Chlorpromazine-N-oxide (BioDeep_00000008417)

 

Secondary id: BioDeep_00001878065

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropanamine oxide

化学式: C17H19ClN2OS (334.0906554)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 21.74%

分子结构信息

SMILES: CN(C)(=O)CCCN1C2=CC=CC=C2SC2=C1C=C(Cl)C=C2
InChI: InChI=1S/C17H19ClN2OS/c1-20(2,21)11-5-10-19-14-6-3-4-7-16(14)22-17-9-8-13(18)12-15(17)19/h3-4,6-9,12H,5,10-11H2,1-2H3

描述信息

Chlorpromazine-N-oxide is a metabolite of chlorpromazine. Chlorpromazine (as chlorpromazine hydrochloride, abbreviated CPZ; marketed in the United States as Thorazine and elsewhere as Largactil) is a typical antipsychotic. First synthesized on December 11, 1950, chlorpromazine was the first drug developed with specific antipsychotic action, and would serve as the prototype for the phenothiazine class of drugs, which later grew to comprise several other agents. (Wikipedia)

同义名列表

4 个代谢物同义名

3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropanamine oxide; 2-Chloro-10-(3-dimethyloxidoaminopropyl)phenothiazine; Chlorpromazine N-oxide; Chlorpromazine-N-oxide



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jinxia Dai, Hui Lin, Yuning Pan, Yanmin Sun, Ye Wang, Jun-Qin Qiao, Hong-Zhen Lian, Chun-Xiang Xu. Determination of chlorpromazine and its metabolites in animal-derived foods using QuEChERS-based extraction, EMR-Lipid cleanup, and UHPLC-Q-Orbitrap MS analysis. Food chemistry. 2023 Mar; 403(?):134298. doi: 10.1016/j.foodchem.2022.134298. [PMID: 36182851]
  • T J Jaworski, E M Hawes, J W Hubbard, G McKay, K K Midha. The metabolites of chlorpromazine N-oxide in rat bile. Xenobiotica; the fate of foreign compounds in biological systems. 1991 Nov; 21(11):1451-9. doi: 10.3109/00498259109044395. [PMID: 1763519]
  • M Chetty, R Miller. Effect of storage on the plasma concentration of chlorpromazine and six of its metabolites. Therapeutic drug monitoring. 1991 Jul; 13(4):350-5. doi: 10.1097/00007691-199107000-00012. [PMID: 1780969]
  • T J Jaworski, E M Hawes, G McKay, K K Midha. The metabolism of chlorpromazine N-oxide in man and dog. Xenobiotica; the fate of foreign compounds in biological systems. 1990 Jan; 20(1):107-15. doi: 10.3109/00498259009046817. [PMID: 2327102]
  • T J Jaworski, E M Hawes, G McKay, K K Midha. The metabolism of chlorpromazine N-oxide in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 1988 Dec; 18(12):1439-47. doi: 10.3109/00498258809042266. [PMID: 3266695]
  • P K Yeung, J W Hubbard, E D Korchinski, K K Midha. Radioimmunoassay for the N-oxide metabolite of chlorpromazine in human plasma and its application to a pharmacokinetic study in healthy humans. Journal of pharmaceutical sciences. 1987 Oct; 76(10):803-8. doi: 10.1002/jps.2600761011. [PMID: 3430345]
  • K K Midha, J W Hubbard, J K Cooper, T Gurnsey, E M Hawes, G McKay, B S Chakraborty, P K Yeung. Therapeutic monitoring of chlorpromazine. IV: Comparison of a new high-performance liquid chromatographic method with radioimmunoassays for parent drug and some of its major metabolites. Therapeutic drug monitoring. 1987 Sep; 9(3):358-65. doi: . [PMID: 3672582]
  • E M Hawes, J W Hubbard, M Martin, G McKay, P K Yeung, K K Midha. Therapeutic monitoring of chlorpromazine. III: Minimal interconversion between chlorpromazine and metabolites in human blood. Therapeutic drug monitoring. 1986; 8(1):37-41. doi: . [PMID: 3961895]
  • J W Hubbard, J K Cooper, E M Hawes, D J Jenden, P R May, M Martin, G McKay, T Van Putten, K K Midha. Therapeutic monitoring of chlorpromazine I: Pitfalls in plasma analysis. Therapeutic drug monitoring. 1985; 7(2):222-8. doi: 10.1097/00007691-198506000-00015. [PMID: 4024218]
  • G McKay, J K Cooper, E M Hawes, J W Hubbard, M Martin, K K Midha. Therapeutic monitoring of chlorpromazine II: Pitfalls in whole blood analysis. Therapeutic drug monitoring. 1985; 7(4):472-7. doi: 10.1097/00007691-198512000-00020. [PMID: 4082244]