5beta-Coprostanol (BioDeep_00000018885)
Secondary id: BioDeep_00000003825, BioDeep_00000398245, BioDeep_00000858812
human metabolite Endogenous
代谢物信息卡片
(1S,2S,5S,7R,10R,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-ol
化学式: C27H48O (388.37049579999996)
中文名称: 粪甾烷-3-醇
谱图信息:
最多检出来源 Homo sapiens(lipidomics) 34.96%
分子结构信息
SMILES: C1[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@]([H])([C@]([H])(C)CCCC(C)C)CC[C@@]4([H])[C@]3([H])CC[C@@]2([H])C[C@H](O)C1
InChI: InChI=1S/C27H48O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-25,28H,6-17H2,1-5H3
描述信息
Coprosterol or coprostanol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. Coprosterol is the odorous principle of feces. It is formed from the biohydrogenation of cholesterol (cholest-5en-3β-ol) in the gut of most higher animals and birds. This compound has frequently been used as a biomarker for the presence of human faecal matter in the environment. American physician Austin Flint named it stercorin (Wikipedia). The transformation of cholesterol into coprosterol in its passage through the body involves a reduction of the C5:C6 double bond, and a transition from the allocholanic- to the cholanic-ring system. Although it is established that the bacterial flora of the intestine is concerned in the reduction process, the mechanism by which the stereochemical change is brought about is unknown. Current data suggests that cholestenone and coprostanone, and not cholesterol itself, are the immediate precursors of coprosterol which is formed from them in the intestine by bacterial reduction. Coprosterol is also a microbial metabolite, it can be produced by Lactobacillus (PMID: 20338415).
Coprosterol or coprostanol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. Coprosterol is the odorous principle of feces. It is formed from the biohydrogenation of cholesterol (cholest-5en-3β-ol) in the gut of most higher animals and birds. This compound has frequently been used as a biomarker for the presence of human faecal matter in the environment. American physician Austin Flint named it stercorin . The transformation of cholesterol into coprosterol in its passage through the body involves a reduction of the C5:C6 double bond, and a transition from the allocholanic- to the cholanic-ring system. Although it is established that the bacterial flora of the intestine is concerned in the reduction process, the mechanism by which the stereochemical change is brought about is unknown. Current data suggests that cholestenone and coprostanone, and not cholesterol itself, are the immediate precursors of coprosterol which is formed from them in the intestine by bacterial reduction. [HMDB]
Same as: D01527
同义名列表
39 个代谢物同义名
(1S,2S,5S,7R,10R,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-ol; Cholestanol, (3alpha, 5beta)-isomer; 5 alpha-Cholestan-3 alpha-ol; 5 alpha Cholestan 3 alpha ol; (3beta,5beta)-Cholestan-3-ol; 5 beta-Cholestan-3 alpha-ol; beta-Cholestan-3 beta-ol, 5; 5 alpha-Cholestan-3 beta-ol; 5 alpha Cholestan 3 beta ol; beta-Ol, 5 beta-cholestan-3; 5alpha-cholestan-3alpha-ol; Cholestan-3-ol, (3.beta.)-; 5 beta Cholestan 3 beta ol; 5 beta-Cholestan-3 beta-ol; 3b-Hydroxy-5b-cholestanol; 5beta-cholestan-3beta-ol; (3b,5b)-Cholestan-3-ol; (3Β,5β)-cholestan-3-ol; Epidihydrocholesterin; Dihydrocholesterol; 5b-Cholestan-3b-ol; 5Β-cholestan-3β-ol; 5beta-Coprostanol; 5beta Coprostanol; beta-Cholestanol; beta Cholestanol; Epi-cholestanol; 5b-Coprostanol; 5Β-coprostanol; Epicholestanol; 5b Coprostanol; 5Β coprostanol; Cholestan-3-ol; Cholestan 3 ol; Cholestanol; coprosterol; Coprostanol; ST 27:0;O; Stercorin
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:143724
- ChEBI: CHEBI:31542
- ChEBI: CHEBI:89519
- KEGG: C12978
- PubChem: 221122
- PubChem: 66066
- PubChem: 3240
- HMDB: HMDB0000577
- ChEMBL: CHEMBL2107718
- ChEMBL: CHEMBL2048325
- Wikipedia: Coprosterol
- LipidMAPS: LMST01010098
- MeSH: Cholestanol
- foodb: FDB022125
- chemspider: 191826
- CAS: 84061-69-8
- CAS: 360-68-9
- CAS: 516-95-0
- PMhub: MS000012078
- PubChem: 583367
- NIKKAJI: J14.274C
- RefMet: Epi-cholestanol
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 942674 - Amphilectus fucorum: 10.1016/S0040-4020(01)85914-7
- 9606 - Homo sapiens: -
- 68564 - Petrosia ficiformis: 10.1016/0039-128X(86)90076-0
- 569429 - Phallusia nigra: 10.1016/0039-128X(82)90021-6
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yun-Yuan Tian, Lin-Lin Bi, Wen-Wen Chen, Shu-Xian Zheng, Yu Cao, Yan-Hua Xie, Hai-Feng Tang, Yun-Yang Lu, Si-Wang Wang. Two previously undescribed cholestanol saponins from the rhizomes of Paris fargesii var. petiolata.
