Pregnanetriol (BioDeep_00000002627)

 

Secondary id: BioDeep_00000710846

human metabolite Endogenous Volatile Flavor Compounds


代谢物信息卡片


(3R,5R,8R,9S,10S,13S,14S,17R)-17-(1-hydroxyethyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol

化学式: C21H36O3 (336.26643060000004)
中文名称: 5β-孕烷-3α,17α,20α-三醇
谱图信息: 最多检出来源 Homo sapiens(urine) 2.7%

分子结构信息

SMILES: CC(C1(CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C)O)O
InChI: InChI=1S/C21H36O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h13-18,22-24H,4-12H2,1-3H3/t13?,14-,15-,16-,17+,18+,19+,20+,21+/m1/s1

描述信息

Pregnanetriol is a metabolite of 17-ALPHA-HYDROXYPROTESTERONE, normally produced in small quantities by the GONADS and the ADRENAL GLANDS, found in URINE. An elevated urinary pregnanetriol is associated with CONGENITAL ADRENAL HYPERPLASIA with a deficiency of STEROID 21-HYDROXYLASE.
A metabolite of 17-ALPHA-HYDROXYPROTESTERONE, normally produced in small quantities by the GONADS and the ADRENAL GLANDS, found in URINE. An elevated urinary pregnanetriol is associated with CONGENITAL ADRENAL HYPERPLASIA with a deficiency of STEROID 21-HYDROXYLASE. [HMDB]
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

8 个代谢物同义名

(3R,5R,8R,9S,10S,13S,14S,17R)-17-(1-hydroxyethyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol; (1S,2S,5R,7R,10R,11S,14R,15S)-14-(1-hydroxyethyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane-5,14-diol; 5beta-Pregnane-3alpha,17alpha,20alpha-triol; Pregnane-3,17,20-triol,(3a,5b,20S)-; 5-beta-Pregnane-3,17,20-triol; 5-Pregnane-3,17,20-triol; Pregnanetriol; 5beta-Pregnane-3alpha,17alpha,20alpha-triol



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Loredana Iannella, Cristiana Colamonici, Davide Curcio, Francesco Botrè, Xavier de la Torre. Detecting the abuse of 19-norsteroids in doping controls: A new gas chromatography coupled to isotope ratio mass spectrometry method for the analysis of 19-norandrosterone and 19-noretiocholanolone. Drug testing and analysis. 2021 Apr; 13(4):770-784. doi: 10.1002/dta.2985. [PMID: 33242373]
  • Tomoyo Itonaga, Masako Izawa, Takashi Hamajima, Yukihiro Hasegawa. First Morning Pregnanetriol and 17-Hydroxyprogesterone Correlated Significantly in 21-Hydroxylase Deficiency. Frontiers in endocrinology. 2021; 12(?):808254. doi: 10.3389/fendo.2021.808254. [PMID: 35140686]
  • Xavier de la Torre, Daniel Jardines, Davide Curcio, Cristiana Colamonici, Francesco Botrè. Isotope ratio mass spectrometry in antidoping analysis: The use of endogenous reference compounds. Rapid communications in mass spectrometry : RCM. 2019 Mar; 33(6):579-586. doi: 10.1002/rcm.8377. [PMID: 30589473]
  • Christopher M Jones, Ashwini Mallappa, Nicole Reisch, Nikolaos Nikolaou, Nils Krone, Beverly A Hughes, Donna M O'Neil, Martin J Whitaker, Jeremy W Tomlinson, Karl-Heinz Storbeck, Deborah P Merke, Richard J Ross, Wiebke Arlt. Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia. The Journal of clinical endocrinology and metabolism. 2017 06; 102(6):1797-1806. doi: 10.1210/jc.2016-2855. [PMID: 27845856]
  • Clemens Kamrath, Michaela F Hartmann, Claudia Boettcher, Klaus-Peter Zimmer, Stefan A Wudy. Diagnosis of 21-hydroxylase deficiency by urinary metabolite ratios using gas chromatography-mass spectrometry analysis: Reference values for neonates and infants. The Journal of steroid biochemistry and molecular biology. 2016 Feb; 156(?):10-6. doi: 10.1016/j.jsbmb.2015.10.013. [PMID: 26493852]
  • Weiming Li, Tyler Buchinger. Pheromone signaling: a pissing contest in tilapia. Current biology : CB. 2014 Sep; 24(18):R843-R845. doi: 10.1016/j.cub.2014.08.001. [PMID: 25247358]
