Allitridin (BioDeep_00000018940)

Main id: BioDeep_00000395522

Secondary id: BioDeep_00000865945

human metabolite PANOMIX_OTCML-2023 Endogenous Antitumor activity


代谢物信息卡片


Prop-2-enyl prop-2-enylthio disulfide

化学式: C6H10S3 (177.994462)
中文名称: 二烯丙基三硫醚, 大蒜精油
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CCSSSCC=C
InChI: InChI=1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2

描述信息

Volatile component from onion (Allium sativum), garlic (Allium sativum) and other commercial garlics. Potential nutriceutical. Allitridin is found in many foods, some of which are onion-family vegetables, garden onion, soft-necked garlic, and garlic.
Allitridin is found in garden onion. Allitridin is a volatile component from onion (Allium sativum), garlic (Allium sativum) and other commercial garlics. Potential nutriceutica
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D009676 - Noxae > D000988 - Antispermatogenic Agents > D013089 - Spermatocidal Agents
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
D020011 - Protective Agents > D000975 - Antioxidants
D010575 - Pesticides > D007306 - Insecticides
D009676 - Noxae > D000963 - Antimetabolites
D016573 - Agrochemicals
Diallyl Trisulfide is isolated from Garlic. Diallyl Trisulfide suppresses the growth of Penicillium expansum (MFC99 value: ≤ 90 μg/mL) and promotes apoptosis via production of reactive oxygen species (ROS) and disintegration of cellular ultrastructure. Anticancer effect[1].
Diallyl Trisulfide is isolated from Garlic. Diallyl Trisulfide suppresses the growth of Penicillium expansum (MFC99 value: ≤ 90 μg/mL) and promotes apoptosis via production of reactive oxygen species (ROS) and disintegration of cellular ultrastructure. Anticancer effect[1].

同义名列表

23 个代谢物同义名

Prop-2-enyl prop-2-enylthio disulfide; Trisulfide, di-2-propenyl (9ci); bis(prop-2-en-1-yl)trisulfane; 4,5,6-Trithia-1,8-nonadiene; Trisulfide, di-2-propenyl; Di-2-propenyl trisulphide; Di-2-propenyl trisulfide; Allyl trisulfide, 8ci; 1,3-Diallyltrisulfane; Diallyl trisulphide; Diallyl Trisulfide; Diallyltrisulfide; Allyl trisulphide; Allyl trisulfide; (CH2=CHCH2S)2S; Garlic oil; Allitridum; Allitridin; FEMA 3265; allitridi; Dasuansu; DATS; DAT