Fitoterapia.
2024 Jun; 175(?):105881. doi:
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Food & function.
2024 Mar; 15(5):2422-2432. doi:
10.1039/d3fo05014a. [PMID: 38329279] - Muhammed Köroğlu, Mustafa Karakaplan, Enes Gündüz, Betül Kesriklioğlu, Emre Ergen, Okan Aslantürk, Zeynep Maraş Özdemir. Cerebrotendinous Xanthomatosis patients with late diagnosed in single orthopedic clinic: two novel variants in the CYP27A1 gene.
Orphanet journal of rare diseases.
2024 Feb; 19(1):53. doi:
10.1186/s13023-024-03082-4. [PMID: 38336741] - Yan Li, Yuanjue Wu, Yanyan Ge, Shanshan Huang, Yang Yang, Zhen Zhang, Ningning Cui, Junan Yan, Yonggang Li, Ping Luo, Liping Hao, Guoping Xiong, Xuefeng Yang. Pregnancy Cholesterol Metabolism Markers and the Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study.
Nutrients.
2023 Aug; 15(17):. doi:
10.3390/nu15173809. [PMID: 37686841] - Laura Stanasila, Pedro Marques-Vidal. Serum Phytosterols Are Not Associated with Inflammatory Markers in Two Cross-Sectional, Swiss Population-Based Studies (The CoLaus PsyCoLaus Study).
Nutrients.
2022 Jun; 14(12):. doi:
10.3390/nu14122500. [PMID: 35745232] - María José Contreras, María Elena Arias, Mauricio Silva, Paulina Cabrera, Ricardo Felmer. Effect of cholestanol and cholesterol-loaded cyclodextrin on stallion sperm function and capacitation post-cryopreservation.
Theriogenology.
2022 Jun; 189(?):1-10. doi:
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Journal of clinical lipidology.
2022 May; 16(3):281-285. doi:
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Nutrients.
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BMJ case reports.
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Orphanet journal of rare diseases.
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The Journal of biological chemistry.
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Molecules (Basel, Switzerland).
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Cell host & microbe.
2020 08; 28(2):245-257.e6. doi:
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Marine pollution bulletin.
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Anticancer research.
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Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2020 Apr; 41(4):943-949. doi:
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Gut.
2020 03; 69(3):487-501. doi:
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Lipids in health and disease.
2019 Dec; 18(1):235. doi:
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Langmuir : the ACS journal of surfaces and colloids.
2019 12; 35(48):16053-16061. doi:
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Journal of neurology.
2019 Aug; 266(8):2043-2050. doi:
10.1007/s00415-019-09377-y. [PMID: 31115677] - Joon Hee Lee, Kyunghoon Lee, Sun Hee Jun, Sang Hoon Song, Choong Ho Shin, Junghan Song. A Multiplex Phytosterol Assay Utilizing Gas Chromatography-Mass Spectrometry for Diagnosis of Inherited Lipid Storage Disorders.
Annals of laboratory medicine.
2019 Jul; 39(4):411-413. doi:
10.3343/alm.2019.39.4.411. [PMID: 30809990] - Maite M Schroor, Henriette P Sennels, Jan Fahrenkrug, Henrik L Jørgensen, Jogchum Plat, Ronald P Mensink. Diurnal Variation of Markers for Cholesterol Synthesis, Cholesterol Absorption, and Bile Acid Synthesis: A Systematic Review and the Bispebjerg Study of Diurnal Variations.
Nutrients.
2019 Jun; 11(7):. doi:
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The Journal of steroid biochemistry and molecular biology.
