Ginsenoside Rb1 (BioDeep_00000000009)

 

Secondary id: BioDeep_00000365343, BioDeep_00001867456

human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs


代谢物信息卡片


2-{[2-(5-{[4,5-dihydroxy-6-(hydroxymethyl)-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-16-hydroxy-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl)-6-methylhept-5-en-2-yl]oxy}-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxane-3,4,5-triol

化学式: C54H92O23 (1108.6029082)
中文名称: 人参皂苷 Rb1, 人参皂苷
谱图信息: 最多检出来源 Viridiplantae(plant) 13.56%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Ginsenoside Rb1. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/ginsenoside_rb1 (retrieved 2024-11-23) (BioDeep RN: BioDeep_00000000009). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(C)(C)[C@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]([C@](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)O5)(C)CC/C=C(\C)/C)([H])[C@@]4([H])[C@H](O)C[C@]3([H])[C@@]12C
InChI: InChI=1S/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3

描述信息

Ginsenoside Rb1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. It has a role as a neuroprotective agent, an anti-obesity agent, an anti-inflammatory drug, an apoptosis inhibitor, a radical scavenger and a plant metabolite. It is a ginsenoside, a glycoside and a tetracyclic triterpenoid. It is functionally related to a ginsenoside Rd.
Ginsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant genus Panax (ginseng). Ginsenosides have been the target of research, as they are viewed as the active compounds behind the claims of ginsengs efficacy. Because ginsenosides appear to affect multiple pathways, their effects are complex and difficult to isolate. Rb1 appears to be most abundant in Panax quinquefolius (American Ginseng). Rb1 seems to affect the reproductive system in animal testicles. Recent research shows that Rb1 affects rat embryo development and has teratogenic effects, causing birth defects. Another study shows that Rb1 may increase testosterone production in male rats indirectly through the stimulation of the luteinizing hormone.
Ginsenoside rb1 is a natural product found in Panax vietnamensis, Gynostemma pentaphyllum, and other organisms with data available.
See also: Asian Ginseng (part of); American Ginseng (part of); Panax notoginseng root (part of).
Ginsenoside Rb1 is found in tea. Ginsenoside Rb1 is a constituent of Panax ginseng (ginseng)
Constituent of Panax ginseng (ginseng). Ginsenoside Rb1 is found in tea.

Ginsenoside Rb1. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=41753-43-9 (retrieved 2024-06-29) (CAS RN: 41753-43-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

同义名列表

44 个代谢物同义名

2-{[2-(5-{[4,5-dihydroxy-6-(hydroxymethyl)-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-16-hydroxy-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl)-6-methylhept-5-en-2-yl]oxy}-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxane-3,4,5-triol; .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-20-((6-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-12-HYDROXYDAMMAR-24-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-; beta-D-Glucopyranoside, (3-beta,12-beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-; beta-D-GLUCOPYRANOSIDE, (3beta,12beta)-20-((6-O-beta-D-GLUCOPYRANOSYL-beta-D-GLUCOPYRANOSYL)OXY)-12-HYDROXYDAMMAR-24-EN-3-YL 2-O-beta-D-GLUCOPYRANOSYL-; (3beta,12beta)-20-{[6-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]oxy}-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; (3beta,12beta)-20-((6-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; (3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; (3beta,12beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; 2-O-beta-Glucopyranosyl-(3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl beta-D-glucopyranoside; 2-O-beta-Glucopyranosyl-(3beta,12beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside; 20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; 3beta-[beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy]-20-[beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy]dammar-24-en-12beta-ol; 3beta-(beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy)-20-(beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy)dammar-24-en-12beta-ol; GINSENOSIDE RB1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]; GINSENOSIDE RB1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG); Ginsenoside Rb1, European Pharmacopoeia (EP) Reference Standard; Ginsenoside Rb1, primary pharmaceutical reference standard; 13 - Ginseng supplement chemical analysis; 3-GlcGlc-20-GlcGlc-ginsenoside; GZYPWOGIYAIIPV-JBDTYSNRSA-N; GINSENOSIDE RB1 [WHO-DD]; GINSENOSIDE RB1 [USP-RS]; GINSENOSIDE RB1 (USP-RS); Ginsenoside Rb1 - 94\\%; (20S)-ginsenoside Rb1; 20(S)-ginsenoside Rb1; pseudoginsenoside D; notoginsenoside Rb1; Gypenoside cento; sanchinoside Rb1; sanchinoside E1; Ginsenoside Rb1; ginsenoside-Rb1; panax saponin E; GinsenosideRb1; panaxoside Rb1; gypenoside III; Panaxsaponin E; arasaponin E1; gynosaponin C; Ginsenoside; GS-Rb1; GRb 1; GSRb1