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jiaqing Wu, Jinyu Liu, Junwei Sun, Yingpin Liu, Tao He, Jing Zhao, Xinyue Mei, Yixiang Liu, Min Yang, Shusheng Zhu. Diallyl Trisulfide Acts as a Soil Disinfestation Against the Ilyonectria destructans through Inducing the Burst of Reactive Oxygen Species. Journal of agricultural and food chemistry. 2024 May; 72(17):9669-9679. doi: 10.1021/acs.jafc.4c01422. [PMID: 38632108]
  • Dominique T Ferguson, Equar Taka, Samia Messeha, Hernan Flores-Rozas, Sarah L Reed, Bryan V Redmond, Karam F A Soliman, Konan J W Kanga, Selina F Darling-Reed. The Garlic Compound, Diallyl Trisulfide, Attenuates Benzo[a]Pyrene-Induced Precancerous Effect through Its Antioxidant Effect, AhR Inhibition, and Increased DNA Repair in Human Breast Epithelial Cells. Nutrients. 2024 Jan; 16(2):. doi: 10.3390/nu16020300. [PMID: 38276538]
  • Sakhawat Shah, Karam Khamis Elgizawy, Meng-Ya Wu, Hucheng Yao, Wen-Han Yan, Yu Li, Xiao-Ping Wang, Gang Wu, Feng-Lian Yang. Diallyl Trisulfide Causes Male Infertility with Oligoasthenoteratospermia in Sitotroga cerealella through the Ubiquitin-Proteasome Pathway. Cells. 2023 10; 12(20):. doi: 10.3390/cells12202507. [PMID: 37887351]
  • Sakhawat Shah, Karam Khamis Elgizawy, Chun-Mei Shi, Hucheng Yao, Wen-Han Yan, Yu Li, Xiao-Ping Wang, Gang Wu, Feng-Lian Yang. Diallyl Trisulfide, a Biologically Active Component of Garlic Essential Oil, Decreases Male Fertility in Sitotroga cerealella by Impairing Dimorphic Spermatogenesis, Sperm Motility and Lipid Homeostasis. Cells. 2023 02; 12(4):. doi: 10.3390/cells12040669. [PMID: 36831336]
  • Yongfei Jian, Shun Feng, Airong Huang, Zhiming Zhu, Jiaomei Zhang, Shicai Tang, Liang Jin, Maozhi Ren, Pan Dong. Integrative mRNA and microRNA Analysis Exploring the Inducing Effect and Mechanism of Diallyl Trisulfide (DATS) on Potato against Late Blight. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043474. [PMID: 36834885]
  • Anindita De, Parikshit Roychowdhury, Nihar Ranjan Bhuyan, Young Tag Ko, Sachin Kumar Singh, Kamal Dua, Gowthamarajan Kuppusamy. Folic Acid Functionalized Diallyl Trisulfide-Solid Lipid Nanoparticles for Targeting Triple Negative Breast Cancer. Molecules (Basel, Switzerland). 2023 Feb; 28(3):. doi: 10.3390/molecules28031393. [PMID: 36771058]
  • Sakhawat Shah, Su-Su Zhang, Karam Khamis Elgizawy, Wen-Han Yan, Ning Tang, Gang Wu, Feng-Lian Yang. Diallyl trisulfide reduced the reproductive capacity of male Sitotroga cerealella via the regulation of juvenile and ecdysone hormones. Ecotoxicology and environmental safety. 2022 Dec; 248(?):114304. doi: 10.1016/j.ecoenv.2022.114304. [PMID: 36403303]
  • Yanzhou Hu, Jia Xu, Ruxin Gao, Ye Xu, Bingxin Huangfu, Charles Asakiya, Xianghui Huang, Feng Zhang, Kunlun Huang, Xiaoyun He, Yunbo Luo. Diallyl Trisulfide Prevents Adipogenesis and Lipogenesis by Regulating the Transcriptional Activation Function of KLF15 on PPARγ to Ameliorate Obesity. Molecular nutrition & food research. 2022 11; 66(22):e2200173. doi: 10.1002/mnfr.202200173. [PMID: 35983694]
  • Xiaojing Zhu, Rongxin Lu, Genrong Zhang, Ling Fan, Yongjiu Zhan, Guoxin Chen, Liang Zhou. Diallyl Trisulfide attenuates alcohol-induced hepatocyte pyroptosis via elevation of hydrogen sulfide. Bioscience, biotechnology, and biochemistry. 2022 Oct; 86(11):1552-1561. doi: 10.1093/bbb/zbac149. [PMID: 36073357]
  • Miaomiao Wang, Zhaoyu Wang, Yueyue Miao, Hongkui Wei, Jian Peng, Yuanfei Zhou. Diallyl Trisulfide Promotes Placental Angiogenesis by Regulating Lipid Metabolism and Alleviating Inflammatory Responses in Obese Pregnant Mice. Nutrients. 2022 May; 14(11):. doi: 10.3390/nu14112230. [PMID: 35684030]