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Current opinion in lipidology.
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Marine pollution bulletin.
2019 Feb; 139(?):111-116. doi:
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Environmental pollution (Barking, Essex : 1987).
2019 Jan; 244(?):818-826. doi:
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Handbook of experimental pharmacology.
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Atherosclerosis.
2018 11; 278(?):91-96. doi:
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Journal of inherited metabolic disease.
2018 09; 41(5):799-807. doi:
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Marine pollution bulletin.
2018 Aug; 133(?):568-577. doi:
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Atherosclerosis.
2018 08; 275(?):346-351. doi:
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Journal of inherited metabolic disease.
2018 07; 41(4):641-646. doi:
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Environmental pollution (Barking, Essex : 1987).
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Lipids.
2018 03; 53(3):323-334. doi:
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Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus.
2017 Dec; 21(6):505-507. doi:
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Metabolic brain disease.
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The Journal of pediatrics.
2017 09; 188(?):198-204.e1. doi:
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American journal of medical genetics. Part A.
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Nutrition research reviews.
2017 Jun; 30(1):36-49. doi:
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Scientific reports.
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Rinsho shinkeigaku = Clinical neurology.
2016 12; 56(12):821-826. doi:
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Rinsho shinkeigaku = Clinical neurology.
2016 10; 56(10):667-671. doi:
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Marine pollution bulletin.
2016 Aug; 109(1):619-623. doi:
10.1016/j.marpolbul.2016.05.022. [PMID: 27207024] - Ivana Matić Bujagić, Svetlana Grujić, Zorica Jauković, Mila Laušević. Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia.
Environmental pollution (Barking, Essex : 1987).
2016 Jun; 213(?):76-83. doi:
10.1016/j.envpol.2015.12.036. [PMID: 26874877] - Wendy Whiteside, Meng Tan, Richard E Ostlund, Sunkyung Yu, Lina Ma, Albert Rocchini. Altered Cholesterol Metabolism and Hypocholesterolemia in Patients with Single Ventricle following Fontan Palliation.
The Journal of pediatrics.
2016 Apr; 171(?):73-7. doi:
10.1016/j.jpeds.2015.12.038. [PMID: 26806364] - Isabel Andrade, Lèlita Santos, Fernando Ramos. Cholesterol absorption and synthesis markers in Portuguese hypercholesterolemic adults: A cross-sectional study.
European journal of internal medicine.
2016 Mar; 28(?):85-90. doi:
10.1016/j.ejim.2015.10.022. [PMID: 26577223] - Jesica P A Rada, Armando C Duarte, Pedro Pato, Anabela Cachada, Renato S Carreira. Sewage contamination of sediments from two Portuguese Atlantic coastal systems, revealed by fecal sterols.
Marine pollution bulletin.
2016 Feb; 103(1-2):319-324. doi:
10.1016/j.marpolbul.2016.01.010. [PMID: 26778497] - Andrea Mignarri, Alessandro Magni, Marina Del Puppo, Gian Nicola Gallus, Ingemar Björkhem, Antonio Federico, Maria Teresa Dotti. Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis.
Journal of inherited metabolic disease.
2016 Jan; 39(1):75-83. doi:
10.1007/s10545-015-9873-1. [PMID: 26153518] - Vijay C Antharam, Daniel C McEwen, Timothy J Garrett, Aaron T Dossey, Eric C Li, Andrew N Kozlov, Zhubene Mesbah, Gary P Wang. An Integrated Metabolomic and Microbiome Analysis Identified Specific Gut Microbiota Associated with Fecal Cholesterol and Coprostanol in Clostridium difficile Infection.
PloS one.
2016; 11(2):e0148824. doi:
10.1371/journal.pone.0148824. [PMID: 26871580] - B P Lyons, M J Devlin, S A Abdul Hamid, A F Al-Otiabi, M Al-Enezi, M S Massoud, A S Al-Zaidan, A J Smith, S Morris, P Bersuder, J L Barber, A Papachlimitzou, H A Al-Sarawi. Microbial water quality and sedimentary faecal sterols as markers of sewage contamination in Kuwait.
Marine pollution bulletin.
2015 Nov; 100(2):689-98. doi:
10.1016/j.marpolbul.2015.07.043. [PMID: 26228071] - Thomas D Dayspring, Stephen A Varvel, Leila Ghaedi, Dawn L Thiselton, James Bruton, Joseph P McConnell. Biomarkers of cholesterol homeostasis in a clinical laboratory database sample comprising 667,718 patients.
