4a-Hydroxytetrahydrobiopterin (BioDeep_00000010758)
Secondary id: BioDeep_00001872616
human metabolite Endogenous
代谢物信息卡片
(4aS,6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4a-hydroxy-4,4a,5,6,7,8-hexahydropteridin-4-one
化学式: C9H15N5O4 (257.11239900000004)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 0.03%
分子结构信息
SMILES: CC(C(C1CN=C2C(N1)(C(=O)NC(=N2)N)O)O)O
InChI: InChI=1S/C9H14N4O3/c1-4(14)7(15)5-2-10-8-6(13-5)9(16)12-3-11-8/h3-5,7,13-15H,2H2,1H3,(H2,10,11,12,16)/t4-,5-,7?/m0/s1
描述信息
Tetrahydrobiopterin (BH4) is essential for catalyzing the conversion of phenylalanine into tyrosine by phenylalanine hydroxylase. During this physiological reaction, the oxidation of BH4 creates 4a-hydroxytetrahydropterin (CAS: 70110-58-6) intermediates and hydrogen peroxide is formed. The hydrogen peroxide and the hydroxytetrahydropterin can both be derived from alternate breakdown routes of a common precursor, the corresponding 4a-hydroperoxytetrahydropterin (PMID: 8323303).
Tetrahydrobiopterin (BH4) is essential to catalyze the conversion of phenylalanine to tyrosine by phenylalanine hydroxylase. During this physiological reaction, the oxidation of BH4 creates 4a-hydroxytetrahydropterin intermediates and hydrogen peroxide is formed. The hydrogen peroxide and the hydroxytetrahydropterin can both derive from alternate routes of breakdown of a common precursor, the corresponding 4a-hydroperoxytetrahydropterin. (PMID 8323303) [HMDB]
同义名列表
11 个代谢物同义名
(4aS,6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4a-hydroxy-4,4a,5,6,7,8-hexahydropteridin-4-one; (4aS,6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4a-hydroxy-5,6,7,8-tetrahydropteridin-4-one; (6R)-6-(L-erythro-1,2-Dihydroxypropyl)-5,6,7,8-tetrahydro-4a- hydroxypterin; (6R)-6-(L-Erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin; 6-[(1R,2S)-1,2-Dihydroxypropyl]-5,6,7,8-tetrahydro-4a-hydroxypterin; (4AS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin; 4a-Hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin; 4a-Hydroxy-5,6,4,8-tetrahydrobiopterin; 4a-Hydroxy-5,6,7,8-tetrahydrobiopterin; 4a-Hydroxytetrahydrobiopterin; 4a-HTHB
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:15642
- KEGG: C15522
- PubChem: 135476778
- PubChem: 135476770
- HMDB: HMDB0002281
- Metlin: METLIN64413
- MetaCyc: CPD-5881
- foodb: FDB022944
- chemspider: 30792101
- CAS: 1379003-93-6
- CAS: 70110-58-6
- PMhub: MS000024643
- PubChem: 17396514
- NIKKAJI: J2.794.818I
- RefMet: 4a-Hydroxytetrahydrobiopterin
分类词条
相关代谢途径
Reactome(7)
PlantCyc(5)
代谢反应
469 个相关的代谢反应过程信息。
Reactome(132)
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Catecholamine biosynthesis:
L-Tyr + Oxygen + Tetrahydrobiopterin ⟶ 4aOH-BH4 + Dopa - Serotonin and melatonin biosynthesis:
5HT + Ac-CoA ⟶ Ac5HT + CoA-SH - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
2OG + L-Tyr ⟶ HPPYRA + L-Glu - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Catecholamine biosynthesis:
NAd + SAM ⟶ ADR + H+ + SAH - Serotonin and melatonin biosynthesis:
5HTP ⟶ 5HT + carbon dioxide - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Catecholamine biosynthesis:
NAd + SAM ⟶ ADR + H+ + SAH - Serotonin and melatonin biosynthesis:
5HTP ⟶ 5HT + carbon dioxide - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
2OG + L-Tyr ⟶ HPPYRA + L-Glu - Metabolism of amine-derived hormones:
MIT + TPNH ⟶ I- + L-Tyr + TPN - Catecholamine biosynthesis:
AscH- + DA + Oxygen ⟶ DHA + H2O + NAd - Serotonin and melatonin biosynthesis:
5HTP ⟶ 5HT + carbon dioxide - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Serotonin and melatonin biosynthesis:
L-Trp + Oxygen + Tetrahydrobiopterin ⟶ 4aOH-BH4 + 5HTP - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
2OG + L-Tyr ⟶ HPPYRA + L-Glu - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Catecholamine biosynthesis:
AscH- + DA + Oxygen ⟶ DHA + H2O + NAd - Serotonin and melatonin biosynthesis:
5HTP ⟶ 5HT + carbon dioxide - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Catecholamine biosynthesis:
NAd + SAM ⟶ ADR + H+ + SAH - Serotonin and melatonin biosynthesis:
5HTP ⟶ 5HT + carbon dioxide - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Catecholamine biosynthesis:
NAd + SAM ⟶ ADR + H+ + SAH - Serotonin and melatonin biosynthesis:
5HTP ⟶ 5HT + carbon dioxide - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Catecholamine biosynthesis:
NAd + SAM ⟶ ADR + H+ + SAH - Serotonin and melatonin biosynthesis:
5HTP ⟶ 5HT + carbon dioxide - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
CARN + SAM ⟶ Anserine + SAH - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Catecholamine biosynthesis:
NAd + SAM ⟶ ADR + H+ + SAH - Serotonin and melatonin biosynthesis:
5HTP ⟶ 5HT + carbon dioxide - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
L-Phe + PYR ⟶ 3IN-PYRA + L-Ala - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
ATP + L-His + b-Ala ⟶ ADP + CARN + Pi - Phenylalanine and tyrosine catabolism:
L-Phe + PYR ⟶ 3IN-PYRA + L-Ala - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Metabolism of amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Catecholamine biosynthesis:
NAd + SAM ⟶ ADR + H+ + SAH - Serotonin and melatonin biosynthesis:
5HTP ⟶ 5HT + carbon dioxide - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
