2-Mercaptoethylguanidine (BioDeep_00000173335)
human metabolite blood metabolite
代谢物信息卡片
2-Mercaptoethylguanidine, sulfate(2:1) salt
化学式: C3H9N3S (119.0517)
中文名称: MEG琥珀酸钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CS)N=C(N)N
InChI: InChI=1S/C3H9N3S/c4-3(5)6-1-2-7/h7H,1-2H2,(H4,4,5,6)
描述信息
D004791 - Enzyme Inhibitors
同义名列表
10 个代谢物同义名
2-Mercaptoethylguanidine, sulfate(2:1) salt; 2-Mercaptoethylguanidine monohydrochloride; 2-Mercaptoethylguanidine monohydrobromide; 2-Mercaptoethylguanidine dihydrobromide; 2-Mercaptoethylguanidine hydrobromide; N-(2-sulfanylethyl)guanidine; 2-Mercaptoethylguanidine; Mercaptoethylguanidine; MEG-2SH; (2-Mercaptoethyl)guanidine
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Torbjørn Breivik, Yngvar Gundersen, Per Gjermo, Inge Fristad, Per Kristian Opstad. Systemic chemical desensitization of peptidergic sensory neurons with resiniferatoxin inhibits experimental periodontitis.
The open dentistry journal.
2011 Jan; 5(?):1-6. doi:
10.2174/1874210601105010001. [PMID: 21339860] - Mustafa Ozturk, Mehmet Ozler, Yasemin Gulcan Kurt, Bekir Ozturk, Bulent Uysal, Nail Ersoz, Mehmet Yasar, Seref Demirbas, Bulent Kurt, Cengizhan Acikel, Yesim Oztas, Fikret Arpaci, Turgut Topal, Ahmet Ozet, Selmin Ataergin, Okan Kuzhan, Sukru Oter, Ahmet Korkmaz. Efficacy of melatonin, mercaptoethylguanidine and 1400W in doxorubicin- and trastuzumab-induced cardiotoxicity.
Journal of pineal research.
2011 Jan; 50(1):89-96. doi:
10.1111/j.1600-079x.2010.00818.x. [PMID: 21062350] - Ying-Hua Yang, Rajesh Rajaiah, David Y-W Lee, Zhongze Ma, Hua Yu, Harry H S Fong, Lixing Lao, Brian M Berman, Kamal D Moudgil. Suppression of ongoing experimental arthritis by a chinese herbal formula (huo-luo-xiao-ling dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):642027. doi:
10.1155/2011/642027. [PMID: 20981317] - Rosimary S Carvalho, Carolina M de Souza, Julliana C S Neves, Sergio A Holanda-Pinto, Lívia M S Pinto, Gerly A C Brito, Geanne M de Andrade. Effect of venlafaxine on bone loss associated with ligature-induced periodontitis in Wistar rats.
Journal of negative results in biomedicine.
2010 Jun; 9(?):3. doi:
10.1186/1477-5751-9-3. [PMID: 20546603] - K B Menaka, Amitha Ramesh, Biju Thomas, N Suchetha Kumari. Estimation of nitric oxide as an inflammatory marker in periodontitis.
Journal of Indian Society of Periodontology.
2009 May; 13(2):75-8. doi:
10.4103/0972-124x.55842. [PMID: 20407654] - Jaouad Bouayed, Hassan Rammal, Rachid Soulimani. Oxidative stress and anxiety: relationship and cellular pathways.
Oxidative medicine and cellular longevity.
2009 Apr; 2(2):63-7. doi:
10.4161/oxim.2.2.7944. [PMID: 20357926] - Fang Du, Liang-jing Lü, Qiong Fu, Min Dai, Jia-lin Teng, Wei Fan, Shun-le Chen, Ping Ye, Nan Shen, Xin-fang Huang, Jie Qian, Chun-de Bao. T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis.
Arthritis research & therapy.
2008; 10(6):R136. doi:
10.1186/ar2554. [PMID: 19019215] - Ahmet Guven, Bulent Uysal, Ozgur Akgul, Hakan Cermik, Gokhan Gundogdu, Ilhami Surer, Haluk Ozturk, Ahmet Korkmaz. Scavenging of peroxynitrite reduces renal ischemia/reperfusion injury.
Renal failure.
2008; 30(7):747-54. doi:
10.1080/08860220802213039. [PMID: 18704824] - M Naviliat, G Gualco, A Cayota, R Radi. Protein 3-nitrotyrosine formation during Trypanosoma cruzi infection in mice.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2005 Dec; 38(12):1825-34. doi:
10.1590/s0100-879x2005001200011. [PMID: 16302097] - Rosanna Di Paola, Emanuela Mazzon, Carmelo Muià, Tiziana Genovese, Marta Menegazzi, Raffaela Zaffini, Hisanory Suzuki, Salvatore Cuzzocrea. Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice.
Respiratory research.