Journal of clinical lipidology.
2015 Nov; 9(6):807-816. doi:
10.1016/j.jacl.2015.08.003. [PMID: 26687702] - Megan L Devane, David Wood, Andrew Chappell, Beth Robson, Jenny Webster-Brown, Brent J Gilpin. Identifying avian sources of faecal contamination using sterol analysis.
Environmental monitoring and assessment.
2015 Oct; 187(10):625. doi:
10.1007/s10661-015-4800-3. [PMID: 26370196] - Xiaobo Wang, Lei Guan, Youyou Zhao, Lin Lei, Yuwei Liu, Ka Ying Ma, Lijun Wang, Sun Wa Man, Junkuan Wang, Yu Huang, Zhen-Yu Chen. Plasma cholesterol-lowering activity of dietary dihydrocholesterol in hypercholesterolemia hamsters.
Atherosclerosis.
2015 Sep; 242(1):77-86. doi:
10.1016/j.atherosclerosis.2015.06.046. [PMID: 26184696] - Alexandra Luister, Hans Frieder Schött, Constanze Husche, Hans-Joachim Schäfers, Michael Böhm, Jogchum Plat, Stefan Gräber, Dieter Lütjohann, Ulrich Laufs, Oliver Weingärtner. Increased plant sterol deposition in vascular tissue characterizes patients with severe aortic stenosis and concomitant coronary artery disease.
Steroids.
2015 Jul; 99(Pt B):272-80. doi:
10.1016/j.steroids.2015.03.011. [PMID: 25814070] - Günther Silbernagel, Günter Fauler, Bernd Genser, Christiane Drechsler, Vera Krane, Hubert Scharnagl, Tanja B Grammer, Iris Baumgartner, Eberhard Ritz, Christoph Wanner, Winfried März. Intestinal cholesterol absorption, treatment with atorvastatin, and cardiovascular risk in hemodialysis patients.
Journal of the American College of Cardiology.
2015 Jun; 65(21):2291-8. doi:
10.1016/j.jacc.2015.03.551. [PMID: 26022817] - Talat Saeed, Fatima Al-Shimmari, Ahmad Al-Mutairi, Hameeda Abdullah. Spatial assessment of the sewage contamination of Kuwait's marine areas.
Marine pollution bulletin.
2015 May; 94(1-2):307-17. doi:
10.1016/j.marpolbul.2015.01.030. [PMID: 25691339] - Matthew G K Benesch, Ruthven N A H Lewis, David A Mannock, Ronald N McElhaney. A DSC and FTIR spectroscopic study of the effects of the epimeric coprostan-3-ols and coprostan-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues.
Chemistry and physics of lipids.
2015 May; 188(?):10-26. doi:
10.1016/j.chemphyslip.2015.03.002. [PMID: 25804450] - Matthew G K Benesch, Ruthven N A H Lewis, David A Mannock, Ronald N McElhaney. A DSC and FTIR spectroscopic study of the effects of the epimeric cholestan-3-ols and cholestan-3-one on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogs.
Chemistry and physics of lipids.
2015 Apr; 187(?):34-49. doi:
10.1016/j.chemphyslip.2015.02.002. [PMID: 25732198] - Renato S Carreira, Ana Cecília R Albergaria-Barbosa, Maria L P M Arguelho, Carlos A B Garcia. Evidence of sewage input to inner shelf sediments in the NE coast of Brazil obtained by molecular markers distribution.
Marine pollution bulletin.
2015 Jan; 90(1-2):312-6. doi:
10.1016/j.marpolbul.2014.11.011. [PMID: 25467184] - Keisuke Matsuoka, Asumi Kase, Takashi Matsuo, Yusuke Ashida. Competitive Solubilization of Cholesterol/Cholesteryl Oleate and Seven Species of Sterol/Stanol in Model Intestinal Solution System.
Journal of oleo science.
2015; 64(7):783-91. doi:
10.5650/jos.ess15044. [PMID: 26136176] - Xiaobo Lin, Susan B Racette, Lina Ma, Michael Wallendorf, Catherine Anderson Spearie, Richard E Ostlund. Plasma biomarker of dietary phytosterol intake.
PloS one.