  • Tina Keller-Costa, Peter C Hubbard, Christian Paetz, Yoko Nakamura, José P da Silva, Ana Rato, Eduardo N Barata, Bernd Schneider, Adelino V M Canario. Identity of a tilapia pheromone released by dominant males that primes females for reproduction. Current biology : CB. 2014 Sep; 24(18):2130-2135. doi: 10.1016/j.cub.2014.07.049. [PMID: 25155507]
  • Clemens Kamrath, Michaela F Hartmann, Claudia Boettcher, Stefan A Wudy. Reduced activity of 11β-hydroxylase accounts for elevated 17α-hydroxyprogesterone in preterms. The Journal of pediatrics. 2014 Aug; 165(2):280-4. doi: 10.1016/j.jpeds.2014.04.011. [PMID: 24862381]
  • Nicole Reisch, Marietta Rottenkolber, Anais Greifenstein, Nils Krone, Heinrich Schmidt, Martin Reincke, Hans-Peter Schwarz, Felix Beuschlein. Testicular adrenal rest tumors develop independently of long-term disease control: a longitudinal analysis of 50 adult men with congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency. The Journal of clinical endocrinology and metabolism. 2013 Nov; 98(11):E1820-6. doi: 10.1210/jc.2012-3181. [PMID: 23969190]
  • Masayuki Hayashi, Yuko Kataoka, Yoshihisa Sugimura, Fumiko Kato, Maki Fukami, Tsutomu Ogata, Keiko Homma, Tomonobu Hasegawa, Yutaka Oiso, Hironobu Sasano, Hiroshi Tanaka. A 68-year-old phenotypically male patient with 21-hydroxylase deficiency and concomitant adrenocortical neoplasm producing testosterone and cortisol. The Tohoku journal of experimental medicine. 2013 10; 231(2):75-84. doi: 10.1620/tjem.231.75. [PMID: 24077358]
  • D Martínez-Brito, M T Correa Vidal, X de la Torre, V García-Mir, O Ledea Lozano, M Granda Fraga. Reference ranges for the urinary steroid profile in a Latin-American population. Drug testing and analysis. 2013 Aug; 5(8):619-26. doi: 10.1002/dta.1448. [PMID: 23339119]
  • Tatsuya Higashi, Katsumi Kawasaki, Nagisa Matsumoto, Shoujiro Ogawa, Kuniko Mitamura, Shigeo Ikegawa. LC/MS/MS of steroids having vicinal diol as electrospray-active boronates. Chemical & pharmaceutical bulletin. 2013; 61(3):326-32. doi: 10.1248/cpb.c12-00979. [PMID: 23449202]
  • Norman F Taylor, Angel O K Chan. New strategies for detecting steroid metabolic disorders--paneling vs profiling. Clinical chemistry. 2012 Aug; 58(8):1262-3. doi: 10.1373/clinchem.2012.189613. [PMID: 22626831]
  • Yuhei Koyama, Keiko Homma, Maki Fukami, Masayuki Miwa, Kazushige Ikeda, Tsutomu Ogata, Tomonobu Hasegawa, Mitsuru Murata. Two-step biochemical differential diagnosis of classic 21-hydroxylase deficiency and cytochrome P450 oxidoreductase deficiency in Japanese infants by GC-MS measurement of urinary pregnanetriolone/ tetrahydroxycortisone ratio and 11β-hydroxyandrosterone. Clinical chemistry. 2012 Apr; 58(4):741-7. doi: 10.1373/clinchem.2011.173286. [PMID: 22273564]
  • Cedric H L Shackleton. Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesis. Lipids. 2012 Jan; 47(1):1-12. doi: 10.1007/s11745-011-3605-6. [PMID: 21874273]
  • Andrew Dauber, Mark Kellogg, Joseph A Majzoub. Monitoring of therapy in congenital adrenal hyperplasia. Clinical chemistry. 2010 Aug; 56(8):1245-51. doi: 10.1373/clinchem.2010.146035. [PMID: 20558634]
  • Yoshiro Toma, Takumi Yanaihara. [Pregnanediol (P2), pregnanetriol (P3)]. Nihon rinsho. Japanese journal of clinical medicine. 2010 Jul; 68 Suppl 7(?):466-70. doi: NULL. [PMID: 20960813]
  • Thomas M K Völkl, Diemud Simm, Antje Körner, Wieland Kiess, Jürgen Kratzsch, Helmuth G Dörr. Adiponectin levels are high in children with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Acta paediatrica (Oslo, Norway : 1992). 2009 May; 98(5):885-91. doi: 10.1111/j.1651-2227.2009.01231.x. [PMID: 19236311]
