Paprazine (BioDeep_00000622782)

PANOMIX_OTCML-2023

代谢物信息卡片

(2e)-3-(4-hydroxyphenyl)-n-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide

化学式: C17H17NO3 (283.1208)
中文名称: N-对反式香豆酰酪胺, 对香豆酰酪胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1CCNC(=O)C=CC2=CC=C(C=C2)O)O
InChI: InChI=1S/C17H17NO3/c19-15-6-1-13(2-7-15)5-10-17(21)18-12-11-14-3-8-16(20)9-4-14/h1-10,19-20H,11-12H2,(H,18,21)/b10-5+

描述信息

N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 μM for T. brucei rhodesiense[1][2].
N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 μM for T. brucei rhodesiense[1][2].

同义名列表

5 个代谢物同义名

(2e)-3-(4-hydroxyphenyl)-n-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide; N-(p-Hydroxyphenyl)ethyl p-hydroxycinnamide; N-p-trans-Coumaroyltyramine; Paprazine; p-Coumaroyltyramine

数据库引用编号

7 个数据库交叉引用编号

ChEBI: CHEBI:65665
PubChem: 5372945
Metlin: METLIN94089
ChEMBL: CHEMBL64286
CAS: 111129-11-4
CAS: 36417-86-4
medchemexpress: HY-N2230

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

59 个相关的物种来源信息

43364 - Aesculus hippocastanum:
35875 - Allium fistulosum: 10.1271/BBB.61.1138
49314 - Annona cherimola: 10.1016/S0031-9422(98)00123-X
301703 - Annona glabra: 10.1002/JCCS.200000124
49857 - Annona montana: 10.1055/S-2006-958035
432629 - Arcangelisia gusanlung: 10.1021/NP100900K
143780 - Aristolochia elegans: 10.1016/J.BMC.2003.10.031
325095 - Aristolochia littoralis: 10.1016/J.BMC.2003.10.031
158555 - Aristolochia manshuriensis: 10.1021/NP0301238
225833 - Artabotrys hexapetalus: 10.1248/CPB.55.1597
12953 - Asimina triloba: 10.1021/NP50081A011
258209 - Berberis vulgaris: 10.1002/PTR.2443
3708 - Brassica napus: 10.3389/FNUT.2022.822033
197417 - Camonea umbellata: 10.3390/MOLECULES15118241
3483 - Cannabis sativa: 10.1016/0091-3057(91)90348-6
4072 - Capsicum annuum:
40321 - Capsicum annuum var. annuum: 10.1080/00021369.1981.10864909
198263 - Celtis bungeana: 10.1007/BF02976684
2682638 - Conchocarpus gaudichaudianus: 10.3987/COM-09-11671
205937 - Crinum asiaticum: 10.1002/CBDV.200800273
35625 - Datura metel: 10.1016/0031-9422(92)83291-6
461588 - Fibraurea tinctoria: 10.1016/J.BMC.2008.09.023
1464615 - Fumaria indica: 10.1016/0031-9422(92)83649-J
4232 - Helianthus annuus:
493319 - Isolona congolana: 10.1016/0031-9422(95)00333-3
493324 - Isolona maitlandii: 10.1016/0031-9422(95)00333-3
332435 - Lindera glauca: 10.1002/JCCS.200100116
39529 - Liriope muscari: 10.1021/NP049864E
112883 - Lycium chinense: 10.1021/NP300655Y
640776 - Macleaya microcarpa: 10.1016/J.PHYTOCHEM.2010.02.007
1619493 - Melicope hayesii: 10.1016/S0031-9422(98)00720-1
1679250 - Mitrephora thorelii: 10.1002/HLCA.200890109
1489755 - Mitrephora tomentosa: 10.1002/HLCA.200890109
4432 - Nelumbo nucifera: 10.1016/J.BMCL.2013.04.013
100506 - Ophiopogon japonicus: 10.1021/NP049864E
100506 - OPhiopogon japonicus ( L.f) Ker-Gawl.: -
2045269 - Peperomia heyneana: 10.1021/NP0604533
467334 - Persicaria orientalis: 10.4268/CJCMM20100303
130385 - Piper auritum: 10.1021/NP0401260
54803 - Piper kadsura: 10.1021/NP0505521
13216 - Piper nigrum: 10.1080/14786410902757998
511552 - Piper sanctum: 10.1021/NP0401260
130418 - Piper umbellatum: 10.1016/J.PHYTOCHEM.2008.02.018
33090 - Plants: -
105757 - Polyalthia suberosa: 10.1016/S0031-9422(99)00535-X
23211 - Pyrus communis:
32247 - Rubus idaeus:
254917 - Saussurea muliensis: 10.1021/NP070618N
1807820 - Solanum annuum:
227722 - Solanum lasiocarpum: 10.1021/NP010186V
4081 - Solanum lycopersicum:
4111 - Solanum melongena:
4111 - Solanum Melongena L: -
329803 - Solanum violaceum:
354522 - Tetradium glabrifolium: 10.1016/0031-9422(95)00248-6
152349 - Tinospora sinensis: 10.1080/14786410802682239
210369 - Tribulus terrestris:
3906 - Vicia faba:
1527549 - Vicia sativa var. sativa:

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表

文献列表

Yuan-Kun Zheng, Bao-Jun Su, Ya-Qi Wang, Heng-Shan Wang, Hai-Bing Liao, Dong Liang. New Tyramine- and Aporphine-Type Alkamides with NO Release Inhibitory Activities from Piper puberulum. Journal of natural products. 2021 04; 84(4):1316-1325. doi: 10.1021/acs.jnatprod.1c00055. [PMID: 33822610]
Jakob K Reinhardt, Amy M Zimmermann-Klemd, Ombeline Danton, Martin Smieško, Carsten Gründemann, Matthias Hamburger. Compounds from Toddalia asiatica: Immunosuppressant Activity and Absolute Configurations. Journal of natural products. 2020 10; 83(10):3012-3020. doi: 10.1021/acs.jnatprod.0c00564. [PMID: 33001647]
Virayu Suthiphasilp, Wisanu Maneerat, Raymond J Andersen, Piyaporn Phukhatmuen, Stephen G Pyne, Surat Laphookhieo. Dasymaschalolactams A-E, Aristolactams from a Twig Extract of Dasymaschalon dasymaschalum. Journal of natural products. 2019 11; 82(11):3176-3180. doi: 10.1021/acs.jnatprod.9b00506. [PMID: 31661271]
Yehyang Kim, Sohun Lee, Ji Hye Ryu, Kee Dong Yoon, Song Seok Shin. Effect of Aurea Helianthus stem extract on anti-melanogenesis. Bioscience, biotechnology, and biochemistry. 2018 Nov; 82(11):1871-1879. doi: 10.1080/09168451.2018.1506311. [PMID: 30146944]
Hyo Hee Yang, Kyung-Eon Oh, Yang Hee Jo, Jong Hoon Ahn, Qing Liu, Ayman Turk, Jae Young Jang, Bang Yeon Hwang, Ki Yong Lee, Mi Kyeong Lee. Characterization of tyrosinase inhibitory constituents from the aerial parts of Humulus japonicus using LC-MS/MS coupled online assay. Bioorganic & medicinal chemistry. 2018 01; 26(2):509-515. doi: 10.1016/j.bmc.2017.12.011. [PMID: 29254897]
Batsukh Odonbayar, Toshihiro Murata, Javzan Batkhuu, Kosho Yasunaga, Rina Goto, Kenroh Sasaki. Antioxidant Flavonols and Phenolic Compounds from Atraphaxis frutescens and Their Inhibitory Activities against Insect Phenoloxidase and Mushroom Tyrosinase. Journal of natural products. 2016 Dec; 79(12):3065-3071. doi: 10.1021/acs.jnatprod.6b00720. [PMID: 28006914]
Thanika Promchai, Atchara Jaidee, Sarot Cheenpracha, Kongkiat Trisuwan, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan, Surat Laphookhieo, Stephen G Pyne, Thunwadee Ritthiwigrom. Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata. Journal of natural products. 2016 Apr; 79(4):978-83. doi: 10.1021/acs.jnatprod.5b01054. [PMID: 26928423]
Jong Hoon Ahn, Eun Sil Kim, Chul Lee, Soonok Kim, Soo-Hyun Cho, Bang Yeon Hwang, Mi Kyeong Lee. Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects. Bioorganic & medicinal chemistry letters. 2013 Jun; 23(12):3604-8. doi: 10.1016/j.bmcl.2013.04.013. [PMID: 23642481]
Jing-Xian Zhang, Shu-Hong Guan, Rui-Hong Feng, Yang Wang, Zhi-Yuan Wu, Yi-Bei Zhang, Xiao-Hui Chen, Kai-Shun Bi, De-An Guo. Neolignanamides, lignanamides, and other phenolic compounds from the root bark of Lycium chinense. Journal of natural products. 2013 Jan; 76(1):51-8. doi: 10.1021/np300655y. [PMID: 23282106]
Ling-Ling Yu, Wei-Cheng Hu, Gang Ding, Rong-Tao Li, Jian-He Wei, Zhong-Mei Zou, Myeong-Hyeon Wang. Gusanlungionosides A-D, potential tyrosinase inhibitors from Arcangelisia gusanlung. Journal of natural products. 2011 May; 74(5):1009-14. doi: 10.1021/np100900k. [PMID: 21500777]
Shuang Song, Yixiu Li, Ziming Feng, Jianshuang Jiang, Peicheng Zhang. Hepatoprotective constituents from the roots and stems of Erycibe hainanesis. Journal of natural products. 2010 Feb; 73(2):177-84. doi: 10.1021/np900593q. [PMID: 20092289]
Rachel Mata, Iliana Morales, Olga Pérez, Isabel Rivero-Cruz, Laura Acevedo, Isolda Enriquez-Mendoza, Robert Bye, Scott Franzblau, Barbara Timmermann. Antimycobacterial compounds from Piper sanctum. Journal of natural products. 2004 Dec; 67(12):1961-8. doi: 10.1021/np0401260. [PMID: 15620234]
Dae Keun Kim, Kieseung Lee. Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase. Archives of pharmacal research. 2003 Sep; 26(9):735-8. doi: 10.1007/bf02976684. [PMID: 14560923]
P Tuchinda, M Pohmakotr, V Reutrakul, W Thanyachareon, S Sophasan, C Yoosook, T Santisuk, J M Pezzuto. 2-substituted furans from Polyalthia suberosa. Planta medica. 2001 Aug; 67(6):572-5. doi: 10.1055/s-2001-16469. [PMID: 11509987]