Tormentic_acid (BioDeep_00000230338)

 

Secondary id: BioDeep_00000264912, BioDeep_00000864372

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(1R,2R,4AS,6AS,6BR,8AR,10R,11R,12AR,12BR,14BS)-1,10,11-TRIHYDROXY-1,2,6A,6B,9,9,12A-HEPTAMETHYL-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-ICOSAHYDROPICENE-4A-CARBOXYLIC ACID

化学式: C30H48O5 (488.3501558)
中文名称: 2Α,19Α-二羟基熊果酸, 委陵菜酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)C)O)O)C)C)C2C1(C)O)C)C(=O)O
InChI: InChI=1S/C30H48O5/c1-17-10-13-30(24(33)34)15-14-27(5)18(22(30)29(17,7)35)8-9-21-26(4)16-19(31)23(32)25(2,3)20(26)11-12-28(21,27)6/h8,17,19-23,31-32,35H,9-16H2,1-7H3,(H,33,34)/t17-,19-,20+,21-,22-,23+,26+,27-,28-,29-,30+/m1/s1

描述信息

Tormentic acid is a triterpenoid. It has a role as a metabolite.
Tormentic acid is a natural product found in Debregeasia saeneb, Chaenomeles speciosa, and other organisms with data available.
A natural product found in Euscaphis japonica.
Tormentic acid, a triterpene isolated from Rosa rugosa, exerts anti-inflammatory, antihyperlipidemic, and anti-atherogenic properties[1][2].
Tormentic acid, a triterpene isolated from Rosa rugosa, exerts anti-inflammatory, antihyperlipidemic, and anti-atherogenic properties[1][2].
Tormentic acid, a triterpene isolated from Rosa rugosa, exerts anti-inflammatory, antihyperlipidemic, and anti-atherogenic properties[1][2].

同义名列表

20 个代谢物同义名

(1R,2R,4AS,6AS,6BR,8AR,10R,11R,12AR,12BR,14BS)-1,10,11-TRIHYDROXY-1,2,6A,6B,9,9,12A-HEPTAMETHYL-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-ICOSAHYDROPICENE-4A-CARBOXYLIC ACID; (1R,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid; URS-12-EN-28-OIC ACID, 2,3,19-TRIHYDROXY-, (2.ALPHA.,3.BETA.)-; 2.alpha.,3.alpha.,19.alpha.-Trihydroxyurs-12-en-28-oic acid; Urs-12-en-28-oic acid, 2,3,19-trihydroxy-, (2alpha,3beta)-; 2.ALPHA.,3.BETA.,19.ALPHA.-TRIHYDROXYURS-12-EN-28-OIC ACID; (2.ALPHA.,3.BETA.)-2,3,19-TRIHYDROXYURS-12-EN-28-OIC ACID; 2,3,19-Trihydroxyurs-12-en-28-oic acid (2alpha,3beta)-; URS-12-EN-28-OIC ACID, 2.ALPHA.,3.BETA.,19-TRIHYDROXY-; 2.alpha.,19.alpha.-Trihydroxy-urs-12-en-28-oic acid; 2.ALPHA.,3.BETA.,19-TRIHYDROXYURS-12-EN-28-OIC ACID; 2.ALPHA.,19.ALPHA.-DIHYDROXYURSOLIC ACID; 2,3,19-Trihydroxyurs-12-en-28-oic acid; TORMENTOLIC ACID; Jacarandic acid; UNII-9WL8LH7U78; Tormentic acid; Tormenticacid; tomentic acid; 9WL8LH7U78



