PMID: 21207145]
  • Mohammad B Ali, Susanne Howard, Shangwu Chen, Yechun Wang, Oliver Yu, Laszlo G Kovacs, Wenping Qiu. Berry skin development in Norton grape: distinct patterns of transcriptional regulation and flavonoid biosynthesis. BMC plant biology. 2011 Jan; 11(?):7. doi: 10.1186/1471-2229-11-7. [PMID: 21219654]
  • Takayuki Maruyama, Takaaki Tomofuji, Yasumasa Endo, Koichiro Irie, Tetsuji Azuma, Daisuke Ekuni, Naofumi Tamaki, Tatsuo Yamamoto, Manabu Morita. Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. Archives of oral biology. 2011 Jan; 56(1):48-53. doi: 10.1016/j.archoralbio.2010.08.015. [PMID: 20869695]
  • Anna Arola-Arnal, Cinta Bladé. Proanthocyanidins modulate microRNA expression in human HepG2 cells. PloS one. 2011; 6(10):e25982. doi: 10.1371/journal.pone.0025982. [PMID: 21998738]
  • Yuma Iwai, Kouki Murakami, Yasuyuki Gomi, Toshihiro Hashimoto, Yoshinori Asakawa, Yoshinobu Okuno, Toyokazu Ishikawa, Dai Hatakeyama, Noriko Echigo, Takashi Kuzuhara. Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts. PloS one. 2011; 6(5):e19825. doi: 10.1371/journal.pone.0019825. [PMID: 21625478]
  • Eisaku Yamamoto, Naoko Nishimura, Ken Okada, Chikako Sekido, Shingo Yamamichi, Keiji Hasumi. Inhibitors of autoactivation of plasma hyaluronan-binding protein (factor VII activating protease). Biological & pharmaceutical bulletin. 2011; 34(4):462-70. doi: 10.1248/bpb.34.462. [PMID: 21467630]
  • M Marin-Kuan, V Ehrlich, T Delatour, C Cavin, B Schilter. Evidence for a role of oxidative stress in the carcinogenicity of ochratoxin a. Journal of toxicology. 2011; 2011(?):645361. doi: 10.1155/2011/645361. [PMID: 21776264]
  • Kathryn Bauerly, Calliandra Harris, Winyoo Chowanadisai, James Graham, Peter J Havel, Eskouhie Tchaparian, Mike Satre, Joel S Karliner, Robert B Rucker. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. PloS one. 2011; 6(7):e21779. doi: 10.1371/journal.pone.0021779. [PMID: 21814553]
  • Rajesh Arora, R Chawla, Rohit Marwah, P Arora, R K Sharma, Vinod Kaushik, R Goel, A Kaur, M Silambarasan, R P Tripathi, J R Bhardwaj. Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):586506. doi: 10.1155/2011/586506. [PMID: 20976081]
  • Harvey Babich, Alyssa G Schuck, Jeffrey H Weisburg, Harriet L Zuckerbraun. Research strategies in the study of the pro-oxidant nature of polyphenol nutraceuticals. Journal of toxicology. 2011; 2011(?):467305. doi: 10.1155/2011/467305. [PMID: 21776260]
  • Alfred Zoechling, Falk Liebner, Alois Jungbauer. Red wine: a source of potent ligands for peroxisome proliferator-activated receptor γ. Food & function. 2011 Jan; 2(1):28-38. doi: 10.1039/c0fo00086h. [PMID: 21773583]
  • Hang Zhao, Min Zhang, Lu Zhao, Ya-Kun Ge, Jun Sheng, Wei Shi. Changes of constituents and activity to apoptosis and cell cycle during fermentation of tea. International journal of molecular sciences. 2011; 12(3):1862-75. doi: 10.3390/ijms12031862. [PMID: 21673927]
  • Sunil Kumar, Smita Narwal, Vipin Kumar, Om Prakash. α-glucosidase inhibitors from plants: A natural approach to treat diabetes. Pharmacognosy reviews. 2011 Jan; 5(9):19-29. doi: 10.4103/0973-7847.79096. [PMID: 22096315]
  • Lanjun Zhao, Shuting Jia, Wenru Tang, Jun Sheng, Ying Luo. Pu-erh tea inhibits tumor cell growth by down-regulating mutant p53. International journal of molecular sciences. 2011; 12(11):7581-93. doi: 10.3390/ijms12117581. [PMID: 22174618]
  • S Yoo, R M Murata, S Duarte. Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans. Caries research. 2011; 45(4):327-35. doi: 10.1159/000329181. [PMID: 21720161]