2015; 10(2):e0116912. doi:
10.1371/journal.pone.0116912. [PMID: 25668184] - Kazutaka Aoki, Takahiro Ijima, Hiroshi Kamiyama, Kazunari Kamiko, Yasuo Terauchi. Anagliptin decreases serum lathosterol level in patients with type 2 diabetes: a pilot study.
Expert opinion on pharmacotherapy.
2015; 16(12):1749-54. doi:
10.1517/14656566.2015.1057120. [PMID: 26098722] - Loïc Harrault, Emilie Jardé, Laurent Jeanneau, Patrice Petitjean. Are fecal stanols suitable to record and identify a pulse of human fecal contamination in short-term exposed shellfish? A microcosm study.
Marine pollution bulletin.
2014 Dec; 89(1-2):40-48. doi:
10.1016/j.marpolbul.2014.10.037. [PMID: 25455370] - Annika Mutanen, Markku J Nissinen, Jouko Lohi, Päivi Heikkilä, Helena Gylling, Mikko P Pakarinen. Serum plant sterols, cholestanol, and cholesterol precursors associate with histological liver injury in pediatric onset intestinal failure.
The American journal of clinical nutrition.
2014 Oct; 100(4):1085-94. doi:
10.3945/ajcn.114.088781. [PMID: 25099547] - I Tolosa, M Mesa, C M Alonso-Hernandez. Steroid markers to assess sewage and other sources of organic contaminants in surface sediments of Cienfuegos Bay, Cuba.
Marine pollution bulletin.
2014 Sep; 86(1-2):84-90. doi:
10.1016/j.marpolbul.2014.07.039. [PMID: 25127498] - César C Martins, Ana Caroline Cabral, Scheyla C T Barbosa-Cintra, Ana Lúcia L Dauner, Fernanda M Souza. An integrated evaluation of molecular marker indices and linear alkylbenzenes (LABs) to measure sewage input in a subtropical estuary (Babitonga Bay, Brazil).
Environmental pollution (Barking, Essex : 1987).
2014 May; 188(?):71-80. doi:
10.1016/j.envpol.2014.01.022. [PMID: 24556228] - Andrea Mignarri, Gian Nicola Gallus, Maria Teresa Dotti, Antonio Federico. A suspicion index for early diagnosis and treatment of cerebrotendinous xanthomatosis.
Journal of inherited metabolic disease.
2014 May; 37(3):421-9. doi:
10.1007/s10545-013-9674-3. [PMID: 24442603] - Maarit Hallikainen, Piia Simonen, Helena Gylling. Cholesterol metabolism and serum non-cholesterol sterols: summary of 13 plant stanol ester interventions.
Lipids in health and disease.
2014 Apr; 13(?):72. doi:
10.1186/1476-511x-13-72. [PMID: 24766766] - Ainara Sistiaga, Carolina Mallol, Bertila Galván, Roger Everett Summons. The Neanderthal meal: a new perspective using faecal biomarkers.
PloS one.
2014; 9(6):e101045. doi:
10.1371/journal.pone.0101045. [PMID: 24963925] - Ingemar Björkhem. Cerebrotendinous xanthomatosis.
Current opinion in lipidology.
2013 Aug; 24(4):283-7. doi:
10.1097/mol.0b013e328362df13. [PMID: 23759795] - Giuseppe Martini, Andrea Mignarri, Martina Ruvio, Roberto Valenti, Beatrice Franci, Marina Del Puppo, Antonio Federico, Ranuccio Nuti, Maria Teresa Dotti. Long-term bone density evaluation in cerebrotendinous xanthomatosis: evidence of improvement after chenodeoxycholic acid treatment.
Calcified tissue international.
2013 Mar; 92(3):282-6. doi:
10.1007/s00223-012-9677-3. [PMID: 23212544] - M Derrien, E Jardé, G Gruau, A M Pourcher, M Gourmelon, A Jadas-Hécart, A C Pierson Wickmann. Origin of fecal contamination in waters from contrasted areas: stanols as Microbial Source Tracking markers.
Water research.
2012 Sep; 46(13):4009-16. doi:
10.1016/j.watres.2012.05.003. [PMID: 22673347] - Annika Kurvinen, Markku J Nissinen, Sture Andersson, Päivi Korhonen, Tarja Ruuska, Mari Taimisto, Marko Kalliomäki, Liisa Lehtonen, Ulla Sankilampi, Pekka Arikoski, Timo Saarela, Tatu A Miettinen, Helena Gylling, Mikko P Pakarinen. Parenteral plant sterols and intestinal failure-associated liver disease in neonates.