  • Faris Alrumaihi, Masood Alam Khan, Ali Yousif Babiker, Mohammed Alsaweed, Faizul Azam, Khaled S Allemailem, Ahmad A Almatroudi, Syed Rizwan Ahamad, Mahdi H Alsugoor, Khloud Nawaf Alharbi, Nahlah Makki Almansour, Arif Khan. Lipid-Based Nanoparticle Formulation of Diallyl Trisulfide Chemosensitizes the Growth Inhibitory Activity of Doxorubicin in Colorectal Cancer Model: A Novel In Vitro, In Vivo and In Silico Analysis. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072192. [PMID: 35408590]
  • Xue Gong, Xiaoqian Su, Hongjia Liu. Diallyl Trisulfide, the Antifungal Component of Garlic Essential Oil and the Bioactivity of Its Nanoemulsions Formed by Spontaneous Emulsification. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237186. [PMID: 34885768]
  • Yun Ding, Ziqiang Yu, Cuili Zhang. Diallyl trisulfide protects against concanavalin A-induced acute liver injury in mice by inhibiting inflammation, oxidative stress and apoptosis. Life sciences. 2021 Aug; 278(?):119631. doi: 10.1016/j.lfs.2021.119631. [PMID: 34022202]
  • Atsushi Miura, Ayana Ikeda, Marina Abe, Kiki Seo, Takahiro Watanabe, Yori Ozaki-Masuzawa, Takashi Hosono, Taiichiro Seki. Diallyl Trisulfide Prevents Obesity and Decreases miRNA-335 Expression in Adipose Tissue in a Diet-Induced Obesity Rat Model. Molecular nutrition & food research. 2021 07; 65(14):e2001199. doi: 10.1002/mnfr.202001199. [PMID: 34014027]
  • Seiya Nagai, Masaki Yoshida, Yuta Takigawa, Seiji Torii, Ichiro Koshiishi. Botanical sulfane sulfur donors inhibit ferroptotic cell death caused by the depletion of cysteine. Food chemistry. 2021 May; 343(?):128511. doi: 10.1016/j.foodchem.2020.128511. [PMID: 33168263]
  • Yuping Liu, Rongping Fu, Shumei Tu, Ding Qu, Congyan Liu, Xiaoqi Li, Yang Zhao, Chengyao Ma, Yan Chen, Li Tao. Extracellular Microparticles Encapsulated with Diallyl Trisulfide Interfere with the Inflammatory Tumor Microenvironment and Lung Metastasis of Invasive Melanoma. Molecular pharmaceutics. 2021 03; 18(3):822-835. doi: 10.1021/acs.molpharmaceut.0c00696. [PMID: 33586986]
  • Sakhawat Shah, Min Ma, Asad Ali, Murat Kaya, Xue-Gang Li, Gang Wu, Feng-Lian Yang. Effects of diallyl trisulfide, an active substance from garlic essential oil, on structural chemistry of chitin in Sitotroga cerealella (Lepidoptera: Gelechiidae). Pesticide biochemistry and physiology. 2021 Feb; 172(?):104765. doi: 10.1016/j.pestbp.2020.104765. [PMID: 33518052]
  • Chenghao Lv, Caiqiong Wang, Ping Li, Yiwen Huang, Xiangyang Lu, Meng Shi, Chaoxi Zeng, Si Qin. Effect of Garlic Organic Sulfides on Gene Expression Profiling in HepG2 Cells and Its Biological Function Analysis by Ingenuity Pathway Analysis System and Bio-Plex-Based Assays. Mediators of inflammation. 2021; 2021(?):7681252. doi: 10.1155/2021/7681252. [PMID: 34887701]
  • Jovana N Jeremic, Vladimir Lj Jakovljevic, Vladimir I Zivkovic, Ivan M Srejovic, Jovana V Bradic, Isidora M Milosavljevic, Slobodanka Lj Mitrovic, Nemanja U Jovicic, Sergey B Bolevich, Andrey A Svistunov, Suresh C Tyagi, Nevena S Jeremic. Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role. International journal of molecular sciences. 2020 Nov; 21(23):. doi: 10.3390/ijms21239100. [PMID: 33265949]
  • Wai-Shing Leung, Wei-Wen Kuo, Da-Tong Ju, Tian-De Wang, William Shao-Tsu Chen, Tsung-Jung Ho, Yu Min Lin, B Mahalakshmi, Jing-Ying Lin, Chih-Yang Huang. Protective effects of diallyl trisulfide (DATS) against doxorubicin-induced inflammation and oxidative stress in the brain of rats. Free radical biology & medicine. 2020 11; 160(?):141-148. doi: 10.1016/j.freeradbiomed.2020.07.018. [PMID: 32745770]