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(1)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

60 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Louyin Ji, Hui Han, Xiaoli Shan, Pei Zhao, Huihua Chen, Chen Zhang, Ming Xu, Rong Lu, Wei Guo. Ginsenoside Rb1 ameliorates lipotoxicity-induced myocardial injury in diabetes mellitus by regulating Mfn2. European journal of pharmacology. 2024 Jul; 974(?):176609. doi: 10.1016/j.ejphar.2024.176609. [PMID: 38677536]
  • Yafei Zhai, Jinmeng Bai, Ying Peng, Jinhua Cao, Guangming Fang, Yiming Dong, Ze Wang, Yanyu Lu, Mengyu Wang, Mengduan Liu, Yangyang Liu, Xiaowei Li, Jianzeng Dong, Xiaoyan Zhao. Ginsenoside Rb1 attenuates doxorubicin induced cardiotoxicity by suppressing autophagy and ferroptosis. Biochemical and biophysical research communications. 2024 May; 710(?):149910. doi: 10.1016/j.bbrc.2024.149910. [PMID: 38593619]
  • Cuihan Zhang, Huan Hou, Changhong Shen, Qian Ran, Fang Cheng, Ziqing Yao, Ruoqi Zhang, Cheng Peng. Protective effect of ginsenoside Rb1 against aconitine cardiotoxicity studied by myocardial injury, action potential, and calcium signaling. Toxicon : official journal of the International Society on Toxinology. 2024 May; 242(?):107693. doi: 10.1016/j.toxicon.2024.107693. [PMID: 38519012]
  • Lianjie Hou, Zhiming Zou, Yu Wang, Hui Pi, Zeyue Yuan, Qin He, Yongfang Kuang, Guojun Zhao. Exploring the anti-atherosclerosis mechanism of ginsenoside Rb1 by integrating network pharmacology and experimental verification. Aging. 2024 Mar; 16(8):6745-6756. doi: 10.18632/aging.205680. [PMID: 38546402]
  • Kang-Xi Zhang, Yue Zhu, Shu-Xia Song, Qing-Yun Bu, Xiao-Yan You, Hong Zou, Guo-Ping Zhao. Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism. Molecules (Basel, Switzerland). 2024 Mar; 29(5):. doi: 10.3390/molecules29051108. [PMID: 38474620]
  • Kailu Zhou, Yangyang Zhang, Yikai Zhou, Minghao Xu, Shanshan Yu. Production of Gypenoside XVII from Ginsenoside Rb1 by Enzymatic Transformation and Their Anti-Inflammatory Activity In Vitro and In Vivo. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28197001. [PMID: 37836844]
  • Liu Bingbing, L I Jieru, S I Jianchao, Chen Qi, Yang Shengchang, J I Ensheng. Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2023 10; 43(5):906-914. doi: 10.19852/j.cnki.jtcm.20221206.004. [PMID: 37679978]
  • Jingyuan Zeng, Xican Li, Rongxin Cai, Ban Chen, Chunhou Li, Qingzhong Hu, Yue Sun. Proposing anti-counterfeiting pharmacopoeia quality markers for Shenlingbaizhu granule based on UHPLC-Q-orbitrap-MS identification. Phytochemical analysis : PCA. 2023 Sep; ?(?):. doi: 10.1002/pca.3284. [PMID: 37735858]
  • Yannan Li, Junnan Li, Lixuan Yang, Feifei Ren, Kaiqiang Dong, Zhonghui Zhao, Wenzhe Duan, Wei Wei, Rongjuan Guo. Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155083. doi: 10.1016/j.phymed.2023.155083. [PMID: 37722244]