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

311 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chinmoy Ghosh, Manash C Das, Shukdeb Acharjee, Samadrita Bhattacharjee, Padmani Sandhu, Monika Kumari, Joyanta Bhowmik, Ranjit Ghosh, Birendranath Banerjee, Utpal Chandra De, Yusuf Akhter, Surajit Bhattacharjee. Combating Staphylococcus aureus biofilm formation: the inhibitory potential of tormentic acid and 23-hydroxycorosolic acid. Archives of microbiology. 2023 Dec; 206(1):25. doi: 10.1007/s00203-023-03762-y. [PMID: 38108905]
  • Jun-Yu He, Jie Li, Yuan-Yuan Zhang, Hai-Bo He, Yu-Min He, Dao-Xiang Xu, Xiao Wang, Hao-Yang Wu, Ji-Hong Zhang, Hasan Jahid, Akter Sadia, Hui-Fan Yu, Jun-Zhi Wang, Kun Zou. Tormentic acid, a triterpenoid isolated from the fruits of Chaenomeles speciose, protected indomethacin-induced gastric mucosal lesion via modulating miR-139 and the CXCR4/CXCL12/PLC/PKC/Rho a/MLC pathway. Pharmaceutical biology. 2023 Dec; 61(1):1343-1363. doi: 10.1080/13880209.2023.2249526. [PMID: 37623313]
  • Veysel Bay, Seray Gür, Oğuz Bayraktar. Plant-derived tormentic acid alters the gut microbiota of the silkworm (Bombyx mori). Scientific reports. 2022 07; 12(1):13005. doi: 10.1038/s41598-022-17478-4. [PMID: 35906393]
  • Huiqiang Wei, Jianghong Guo, Xiao Sun, Wenfeng Gou, Hongxin Ning, Haihua Shang, Qiang Liu, Wenbin Hou, Yiliang Li. Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study. Journal of natural products. 2022 05; 85(5):1248-1255. doi: 10.1021/acs.jnatprod.1c01166. [PMID: 35500202]
  • Marta Olech, Wojciech Ziemichód, Natalia Nowacka-Jechalke. The Occurrence and Biological Activity of Tormentic Acid-A Review. Molecules (Basel, Switzerland). 2021 Jun; 26(13):. doi: 10.3390/molecules26133797. [PMID: 34206442]
  • Zhi-Wen Duan, Shuang-Yan Wang, Xu Pang, Jie Zhang, Ye Zhao, Xiao-Hui Zheng, Bai-Ping Ma. [Terpenoids from leaves of Chinese hawthorn]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Jun; 46(11):2830-2836. doi: 10.19540/j.cnki.cjcmm.20210222.601. [PMID: 34296582]
  • Xin Ji, Xiao-Qian Liu, Lu Gao, Su-Ping Xiao, Yao-Hua Liang, Chun Li, Zhi-Min Wang. [Qualitative and quantitative analysis on triterpenoids in Ligustri Lucidi Fructus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Mar; 46(5):1168-1178. doi: 10.19540/j.cnki.cjcmm.20200706.204. [PMID: 33787112]
  • Chido Bvumbi, Godloves Fru Chi, Marc Y Stevens, Molly Mombeshora, Stanley Mukanganyama. The Effects of Tormentic Acid and Extracts from Callistemon citrinus on Candida albicans and Candida tropicalis Growth and Inhibition of Ergosterol Biosynthesis in Candida albicans. TheScientificWorldJournal. 2021; 2021(?):8856147. doi: 10.1155/2021/8856147. [PMID: 34594161]
  • Mahmoud A Al-Qudah, Hasan I Tashtoush, Ethar F Khlaifat, Sahar O Ibrahim, Ayman M Saleh, Hala I Al-Jaber, Musa H Abu Zarga, Sultan T Abu Orabi. Chemical constituents of the aerial parts of Salvia judaica Boiss. from Jordan. Natural product research. 2020 Oct; 34(20):2981-2985. doi: 10.1080/14786419.2019.1597349. [PMID: 31161797]
  • Chung Sub Kim, Lalita Subedi, Joonseok Oh, Sun Yeou Kim, Sang Un Choi, Kang Ro Lee. Bioactive Triterpenoids from the Twigs of Chaenomeles sinensis. Journal of natural products. 2017 04; 80(4):1134-1140. doi: 10.1021/acs.jnatprod.7b00111. [PMID: 28358502]
  • Man-Man Li, Xiao-Qin Su, Jing Sun, Yu-Fan Gu, Zheng Huang, Ke-Wu Zeng, Qian Zhang, Yun-Fang Zhao, Daneel Ferreira, Jordan K Zjawiony, Jun Li, Peng-Fei Tu. Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia. Journal of natural products. 2014 Oct; 77(10):2248-54. doi: 10.1021/np500509q. [PMID: 25245917]
  • Judith M Rollinger, Denise V Kratschmar, Daniela Schuster, Petra H Pfisterer, Christel Gumy, Evelyne M Aubry, Sarah Brandstötter, Hermann Stuppner, Gerhard Wolber, Alex Odermatt. 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. Bioorganic & medicinal chemistry. 2010 Feb; 18(4):1507-15. doi: 10.1016/j.bmc.2010.01.010. [PMID: 20100662]
  • Gleice da Graça Rocha, Marisol Simões, Kelly Araujo Lúcio, Rodrigo Rodrigues Oliveira, Maria Auxiliadora Coelho Kaplan, Cerli Rocha Gattass. Natural triterpenoids from Cecropia lyratiloba are cytotoxic to both sensitive and multidrug resistant leukemia cell lines. Bioorganic & medicinal chemistry. 2007 Dec; 15(23):7355-60. doi: 10.1016/j.bmc.2007.07.020. [PMID: 17889544]
  • C L Cantrell, S G Franzblau, N H Fischer. Antimycobacterial plant terpenoids. Planta medica. 2001 Nov; 67(8):685-94. doi: 10.1055/s-2001-18365. [PMID: 11731906]
  • Y Kashiwada, H K Wang, T Nagao, S Kitanaka, I Yasuda, T Fujioka, T Yamagishi, L M Cosentino, M Kozuka, H Okabe, Y Ikeshiro, C Q Hu, E Yeh, K H Lee. Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. Journal of natural products. 1998 Sep; 61(9):1090-5. doi: 10.1021/np9800710. [PMID: 9748372]
  • H X Xu, F Q Zeng, M Wan, K Y Sim. Anti-HIV triterpene acids from Geum japonicum. Journal of natural products. 1996 Jul; 59(7):643-5. doi: 10.1021/np960165e. [PMID: 8759159]