Hernandulcin (BioDeep_00000007539)

 

Secondary id: BioDeep_00001869499

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


6-(2-hydroxy-6-methylhept-5-en-2-yl)-3-methylcyclohex-2-en-1-one

化学式: C15H24O2 (236.1776)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(otcml) 8.88%

分子结构信息

SMILES: CC(C)=CCCC(C)(O)C1CCC(C)=CC1=O
InChI: InChI=1S/C15H24O2/c1-11(2)6-5-9-15(4,17)13-8-7-12(3)10-14(13)16/h6,10,13,17H,5,7-9H2,1-4H3

描述信息

Hernandulcin is a constituent of Lippia dulcis leaves and flowers. Natural sweetener more than 1000 times sweeter than sucrose Hernandulcin is a sesquiterpene with the molecular formula C15H24O2. By slightly modifying the compound, researchers have identified the two chemical groups which caused the sweet taste - the carbonyl group, and the hydroxyl group. The structure of hernandulcin is very simple, and after a panel of volunteers tasted hernandulcin, it was determined that it was 1,000 times sweeter than sugar. Hernandulcin also has a bitter aftertaste, and does not cause tooth decay, which would make it a good candidate for a mouthwash. Hernandulcin is an intensely sweet chemical compound gained from the chiefly Mexican and South American plant Lippia dulcis.
Constituent of Lippia dulcis leaves and flowers. Natural sweetener more than 1000 times sweeter than sucrose

同义名列表

4 个代谢物同义名

6-(2-hydroxy-6-methylhept-5-en-2-yl)-3-methylcyclohex-2-en-1-one; Hernandulcin; CID 3504251; Hernandulcin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

29 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Carlos Jonnathan Castro-Juárez, Silvia Luna-Suárez, Flor de Fátima Rosas-Cárdenas, Nemesio Villa-Ruano. Hernandulcin Production in Elicited Hairy Roots of Phyla scaberrima: Toward Sustainable Production of a Non-Caloric Sweetener with Nutraceutical Properties. Chemistry & biodiversity. 2024 Mar; 21(3):e202302095. doi: 10.1002/cbdv.202302095. [PMID: 38334300]
  • Nemesio Villa-Ruano, Carlos J Castro-Juárez, Edmundo Lozoya-Gloria, Sergio Alberto Ramírez-García, Ramiro Cruz-Durán, Jenaro Leocadio Varela-Caselis. Hernandulcin Production in Cell Suspensions of Phyla Scaberrima: Exploring Hernandulcin Accumulation through Physical and Chemical Stimuli. Chemistry & biodiversity. 2021 Nov; 18(11):e2100611. doi: 10.1002/cbdv.202100611. [PMID: 34547168]
  • Mohamed Attia, Soo-Un Kim, Dae-Kyun Ro. Molecular cloning and characterization of (+)-epi-α-bisabolol synthase, catalyzing the first step in the biosynthesis of the natural sweetener, hernandulcin, in Lippia dulcis. Archives of biochemistry and biophysics. 2012 Nov; 527(1):37-44. doi: 10.1016/j.abb.2012.07.010. [PMID: 22867794]
  • Bárbara Moreno-Murillo, Clara Quijano-Célis, Arturo R Romero, Jorge A Pino. Essential oil from leaves of Lippia dulcis grown in Colombia. Natural product communications. 2010 Apr; 5(4):613-4. doi: . [PMID: 20433082]
  • C M Compadre, E F Robbins, A D Kinghorn. The intensely sweet herb, Lippia dulcis Trev.: historical uses, field inquiries, and constituents. Journal of ethnopharmacology. 1986 Jan; 15(1):89-106. doi: 10.1016/0378-8741(86)90105-4. [PMID: 3520154]
  • C M Compadre, J M Pezzuto, A D Kinghorn, S K Kamath. Hernandulcin: an intensely sweet compound discovered by review of ancient literature. Science (New York, N.Y.). 1985 Jan; 227(4685):417-9. doi: 10.1126/science.3880922. [PMID: 3880922]
  • C Teasdale, A M Mander, R Fifield, J W Keyser, R G Newcombe, L E Hughes. Serum beta2-microglobulin in controls and cancer patients. Clinica chimica acta; international journal of clinical chemistry. 1977 Jul; 78(1):135-43. doi: 10.1016/0009-8981(77)90346-1. [PMID: 69507]