2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (BioDeep_00000009204)
Secondary id: BioDeep_00000226851, BioDeep_00001877520
human metabolite
代谢物信息卡片
化学式: C5H6N4O5 (202.0338)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 20.68%
分子结构信息
SMILES: C1(=NC(=O)NC1(C(=O)O)O)NC(=O)N
InChI: InChI=1S/C5H6N4O5/c6-3(12)7-1-5(14,2(10)11)9-4(13)8-1/h14H,(H,10,11)(H4,6,7,8,9,12,13)
描述信息
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1h-imidazole-5-carboxylate, also known as 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline, belongs to alpha amino acids and derivatives class of compounds. Those are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1h-imidazole-5-carboxylate is slightly soluble (in water) and a moderately acidic compound (based on its pKa). 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1h-imidazole-5-carboxylate can be found in soy bean, which makes 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1h-imidazole-5-carboxylate a potential biomarker for the consumption of this food product. 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1h-imidazole-5-carboxylate exists in all living organisms, ranging from bacteria to humans.
2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (CAS: 255828-59-2), also known as OHCU, belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. Outside of the human body, 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline has been detected, but not quantified, in soybeans. This could make 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline a potential biomarker for the consumption of these foods. 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline is part of the purine metabolism pathway. It is a substrate for putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase.
同义名列表
15 个代谢物同义名
(5S)-2,5-Dihydroxy-4-[(C-hydroxycarbonimidoyl)imino]-4,5-dihydro-1H-imidazole-5-carboxylate; (5S)-4-[(Aminocarbonyl)amino]-2,5-dihydro-5-hydroxy-2-oxo-1H-imidazole-5-carboxylic acid; 4-[(Aminocarbonyl)amino]-2,5-dihydro-5-hydroxy-2-oxo-1H-imidazole-5-carboxylic acid; (5S)-4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylic acid; 4-(Carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylate; (4S)-5-(carbamoylamino)-4-hydroxy-2-oxo-3H-imidazole-4-carboxylic acid; (4S)-5-(Carbamoylimino)-4-hydroxy-2-oxoimidazolidine-4-carboxylic acid; (S)-5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate; 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid; 5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate; (S)-2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline; 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline; 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazole; (S)-OHCU; OHCU
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:31132
- KEGG: C12248
- PubChem: 101957722
- PubChem: 443736
- HMDB: HMDB0059663
- Metlin: METLIN63396
- MetaCyc: CPD-5821
- foodb: FDB001617
- chemspider: 61493300
- CAS: 1320343-65-4
- PMhub: MS000022961
- PubChem: 14393
- KNApSAcK: C00007532
- 3DMET: B05622
- NIKKAJI: J861.997B
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(3)
代谢反应
131 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(129)
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- superpathway of purines degradation in plants:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin II:
H+ + NADH + O2 + urate ⟶ (S)-5-hydroxyisourate + H2O + NAD+
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- superpathway of purines degradation in plants:
H2O + NAD+ + xanthine ⟶ H+ + NADH + urate
- ureide biosynthesis:
H2O + NAD+ + xanthine ⟶ H+ + NADH + urate
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin II:
H+ + NADH + O2 + urate ⟶ (S)-5-hydroxyisourate + H2O + NAD+
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- superpathway of purines degradation in plants:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- ureide biosynthesis:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- superpathway of purines degradation in plants:
H2O + NAD+ + xanthine ⟶ H+ + NADH + urate
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- urate conversion to allantoin I:
H2O + O2 + urate ⟶ (S)-5-hydroxyisourate + hydrogen peroxide
- ureide biosynthesis:
H2O + NAD+ + xanthine ⟶ H+ + NADH + urate
COVID-19 Disease Map(0)
PathBank(2)
- Urate Degradation to Ureidoglycolate:
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + Hydrogen Ion ⟶ Allantoin + Carbon dioxide
- Urate Degradation to Glyoxylate:
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + Hydrogen Ion ⟶ Allantoin + Carbon dioxide
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 | |
---|---|---|
Cytoplasm | 1 | RFK |
cytosol | 1 | RFK |
extracellular exosome | 1 | TTR |
extracellular space | 1 | TTR |
mitochondrion | 1 | RFK |
Secreted | 1 | TTR |
extracellular region | 1 | TTR |
Peroxisome | 1 | URAD |
azurophil granule lumen | 1 | TTR |
文献列表
- Ileana Ramazzina, Claudia Folli, Andrea Secchi, Rodolfo Berni, Riccardo Percudani. Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes.
Nature chemical biology.
2006 Mar; 2(3):144-8. doi:
10.1038/nchembio768
. [PMID: 16462750]