Phenazocine, (-)- (BioDeep_00000008872)

 

Secondary id: BioDeep_00001868876


代谢物信息卡片


Phenazocine, (-)-

化学式: C22H27NO (321.2093)
中文名称: 非那佐辛
谱图信息: 最多检出来源 Mentha canadensis(plant) 45.45%

分子结构信息

SMILES: CC1C2CC3=C(C1(CCN2CCC4=CC=CC=C4)C)C=C(C=C3)O
InChI: InChI=1S/C22H27NO/c1-16-21-14-18-8-9-19(24)15-20(18)22(16,2)11-13-23(21)12-10-17-6-4-3-5-7-17/h3-9,15-16,21,24H,10-14H2,1-2H3

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
N - Nervous system > N02 - Analgesics > N02A - Opioids > N02AD - Benzomorphan derivatives
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics

同义名列表

4 个代谢物同义名

Phenazocine, (-)-; PHENAZOCINE; Phenazocine; Phenazocine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Masaya Asano, Serika Motoike, Chika Yokota, Naoto Usuki, Hikaru Yamamoto, Tomoaki Urabe, Kazusa Katarao, Izumi Hide, Shigeru Tanaka, Masashi Kawamoto, Masahiro Irifune, Norio Sakai. SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism. Journal of pharmacological sciences. 2019 Jan; 139(1):29-36. doi: 10.1016/j.jphs.2018.11.005. [PMID: 30522963]
  • Mohan Pabba, Adrian Y C Wong, Nina Ahlskog, Elitza Hristova, Dante Biscaro, Wissam Nassrallah, Johnny K Ngsee, Melissa Snyder, Jean-Claude Beique, Richard Bergeron. NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Aug; 34(34):11325-38. doi: 10.1523/jneurosci.0458-14.2014. [PMID: 25143613]
  • Molly Johannessen, Dominique Fontanilla, Timur Mavlyutov, Arnold E Ruoho, Meyer B Jackson. Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels. American journal of physiology. Cell physiology. 2011 Feb; 300(2):C328-37. doi: 10.1152/ajpcell.00383.2010. [PMID: 21084640]
  • Molly Johannessen, Subramaniam Ramachandran, Logan Riemer, Andrea Ramos-Serrano, Arnold E Ruoho, Meyer B Jackson. Voltage-gated sodium channel modulation by sigma-receptors in cardiac myocytes and heterologous systems. American journal of physiology. Cell physiology. 2009 May; 296(5):C1049-57. doi: 10.1152/ajpcell.00431.2008. [PMID: 19279232]
  • Christopher P Palmer, Robert Mahen, Eva Schnell, Mustafa B A Djamgoz, Ebru Aydar. Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines. Cancer research. 2007 Dec; 67(23):11166-75. doi: 10.1158/0008-5472.can-07-1771. [PMID: 18056441]
  • Y Noda, H Kamei, Y Kamei, T Nagai, M Nishida, T Nabeshima. Neurosteroids ameliorate conditioned fear stress: an association with sigma receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2000 Sep; 23(3):276-84. doi: 10.1016/s0893-133x(00)00103-2. [PMID: 10942851]
  • M P Morin-Surun, T Collin, M Denavit-Saubié, E E Baulieu, F P Monnet. Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem. Proceedings of the National Academy of Sciences of the United States of America. 1999 Jul; 96(14):8196-9. doi: 10.1073/pnas.96.14.8196. [PMID: 10393971]
  • S Patel, S Freedman, K L Chapman, F Emms, A E Fletcher, M Knowles, R Marwood, G Mcallister, J Myers, N Curtis, J J Kulagowski, P D Leeson, M Ridgill, M Graham, S Matheson, D Rathbone, A P Watt, L J Bristow, N M Rupniak, E Baskin, J J Lynch, C I Ragan. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. The Journal of pharmacology and experimental therapeutics. 1997 Nov; 283(2):636-47. doi: NULL. [PMID: 9353380]
  • C Torrence-Campbell, W D Bowen. Differential solubilization of rat liver sigma 1 and sigma 2 receptors: retention of sigma 2 sites in particulate fractions. European journal of pharmacology. 1996 May; 304(1-3):201-10. doi: 10.1016/0014-2999(96)00109-4. [PMID: 8813603]
  • N N Samovilova, N V Prokazova. [Search for an endogenous ligand for sigma receptors]. Voprosy meditsinskoi khimii. 1995 Sep; 41(5):9-13. doi: ". [PMID: 8553633]
  • D I Schuster, F J Arnold, R B Murphy. Purification, pharmacological characterization and photoaffinity labeling of sigma receptors from rat and bovine brain. Brain research. 1995 Jan; 670(1):14-28. doi: 10.1016/0006-8993(94)01123-y. [PMID: 7719713]