  • Takashi Hosono, Asuka Sato, Natsumi Nakaguchi, Yori Ozaki-Masuzawa, Taiichiro Seki. Diallyl Trisulfide Inhibits Platelet Aggregation through the Modification of Sulfhydryl Groups. Journal of agricultural and food chemistry. 2020 Feb; 68(6):1571-1578. doi: 10.1021/acs.jafc.9b05557. [PMID: 31927886]
  • Chinatsu Nakagawa, Manami Suzuki-Karasaki, Miki Suzuki-Karasaki, Toyoko Ochiai, Yoshihiro Suzuki-Karasaki. The Mitochondrial Ca2+ Overload via Voltage-Gated Ca2+ Entry Contributes to an Anti-Melanoma Effect of Diallyl Trisulfide. International journal of molecular sciences. 2020 Jan; 21(2):. doi: 10.3390/ijms21020491. [PMID: 31940976]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Wenting Han, Ruogu Liu, Xiaoshuai Zhang, Peng Lv, Ming Li, Xujing Wang. The potential agents from food for preventing leukopenia induced by benzene: garlic preparations. Toxicology mechanisms and methods. 2019 Nov; 29(9):702-709. doi: 10.1080/15376516.2019.1650148. [PMID: 31364917]
  • Yongchang Lai, Xiongfa Liang, Fangling Zhong, Weizhou Wu, Tao Zeng, Jian Huang, Xiaolu Duan, Shujue Li, Guohua Zeng, Wenqi Wu. Allicin attenuates calcium oxalate crystal deposition in the rat kidney by regulating gap junction function. Journal of cellular physiology. 2019 06; 234(6):9640-9651. doi: 10.1002/jcp.27651. [PMID: 30378099]
  • Yuping Liu, Xiangliang Jiang, Yue Gu, Yan Chen. Preventive effect of Diallyl Trisulfide on cutaneous toxicities induced by EGFR inhibitor. International immunopharmacology. 2019 Apr; 69(?):79-87. doi: 10.1016/j.intimp.2019.01.023. [PMID: 30682720]
  • Wei-Chih Lin, Wen-Yu Pan, Chen-Kao Liu, Wu-Xuan Huang, Hsiang-Lin Song, Kai-Sheng Chang, Meng-Ju Li, Hsing-Wen Sung. In situ self-spray coating system that can uniformly disperse a poorly water-soluble H2S donor on the colorectal surface to treat inflammatory bowel diseases. Biomaterials. 2018 11; 182(?):289-298. doi: 10.1016/j.biomaterials.2018.07.044. [PMID: 30144577]
  • Peter Rose, Philip Keith Moore, Yi-Zhun Zhu. Garlic and Gaseous Mediators. Trends in pharmacological sciences. 2018 07; 39(7):624-634. doi: 10.1016/j.tips.2018.03.009. [PMID: 29706261]
  • Hai-Bing Yang, Hui-Min Liu, Jin-Chuan Yan, Zhao-Yang Lu. Effect of Diallyl Trisulfide on Ischemic Tissue Injury and Revascularization in a Diabetic Mouse Model. Journal of cardiovascular pharmacology. 2018 06; 71(6):367-374. doi: 10.1097/fjc.0000000000000579. [PMID: 29642134]
  • Qi Zhang, Xiao-Ting Li, Yue Chen, Jia-Qi Chen, Jian-Yun Zhu, Yu Meng, Xiao-Qian Wang, Yuan Li, Shan-Shan Geng, Chun-Feng Xie, Jie-Shu Wu, Cai-Yun Zhong, Hong-Yu Han. Wnt/β-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells. Cancer chemotherapy and pharmacology. 2018 06; 81(6):969-977. doi: 10.1007/s00280-018-3565-0. [PMID: 29594332]
  • Wenting Han, Shuo Wang, Ming Li, Lulu Jiang, Xujing Wang, Keqin Xie. The protective effect of diallyl trisulfide on cytopenia induced by benzene through modulating benzene metabolism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Feb; 112(?):393-399. doi: 10.1016/j.fct.2017.12.060. [PMID: 29305270]
  • Yuping Liu, Yang Zhao, Zhonghong Wei, Li Tao, Xiaobo Sheng, Siliang Wang, Jiao Chen, Junshan Ruan, Zhaoguo Liu, Yuzhu Cao, Yunlong Shan, Aiyun Wang, Wenxing Chen, Yin Lu. Targeting Thioredoxin System with an Organosulfur Compound, Diallyl Trisulfide (DATS), Attenuates Progression and Metastasis of Triple-Negative Breast Cancer (TNBC). Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 50(5):1945-1963. doi: 10.1159/000494874. [PMID: 30396169]
