Methylparaben (BioDeep_00000409799)

Main id: BioDeep_00000017247

 

PANOMIX_OTCML-2023


代谢物信息卡片


Prodelphinidin trimer GC-C-C

化学式: C8H8O3 (152.0473418)
中文名称: 尼泊金甲酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC(=O)C1=CC=C(C=C1)O
InChI: InChI=1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3

描述信息

Prodelphinidin trimer gc-c-c is a member of the class of compounds known as biflavonoids and polyflavonoids. Biflavonoids and polyflavonoids are organic compounds containing at least two flavan/flavone units. These units are usually linked through CC or C-O-C bonds. Some examples include C2-O-C3, C2-O-C4, C3-C3, and C6-C8. Prodelphinidin trimer gc-c-c is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Prodelphinidin trimer gc-c-c can be found in beer, which makes prodelphinidin trimer gc-c-c a potential biomarker for the consumption of this food product.
D010592 - Pharmaceutic Aids > D011310 - Preservatives, Pharmaceutical > D010226 - Parabens
CONFIDENCE standard compound; INTERNAL_ID 1106; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3579; ORIGINAL_PRECURSOR_SCAN_NO 3578
CONFIDENCE standard compound; INTERNAL_ID 1106; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3566; ORIGINAL_PRECURSOR_SCAN_NO 3561
CONFIDENCE standard compound; INTERNAL_ID 1106; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3549; ORIGINAL_PRECURSOR_SCAN_NO 3546
CONFIDENCE standard compound; INTERNAL_ID 1106; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3560; ORIGINAL_PRECURSOR_SCAN_NO 3556
CONFIDENCE standard compound; INTERNAL_ID 1106; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3573; ORIGINAL_PRECURSOR_SCAN_NO 3570
CONFIDENCE standard compound; INTERNAL_ID 1106; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3577; ORIGINAL_PRECURSOR_SCAN_NO 3575
CONFIDENCE standard compound; INTERNAL_ID 2371
Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[1].
Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[1].

同义名列表

5 个代谢物同义名

Prodelphinidin trimer GC-C-C; Methylparaben; methyl-4-hydroxybenzoate; Methyl 4-hydroxybenzoate; Methyl paraben



