(S)-4',7-Dihydroxy-3',8-diprenylflavanone (BioDeep_00000018761)

Main id: BioDeep_00000230124

 

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-8-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H-1-benzopyran-4-one

化学式: C25H28O4 (392.19874880000003)
中文名称: 光甘草酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCC1=C(C=CC(=C1)C2CC(=O)C3=C(O2)C(=C(C=C3)O)CC=C(C)C)O)C
InChI: InChI=1S/C25H28O4/c1-15(2)5-7-17-13-18(8-11-21(17)26)24-14-23(28)20-10-12-22(27)19(25(20)29-24)9-6-16(3)4/h5-6,8,10-13,24,26-27H,7,9,14H2,1-4H3

描述信息

(S)-4,7-Dihydroxy-3,8-diprenylflavanone is found in herbs and spices. (S)-4,7-Dihydroxy-3,8-diprenylflavanone is a constituent of roots of Glycyrrhiza glabra (licorice)
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity[1].
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity[1].
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity[1].

同义名列表

3 个代谢物同义名

7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-8-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H-1-benzopyran-4-one; (S)-4,7-Dihydroxy-3,8-diprenylflavanone; Glabrol



数据库引用编号

11 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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40 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rajni Sharma, Linda Gatchie, Ibidapo S Williams, Shreyans K Jain, Ram A Vishwakarma, Bhabatosh Chaudhuri, Sandip B Bharate. Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme. Bioorganic & medicinal chemistry letters. 2017 12; 27(24):5400-5403. doi: 10.1016/j.bmcl.2017.11.013. [PMID: 29150398]
  • Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Shuai Ji, Kuan Chen, Wei Song, Xue Qiao, Min Ye. Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice. Bioorganic & medicinal chemistry. 2017 10; 25(20):5522-5530. doi: 10.1016/j.bmc.2017.08.018. [PMID: 28835349]
  • Suengmok Cho, Ji-Hae Park, Ae Nim Pae, Daeseok Han, Dongsoo Kim, Nam-Chul Cho, Kyoung Tai No, Hyejin Yang, Minseok Yoon, Changho Lee, Makoto Shimizu, Nam-In Baek. Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol. Bioorganic & medicinal chemistry. 2012 Jun; 20(11):3493-501. doi: 10.1016/j.bmc.2012.04.011. [PMID: 22543233]
  • Zhihong Lin, Jie Gu, Jin Xiu, Tingyan Mi, Jie Dong, Jyoti Kumar Tiwari. Traditional chinese medicine for senile dementia. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):692621. doi: 10.1155/2012/692621. [PMID: 21808655]
  • Jung Ho Choi, Ji Na Choi, Sung Yoon Lee, Sung Jae Lee, Koanhoi Kim, Young Kook Kim. Inhibitory activity of diacylglycerol acyltransferase by glabrol isolated from the roots of licorice. Archives of pharmacal research. 2010 Feb; 33(2):237-42. doi: 10.1007/s12272-010-0208-3. [PMID: 20195824]
  • Minpei Kuroda, Yoshihiro Mimaki, Shinichi Honda, Hozumi Tanaka, Shinichi Yokota, Tatsumasa Mae. Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity. Bioorganic & medicinal chemistry. 2010 Jan; 18(2):962-70. doi: 10.1016/j.bmc.2009.11.027. [PMID: 20022509]
  • Jung Ho Choi, Mun-Chual Rho, Seung Woong Lee, Oh Eok Kwon, Hye Ran Park, Ji Yun Kang, Seung Ho Lee, Hyun Sun Lee, Ki Hwan Bae, Young Kook Kim. Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots. Journal of ethnopharmacology. 2007 Apr; 110(3):563-6. doi: 10.1016/j.jep.2006.10.012. [PMID: 17123760]