  • S Miltonprabu, N C Sumedha, P Senthilraja. Diallyl trisulfide, a garlic polysulfide protects against As-induced renal oxidative nephrotoxicity, apoptosis and inflammation in rats by activating the Nrf2/ARE signaling pathway. International immunopharmacology. 2017 Sep; 50(?):107-120. doi: 10.1016/j.intimp.2017.06.011. [PMID: 28648972]
  • Sivakumar Annamalai, Lavanya Mohanam, Veena Raja, Alwin Dev, Venkataraman Prabhu. Antiobesity, antioxidant and hepatoprotective effects of Diallyl trisulphide (DATS) alone or in combination with Orlistat on HFD induced obese rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Sep; 93(?):81-87. doi: 10.1016/j.biopha.2017.06.035. [PMID: 28624425]
  • Michael T Puccinelli, Silvia D Stan. Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment. International journal of molecular sciences. 2017 Jul; 18(8):. doi: 10.3390/ijms18081645. [PMID: 28788092]
  • Xiaoyan Jiang, Xiaosong Zhu, Weizhen Huang, Hongya Xu, Zhongxi Zhao, Siying Li, Shanzhong Li, Jianhua Cai, Jimin Cao. Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice. International immunopharmacology. 2017 Jul; 48(?):135-145. doi: 10.1016/j.intimp.2017.05.004. [PMID: 28501767]
  • Hoda S El-Sayed, Remigius Chizzola, Asmaa A Ramadan, Amr E Edris. Chemical composition and antimicrobial activity of garlic essential oils evaluated in organic solvent, emulsifying, and self-microemulsifying water based delivery systems. Food chemistry. 2017 Apr; 221(?):196-204. doi: 10.1016/j.foodchem.2016.10.052. [PMID: 27979186]
  • Restituto Tocmo, Yuchen Wu, Dong Liang, Vincenzo Fogliano, Dejian Huang. Boiling enriches the linear polysulfides and the hydrogen sulfide-releasing activity of garlic. Food chemistry. 2017 Apr; 221(?):1867-1873. doi: 10.1016/j.foodchem.2016.10.076. [PMID: 27979174]
  • Feng Zhang, Huanhuan Jin, Li Wu, Jiangjuan Shao, Xiaojing Zhu, Anping Chen, Shizhong Zheng. Diallyl Trisulfide Suppresses Oxidative Stress-Induced Activation of Hepatic Stellate Cells through Production of Hydrogen Sulfide. Oxidative medicine and cellular longevity. 2017; 2017(?):1406726. doi: 10.1155/2017/1406726. [PMID: 28303169]
  • Nathan L Horn, Frank Ruch, Guy Miller, Kolapo M Ajuwon, Olayiwola Adeola. Determination of the adequate dose of garlic diallyl disulfide and diallyl trisulfide for effecting changes in growth performance, total-tract nutrient and energy digestibility, ileal characteristics, and serum immune parameters in broiler chickens. Poultry science. 2016 Oct; 95(10):2360-5. doi: 10.3382/ps/pew126. [PMID: 27190110]
  • M Ma, M-M Chang, C-L Lei, F-L Yang. A garlic substance disrupts odorant-binding protein recognition of insect pheromones released from adults of the angoumois grain moth, Sitotroga cerealella (Lepidoptera: Gelechiidae). Insect molecular biology. 2016 10; 25(5):530-40. doi: 10.1111/imb.12240. [PMID: 27111111]
  • Lian-Yun Chen, Qin Chen, Xiao-Jing Zhu, De-Song Kong, Li Wu, Jiang-Juan Shao, Shi-Zhong Zheng. Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism. International immunopharmacology. 2016 Jul; 36(?):23-30. doi: 10.1016/j.intimp.2016.04.015. [PMID: 27107369]
  • Fang Zhang, Yongchun Zhang, Kaiming Wang, Guangpu Liu, Min Yang, Zhongxi Zhao, Shanzhong Li, Jianhua Cai, Jimin Cao. Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice. International journal of immunopathology and pharmacology. 2016 Jun; 29(2):205-16. doi: 10.1177/0394632015627160. [PMID: 26813860]