  • Manfred Rauh. Steroid measurement with LC-MS/MS in pediatric endocrinology. Molecular and cellular endocrinology. 2009 Mar; 301(1-2):272-81. doi: 10.1016/j.mce.2008.10.007. [PMID: 19007847]
  • Thomas M K Völkl, Diemud Simm, Antje Körner, Wolfgang Rascher, Wieland Kiess, Jürgen Kratzsch, Helmuth G Dörr. Does an altered leptin axis play a role in obesity among children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency?. European journal of endocrinology. 2009 Feb; 160(2):239-47. doi: 10.1530/eje-08-0770. [PMID: 19004982]
  • M Nováková, R Palme, H Kutalová, L Janský, D Frynta. The effects of sex, age and commensal way of life on levels of fecal glucocorticoid metabolites in spiny mice (Acomys cahirinus). Physiology & behavior. 2008 Sep; 95(1-2):187-93. doi: 10.1016/j.physbeh.2008.05.017. [PMID: 18586285]
  • Cedric H L Shackleton, Josep Marcos, Glenn E Palomaki, Wendy Y Craig, Richard I Kelley, Lisa E Kratz, James E Haddow. Dehydrosteroid measurements in maternal urine or serum for the prenatal diagnosis of Smith-Lemli-Opitz syndrome (SLOS). American journal of medical genetics. Part A. 2007 Sep; 143A(18):2129-36. doi: 10.1002/ajmg.a.31901. [PMID: 17702049]
  • A Jezela-Stanek, E M Małunowicz, E Ciara, E Popowska, B Goryluk-Kozakiewicz, K Spodar, M Czerwiecka, J Jezuita, M J M Nowaczyk, M Krajewska-Walasek. Maternal urinary steroid profiles in prenatal diagnosis of Smith-Lemli-Opitz syndrome: first patient series comparing biochemical and molecular studies. Clinical genetics. 2006 Jan; 69(1):77-85. doi: 10.1111/j.1399-0004.2006.00551.x. [PMID: 16451140]
  • Yoshiro Toma, Takumi Yanaihara. [Pregnanediol (P2), pregnanetriol (P3)]. Nihon rinsho. Japanese journal of clinical medicine. 2005 Aug; 63 Suppl 8(?):443-7. doi: NULL. [PMID: 16149547]
  • Jing-zhu Wang, Mou-tian Wu, Yi-nong Zhang, Xin Liu, Zhi-yong Yang. [Detection of the metabolites of dehydroepiandrosterone in urine with gas chromatography-combustion-isotope ratio mass spectrometry]. Yao xue xue bao = Acta pharmaceutica Sinica. 2005 Feb; 40(2):159-63. doi: NULL. [PMID: 15875674]
  • Keiko Homma, Tomonobu Hasegawa, Eiko Takeshita, Kiyoaki Watanabe, Makoto Anzo, Takio Toyoura, Kazuhiko Jinno, Toya Ohashi, Takashi Hamajima, Yukihiro Takahashi, Takao Takahashi, Nobutake Matsuo. Elevated urine pregnanetriolone definitively establishes the diagnosis of classical 21-hydroxylase deficiency in term and preterm neonates. The Journal of clinical endocrinology and metabolism. 2004 Dec; 89(12):6087-91. doi: 10.1210/jc.2004-0473. [PMID: 15579762]
  • Haruo Mizuno, Yoichiro Ohro, Yukari Sugiyama, Tetsuya Ito, Tomonobu Hasegawa, Keiko Homma, Hajime Ueshiba, Makoto Ono, Hajime Togari. Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products. Hormone research. 2004; 61(5):242-5. doi: 10.1159/000076961. [PMID: 14988602]
  • M Dehnhard, M Heistermann, F Göritz, R Hermes, T Hildebrandt, H Haber. Demonstration of 2-unsaturated C19-steroids in the urine of female Asian elephants, Elephas maximus, and their dependence on ovarian activity. Reproduction (Cambridge, England). 2001 Mar; 121(3):475-84. doi: 10.1530/rep.0.1210475. [PMID: 11226074]
  • C H Shackleton, E Roitman, L Kratz, R Kelley. Dehydro-oestriol and dehydropregnanetriol are candidate analytes for prenatal diagnosis of Smith-Lemli-Opitz syndrome. Prenatal diagnosis. 2001 Mar; 21(3):207-12. doi: 10.1002/1097-0223(200103)21:3<207::aid-pd27>3.0.co;2-i. [PMID: 11260610]
  • H Vierhapper, P Nowotny. The stress of being a doctor: steroid excretion rates in internal medicine residents on and off duty. The American journal of medicine. 2000 Oct; 109(6):492-4. doi: 10.1016/s0002-9343(00)00578-7. [PMID: 11042240]