  • Likang Lu, Hui Ao, Jingxin Fu, Manzhen Li, Yaoyao Guo, Yifei Guo, Meihua Han, Rongxing Shi, Xiangtao Wang. Ginsenoside Rb1 stabilized and paclitaxel / protopanaxadiol co-loaded nanoparticles for synergistic treatment of breast tumor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 163(?):114870. doi: 10.1016/j.biopha.2023.114870. [PMID: 37187019]
  • Min Zhang, Wei Lin, Xiaoyue Tao, Wei Zhou, Zhiming Liu, Zhe Zhang, Shuqing Jin, Haojie Zhang, Cheng Teng, Jianghu Zhu, Xiaoling Guo, Zhenlang Lin. Ginsenoside Rb1 inhibits ferroptosis to ameliorate hypoxic-ischemic brain damage in neonatal rats. International immunopharmacology. 2023 Jun; 121(?):110503. doi: 10.1016/j.intimp.2023.110503. [PMID: 37364327]
  • Chuting Li, Xuting Zhang, Jie Li, Liyin Liang, Jingran Zeng, Min Wen, Linjie Pan, Dongxin Lv, Min Liu, Yuanyuan Cheng, Heqing Huang. Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure. European journal of pharmacology. 2023 Mar; 947(?):175676. doi: 10.1016/j.ejphar.2023.175676. [PMID: 37001580]
  • Junchen Liu, Yuehang Wu, Wenrui Ma, Hongyan Zhang, Xianyao Meng, Huirong Zhang, Miaomiao Guo, Xiao Ling, Li Li. Anti-Inflammatory Activity of Panax notoginseng Flower Saponins Quantified Using LC/MS/MS. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052416. [PMID: 36903661]
  • Rongrong Zhou, Dan He, Haichao Zhang, Jing Xie, Shuihan Zhang, Xuefei Tian, Hongliang Zeng, Yuhui Qin, Luqi Huang. Ginsenoside Rb1 protects against diabetes-associated metabolic disorders in Kkay mice by reshaping gut microbiota and fecal metabolic profiles. Journal of ethnopharmacology. 2023 Mar; 303(?):115997. doi: 10.1016/j.jep.2022.115997. [PMID: 36509256]
  • Linwei Chen, Nina Wei, Yong Jiang, Chengye Yuan, Luwei Xu, Jindong Li, Min Kong, Yan Chen, Qin Wang. Comparative pharmacokinetics of seven bioactive components after oral administration of crude and processed Qixue Shuangbu Prescription in chronic heart failure rats by microdialysis combined with UPLC-MS/MS. Journal of ethnopharmacology. 2023 Mar; 303(?):116035. doi: 10.1016/j.jep.2022.116035. [PMID: 36513265]
  • Amany Mohamed Shalaby, Sulaiman Mohammed Alnasser, Dina Ahmed Khairy, Mohamed Ali Alabiad, Mohammed Alorini, Fatima A Jaber, Shereen Elsayed Tawfeek. The neuroprotective effect of ginsenoside Rb1 on the cerebral cortex changes induced by aluminium chloride in a mouse model of Alzheimer's disease: A histological, immunohistochemical, and biochemical study. Journal of chemical neuroanatomy. 2023 Feb; 129(?):102248. doi: 10.1016/j.jchemneu.2023.102248. [PMID: 36764334]
  • Ling Wang, Qing Qing Zhang, Yu Yu Xu, Rui Zhang, Qing Zhao, Yu-Qing Zhang, Xue-Hong Huang, Bin Jiang, Min Ni. Ginsenoside Rb1 Suppresses AOM/DSS-Induced Colon Carcinogenesis. Anti-cancer agents in medicinal chemistry. 2023 Jan; ?(?):. doi: 10.2174/1871520623666230119092735. [PMID: 36655530]
  • Zhuoqun Meng, Jianing Lu, Guangcai Ge, Guang Wang, Ran Zhang, Yuhan Li, Shuang Guan, Jing Lu. Ginsenoside Rb1 induces autophagic lipid degradation via miR-128 targeting TFEB. Food & function. 2023 Jan; 14(1):240-249. doi: 10.1039/d2fo02719d. [PMID: 36484324]