  • Enzo A Palombo. Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):680354. doi: 10.1093/ecam/nep067. [PMID: 19596745]
  • Cleber A Schmidt, Renato Murillo, Torsten Bruhn, Gerhard Bringmann, Marcia Goettert, Berta Heinzmann, Volker Brecht, Stefan A Laufer, Irmgard Merfort. Catechin derivatives from Parapiptadenia rigida with in vitro wound-healing properties. Journal of natural products. 2010 Dec; 73(12):2035-41. doi: 10.1021/np100523s. [PMID: 21080642]
  • Chwan-Li Shen, Ming-Chien Chyu, Barbara C Pence, James K Yeh, Yan Zhang, Carol K Felton, Susan Doctolero, Jia-Sheng Wang. Green tea polyphenols supplementation and Tai Chi exercise for postmenopausal osteopenic women: safety and quality of life report. BMC complementary and alternative medicine. 2010 Dec; 10(?):76. doi: 10.1186/1472-6882-10-76. [PMID: 21143878]
  • Suma Mohan, Aswathy Sheena, Ninu Poulose, Gopalakrishnapillai Anilkumar. Molecular dynamics simulation studies of GLUT4: substrate-free and substrate-induced dynamics and ATP-mediated glucose transport inhibition. PloS one. 2010 Dec; 5(12):e14217. doi: 10.1371/journal.pone.0014217. [PMID: 21151967]
  • A Ziaedini, A Jafari, A Zakeri. Extraction of antioxidants and caffeine from green tea (Camelia sinensis) leaves: kinetics and modeling. Food science and technology international = Ciencia y tecnologia de los alimentos internacional. 2010 Dec; 16(6):505-10. doi: 10.1177/1082013210367567. [PMID: 21339166]
  • Motoki Iwasaki, Manami Inoue, Shizuka Sasazuki, Tsutomu Miura, Norie Sawada, Taiki Yamaji, Taichi Shimazu, Walter C Willett, Shoichiro Tsugane. Plasma tea polyphenol levels and subsequent risk of breast cancer among Japanese women: a nested case-control study. Breast cancer research and treatment. 2010 Dec; 124(3):827-34. doi: 10.1007/s10549-010-0916-x. [PMID: 20440552]
  • Julija Josic, Anna Tholén Olsson, Jennie Wickeberg, Sandra Lindstedt, Joanna Hlebowicz. Does green tea affect postprandial glucose, insulin and satiety in healthy subjects: a randomized controlled trial. Nutrition journal. 2010 Nov; 9(?):63. doi: 10.1186/1475-2891-9-63. [PMID: 21118565]
  • Joaudimir Castro, Tara Pregibon, Kristina Chumanov, R Kenneth Marcus. Determination of catechins and caffeine in proposed green tea standard reference materials by liquid chromatography-particle beam/electron ionization mass spectrometry (LC-PB/EIMS). Talanta. 2010 Oct; 82(5):1687-95. doi: 10.1016/j.talanta.2010.07.054. [PMID: 20875564]
  • Markus Schantz, Thomas Erk, Elke Richling. Metabolism of green tea catechins by the human small intestine. Biotechnology journal. 2010 Oct; 5(10):1050-9. doi: 10.1002/biot.201000214. [PMID: 20931601]
  • C T Ranjith-Kumar, Yvonne Lai, Robert T Sarisky, C Cheng Kao. Green tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-I. PloS one. 2010 Sep; 5(9):e12878. doi: 10.1371/journal.pone.0012878. [PMID: 20877565]
  • Janet Calero Sánchez, Roberto Faure García, Ma Teresa Mitjavila Cors. 1,1-Diphenyl-2-picrylhydrazyl radical and superoxide anion scavenging activity of Rhizophora mangle (L.) bark. Pharmacognosy research. 2010 Sep; 2(5):279-84. doi: 10.4103/0974-8490.72323. [PMID: 21589751]
  • Mark Lehnert, Henrik Lind, Zhi Zhong, Robert Schoonhoven, Ingo Marzi, John J Lemasters. Polyphenols of Camellia sinenesis decrease mortality, hepatic injury and generation of cytokines and reactive oxygen and nitrogen species after hemorrhage/resuscitation in rats. BMC complementary and alternative medicine. 2010 Aug; 10(?):46. doi: 10.1186/1472-6882-10-46. [PMID: 20735845]