  • S Fürst-Recktenwald, H G Dörr, F Rosanowski. Androglottia in a young female adolescent with congenital adrenal hyperplasia and 21-hydroxylase deficiency. Journal of pediatric endocrinology & metabolism : JPEM. 2000 Jul; 13(7):959-62. doi: 10.1515/jpem.2000.13.7.959. [PMID: 10968487]
  • H Tveiten, A P Scott, H K Johnsen. Plasma-sulfated C21-steroids increase during the periovulatory period in female common wolffish and are influenced by temperature during vitellogenesis. General and comparative endocrinology. 2000 Mar; 117(3):464-73. doi: 10.1006/gcen.1999.7433. [PMID: 10764557]
  • Y Toma, T Yanaihara. [Pregnanediol (P2), pregnanetriol (P3)]. Nihon rinsho. Japanese journal of clinical medicine. 1999 Dec; 57 Suppl(?):274-8. doi: NULL. [PMID: 10778116]
  • M Takeyasu, T Kato. [Urinary excretion of steroid hormone and 3 beta-hydroxysteroid dehydrogenase activity in normal young adult women]. Rinsho byori. The Japanese journal of clinical pathology. 1999 Jan; 47(1):70-5. doi: NULL. [PMID: 10067368]
  • S Frenzel, H G Dörr. [Problems of delayed diagnosis of an uncomplicated adrenogenital syndrome (AGS) with 21-hydroxylase defect in a 7-year-old boy]. Deutsche medizinische Wochenschrift (1946). 1998 Jul; 123(27):827-31. doi: 10.1055/s-2007-1024074. [PMID: 9685841]
  • G Phillipov. Effect of hypercortisolism and ACTH on the metabolism of cortisol. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 1998; 106(1):57-60. doi: 10.1055/s-0029-1211951. [PMID: 9516061]
  • A P Scott, R M Inbaraj, E L Vermeirssen. Use of a radioimmunoassay which detects C21 steroids with a 17, 20beta-dihydroxyl configuration to identify and measure steroids involved in final oocyte maturation in female plaice (Pleuronectes platessa). General and comparative endocrinology. 1997 Jan; 105(1):62-70. doi: 10.1006/gcen.1996.6798. [PMID: 9000468]
  • R M Inbaraj, A P Scott, E L Vermeirssen. Use of a radioimmunoassay which detects C21 steroids with a 5beta-reduced, 3alpha-hydroxylated configuration to identify and measure steroids involved in final oocyte maturation in female plaice (Pleuronectes platessa). General and comparative endocrinology. 1997 Jan; 105(1):50-61. doi: 10.1006/gcen.1996.6797. [PMID: 9000467]
  • L J Meng, W J Griffiths, J Sjövall. The identification of novel steroid N-acetylglucosaminides in the urine of pregnant women. The Journal of steroid biochemistry and molecular biology. 1996 Aug; 58(5-6):585-98. doi: 10.1016/0960-0760(96)00080-5. [PMID: 8918986]
  • Y Yang, S Saisho, T Toyoura, K Shimozawa, J Yata. Urinary pregnanetriol-3-glucuronide in children: age-related change and application to the management of 21-hydroxylase deficiency. Acta paediatrica Japonica : Overseas edition. 1996 Apr; 38(2):107-13. doi: 10.1111/j.1442-200x.1996.tb03449.x. [PMID: 8677783]
  • A Y Reeder, G E Joannou. 15 beta-hydroxysteroids (Part IV). Steroids of the human perinatal period: the synthesis of 3 alpha,15 beta,17 alpha-trihydroxy-5 alpha-pregnan-20-one and its A/B-ring configurational isomers. Steroids. 1995 Dec; 60(12):796-801. doi: 10.1016/0039-128x(95)00142-d. [PMID: 8650701]
  • A Kambegawa. [Pregnanetriol (P3)]. Nihon rinsho. Japanese journal of clinical medicine. 1995 Mar; 53 Su Pt 2(?):580-3. doi: NULL. [PMID: 8753309]
  • Y J Lim, A B Yong, G L Warne, J Montalto. Urinary 17 alpha-hydroxyprogesterone in management of 21-hydroxylase deficiency. Journal of paediatrics and child health. 1995 Feb; 31(1):47-50. doi: 10.1111/j.1440-1754.1995.tb02913.x. [PMID: 7748691]
  • C A Niemuller, H J Shaw, J K Hodges. Non-invasive monitoring of ovarian function in Asian elephants (Elephas maximus) by measurement of urinary 5 beta-pregnanetriol. Journal of reproduction and fertility. 1993 Nov; 99(2):617-25. doi: 10.1530/jrf.0.0990617. [PMID: 8107047]