Journal of pediatric gastroenterology and nutrition.
2012 Jun; 54(6):803-11. doi:
10.1097/mpg.0b013e3182474118. [PMID: 22197940] - Kyrill S Rogacev, Tobias Pinsdorf, Oliver Weingärtner, Markus K Gerhart, Elena Welzel, Kai van Bentum, Julius Popp, Andreas Menzner, Danilo Fliser, Dieter Lütjohann, Gunnar H Heine. Cholesterol synthesis, cholesterol absorption, and mortality in hemodialysis patients.
Clinical journal of the American Society of Nephrology : CJASN.
2012 Jun; 7(6):943-8. doi:
10.2215/cjn.05170511. [PMID: 22461539] - Martin Kaczocha, Qingqing Lin, Lindsay D Nelson, Michelle K McKinney, Benjamin F Cravatt, Erwin London, Dale G Deutsch. Anandamide externally added to lipid vesicles containing trapped fatty acid amide hydrolase (FAAH) is readily hydrolyzed in a sterol-modulated fashion.
ACS chemical neuroscience.
2012 May; 3(5):364-8. doi:
10.1021/cn300001w. [PMID: 22860204] - Charles Desmarchelier, Christoph Dahlhoff, Sylvia Keller, Manuela Sailer, Gerhard Jahreis, Hannelore Daniel. C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia.
BMC genomics.
2012 Mar; 13(?):84. doi:
10.1186/1471-2164-13-84. [PMID: 22394543] - S Pande, K Platel, K Srinivasan. Antihypercholesterolaemic influence of dietary tender cluster beans (Cyamopsis tetragonoloba) in cholesterol fed rats.
The Indian journal of medical research.
2012 Mar; 135(?):401-6. doi:
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The Science of the total environment.
2012 Jan; 414(?):6-21. doi:
10.1016/j.scitotenv.2011.11.015. [PMID: 22137478] - Kotaro Nochioka, Shin-ichi Tanaka, Masanobu Miura, Do E Zhulanqiqige, Yoshihiro Fukumoto, Nobuyuki Shiba, Hiroaki Shimokawa. Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans.
Circulation journal : official journal of the Japanese Circulation Society.
2012; 76(8):2023-30. doi:
10.1253/circj.cj-12-0331. [PMID: 22640986] - Sunghwan Suh, Hee Kyung Kim, Hyung-Doo Park, Chang-Seok Ki, Mi Yeon Kim, Sang-Man Jin, Se Won Kim, Kyu Yeon Hur, Kwang-Won Kim, Jae Hyeon Kim. Three siblings with Cerebrotendinous Xanthomatosis: a novel mutation in the CYP27A1 gene.
European journal of medical genetics.
2012 Jan; 55(1):71-4. doi:
10.1016/j.ejmg.2011.08.003. [PMID: 21958693] - Manoj Kumar, Ravinder Nagpal, Rajesh Kumar, R Hemalatha, Vinod Verma, Ashok Kumar, Chaitali Chakraborty, Birbal Singh, Francesco Marotta, Shalini Jain, Hariom Yadav. Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases.
Experimental diabetes research.
2012; 2012(?):902917. doi:
10.1155/2012/902917. [PMID: 22611376] - Eric J Niesor, Evelyne Chaput, Andreas Staempfli, Denise Blum, Michael Derks, David Kallend. Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects.
Atherosclerosis.
2011 Dec; 219(2):761-7. doi:
10.1016/j.atherosclerosis.2011.09.017. [PMID: 21982411] - Monika Ostrowska, Krzysztof Banaszkiewicz, Anna Kiławiec, Teresa Róg, Dieter Lütjohann, Andrzej Szczudlik. Cerebrotendinous xanthomatosis: a rare cause of spinocerebellar syndrome.
Neurologia i neurochirurgia polska.
2011 Nov; 45(6):600-603. doi:
10.1016/s0028-3843(14)60128-6. [PMID: 22212991] - Minkyu Choi, Edward T Furlong, Hyo-Bang Moon, Jun Yu, Hee-Gu Choi. Contamination of nonylphenolic compounds in creek water, wastewater treatment plant effluents, and sediments from Lake Shihwa and vicinity, Korea: comparison with fecal pollution.
Chemosphere.