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

83 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yilin Ren, Xinyi Shi, Jing Mu, Shenyin Liu, Xin Qian, Wenlong Pei, Shanhong Ni, Zhengduo Zhang, Lei Li, Zhan Zhang. Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism. Food & function. 2024 Feb; 15(3):1562-1574. doi: 10.1039/d3fo04347a. [PMID: 38236135]
  • Yaxin Xiong, Qingyang Shi, Jun Li, Nathan Darlucio Sy, Daniel Schlenk, Jay Gan. Methylation and Demethylation of Emerging Contaminants in Plants. Environmental science & technology. 2024 Jan; 58(4):1998-2006. doi: 10.1021/acs.est.3c03171. [PMID: 38240245]
  • Haining Du, Jiaxin Li, Xiangjuan Wei, Daqian Yang, Boya Zhang, Xingpei Fan, Meimei Zhao, Ruijiao Zhu, Ziyi Zhang, Yuxia Zhang, Xiaoyan Li, Ning Gu. Methylparaben induces hepatic glycolipid metabolism disorder by activating the IRE1α-XBP1 signaling pathway in male mice. Environment international. 2024 Jan; 184(?):108445. doi: 10.1016/j.envint.2024.108445. [PMID: 38262168]
  • Michael T Penrose, George P Cobb. Influences of Wastewater Treatment on the Occurrence of Parabens, p-Hydroxybenzoic Acid and Their Chlorinated and Hydroxylated Transformation Products in the Brazos River (Texas, USA). Archives of environmental contamination and toxicology. 2023 Aug; ?(?):. doi: 10.1007/s00244-023-01025-x. [PMID: 37558810]
  • Xiao-Pan Ning, Qian Yao, Zhong-Xiang Xu, Yao Yin, Han Liu, Xiao-Yan Zhang, Tao Ding, Yong Zhang, Yu Hou, Meng-Ru Wang, Li-Na Wu, Qi-Ting Tang. [Determination of seven paraben preservatives in aquatic seasoning using solid-phase extraction coupled with high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2023 Jun; 41(6):513-519. doi: 10.3724/sp.j.1123.2022.10004. [PMID: 37259876]
  • Gabrielle Cristina Dos Santos Gonçalves Nascimento, Elisângela Dusman, Regiane da Silva Gonzalez, João Victor Nicola, Matheus Augusto de Souza Moura, Karine Mares de Oliveira, Anna Karolina Gomes Oliveira, Patricia Aline Bressani, Diego Espirito Santo, Ádila Cristina Krukoski Filipi, Eduardo Michel Vieira Gomes, Juan Carlos Pokrywiecki, Débora Cristina de Souza, Ana Paula Peron. Toxicity of methylparaben and its chlorinated derivatives to Allium cepa L. and Eisenia fetida Sav. Environmental science and pollution research international. 2023 Mar; ?(?):. doi: 10.1007/s11356-023-26539-8. [PMID: 36971943]
  • Fátima C Martins, M M Oliveira, Isabel Gaivão, Romeu A Videira, Francisco Peixoto. The administration of methyl and butyl parabens interferes with the enzymatic antioxidant system and induces genotoxicity in rat testis: possible relation to male infertility. Drug and chemical toxicology. 2023 Feb; ?(?):1-8. doi: 10.1080/01480545.2023.2176512. [PMID: 36756703]
  • Chenyan Hu, Baili Sun, Lizhu Tang, Mengyuan Liu, Zileng Huang, Xiangzhen Zhou, Lianguo Chen. Hepatotoxicity caused by methylparaben in adult zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 2022 Sep; 250(?):106255. doi: 10.1016/j.aquatox.2022.106255. [PMID: 35905631]
  • Paulina Jedynak, Jörg Tost, Antonia M Calafat, Ekaterina Bourova-Flin, Florence Busato, Anne Forhan, Barbara Heude, Milan Jakobi, Sophie Rousseaux, Joel Schwartz, Rémy Slama, Daniel Vaiman, Claire Philippat, Johanna Lepeule. Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort. Environmental pollution (Barking, Essex : 1987). 2021 Dec; 290(?):118024. doi: 10.1016/j.envpol.2021.118024. [PMID: 34523531]
  • Jingwei Feng, Peng Nian, Lu Peng, Aiyong Zhang, Yabing Sun. Degradation of aqueous methylparaben by non-thermal plasma combined with ZnFe2O4-rGO nanocomposites: Performance, multi-catalytic mechanism, influencing factors and degradation pathways. Chemosphere. 2021 May; 271(?):129575. doi: 10.1016/j.chemosphere.2021.129575. [PMID: 33460902]
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  • Anthi Parla, Eirini Zormpa, Nikolaos Paloumpis, Abuzar Kabir, Kenneth G Furton, Željka Roje, Victoria Samanidou, Ivana Vinković Vrček, Irene Panderi. Determination of Intact Parabens in the Human Plasma of Cancer and Non-Cancer Patients Using a Validated Fabric Phase Sorptive Extraction Reversed-Phase Liquid Chromatography Method with UV Detection. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061526. [PMID: 33799523]
  • Yujin Lee, Eun Lee, Dong Keon Yon, Hye Mi Jee, Hey Sung Baek, Seung Won Lee, Joo-Youn Cho, Man Yong Han. The potential pathways underlying the association of propyl-paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis. Scientific reports. 2021 02; 11(1):3772. doi: 10.1038/s41598-021-83288-9. [PMID: 33580129]
  • Yaghoub Hajizadeh, Ghasem Kiani Feizabadi, Awat Feizi. Dietary Habits and Personal Care Product Use as Predictors of Urinary Concentrations of Parabens in Iranian Adolescents. Environmental toxicology and chemistry. 2020 12; 39(12):2378-2388. doi: 10.1002/etc.4861. [PMID: 32845562]
  • Ghasem Kiani Feizabadi, Yaghoub Hajizadeh, Awat Feizi, Karim Ebrahimpour. Urinary Concentrations of Parabens in a Population of Iranian Adolescent and Their Association with Sociodemographic Indicators. Archives of environmental contamination and toxicology. 2020 Aug; 79(2):195-207. doi: 10.1007/s00244-020-00746-7. [PMID: 32572517]