  • Lian-Yun Chen, Qin Chen, Yi-Feng Cheng, Huan-Huan Jin, De-Song Kong, Feng Zhang, Li Wu, Jiang-Juan Shao, Shi-Zhong Zheng. Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Apr; 79(?):35-43. doi: 10.1016/j.biopha.2016.01.009. [PMID: 27044810]
  • C F Williams, A R Vacca, L Dunham, D Lloyd, M P Coogan, G Evans, M Graz, J Cable. The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens. Molecular and biochemical parasitology. 2016 Mar; 206(1-2):20-8. doi: 10.1016/j.molbiopara.2016.03.001. [PMID: 26968264]
  • N C Sumedha, S Miltonprabu. Diallyl trisulfide ameliorates arsenic-induced hepatotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats. Human & experimental toxicology. 2015 May; 34(5):506-25. doi: 10.1177/0960327114543933. [PMID: 25062976]
  • Azucena Gándara-Ledezma, Consuelo Corrales-Maldonado, Marisela Rivera-Domínguez, Miguel Ángel Martínez-Téllez, Irasema Vargas-Arispuro. Post-harvest control of gray mold in table grapes using volatile sulfur compounds from Allium sativum. Journal of the science of food and agriculture. 2015 Feb; 95(3):497-503. doi: 10.1002/jsfa.6757. [PMID: 24862582]
  • Simona Casiglia, Maurizio Bruno, Federica Senatore, Felice Senatore. Composition of the Essential Oil of Allium neapolitanum Cirillo Growing Wild in Sicily and its Activity on Microorganisms Affecting Historical Art Crafts. Journal of oleo science. 2015; 64(12):1315-20. doi: 10.5650/jos.ess15188. [PMID: 26632947]
  • Yuping Liu, Pingting Zhu, Yingyu Wang, Zhonghong Wei, Li Tao, Zhijie Zhu, Xiaobo Sheng, Siliang Wang, Junshan Ruan, Zhaoguo Liu, Yuzhu Cao, Yunlong Shan, Lihua Sun, Aiyun Wang, Wenxing Chen, Yin Lu. Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways. PloS one. 2015; 10(4):e0123781. doi: 10.1371/journal.pone.0123781. [PMID: 25927362]
  • Su-Chen Ho, Min-Sheng Su. Evaluating the anti-neuroinflammatory capacity of raw and steamed garlic as well as five organosulfur compounds. Molecules (Basel, Switzerland). 2014 Oct; 19(11):17697-714. doi: 10.3390/molecules191117697. [PMID: 25365295]
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  • Xiaomin Nie, Lixiao Su, Yajing Zhou, Xiping Li, Mingyu Shang, Yongxiang Wei. [Effects of allitridi capsules on endothelial function and clinical prognosis in coronary artery disease patients with obstructive sleep apnea hypopnea syndrome]. Zhonghua yi xue za zhi. 2014 Jul; 94(28):2184-7. doi: NULL. [PMID: 25331468]
  • Selvaraj Milton Prabu, Naorem Chanu Sumedha. Ameliorative effect of diallyl trisulphide on arsenic-induced oxidative stress in rat erythrocytes and DNA damage in lymphocytes. Journal of basic and clinical physiology and pharmacology. 2014 May; 25(2):181-97. doi: 10.1515/jbcpp-2013-0047. [PMID: 24114904]
  • Xiaojing Zhu, Feng Zhang, Liang Zhou, Desong Kong, Li Chen, Yin Lu, Shizhong Zheng. Diallyl trisulfide attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic oxidative stress in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2014 May; 387(5):445-55. doi: 10.1007/s00210-014-0959-3. [PMID: 24557053]
  • S Miltonprabu, N C Sumedha. Arsenic-induced hepatic mitochondrial toxicity in rats and its amelioration by diallyl trisulfide. Toxicology mechanisms and methods. 2014 Feb; 24(2):124-35. doi: 10.3109/15376516.2013.869778. [PMID: 24295472]
  • Guoliang Li, Gong Cheng, Jine Wu, Shuting Ma, Aifeng Zhang, Wenqi Han, Chaofeng Sun. Allitridin reduces I Kr current by disrupting the trafficking of human ether-à-go-go-related gene channels. Cardiology. 2014; 128(1):1-8. doi: 10.1159/000357232. [PMID: 24504171]
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