  • Chuanqi Wan, Rufeng Lu, Chen Zhu, Haibo Wu, Guannan Shen, Yang Yang, Xiaowei Wu, Bangjiang Fang, Yuzhou He. Ginsenoside Rb1 enhanced immunity and altered the gut microflora in mice immunized by H1N1 influenza vaccine. PeerJ. 2023; 11(?):e16226. doi: 10.7717/peerj.16226. [PMID: 37868069]
  • Lili Niu, Xiangyu Qin, Litao Wang, Na Guo, Hongyan Cao, Hanghang Li, Chunjian Zhao, Huimei Wang, Yujie Fu. Upgrading the accumulation of ginsenoside Rd in Panax notoginseng by a novel glycosidase-producing endophytic fungus G11-7. Folia microbiologica. 2022 Dec; ?(?):. doi: 10.1007/s12223-022-01020-0. [PMID: 36571675]
  • Hong-Shi Li, Jiang-Ying Kuang, Gui-Jun Liu, Wei-Jie Wu, Xian-Lun Yin, Hao-Dong Li, Lei Wang, Tao Qin, Wen-Cheng Zhang, Yuan-Yuan Sun. Myostain is involved in ginsenoside Rb1-mediated anti-obesity. Pharmaceutical biology. 2022 Dec; 60(1):1106-1115. doi: 10.1080/13880209.2022.2074056. [PMID: 35639355]
  • Danni Feng, Zhongxiang Fang, Pangzhen Zhang. The melanin inhibitory effect of plants and phytochemicals: A systematic review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154449. doi: 10.1016/j.phymed.2022.154449. [PMID: 36126406]
  • Wen-Tao Sun, Cindy L H Yang, Terry C T Or, Dan Luo, James C B Li. Ginsenoside Rb1 from Panax notoginseng Suppressed TNF-α-Induced Matrix Metalloproteinase-9 via the Suppression of Double-Strand RNA-Dependent Protein Kinase (PKR)/NF-κB Pathway. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27228050. [PMID: 36432152]
  • Yue Jiang, Sizhang Liu, Li Li, Kaiyou Zang, Yanfang Wang, Mingzhu Zhao, Kangyu Wang, Lei Zhu, Ping Chen, Jun Lei, Yi Wang, Meiping Zhang. Transcriptome and Phenotype Integrated Analysis Identifies Genes Controlling Ginsenoside Rb1 Biosynthesis and Reveals Their Interactions in the Process in Panax ginseng. International journal of molecular sciences. 2022 Nov; 23(22):. doi: 10.3390/ijms232214016. [PMID: 36430494]
  • Zi-Chao Wang, Kai-Ming Niu, Yu-Jie Wu, Kai-Rui Du, Lian-Wen Qi, Ye-Bo Zhou, Hai-Jian Sun. A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis. Cell death & disease. 2022 09; 13(9):824. doi: 10.1038/s41419-022-05274-x. [PMID: 36163178]
  • Xue-Chun Ni, Hong-Fei Wang, Yuan-Yuan Cai, Dai Yang, Raphael N Alolga, Baolin Liu, Jia Li, Feng-Qing Huang. Ginsenoside Rb1 inhibits astrocyte activation and promotes transfer of astrocytic mitochondria to neurons against ischemic stroke. Redox biology. 2022 08; 54(?):102363. doi: 10.1016/j.redox.2022.102363. [PMID: 35696763]
  • Mengdie Yin, Juanfang Lin, Mingyue Yang, Chao Li, Pengyu Wu, Junjie Zou, Yajing Jiang, Jingwei Shao. Platelet membrane-cloaked selenium/ginsenoside Rb1 nanosystem as biomimetic reactor for atherosclerosis therapy. Colloids and surfaces. B, Biointerfaces. 2022 Jun; 214(?):112464. doi: 10.1016/j.colsurfb.2022.112464. [PMID: 35334311]
  • Jia-Yi He, Quan Hong, Bi-Xia Chen, Shao-Yuan Cui, Ran Liu, Guang-Yan Cai, Jiao Guo, Xiang-Mei Chen. Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity. Acta pharmacologica Sinica. 2022 Feb; 43(2):342-353. doi: 10.1038/s41401-021-00788-0. [PMID: 34811512]