  • Wei Feng, Gennady Cherednichenko, Chris W Ward, Isela T Padilla, Elaine Cabrales, José R Lopez, José M Eltit, Paul D Allen, Isaac N Pessah. Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1). Biochemical pharmacology. 2010 Aug; 80(4):512-21. doi: 10.1016/j.bcp.2010.05.004. [PMID: 20471964]
  • S M Kamruzzaman, Mehari Endale, Won Jun Oh, Seung-Chun Park, Kil-Soo Kim, Joo Heon Hong, Yi-Seong Kwak, Bong-Sik Yun, Man Hee Rhee. Inhibitory effects of Bulnesia sarmienti aqueous extract on agonist-induced platelet activation and thrombus formation involves mitogen-activated protein kinases. Journal of ethnopharmacology. 2010 Aug; 130(3):614-20. doi: 10.1016/j.jep.2010.05.049. [PMID: 20558266]
  • Damian Duhon, Rebecca L H Bigelow, David T Coleman, Joshua J Steffan, Chris Yu, Will Langston, Christopher G Kevil, James A Cardelli. The polyphenol epigallocatechin-3-gallate affects lipid rafts to block activation of the c-Met receptor in prostate cancer cells. Molecular carcinogenesis. 2010 Aug; 49(8):739-49. doi: 10.1002/mc.20649. [PMID: 20623641]
  • Piwen Wang, William J Aronson, Min Huang, Yanjun Zhang, Ru-Po Lee, David Heber, Susanne M Henning. Green tea polyphenols and metabolites in prostatectomy tissue: implications for cancer prevention. Cancer prevention research (Philadelphia, Pa.). 2010 Aug; 3(8):985-93. doi: 10.1158/1940-6207.capr-09-0210. [PMID: 20628004]
  • Nobuyuki Hayashi, Ronggang Chen, Masamitsu Hiraoka, Tomomi Ujihara, Hidekazu Ikezaki. Beta-cyclodextrin/surface plasmon resonance detection system for sensing bitter-astringent taste intensity of green tea catechins. Journal of agricultural and food chemistry. 2010 Jul; 58(14):8351-6. doi: 10.1021/jf1012693. [PMID: 20572674]
  • John H Grabber, Paul F Schatz, Hoon Kim, Fachuang Lu, John Ralph. Identifying new lignin bioengineering targets: 1. Monolignol-substitute impacts on lignin formation and cell wall fermentability. BMC plant biology. 2010 Jun; 10(?):114. doi: 10.1186/1471-2229-10-114. [PMID: 20565789]
  • De-Qiang Li, Zheng-Ming Qian, Shao-Ping Li. Inhibition of three selected beverage extracts on alpha-glucosidase and rapid identification of their active compounds using HPLC-DAD-MS/MS and biochemical detection. Journal of agricultural and food chemistry. 2010 Jun; 58(11):6608-13. doi: 10.1021/jf100853c. [PMID: 20443596]
  • Yong-Seo Park, Mi-Kyung Lee, Buk-Gu Heo, Kyung-Sik Ham, Seong-Gook Kang, Ja-Yong Cho, Shela Gorinstein. Comparison of the nutrient and chemical contents of traditional Korean Chungtaejeon and green teas. Plant foods for human nutrition (Dordrecht, Netherlands). 2010 Jun; 65(2):186-91. doi: 10.1007/s11130-010-0170-8. [PMID: 20490689]
  • Sonia A Tucci, Emma J Boyland, Jason Cg Halford. The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents. Diabetes, metabolic syndrome and obesity : targets and therapy. 2010 May; 3(?):125-43. doi: 10.2147/dmsott.s7005. [PMID: 21437083]
  • Sonia de Pascual-Teresa, Diego A Moreno, Cristina García-Viguera. Flavanols and anthocyanins in cardiovascular health: a review of current evidence. International journal of molecular sciences. 2010 Apr; 11(4):1679-703. doi: 10.3390/ijms11041679. [PMID: 20480037]
  • Elías Obreque-Slier, Alvaro Peña-Neira, Remigio López-Solís, Fernando Zamora-Marín, Jorge M Ricardo-da Silva, Olga Laureano. Comparative study of the phenolic composition of seeds and skins from Carménère and Cabernet Sauvignon grape varieties (Vitis vinifera L.) during ripening. Journal of agricultural and food chemistry. 2010 Mar; 58(6):3591-9. doi: 10.1021/jf904314u. [PMID: 20163111]