Paramethasone (BioDeep_00000004017)

 

Secondary id: BioDeep_00000409851

human metabolite blood metabolite


代谢物信息卡片


(1S,2R,8S,10S,11S,13R,14R,15S,17S)-8-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one

化学式: C22H29FO5 (392.1999)
中文名称: 帕拉米松
谱图信息: 最多检出来源 Homo sapiens(blood) 19.57%

分子结构信息

SMILES: CC1CC2C3CC(C4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)CO)O)C)O)C)F
InChI: InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1

描述信息

A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone. (From Martindale, The Extra Pharmacopoeia, 30th ed, p737)
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AB - Glucocorticoids
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents

同义名列表

5 个代谢物同义名

(1S,2R,8S,10S,11S,13R,14R,15S,17S)-8-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one; Paramethasone; VA11487; Dillar; Paramethasone



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ivan Bel, Luis-Alfonso Moreno, Carmen Gomar. Epidural dextran-40 and paramethasone injection for treatment of spontaneous intracranial hypotension. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2006 Jun; 53(6):591-4. doi: 10.1007/bf03021850. [PMID: 16738294]
  • Y Nishi. Nonclassical 3 beta-hydroxysteroid dehydrogenase deficiency in young girls with hirsutism and premature pubarche. Endocrinologia japonica. 1990 Oct; 37(5):763-7. doi: 10.1507/endocrj1954.37.763. [PMID: 2150813]
  • V Cortés-Gallegos, R Alonso, G Castañeda, I Sojo, A Carranco, C Cervantes, A Parra. Paramethasone acetate (PA): corticosteroid potency vs hypothalamic pituitary-gonadal axis. Journal of steroid biochemistry. 1984 Jan; 20(1):353-6. doi: 10.1016/0022-4731(84)90232-2. [PMID: 6423900]
  • B P Stuart, D B Sisk, D M Bedell, H S Gosser. Demonstration of immunity against Isospora suis in swine. Veterinary parasitology. 1982 Feb; 9(3-4):185-91. doi: NULL. [PMID: 7201193]
  • V Cortés-Gallegos, M E Alonso-Uriarte, L E Said, C Cervantes, A Parra. Effect of paramethasone acetate on women with secondary amenorrhea: a preliminary report. Fertility and sterility. 1978 Apr; 29(4):402-6. doi: 10.1016/s0015-0282(16)43213-9. [PMID: 77230]
  • H Nakamura, K Matsushita, M Hata, H Sakaguchi. Less toxic corticosteroid therapy in canine renal allografts. The Keio journal of medicine. 1978 Apr; 27(1):15-21. doi: 10.2302/kjm.27.15. [PMID: 216844]
  • S Yamamoto, N Ohsawa. Effects of dexamethasone on the levels of plasma corticosteroid binding globulin in rats and monkeys. Biochemical and biophysical research communications. 1976 Sep; 72(2):489-98. doi: 10.1016/s0006-291x(76)80068-x. [PMID: 62575]
  • V Cortés-Gallegos, A J Gallegos, N B Tovar, C Cervantes, A Parra. Effect of paramethasone acetate on ovarian steroids and gonadotropins. I. Normal menstrual cycle. The Journal of clinical endocrinology and metabolism. 1975 Aug; 41(2):215-20. doi: 10.1210/jcem-41-2-215. [PMID: 1159039]
  • L J Ignarro, S Y Cech. Lysosomal enzyme secretion from human neutrophils mediated by cyclic CMP: inhibition of cyclic GMP accumulation and neutrophil function by glucocorticosteroids. Journal of cyclic nucleotide research. 1975; 1(6):283-92. doi: . [PMID: 5468]
  • S P Makker, W Heymann. The idiopathic nephrotic syndrome of childhood. A clinical reevaluation of 148 cases. American journal of diseases of children (1960). 1974 Jun; 127(6):830-7. doi: 10.1001/archpedi.1974.02110250056008. [PMID: 4834775]
  • H Selye, S Szabo, Y Taché, P Kourounakis, I Mécs I+MECS, J Taché J+TACHE. Effect of glucocorticoids upon resistance to various toxicants. Steroids and lipids research. 1974; 5(1):10-22. doi: NULL. [PMID: 4418494]
  • J S Lowe, E H Turner. The effect of adjuvant arthritis and drugs on the ability of rat plasma to inhibit the triton X-100 induced lysis of rabbit polymorphonuclear leucocyte granules. Biochemical pharmacology. 1973 Sep; 22(17):2069-78. doi: 10.1016/0006-2952(73)90105-6. [PMID: 4582140]