  • Wenyi Liang, Yue Liu, Kun Zhou, Ping Jian, Qiunan Zhang, Zihao Chang, Lingfang Wu, Hongsheng Chang, Lanzhen Zhang. Ginsenoside Rb1 prevents lipopolysaccharide-induced depressive-like behavior by inhibiting inflammation and neural dysfunction and F2 elicits a novel antidepressant-like effect: A metabolite-based network pharmacology study. Journal of ethnopharmacology. 2022 Jan; 282(?):114655. doi: 10.1016/j.jep.2021.114655. [PMID: 34537284]
  • Jingjing Liu, Guoqing Fan, Ningning Tao, Feifei Feng, Chao Meng, Tieying Sun. Ginsenoside Rb1 Alleviates Bleomycin-Induced Pulmonary Inflammation and Fibrosis by Suppressing Central Nucleotide-Binding Oligomerization-, Leucine-Rich Repeat-, and Pyrin Domains-Containing Protein Three Inflammasome Activation and the NF-κB Pathway. Drug design, development and therapy. 2022; 16(?):1793-1809. doi: 10.2147/dddt.s361748. [PMID: 35719213]
  • Zhixing Cai, Yue Chen. Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha-induced inflammation in adipocytes. Bioengineered. 2021 12; 12(2):11784-11796. doi: 10.1080/21655979.2021.1996508. [PMID: 34699329]
  • Jianing Lu, Jing Lu, Xiujuan Bu, Yazhuo Li, Guangcai Ge, Shuang Guan. Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux. Journal of food science. 2021 Dec; 86(12):5503-5515. doi: 10.1111/1750-3841.15968. [PMID: 34812491]
  • Shiye Ke, Lin Wu, Min Wang, Dinghui Liu, Guangyao Shi, Jieming Zhu, Xiaoxian Qian. Ginsenoside Rb1 attenuates age-associated vascular impairment by modulating the Gas6 pathway. Pharmaceutical biology. 2021 Dec; 59(1):1369-1377. doi: 10.1080/13880209.2021.1986076. [PMID: 34629012]
  • Aftab Shaukat, Irfan Shaukat, Shahid Ali Rajput, Rizwan Shukat, Sana Hanif, Imran Shaukat, Xinxin Zhang, Chao Chen, Xuyang Sun, Tingzhu Ye, Kaifeng Niu, Zhiqiu Yao, Shadab Shaukat, Muhammad Safdar, Mohamed Abdelrahman, Umair Riaz, Junwei Zhao, Xiaoying Gu, Liguo Yang. Ginsenoside Rb1 Mitigates Escherichia coli Lipopolysaccharide-Induced Endometritis through TLR4-Mediated NF-κB Pathway. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237089. [PMID: 34885671]
  • Shuai Zhou, Shan Lu, Sen Guo, Luosha Zhao, Zhanying Han, Zhenzhen Li. Protective Effect of Ginsenoside Rb1 Nanoparticles Against Contrast-Induced Nephropathy by Inhibiting High Mobility Group Box 1 Gene/Toll-Like Receptor 4/NF-κB Signaling Pathway. Journal of biomedical nanotechnology. 2021 Oct; 17(10):2085-2098. doi: 10.1166/jbn.2021.3163. [PMID: 34706808]
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  • Aftab Shaukat, Irfan Shaukat, Shahid Ali Rajput, Rizwan Shukat, Sana Hanif, Kangfeng Jiang, Tao Zhang, Muhammad Akhtar, Imran Shaukat, Xiaofei Ma, Junfeng Liu, Shadab Shaukat, Talha Umar, Masood Akhtar, Liguo Yang, Ganzhen Deng. Ginsenoside Rb1 protects from Staphylococcus aureus-induced oxidative damage and apoptosis through endoplasmic reticulum-stress and death receptor-mediated pathways. Ecotoxicology and environmental safety. 2021 Aug; 219(?):112353. doi: 10.1016/j.ecoenv.2021.112353. [PMID: 34034046]
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