  • S Einaudi, R Lala, A Corrias, P Matarazzo, S Pagliardini, C de Sanctis. Auxological and biochemical parameters in assessing treatment of infants and toddlers with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. The Journal of pediatric endocrinology. 1993 Apr; 6(2):173-8. doi: NULL. [PMID: 8348221]
  • D E Kime, A P Scott, A V Canario. In vitro biosynthesis of steroids, including 11-deoxycortisol and 5 alpha-pregnane-3 beta,7 alpha,17,20 beta-tetrol, by ovaries of the goldfish Carassius auratus during the stage of oocyte final maturation. General and comparative endocrinology. 1992 Sep; 87(3):375-84. doi: 10.1016/0016-6480(92)90044-k. [PMID: 1426940]
  • Y Shibata. [Determination of urinary 17 alpha-hydroxyprogesterone excretion using ELISA--evaluation of normal subjects and patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency]. Nihon Naibunpi Gakkai zasshi. 1991 Aug; 67(8):819-39. doi: 10.1507/endocrine1927.67.8_819. [PMID: 1813324]
  • A V Canario, A P Scott. Levels of 17 alpha,20 alpha-dihydroxy-4-pregnen-3-one, 3 beta,17 alpha,20 alpha-trihydroxy-5 beta-pregnane, and other sex steroids, in blood plasma of male dab, Limanda limanda (marine flatfish) injected with human chorionic gonadotrophin. General and comparative endocrinology. 1991 Aug; 83(2):258-64. doi: 10.1016/0016-6480(91)90029-6. [PMID: 1916213]
  • S B Solish, M A Goldsmith, R Voutilainen, W L Miller. Molecular characterization of a Leydig cell tumor presenting as congenital adrenal hyperplasia. The Journal of clinical endocrinology and metabolism. 1989 Dec; 69(6):1148-52. doi: 10.1210/jcem-69-6-1148. [PMID: 2555382]
  • A Nanbu, Y Kumamoto, H Tachiki, N Itoh, N Mikuma, T Tsunekawa, Y Takagi, H Maruta. [A clinical study of congenital adrenal hyperplasia]. Hinyokika kiyo. Acta urologica Japonica. 1989 Nov; 35(11):1831-7. doi: NULL. [PMID: 2559616]
  • A V Canario, A P Scott. Synthesis of 20 alpha-hydroxylated steroids by ovaries of the dab (Limanda limanda). General and comparative endocrinology. 1989 Oct; 76(1):147-58. doi: 10.1016/0016-6480(89)90041-5. [PMID: 2599344]
  • P Pinzani, A Magini, F Franceschetti, G Messeri, M Pazzagli. A chemiluminescent method for the measurement of pregnanetriol-3 alpha-glucuronide in human diluted urine. Journal of bioluminescence and chemiluminescence. 1989 Jul; 4(1):580-6. doi: 10.1002/bio.1170040176. [PMID: 2552757]
  • A B Yong, J J Pitt, J Montalto, H E Davies, G L Warne, J F Connelly. Diagnosis of 21-hydroxylase deficiency in newborn infants by GC-MS of urinary steroids. Australian paediatric journal. 1988 Oct; 24(5):280-5. doi: 10.1111/j.1440-1754.1988.tb01363.x. [PMID: 3265870]
  • J Homoki, J Solyom, W M Teller. Detection of late onset steroid 21-hydroxylase deficiency by capillary gas chromatographic profiling of urinary steroids in children and adolescents. European journal of pediatrics. 1988 Apr; 147(3):257-62. doi: 10.1007/bf00442691. [PMID: 3260557]
  • W G Schoonen, M T Penders, G H Van Dam, J G Lambert. 5 beta-pregnane-3 alpha,6 alpha,17 alpha,20 beta-tetrol and 5 beta-pregnane-3 alpha,6 alpha,17 alpha-triol-20-one: steroids of ovarian origin in the African catfish, Clarias gariepinus, during oocyte maturation. General and comparative endocrinology. 1988 Feb; 69(2):181-7. doi: 10.1016/0016-6480(88)90004-4. [PMID: 3366354]
  • C H Shackleton, J Irias, C McDonald, J Imperato-McGinley. Late-onset 21-hydroxylase deficiency: reliable diagnosis by steroid analysis of random urine collections. Steroids. 1986 Sep; 48(3-4):239-50. doi: 10.1016/0039-128x(86)90007-3. [PMID: 3502202]