  • Brennan H Baker, Haotian Wu, Hannah E Laue, Amélie Boivin, Virginie Gillet, Marie-France Langlois, Jean-Philippe Bellenger, Andrea A Baccarelli, Larissa Takser. Methylparaben in meconium and risk of maternal thyroid dysfunction, adverse birth outcomes, and Attention-Deficit Hyperactivity Disorder (ADHD). Environment international. 2020 06; 139(?):105716. doi: 10.1016/j.envint.2020.105716. [PMID: 32283359]
  • Mostafa Alilou, Dya Fita Dibwe, Stefan Schwaiger, Mojtaba Khodami, Jakob Troppmair, Suresh Awale, Hermann Stuppner. Antiausterity Activity of Secondary Metabolites from the Roots of Ferula hezarlalehzarica against the PANC-1 Human Pancreatic Cancer Cell Line. Journal of natural products. 2020 04; 83(4):1099-1106. doi: 10.1021/acs.jnatprod.9b01109. [PMID: 32163286]
  • Traci N Bethea, Amelia K Wesselink, Jennifer Weuve, Michael D McClean, Russ Hauser, Paige L Williams, Xiaoyun Ye, Antonia M Calafat, Donna D Baird, Lauren A Wise. Correlates of exposure to phenols, parabens, and triclocarban in the Study of Environment, Lifestyle and Fibroids. Journal of exposure science & environmental epidemiology. 2020 01; 30(1):117-136. doi: 10.1038/s41370-019-0114-9. [PMID: 30692588]
  • Na-Youn Park, Yoon Hee Cho, Kyungho Choi, Eun-Hee Lee, Yang Jee Kim, Jung Hoan Kim, Younglim Kho. Parabens in breast milk and possible sources of exposure among lactating women in Korea. Environmental pollution (Barking, Essex : 1987). 2019 Dec; 255(Pt 2):113142. doi: 10.1016/j.envpol.2019.113142. [PMID: 31563777]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Shaoyou Lu, Lu Ren, Yanlin Liu, Huimin Ma, Shan Liu, Zhou Zhu, Zhi Tang, Li Kang, Shicheng Liao. Urinary parabens in children from South China: Implications for human exposure and health risks. Environmental pollution (Barking, Essex : 1987). 2019 Nov; 254(Pt A):113007. doi: 10.1016/j.envpol.2019.113007. [PMID: 31421570]
  • Yingxin Yu, Wenbo Li, Shaoyou Lu, Suyang Wu, Feng Wang, Lap Ah Tse, Li Kang, Shengtao Ma. Urinary parabens in adults from South China: Implications for human exposure and health risks. Ecotoxicology and environmental safety. 2019 Oct; 182(?):109419. doi: 10.1016/j.ecoenv.2019.109419. [PMID: 31301591]
  • Jillian M Hagel, Xue Chen, Peter J Facchini. Production of methylparaben in Escherichia coli. Journal of industrial microbiology & biotechnology. 2019 Jan; 46(1):91-99. doi: 10.1007/s10295-018-2102-9. [PMID: 30392093]
  • Nuria Vela, May Calín, María J Yáñez-Gascón, Isabel Garrido, Gabriel Pérez-Lucas, José Fenoll, Simón Navarro. Photocatalytic oxidation of six endocrine disruptor chemicals in wastewater using ZnO at pilot plant scale under natural sunlight. Environmental science and pollution research international. 2018 Dec; 25(35):34995-35007. doi: 10.1007/s11356-018-1716-9. [PMID: 29558788]
  • L Kolatorova, M Sramkova, J Vitku, J Vcelak, O Lischkova, L Starka, M Duskova. Parabens and their relation to obesity. Physiological research. 2018 11; 67(Suppl 3):S465-S472. doi: 10.33549/physiolres.934004. [PMID: 30484673]
  • Chenlu Wang, Wei Zhou, Xiaoyan Liao, Xuemei Wang, Zilin Chen. Covalent immobilization of metal organic frameworks onto chemical resistant poly(ether ether ketone) jacket for stir bar extraction. Analytica chimica acta. 2018 Sep; 1025(?):124-133. doi: 10.1016/j.aca.2018.04.056. [PMID: 29801601]
  • Águeda Bellver-Domingo, Ramón Fuentes, Francesc Hernández-Sancho, Eric Carmona, Yolanda Picó, Vicent Hernández-Chover. Monetary valuation of salicylic acid, methylparaben and THCOOH in a Mediterranean coastal wetland through the shadow prices methodology. The Science of the total environment. 2018 Jun; 627(?):869-879. doi: 10.1016/j.scitotenv.2018.01.303. [PMID: 29426212]
  • Amira M Aker, Lauren Johns, Thomas F McElrath, David E Cantonwine, Bhramar Mukherjee, John D Meeker. Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study. Environment international. 2018 04; 113(?):341-349. doi: 10.1016/j.envint.2018.01.006. [PMID: 29366524]
  • Perihan Seda Ateş, İsmail Ünal, Ünsal Veli Üstündağ, Ahmet Ata Alturfan, Türkan Yiğitbaşı, Ebru Emekli-Alturfan. Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos. Journal of biochemical and molecular toxicology. 2018 Mar; 32(3):e22036. doi: 10.1002/jbt.22036. [PMID: 29360218]
  • Divya Dubey, Deepti Chopra, Jyoti Singh, Ajeet K Srivastav, Smita Kumari, Ankit Verma, Ratan Singh Ray. Photosensitized methyl paraben induces apoptosis via caspase dependent pathway under ambient UVB exposure in human skin cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Oct; 108(Pt A):171-185. doi: 10.1016/j.fct.2017.07.056. [PMID: 28764904]
  • Ulla N Joensen, Niels Jørgensen, Jacob P Thyssen, Jørgen Holm Petersen, Pal B Szecsi, Steen Stender, Anne-Maria Andersson, Niels E Skakkebæk, Hanne Frederiksen. Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population. Environment international. 2017 08; 105(?):105-111. doi: 10.1016/j.envint.2017.05.013. [PMID: 28525834]
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  • Sudhanshu Shekhar, Surbhi Sood, Sadiya Showkat, Christy Lite, Anjalakshi Chandrasekhar, Mariappanadar Vairamani, S Barathi, Winkins Santosh. Detection of phenolic endocrine disrupting chemicals (EDCs) from maternal blood plasma and amniotic fluid in Indian population. General and comparative endocrinology. 2017 01; 241(?):100-107. doi: 10.1016/j.ygcen.2016.05.025. [PMID: 27235644]
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