  • J Badía Flores, M Martínez Limón. [Paramethasone in rheumatoid arthritis. Comparison of its clinical aspects using the oral and intramuscular route of administration]. La Prensa medica mexicana. 1973 Jan; 38(1):57-60. doi: . [PMID: 4745926]
  • M Kawase. [Studies on transcortin and aldosterone-binding proteins in human plasma. I. Studies on the plasma protein binding of various radioactive steroid hormones in normal subjects]. Naika hokan. Japanese archives of internal medicine. 1971; 18(5):155-63. doi: NULL. [PMID: 5106348]
  • M Kawase. [Studies on transcortin and aldosterone-binding proteins in human plasma. II. Studies on the plasma protein binding of various radioactive steroid hormones in patients with various disorders, pregnant women and estrogen-treated patients]. Naika hokan. Japanese archives of internal medicine. 1971; 18(5):165-76. doi: NULL. [PMID: 5106349]
  • F M Dietrich, A Komarek, C Pericin. Hypersensitivity in mice. II. The effect of chemical compounds on systemic active anaphylaxis and on anaphylaxis-like reactions in normal and B. pertussis-pretreated mice. International archives of allergy and applied immunology. 1971; 40(4-5):495-506. doi: NULL. [PMID: 4102842]
  • J Zuckner, J Uddin, R H Ramsey. Adrenal-pituitary relationships with prolonged low dosage steroid therapy in rheumatoid arthritis. Missouri medicine. 1969 Aug; 66(8):649-53 passim. doi: NULL. [PMID: 5807539]
  • S J Piliero, C Colombo. Action of antiinflammatory drugs on the lysozyme activity and 'turbidity' of serum from rats with adjuvant arthritis or endocrine deficiency. The Journal of pharmacology and experimental therapeutics. 1969 Feb; 165(2):294-9. doi: NULL. [PMID: 5763064]
  • C Colombo, S J Piliero, L Grosso. Serum turbidity responses of anti-inflammatory drugs in endocrine-deficient rats. Journal of pharmaceutical sciences. 1968 Sep; 57(9):1526-30. doi: 10.1002/jps.2600570912. [PMID: 4299890]
  • C F Colucci, A Castaldo, F P De Luca. [Behavior of glomerular filtrate and water sodium and potassium diuresis in ascitic liver cirrhosis during prolonged administration of cortisone drugs]. Il Policlinico. Sezione pratica. 1968 Aug; 75(34):1101-8. doi: NULL. [PMID: 5736920]
  • B Strandberg. Certain muscular diseases in patients with rheumatoid arthritis. Acta rheumatologica Scandinavica. 1968; ?(?):Suppl 12:1-36. doi: 10.3109/rhe1.1968.13.suppl-12.01. [PMID: 5637840]
  • E Maillard, G Fontaine. [Paramethasone acetate in pediatrics]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille. 1967 Nov; 12(9):Suppl:1129-33. doi: NULL. [PMID: 5310464]
  • T Nagano. [Urinary excretion of pregnanetriol in various internal diseases]. Nihon Naibunpi Gakkai zasshi. 1966 Dec; 42(9):1035-47. doi: NULL. [PMID: 4291583]
  • R Nazaki. [Clinical study on adrenal suppression and estrogens in recurrent breast cancer]. Nihon Naibunpi Gakkai zasshi. 1966 Oct; 42(7):788-800. doi: 10.1507/endocrine1927.42.7_788. [PMID: 6008079]
  • L Brunelli, L Gardoni. [Paramethasone acetate and function of the pituitary-adrenal axis in childhood]. Folia endocrinologica. 1966 Feb; 19(1):125-30. doi: NULL. [PMID: 5953699]
  • M SAWAKI, M MAKI, M MINATOGAWA, J MORIWAKI. [CASE OF MYOCARDIAL INFARCT ASSOCIATED WITH ADAMS-STOKES SYNDROME IN A 17-YEAR OLD GIRL]. Japanese circulation journal. 1965 Feb; 29(?):125-31. doi: 10.1253/jcj.29.125. [PMID: 14264333]
  • B A WHITTLE. THE USE OF CHANGES IN CAPILLARY PERMEABILITY IN MICE TO DISTINGUISH BETWEEN NARCOTIC AND NONNARCOTIC ALALGESICS. British journal of pharmacology and chemotherapy. 1964 Apr; 22(?):246-53. doi: 10.1111/j.1476-5381.1964.tb02030.x. [PMID: 14190460]
  • K MIRA, E KUMAGAYA, M KATO, T OTOMO, S SATO, I KATSUSHIMA, C SASAKI. [STUDIES ON SIDE EFFECTS OF ADRENAL CORTEX HORMONOTHERAPY, WITH SPECIAL REFERENCE TO SEVERE SIDE EFFECTS]. [Sogo rinsho] Clinic all-round. 1964 Apr; 13(?):719-33. doi: NULL. [PMID: 14142735]
  • Y UEDA, T MIYAHARA, S MINAMI, T SAITO, Y OGURA. [A CASE OF RENAL CELL CARCINOMA MANIFESTED. A TYPICAL NEPHROTIC SYNDROME]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 1964 Jan; 52(?):1243-7. doi: 10.2169/naika.52.1243. [PMID: 14153497]