2005 Jun; 6(?):66. doi:
10.1186/1465-9921-6-66. [PMID: 15987519] - Takeo Anazawa, Paul C Dimayuga, Hongyan Li, Shigemasa Tani, Jason Bradfield, Kuang-Yuh Chyu, Sanjay Kaul, Prediman K Shah, Bojan Cercek. Effect of exposure to cigarette smoke on carotid artery intimal thickening: the role of inducible NO synthase.
Arteriosclerosis, thrombosis, and vascular biology.
2004 Sep; 24(9):1652-8. doi:
10.1161/01.atv.0000139925.84444.ad. [PMID: 15271786] - Steve Lancel, Stéphanie Tissier, Serge Mordon, Xavier Marechal, Florence Depontieu, Arnaud Scherpereel, Claude Chopin, Remi Neviere. Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats.
Journal of the American College of Cardiology.
2004 Jun; 43(12):2348-58. doi:
10.1016/j.jacc.2004.01.047. [PMID: 15193704] - K Soejima, F C Schmalstieg, L D Traber, C Szabo, A Salzman, D L Traber. Role of nitric oxide in myocardial dysfunction after combined burn and smoke inhalation injury.
Burns : journal of the International Society for Burn Injuries.
2001 Dec; 27(8):809-15. doi:
10.1016/s0305-4179(01)00051-1. [PMID: 11718983] - F Ploner, P Radermacher, M Theisen, I F Tugtekin, M Matejovic, A Stehr, C Szabó, G J Southan, M Georgieff, U B Bruckner, K Träger. Effects of combined selective iNOS inhibition and peroxynitrite blockade during endotoxemia in pigs.
Shock (Augusta, Ga.).
2001 Aug; 16(2):130-6. doi:
10.1097/00024382-200116020-00008. [PMID: 11508865] - K Soejima, L D Traber, F C Schmalstieg, H Hawkins, J M Jodoin, C Szabo, E Szabo, L Virag, A Salzman, D L Traber, L Varig. Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury.
American journal of respiratory and critical care medicine.
2001 Mar; 163(3 Pt 1):745-52. doi:
10.1164/ajrccm.163.3.9912052. [PMID: 11254534] - N Bank, M Kiroycheva, P C Singhal, G M Anthony, G J Southan, C Szabo. Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys.
Kidney international.
2000 Jul; 58(1):82-9. doi:
10.1046/j.1523-1755.2000.00143.x. [PMID: 10886552] - J E Irazuzta, L D Mirkin, B Zingarelli. Mercaptoethylguanidine attenuates inflammation in bacterial meningitis in rabbits.
Life sciences.
2000 Jun; 67(4):365-72. doi:
10.1016/s0024-3205(00)00637-8. [PMID: 11003046] - Militza Kiroycheva, Fayyaz Ahmed, Gillian M Anthony, Csaba Szabo, Garry J Southan, Norman Bank. Mitogen-activated protein kinase phosphorylation in kidneys of beta(s) sickle cell mice.
Journal of the American Society of Nephrology : JASN.
2000 Jun; 11(6):1026-1032. doi:
10.1681/asn.v1161026. [PMID: 10820166] - A Szabó, P Hake, A L Salzman, C Szabó. Beneficial effects of mercaptoethylguanidine, an inhibitor of the inducible isoform of nitric oxide synthase and a scavenger of peroxynitrite, in a porcine model of delayed hemorrhagic shock.
Critical care medicine.
1999 Jul; 27(7):1343-50. doi:
10.1097/00003246-199907000-00027. [PMID: 10446830] - M Whiteman, C Szabó, B Halliwell. Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of alpha1-antiproteinase by mercaptoethylguanidine.
British journal of pharmacology.
1999 Apr; 126(7):1646-52. doi:
10.1038/sj.bjp.0702465. [PMID: 10323598] - E Brahn, M L Banquerigo, G S Firestein, D L Boyle, A L Salzman, C Szabó. Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action.
The Journal of rheumatology.
1998 Sep; 25(9):1785-93. doi:
NULL. [PMID: 9733461] - Z Lohinai, P Benedek, E Fehér, A Györfi, L Rosivall, A Fazekas, A L Salzman, C Szabó. Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat.
British journal of pharmacology.
1998 Feb; 123(3):353-60. doi:
10.1038/sj.bjp.0701604. [PMID: 9504374] - A Vromen, M S Arkovitz, B Zingarelli, A L Salzman, V F Garcia, C Szabó. Low-level expression and limited role for the inducible isoform of nitric oxide synthase in the vascular hyporeactivity and mortality associated with cecal ligation and puncture in the rat.
Shock (Augusta, Ga.).
1996 Oct; 6(4):248-53. doi:
10.1097/00024382-199610000-00004. [PMID: 8902940] - B SHAPIRO, G KOLLMANN, E E SCHWARTZ. THE DISTRIBUTION AND METABOLISM OF ORALLY ADMINISTERED 2-MERCAPTOETHYLGUANIDINE (MEG) AND BIS(2-GUANIDOETHYL) DISULFIDE (GED) IN PROTECTED MICE.
Annals of the New York Academy of Sciences.
1964 Mar; 114(?):597-601. doi:
10.1111/j.1749-6632.1964.tb53612.x. [PMID: 14128249]