2OG + L-Tyr ⟶ HPPYRA + L-Glu - Amine-derived hormones:
Iodine + L-Tyr ⟶ HI + MIT - Catecholamine biosynthesis:
DA + Oxygen + VitC ⟶ DHA + H2O + NAd - Serotonin and melatonin biosynthesis:
5HTP ⟶ 5HT + carbon dioxide - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Phenylalanine and tyrosine catabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Metabolism of amine-derived hormones:
NAd + SAM ⟶ ADR + H+ + SAH - Catecholamine biosynthesis:
NAd + SAM ⟶ ADR + H+ + SAH - Catecholamine biosynthesis:
L-Tyr + Oxygen + Tetrahydrobiopterin ⟶ 4aOH-BH4 + Dopa - Phenylalanine and tyrosine catabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine and tyrosine metabolism:
2OG + L-Tyr ⟶ HPPYRA + L-Glu - Phenylalanine metabolism:
L-Phe + PYR ⟶ 3IN-PYRA + L-Ala - Phenylalanine and tyrosine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine and tyrosine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine and tyrosine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine and tyrosine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine and tyrosine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine and tyrosine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine and tyrosine metabolism:
L-Phe + PYR ⟶ 3IN-PYRA + L-Ala - Phenylalanine metabolism:
L-Phe + PYR ⟶ 3IN-PYRA + L-Ala - Phenylalanine and tyrosine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine and tyrosine metabolism:
2OG + L-Tyr ⟶ HPPYRA + L-Glu - Phenylalanine metabolism:
L-Phe + PYR ⟶ 3IN-PYRA + L-Ala - Phenylalanine and tyrosine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine and tyrosine metabolism:
L-Phe + PYR ⟶ 3IN-PYRA + L-Ala - Phenylalanine metabolism:
L-Phe + PYR ⟶ 3IN-PYRA + L-Ala - Phenylalanine and tyrosine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine and tyrosine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine metabolism:
H2O + L-Phe + Oxygen ⟶ H2O2 + ammonia + kPPV - Phenylalanine and tyrosine metabolism:
4aOH-BH4 ⟶ H2O + qDHB - Phenylalanine metabolism:
4aOH-BH4 ⟶ H2O + qDHB
BioCyc(2)
- biopterin metabolism:
NADPH + biopterin ⟶ 7,8-dihydrobiopterin + NADP+ - phenylalanine degradation:
O2 + phe + tetrahydrobiopterin ⟶ 4α-hydroxy-tetrahydrobiopterin + tyr
WikiPathways(1)
- Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine:
5-OH-Trp ⟶ Serotonin
Plant Reactome(0)
INOH(0)
PlantCyc(334)
- rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - (S)-reticuline biosynthesis I:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyramine ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + dopamine - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of betalain biosynthesis:
UDP-α-D-glucose + leucodopachrome ⟶ H+ + UDP + cyclo-dopa 5-O-glucoside - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - betalamic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - (S)-reticuline biosynthesis I:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyramine ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + dopamine - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - betalamic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - betalamic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ ⟶ 3-(3,4-dihydroxyphenyl)pyruvate + H+ + NAD(P)H - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - betalamic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - betalamic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - betalamic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - rosmarinic acid biosynthesis II:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - serotonin and melatonin biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + trp ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + 5-hydroxy-L-tryptophan - superpathway of rosmarinic acid biosynthesis:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 + tyr ⟶ (6R)-4a-hydroxy-tetrahydrobiopterin + L-dopa - superpathway of rosmarinic acid biosynthesis:
(R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ ⟶ 3-(3,4-dihydroxyphenyl)pyruvate + H+ + NAD(P)H - rosmarinic acid biosynthesis II:
(R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ ⟶ 3-(3,4-dihydroxyphenyl)pyruvate + H+ + NAD(P)H - rosmarinic acid biosynthesis II:
(R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ ⟶ 3-(3,4-dihydroxyphenyl)pyruvate + H+ + NAD(P)H - serotonin and melatonin biosynthesis:
N-acetyl-serotonin + SAM ⟶ H+ + SAH + melatonin - superpathway of rosmarinic acid biosynthesis:
(R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ ⟶ 3-(3,4-dihydroxyphenyl)pyruvate + H+ + NAD(P)H - superpathway of rosmarinic acid biosynthesis:
(R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ ⟶ 3-(3,4-dihydroxyphenyl)pyruvate + H+ + NAD(P)H - superpathway of rosmarinic acid biosynthesis:
(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ ⟶ 3-(4-hydroxyphenyl)pyruvate + H+ + NAD(P)H - superpathway of rosmarinic acid biosynthesis:
(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ ⟶ 3-(4-hydroxyphenyl)pyruvate + H+ + NAD(P)H - rosmarinic acid biosynthesis II:
(R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ ⟶ 3-(3,4-dihydroxyphenyl)pyruvate + H+ + NAD(P)H
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2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。