Dothistromin (BioDeep_00000008028)

   

PANOMIX_OTCML-2023


代谢物信息卡片


Anthra(2,3-b)furo(3,2-d)furan-5,10-dione, 2,3,3a,12a-tetrahydro-2,3a,4,6,9-pentahydroxy-, (2R,3aR,12aS)-

化学式: C18H12O9 (372.0481302)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 5.56%

分子结构信息

SMILES: C1C(OC2C1(C3=C(O2)C=C4C(=C3O)C(=O)C5=C(C=CC(=C5C4=O)O)O)O)O
InChI: InChI=1S/C18H12O9/c19-6-1-2-7(20)12-11(6)14(22)5-3-8-13(16(24)10(5)15(12)23)18(25)4-9(21)27-17(18)26-8/h1-3,9,17,19-21,24-25H,4H2/t9-,17+,18-/m1/s1

描述信息

同义名列表

2 个代谢物同义名

Dothistromin; Anthra(2,3-b)furo(3,2-d)furan-5,10-dione, 2,3,3a,12a-tetrahydro-2,3a,4,6,9-pentahydroxy-, (2R,3aR,12aS)-



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rosie E Bradshaw, Andre D Sim, Pranav Chettri, Pierre-Yves Dupont, Yanan Guo, Lukas Hunziker, Rebecca L McDougal, Ariska Van der Nest, Arista Fourie, David Wheeler, Murray P Cox, Irene Barnes. Global population genomics of the forest pathogen Dothistroma septosporum reveal chromosome duplications in high dothistromin-producing strains. Molecular plant pathology. 2019 06; 20(6):784-799. doi: 10.1111/mpp.12791. [PMID: 30938073]
  • I Kutay Ozturk, Pierre-Yves Dupont, Pranav Chettri, Rebecca McDougal, Ole J Böhl, Russell J Cox, Rosie E Bradshaw. Evolutionary relics dominate the small number of secondary metabolism genes in the hemibiotrophic fungus Dothistroma septosporum. Fungal biology. 2019 05; 123(5):397-407. doi: 10.1016/j.funbio.2019.02.006. [PMID: 31053329]
  • Pranav Chettri, Rosie E Bradshaw. LaeA negatively regulates dothistromin production in the pine needle pathogen Dothistroma septosporum. Fungal genetics and biology : FG & B. 2016 12; 97(?):24-32. doi: 10.1016/j.fgb.2016.11.001. [PMID: 27818262]
  • Rosie E Bradshaw, Jason C Slot, Geromy G Moore, Pranav Chettri, Pierre J G M de Wit, Kenneth C Ehrlich, Austen R D Ganley, Malin A Olson, Antonis Rokas, Ignazio Carbone, Murray P Cox. Fragmentation of an aflatoxin-like gene cluster in a forest pathogen. The New phytologist. 2013 Apr; 198(2):525-535. doi: 10.1111/nph.12161. [PMID: 23448391]
  • Pranav Chettri, Ana M Calvo, Jeffrey W Cary, Sourabh Dhingra, Yanan Guo, Rebecca L McDougal, Rosie E Bradshaw. The veA gene of the pine needle pathogen Dothistroma septosporum regulates sporulation and secondary metabolism. Fungal genetics and biology : FG & B. 2012 Feb; 49(2):141-51. doi: 10.1016/j.fgb.2011.11.009. [PMID: 22227160]
  • Arne Schwelm, Rosie E Bradshaw. Genetics of dothistromin biosynthesis of Dothistroma septosporum: an update. Toxins. 2010 11; 2(11):2680-98. doi: 10.3390/toxins2112680. [PMID: 22069571]
  • Arne Schwelm, Naydene J Barron, Shuguang Zhang, Rosie E Bradshaw. Early expression of aflatoxin-like dothistromin genes in the forest pathogen Dothistroma septosporum. Mycological research. 2008 Feb; 112(Pt 2):138-46. doi: 10.1016/j.mycres.2007.03.018. [PMID: 18262779]
  • Rosie E Bradshaw, Shuguang Zhang. Biosynthesis of dothistromin. Mycopathologia. 2006 Sep; 162(3):201-13. doi: 10.1007/s11046-006-0054-5. [PMID: 16944287]
  • P W Sutherland, W T Jones, D Harvey. Sieve element specific labeling with an anti-idiotypic monoclonal antibody mimic of the phytotoxin dothistromin. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2003 Apr; 78(2):71-4. doi: 10.1080/10520290310001593883. [PMID: 14533843]
  • Rosie E Bradshaw, Deepak Bhatnagar, Rebecca J Ganley, Carmel J Gillman, Brendon J Monahan, Janet M Seconi. Dothistroma pini, a forest pathogen, contains homologs of aflatoxin biosynthetic pathway genes. Applied and environmental microbiology. 2002 Jun; 68(6):2885-92. doi: 10.1128/aem.68.6.2885-2892.2002. [PMID: 12039746]
  • A Stoessl, Z Abramowski, H H Lester, G L Rock, G H Towers. Further toxic properties of the fungal metabolite dothistromin. Mycopathologia. 1990 Dec; 112(3):179-86. doi: 10.1007/bf00436652. [PMID: 2089260]