  • B R Bevan, M Savvas, J M Jenkins, K Baker, G W Pennington, N F Taylor. Abnormal steroid excretion in gestational trophoblastic disease complicated by ovarian theca-lutein cysts. Journal of clinical pathology. 1986 Jun; 39(6):627-34. doi: 10.1136/jcp.39.6.627. [PMID: 3013946]
  • N Bedolla-Tovar, J Landeros, G Pérez-Palacios, W P Collins, C Romero, A E Kellie, P Samarajeewa, J Spieler. Prediction and detection of ovulation by the measurement of urinary pregnanetriol-3 alpha-glucuronide. A multicentre study. Journal of steroid biochemistry. 1986 Apr; 24(4):921-7. doi: 10.1016/0022-4731(86)90455-3. [PMID: 3702465]
  • T Kawasaki, M Maeda, A Tsuji. Fluorescence high performance liquid chromatographic determination of 3 alpha-hydroxysteroids in urine of 21-hydroxylase deficiency. Biomedical chromatography : BMC. 1986 Feb; 1(1):1-6. doi: 10.1002/bmc.1130010102. [PMID: 3506812]
  • H V Henning, H Ludwig-Köhn. Neutral steroid metabolites in body fluids of patients with uremia and after renal transplantation. Contributions to nephrology. 1986; 50(?):153-66. doi: 10.1159/000412996. [PMID: 3542370]
  • J C Job, A Munck, J L Chaussain, P Canlorbe. [Treatment of virilizing adrenal hyperplasia in adolescents. Use and side-effects of dexamethasone]. Archives francaises de pediatrie. 1985 Nov; 42(9):765-9. doi: NULL. [PMID: 4083978]
  • H Sumiya, K Kawamura, Z Kataumi, H Fuse, H Ito, J Shimazaki. [A case of congenital adrenogenital syndrome]. Hinyokika kiyo. Acta urologica Japonica. 1985 Aug; 31(8):1433-9. doi: NULL. [PMID: 3878668]
  • P Samarajeewa, A E Kellie. The radioimmunoassay of pregnanetriol 3 alpha-glucuronide. Journal of steroid biochemistry. 1985 Jun; 22(6):843-9. doi: 10.1016/0022-4731(85)90295-x. [PMID: 4021487]
  • Y Hikita. [Reevaluation of recalled infants by neonatal mass screening for congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Diagnostic value of pregnanetriolone in a single urine specimen using glass capillary gas chromatography]. Nihon Naibunpi Gakkai zasshi. 1985 Mar; 61(3):197-219. doi: 10.1507/endocrine1927.61.3_197. [PMID: 3874793]
  • H Vierhapper, P Nowotny, W Waldhäusl, H Frisch. Capillary gas chromatography as a tool for characterization of urinary steroid excretion in patients with congenital adrenal hyperplasia. Journal of steroid biochemistry. 1985 Mar; 22(3):363-9. doi: 10.1016/0022-4731(85)90439-x. [PMID: 3990286]
  • N B Goldring, J Orly. Concerted metabolism of steroid hormones produced by cocultured ovarian cell types. The Journal of biological chemistry. 1985 Jan; 260(2):913-21. doi: 10.1016/s0021-9258(20)71186-5. [PMID: 3918035]
  • J Winterer, G P Chrousos, D L Loriaux, G B Cutler. Effect of hydrocortisone dose schedule on adrenal steroid secretion in congenital adrenal hyperplasia. The Journal of pediatrics. 1985 Jan; 106(1):137-42. doi: 10.1016/s0022-3476(85)80486-8. [PMID: 3871229]
  • A Cattani, D Mahaha, P Michaud, J A Rodríguez, J M López, H García, A Foradori, C G Velásquez. [Virilizing congenital adrenal hyperplasia due to 21-hydroxylase deficiency: early diagnosis and response to 2 treatment schedules]. Revista chilena de pediatria. 1984 Nov; 55(6):374-9. doi: NULL. [PMID: 6536989]
  • A T Masi, D B Josipović, W E Jefferson. Low adrenal androgenic-anabolic steroids in women with rheumatoid arthritis (RA): gas-liquid chromatographic studies of RA patients and matched normal control women indicating decreased 11-deoxy-17-ketosteroid excretion. Seminars in arthritis and rheumatism. 1984 Aug; 14(1):1-23. doi: 10.1016/0049-0172(84)90005-2. [PMID: 6091273]
  • I Tóth, I Faredin. Metabolism and concentration of androgenic steroids in abdominal skin of hirsute women with androgenital syndrome. Acta medica Hungarica. 1984; 41(1):7-18. doi: . [PMID: 6234510]