  • R N Pechnick, R E Poland. Neuroendocrine responses produced by enantiomeric pairs of drugs that interact with phencyclidine and sigma receptors. European journal of pharmacology. 1994 Sep; 263(1-2):115-20. doi: 10.1016/0014-2999(94)90531-2. [PMID: 7821343]
  • D J McCann, A D Weissman, T P Su. Sigma-1 and sigma-2 sites in rat brain: comparison of regional, ontogenetic, and subcellular patterns. Synapse (New York, N.Y.). 1994 Jul; 17(3):182-9. doi: 10.1002/syn.890170307. [PMID: 7974201]
  • M Watanabe, D Rominger, S D Hurt, E B De Souza, S W Tam. [3H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) piperidine HBr (DuP 734). A selective ligand for sigma receptors in mouse brain in vivo. The Journal of pharmacology and experimental therapeutics. 1993 Sep; 266(3):1541-8. doi: NULL. [PMID: 8371156]
  • N N Samovilova, V A Vinogradov. Subcellular distribution of (+)-[3H]SKF 10,047 binding sites in rat liver. European journal of pharmacology. 1992 Jan; 225(1):69-74. doi: 10.1016/0922-4106(92)90041-s. [PMID: 1311691]
  • D J McCann, T P Su. Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (sigma sites) exhibit a unique distribution in rat brain subcellular fractions. European journal of pharmacology. 1990 Apr; 188(4-5):211-8. doi: 10.1016/0922-4106(90)90004-h. [PMID: 2163873]
  • D B Vaupel, E J Cone, R E Johnson, T P Su. Kappa opioid partial agonist activity of the enkephalin-like pentapeptide BW942C based on urination and in vitro studies in humans and animals. The Journal of pharmacology and experimental therapeutics. 1990 Jan; 252(1):225-34. doi: NULL. [PMID: 2153801]
  • R M Eisenberg. Plasma corticosterone changes in response to central or peripheral administration of kappa and sigma opiate agonists. The Journal of pharmacology and experimental therapeutics. 1985 Jun; 233(3):863-9. doi: NULL. [PMID: 2989500]
  • R Pechnick, R George, R E Poland. Identification of multiple opiate receptors through neuroendocrine responses. II. Antagonism of mu, kappa and sigma agonists by naloxone and WIN 44,441-3. The Journal of pharmacology and experimental therapeutics. 1985 Jan; 232(1):170-7. doi: NULL. [PMID: 2981314]
  • R Pechnick, R George, R E Poland. Identification of multiple opiate receptors through neuroendocrine responses. I. Effects of agonists. The Journal of pharmacology and experimental therapeutics. 1985 Jan; 232(1):163-9. doi: NULL. [PMID: 2981313]
  • T J Cicero, D P Owens, P F Schmoeker, E R Meyer. Opiate-induced enhancement of the effects of naloxone on serum luteinizing hormone levels in the male rat: specificity for Mu agonists. The Journal of pharmacology and experimental therapeutics. 1983 Sep; 226(3):770-5. doi: . [PMID: 6310081]
  • S Lindgren, P Collste, B Norlander, F Sjöqvist. Gas chromatographic assessment of the reproducibility of phenazone plasma half-life in young healthy volunteers. European journal of clinical pharmacology. 1974 Aug; 7(5):381-5. doi: 10.1007/bf00558211. [PMID: 4418356]
  • T A Williams, K A Pittman. Pentazocine radioimmunoassay. Research communications in chemical pathology and pharmacology. 1974 Jan; 7(1):119-43. doi: NULL. [PMID: 4855777]
  • F Medzihradsky, P S Nandhasri. Effects of some analgesics and antidepressants on the (Na + + K + )-adenosine triphosphatase from cortices of brain and kidney. Biochemical pharmacology. 1972 Aug; 21(15):2103-9. doi: 10.1016/0006-2952(72)90163-3. [PMID: 4264878]
  • K Ahmad, F Medzihradsky. The determination of benzomorphan derivatives in plasma by gas chromatography. Life sciences. Pt. 1: Physiology and pharmacology. 1971 Jun; 10(12):707-10. doi: 10.1016/0024-3205(71)90014-2. [PMID: 5556758]
  • B P Lustgarten, A Kopeloff, S Fisch, A C DeGraff, M M Hotz. The effects of phenazocine hydrobromide on water and mercurial diuresis in man. The American journal of the medical sciences. 1965 Sep; 250(3):284-91. doi: 10.1097/00000441-196509000-00006. [PMID: 5829381]