8-Amino-7-oxononanoic acid (BioDeep_00000004568)

 

Secondary id: BioDeep_00000629158, BioDeep_00001869214, BioDeep_00001900970

human metabolite


代谢物信息卡片


(8S)-8-Amino-7-oxononanoic acid

化学式: C9H17NO3 (187.1208)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(plant) 10.49%

分子结构信息

SMILES: CC(C(=O)CCCCCC(=O)O)N
InChI: InChI=1S/C9H17NO3/c1-7(10)8(11)5-3-2-4-6-9(12)13/h7H,2-6,10H2,1H3,(H,12,13)

描述信息

8-Amino-7-oxononanoic acid, also known as 7-keto-8-aminopelargonic acid (7-KAP) or KAPA, belongs to the class of organic compounds known as medium-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms. 8-Amino-7-oxononanoic acid has been identified in urine (PMID: 22409530).

同义名列表

14 个代谢物同义名

(8S)-8-Amino-7-oxononanoic acid; 7-Keto-8-aminopelargonic acid; 8-Amino-7-ketopelargonic acid; 7-keto-8-Aminopelargomic Acid; 7-oxo-8-Aminopelargonic acid; 8-Amino-7-oxopelargonic acid; (8S)-8-Amino-7-oxononanoate; 8-amino-7-oxo-nonanoic acid; 8-Amino-7-oxononanoic acid; 7-Keto-8-aminopelargonate; 8-Amino-7-oxononanoate; KAPA CPD; 7-KAP; KAPA



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

246 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(246)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • David Cobessi, Renaud Dumas, Virginie Pautre, Céline Meinguet, Jean-Luc Ferrer, Claude Alban. Biochemical and structural characterization of the Arabidopsis bifunctional enzyme dethiobiotin synthetase-diaminopelargonic acid aminotransferase: evidence for substrate channeling in biotin synthesis. The Plant cell. 2012 Apr; 24(4):1608-25. doi: 10.1105/tpc.112.097675. [PMID: 22547782]
  • Jeffrey C Waller, Kenneth W Ellens, Sophie Alvarez, Karen Loizeau, Stéphane Ravanel, Andrew D Hanson. Mitochondrial and plastidial COG0354 proteins have folate-dependent functions in iron-sulphur cluster metabolism. Journal of experimental botany. 2012 Jan; 63(1):403-11. doi: 10.1093/jxb/err286. [PMID: 21984653]
  • Pasqualina Magliano, Michel Flipphi, Bulak A Arpat, Syndie Delessert, Yves Poirier. Contributions of the peroxisome and β-oxidation cycle to biotin synthesis in fungi. The Journal of biological chemistry. 2011 Dec; 286(49):42133-42140. doi: 10.1074/jbc.m111.279687. [PMID: 21998305]
  • Yasuko Tanabe, Jun-Ichi Maruyama, Shohei Yamaoka, Daiki Yahagi, Ichiro Matsuo, Nobuhiro Tsutsumi, Katsuhiko Kitamoto. Peroxisomes are involved in biotin biosynthesis in Aspergillus and Arabidopsis. The Journal of biological chemistry. 2011 Sep; 286(35):30455-30461. doi: 10.1074/jbc.m111.247338. [PMID: 21730067]
  • Xu Li, Hilal Ilarslan, Libuse Brachova, Hui-Rong Qian, Ling Li, Ping Che, Eve Syrkin Wurtele, Basil J Nikolau. Reverse-genetic analysis of the two biotin-containing subunit genes of the heteromeric acetyl-coenzyme A carboxylase in Arabidopsis indicates a unidirectional functional redundancy. Plant physiology. 2011 Jan; 155(1):293-314. doi: 10.1104/pp.110.165910. [PMID: 21030508]
  • Marie-Laure Rosso, Sylvie Chauvaux, Rodrigue Dessein, Caroline Laurans, Lionel Frangeul, Céline Lacroix, Angèle Schiavo, Marie-Agnès Dillies, Jeannine Foulon, Jean-Yves Coppée, Claudine Médigue, Elisabeth Carniel, Michel Simonet, Michaël Marceau. Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression. BMC microbiology. 2008 Dec; 8(?):211. doi: 10.1186/1471-2180-8-211. [PMID: 19055764]
  • Matthias Weider, Agnes Machnik, Franz Klebl, Norbert Sauer. Vhr1p, a new transcription factor from budding yeast, regulates biotin-dependent expression of VHT1 and BIO5. The Journal of biological chemistry. 2006 May; 281(19):13513-13524. doi: 10.1074/jbc.m512158200. [PMID: 16533810]
  • Vikrant M Bhor, Sagarika Dev, Ganga Ramu Vasanthakumar, Avadhesha Surolia. Spectral and kinetic characterization of 7,8-diaminopelargonic acid synthase from Mycobacterium tuberculosis. IUBMB life. 2006 Apr; 58(4):225-33. doi: 10.1080/15216540600746997. [PMID: 16754301]
  • Violaine Pinon, Stéphane Ravanel, Roland Douce, Claude Alban. Biotin synthesis in plants. The first committed step of the pathway is catalyzed by a cytosolic 7-keto-8-aminopelargonic acid synthase. Plant physiology. 2005 Dec; 139(4):1666-76. doi: 10.1104/pp.105.070144. [PMID: 16299174]