  • I Faredin, I Tóth. Metabolism and concentration of androgenic steroids in the abdominal skin of women with idiopathic hirsutism. Acta medica Hungarica. 1984; 41(1):19-34. doi: . [PMID: 6234509]
  • L Gregolini, S Ferrari, R Marcolongo, M F Aleo, E Marinello, E Bianchi. Hormonal aspects of human gout--excretion of adrenal hormone derivatives in gouty patients. Clinica chimica acta; international journal of clinical chemistry. 1983 Jun; 130(3):269-77. doi: 10.1016/0009-8981(83)90300-5. [PMID: 6223725]
  • M Zachmann, D Tassinari, A Prader. Clinical and biochemical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. A study of 25 patients. The Journal of clinical endocrinology and metabolism. 1983 Feb; 56(2):222-9. doi: 10.1210/jcem-56-2-222. [PMID: 6296182]
  • F Loré, G Manasse. Adrenal function and essential hypertension. Postgraduate medical journal. 1983; 59 Suppl 3(?):165-6. doi: NULL. [PMID: 6647202]
  • H Vierhapper, P Nowotny, K Krisch, K Kletter, W Waldhäusl. [Androgen-producing adrenal adenoma in an 18 year-old woman: diagnosis by gas-chromatographic steroid analysis, histology and postoperative course]. Wiener klinische Wochenschrift. 1982 Dec; 94(24):670-3. doi: NULL. [PMID: 6221472]
  • J A Kuti, J G Devlin. Urinary free cortisol--a good screening test in adult onset hirsutism. East African medical journal. 1982 Dec; 59(12):824-8. doi: NULL. [PMID: 7184763]
  • H L Makin, D J Trafford. A semi-automated computerised gas-liquid chromatographic system for urinary steroid profile analysis. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1982 Dec; 20(12):899-905. doi: 10.1515/cclm.1982.20.12.899. [PMID: 6820659]
  • A Kambegawa. [Chemical analysis of steroid hormones]. Rinsho byori. The Japanese journal of clinical pathology. 1982 Nov; Suppl 52(?):55-65. doi: NULL. [PMID: 6820092]
  • Y Igarashi, H Ogawa, Y Hikita. [Abnormal steroid hormone production (in children)--special reference to microanalysis of urinary steroids by glass capillary gas chromatography and its application]. Rinsho byori. The Japanese journal of clinical pathology. 1982 Nov; Suppl 52(?):143-55. doi: NULL. [PMID: 6762451]
  • M Zachmann, E A Werder, A Prader. Two types of male pseudohermaphroditism due to 17, 20-desmolase deficiency. The Journal of clinical endocrinology and metabolism. 1982 Sep; 55(3):487-90. doi: 10.1210/jcem-55-3-487. [PMID: 6212590]
  • H Djursing, H C Nyholm, C Hagen, L Carstensen, L M Pedersen. Clinical and hormonal characteristics in women with anovulation and insulin-treated diabetes mellitus. American journal of obstetrics and gynecology. 1982 Aug; 143(8):876-82. doi: 10.1016/0002-9378(82)90466-5. [PMID: 7102763]
  • M Shaarawy, K Z Mahmoud. Endocrine profile and semen characteristics in male smokers. Fertility and sterility. 1982 Aug; 38(2):255-7. doi: 10.1016/s0015-0282(16)46470-8. [PMID: 6809501]
  • W Schönberger, P Benes, B Morsches, B Zabel, E Scheidt. [Improvement in the longitudinal growth in Ullrich-Turner syndrome with oxandrolone. Function of urinary excretion of steroid hormones]. Deutsche medizinische Wochenschrift (1946). 1982 Jul; 107(26):1008-11. doi: 10.1055/s-2008-1070063. [PMID: 6211346]
  • D Knorr, F Bidlingmaier, U Kuhnle. Diagnosis and monitoring of therapy of the various enzymatic defects causing congenital adrenal hyperplasia by semiautomatic capillary gas-liquid chromatography. Hormone research. 1982 Jul; 16(4):201-8. doi: 10.1159/000179503. [PMID: 6982215]
  • F Cassorla. [17-hydroxyprogesterone in the diagnosis and treatment of adrenogenital syndrome]. Revista chilena de pediatria. 1982 Jul; 53(4):295-304. doi: NULL. [PMID: 7163538]