2011 Nov; 85(8):1406-13. doi:
10.1016/j.chemosphere.2011.08.016. [PMID: 21890169] - Estelle Wolff, Marie-France Vergnes, Henri Portugal, Catherine Defoort, Marie-Jo Amiot-Carlin, Denis Lairon, Alain Nicolay. Cholesterol-absorber status modifies the LDL cholesterol-lowering effect of a Mediterranean-type diet in adults with moderate cardiovascular risk factors.
The Journal of nutrition.
2011 Oct; 141(10):1791-8. doi:
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Water research.
2011 Oct; 45(15):4623-33. doi:
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Neurologia (Barcelona, Spain).
2011 Sep; 26(7):397-404. doi:
10.1016/j.nrl.2010.12.009. [PMID: 21345536] - G Lupattelli, S De Vuono, E Mannarino. Patterns of cholesterol metabolism: pathophysiological and therapeutic implications for dyslipidemias and the metabolic syndrome.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2011 Sep; 21(9):620-7. doi:
10.1016/j.numecd.2011.04.010. [PMID: 21855307] - Ning Xie, Yi Cui, Ya-Ni Yin, Xin Zhao, Jun-Wen Yang, Zheng-Gen Wang, Nian Fu, Yong Tang, Xue-Hong Wang, Xiao-Wei Liu, Chun-Lian Wang, Fang-Gen Lu. Effects of two Lactobacillus strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet.
BMC complementary and alternative medicine.
2011 Jul; 11(?):53. doi:
10.1186/1472-6882-11-53. [PMID: 21722398] - Laura N Rodríguez-Cantú, Janet A Gutiérrez-Uribe, Jennifer Arriola-Vucovich, Rocio I Díaz-De La Garza, Jed W Fahey, Sergio O Serna-Saldivar. Broccoli ( Brassica oleracea var. italica) sprouts and extracts rich in glucosinolates and isothiocyanates affect cholesterol metabolism and genes involved in lipid homeostasis in hamsters.
Journal of agricultural and food chemistry.
2011 Feb; 59(4):1095-103. doi:
10.1021/jf103513w. [PMID: 21254774] - T Inoue, I Taguchi, S Abe, S Toyoda, M Sakuma, K Node. Inhibition of intestinal cholesterol absorption might explain cholesterol-lowering effect of telmisartan.
Journal of clinical pharmacy and therapeutics.
2011 Feb; 36(1):103-10. doi:
10.1111/j.1365-2710.2010.01161.x. [PMID: 21198725] - Ivone de Andrade Rosa, Débora Afonso Silva Rocha, Wanderley de Souza, Julio A Urbina, Marlene Benchimol. Ultrastructural alterations induced by Δ(24(25))-sterol methyltransferase inhibitors on Trichomonas vaginalis.
FEMS microbiology letters.
2011 Feb; 315(1):72-8. doi:
10.1111/j.1574-6968.2010.02178.x. [PMID: 21175744] - Matthew G K Benesch, David A Mannock, Ronald N McElhaney. Sterol chemical configuration and conformation influence the thermotropic phase behaviour of dipalmitoylphosphatidylcholine mixtures containing 5β-cholestan-3β- and -3α-ol.
Chemistry and physics of lipids.
2011 Jan; 164(1):70-7. doi:
10.1016/j.chemphyslip.2010.10.005. [PMID: 21055393] - Lin Yang, Jiahou Chen, Tong Xu, Wei Qiu, Yan Zhang, Lanwei Zhang, Fuping Xu, Hongbo Liu. Rice protein extracted by different methods affects cholesterol metabolism in rats due to its lower digestibility.
International journal of molecular sciences.
2011; 12(11):7594-608. doi:
10.3390/ijms12117594. [PMID: 22174619] - Matthew G K Benesch, David A Mannock, Ronald N McElhaney. Sterol chemical configuration influences the thermotropic phase behaviour of dipalmitoylphosphatidylcholine bilayers containing 5α-cholestan-3β- and 3α-ol.
Chemistry and physics of lipids.
2011 Jan; 164(1):62-9. doi:
10.1016/j.chemphyslip.2010.10.003. [PMID: 21055394] - Susumu Tomono, Noriyuki Miyoshi, Hidemi Shiokawa, Tomoe Iwabuchi, Yasuaki Aratani, Tatsuya Higashi, Haruo Nukaya, Hiroshi Ohshima. Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway.
Journal of lipid research.
2011 Jan; 52(1):87-97. doi:
10.1194/jlr.m006775. [PMID: 20921334]