D-Mannose 1-phosphate (BioDeep_00000014560)

 

Secondary id: BioDeep_00000014852, BioDeep_00000400426, BioDeep_00001868849

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid

化学式: C6H13O9P (260.0297178)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 0.17%

分子结构信息

SMILES: C(C1C(C(C(C(O1)OP(=O)(O)O)O)O)O)O
InChI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)

描述信息

D-Mannose 1-phosphate (CAS: 27251-84-9) is a normal metabolite intermediate in fructose and mannose metabolism. It is a substrate of phosphomannomutase 1 (PMM, EC 5.4.2.8), an enzyme necessary for the synthesis of GDP-mannose (a substrate for dolichol-linked oligosaccharide synthesis). PMM converts mannose 6-phosphate into mannose-1-phosphate. A deficiency of phosphomannomutase in carbohydrate-deficient glycoprotein syndrome (CDGS) type I is associated with a decreased synthesis of mannose 1-phosphate. CDGS is a group of autosomal recessively transmitted disorders in which abnormally glycosylated proteins are formed (PMID: 9451026, 8549746, 12729595).
α-d-mannose 1-phosphate is a member of the class of compounds known as monosaccharide phosphates. Monosaccharide phosphates are monosaccharides comprising a phosphated group linked to the carbohydrate unit. α-d-mannose 1-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). α-d-mannose 1-phosphate can be found in a number of food items such as lettuce, beech nut, red beetroot, and japanese pumpkin, which makes α-d-mannose 1-phosphate a potential biomarker for the consumption of these food products.
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID M080

同义名列表

23 个代谢物同义名

{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid; alpha-D(+)Mannose 1-phosphate bis(cyclohexylammonium) salt; alpha-D-(+)-mannose-1-phosphate sodium salt hydrate; 1-O-Phosphono-alpha-D-mannopyranose; α-D-Mannopyranosyl phosphate; alpha-D-Mannose 1-phosphoric acid; alpha-D-Mannopyranosyl phosphate; α-D(+)Mannose 1-phosphate; alpha-D-(+)-mannose-1-phosphate; 1-O-Phosphono-a-D-mannopyranose; 1-O-Phosphono-α-D-mannopyranose; α-D-Mannose 1-phosphate; Α-D-mannose 1-phosphoric acid; a-D-Mannose 1-phosphoric acid; Α-D-mannopyranosyl phosphate; alpha-D-Mannose 1-phosphate; D-Mannose 1-phosphoric acid; a-D-Mannose 1-phosphate; Α-D-mannose 1-phosphate; D-Mannose 1-phosphate; Mannose 1-phosphate; Mannosyl phosphate; Mannose phosphate



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(1)

PlantCyc(0)

代谢反应

510 个相关的代谢反应过程信息。

Reactome(90)

BioCyc(7)

WikiPathways(1)

Plant Reactome(410)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • S Shak, M A Davitz, M L Wolinsky, V Nussenzweig, M J Turner, A Gurnett. Partial characterization of the cross-reacting determinant, a carbohydrate epitope shared by decay accelerating factor and the variant surface glycoprotein of the African Trypanosoma brucei. Journal of immunology (Baltimore, Md. : 1950). 1988 Mar; 140(6):2046-50. doi: . [PMID: 2450138]