  • K R van der Ploeg, B G Wolthers, G T Nagel, M Volmer, N M Drayer. The diagnosis of 21-hydroxylase deficiency in a prematurely born infant on the basis of the urinary steroid excretion pattern. Clinica chimica acta; international journal of clinical chemistry. 1982 Apr; 120(3):341-53. doi: 10.1016/0009-8981(82)90375-8. [PMID: 6978779]
  • S A Hendricks, B M Lippe, S A Kaplan, N Lavin, D M Mayes. Urinary and serum steroid concentrations in the management of congenital adrenal hyperplasia. Lack of physiologic correlations. American journal of diseases of children (1960). 1982 Mar; 136(3):229-32. doi: 10.1001/archpedi.1982.03970390043014. [PMID: 7064949]
  • D T Mininberg, L S Levine, M I New. Current concepts in congenital adrenal hyperplasia. Pathology annual. 1982; 17 Pt 2(?):179-95. doi: NULL. [PMID: 6897824]
  • L S Ross. Routine hormonal screening of infertile men: is it worthwhile?. The Journal of urology. 1981 Dec; 126(6):756-8. doi: 10.1016/s0022-5347(17)54737-0. [PMID: 6459466]
  • I A Hughes. Management of hirsutism. British journal of hospital medicine. 1981 Nov; 26(5):562. doi: NULL. [PMID: 7326525]
  • G E Joannou. Identification of 15 beta-hydroxylated C21 steroids in the neo-natal period: the role of 3 alpha,15 beta,17 alpha-trihydroxy-5 beta-pregnan-20-one in the perinatal diagnosis of congenital adrenal hyperplasia (CAH) due to a 21-hydroxylase deficiency. Journal of steroid biochemistry. 1981 Sep; 14(9):901-12. doi: 10.1016/0022-4731(81)90239-9. [PMID: 6975400]
  • A B Granoff. Treatment of menstrual irregularities with dexamethasone in congenital adrenal hyperplasia. Journal of adolescent health care : official publication of the Society for Adolescent Medicine. 1981 Sep; 2(1):23-7. doi: 10.1016/s0197-0070(81)80081-2. [PMID: 7333940]
  • V Toscano, M V Adamo, B Boscherini, A M Pasquino, L Herlitzka, E Petrangeli, F Sciarra. The hormone pattern in a case of arrhenoblastoma. European journal of pediatrics. 1981 May; 136(2):203-6. doi: 10.1007/bf00441925. [PMID: 6262084]
  • R J Begue, M Moriniere, C Nivois, D Sandre, P Padieu. Identification of 5 beta-pregnane-3 alpha,6 alpha,20 alpha-triol in urine of normal newborn infant. Journal of steroid biochemistry. 1981 May; 14(5):489-91. doi: 10.1016/0022-4731(81)90361-7. [PMID: 7300341]
  • H Frisch, K Parth, E Schober, W Swoboda. Circadian patterns of plasma cortisol, 17-hydroxyprogesterone, and testosterone in congenital adrenal hyperplasia. Archives of disease in childhood. 1981 Mar; 56(3):208-13. doi: 10.1136/adc.56.3.208. [PMID: 7212759]
  • M Jansen, J M Wit, J L van den Brande. Reinstitution of mineralocorticoid therapy in congenital adrenal hyperplasia. Effects on control and growth. Acta paediatrica Scandinavica. 1981 Mar; 70(2):229-33. doi: 10.1111/j.1651-2227.1981.tb05547.x. [PMID: 7015786]
  • L Kecskés, G Czira. Steroid spectrum in human urine as revealed by gas chromatography V. Identification and quantitation of 3 alpha, 20 alpha-dihydroxy-5-beta pregnan-11-one (11-keto-pregnanediol) during different stages of development in children with C/21 hydroxylase deficiency. Acta biochimica et biophysica; Academiae Scientiarum Hungaricae. 1981; 16(3-4):179-88. doi: . [PMID: 6982583]
  • P Biffignandi, C Manieri, M Massobrio, S Mazzocchi, M Messina, G M Molinatti. Androgen receptors: a quantitative investigation in female unexplained hirsutism. Panminerva medica. 1981 Jan; 23(1):1-4. doi: NULL. [PMID: 7290720]
  • F Lorè, G Manasse. [Urinary excretion of 17-ketosteroids, pregnanediol and pregnanetriol in essential arterial hypertension]. Bollettino della Societa italiana di cardiologia. 1981; 26(4):339-43. doi: NULL. [PMID: 7340867]