Indole-3-carbinol (BioDeep_00000395792)

 

Secondary id: BioDeep_00000018464

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Indole-3-carbinol

化学式: C9H9NO (147.0684)
中文名称: 3-吲哚甲醇, 吲哚-3-甲醇
谱图信息: 最多检出来源 Viridiplantae(plant) 17.5%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=CN2)CO
InChI: InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2

描述信息

D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
D000970 - Antineoplastic Agents
IPB_RECORD: 276; CONFIDENCE confident structure
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

同义名列表

2 个代谢物同义名

Indole-3-carbinol; Indole-3-methanol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

40 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yuan He, Ying Zhu, Xiaorong Shui, Zufeng Huang, Kongwei Li, Wei Lei. Gut microbiome and metabolomic profiles reveal the antiatherosclerotic effect of indole-3-carbinol in high-choline-fed ApoE-/- mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155621. doi: 10.1016/j.phymed.2024.155621. [PMID: 38678950]
  • Gabriel P Bacil, Guilherme R Romualdo, Josias Rodrigues, Luís F Barbisan. Indole-3-carbinol and chlorogenic acid combination modulates gut microbiome and attenuates nonalcoholic steatohepatitis in a murine model. Food research international (Ottawa, Ont.). 2023 Dec; 174(Pt 1):113513. doi: 10.1016/j.foodres.2023.113513. [PMID: 37986509]
  • Mojgan Noroozi Karimabad, Maryam Mohamadi, Seyedeh Atekeh Torabizadeh, Gholamhossein Hassanshahi. Indole-3-carbinol (I3C) as Leukemia Therapeutic Agents: Review. Mini reviews in medicinal chemistry. 2023; 23(2):150-158. doi: 10.2174/1389557522666220325145003. [PMID: 35339173]
  • Jia Cheng Qian, Dan Liu, Li Ping Lin, Wen Jing Zhu, Ren Xiang Tan. Minor bioactive indoles from kimchi mirror the regioselectivity in indole-3-carbinol oligomerization. Food chemistry. 2022 Jul; 382(?):132571. doi: 10.1016/j.foodchem.2022.132571. [PMID: 35245758]
  • Kakarla Ramakrishna, Shreyans K Jain, Sairam Krishnamurthy. Pharmacokinetic and Pharmacodynamic Properties of Indole-3-carbinol in Experimental Focal Ischemic Injury. European journal of drug metabolism and pharmacokinetics. 2022 Jul; 47(4):593-605. doi: 10.1007/s13318-022-00771-y. [PMID: 35482227]
  • Thoria Donia, Marian N Gerges, Tarek M Mohamed. Anticancer Effects of Combination of Indole-3-Carbinol and Hydroxychloroquine on Ehrlich Ascites Carcinoma via Targeting Autophagy and Apoptosis. Nutrition and cancer. 2022; 74(5):1802-1818. doi: 10.1080/01635581.2021.1960388. [PMID: 34379013]
  • Monica L Vermillion Maier, Lisbeth K Siddens, Sandra L Uesugi, Jaewoo Choi, Scott W Leonard, Jamie M Pennington, Susan C Tilton, Jordan N Smith, Emily Ho, H H Sherry Chow, Bach D Nguyen, Siva K Kolluri, David E Williams. 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. Drug metabolism and disposition: the biological fate of chemicals. 2021 08; 49(8):694-705. doi: 10.1124/dmd.120.000346. [PMID: 34035125]
  • Regan Odongo, Asuman Demiroglu-Zergeroglu, Tunahan Çakır. A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data. BMC complementary medicine and therapies. 2021 Jun; 21(1):181. doi: 10.1186/s12906-021-03340-z. [PMID: 34193143]
  • Micael Nunes Melo, Fernanda Menezes Pereira, Matheus Alves Rocha, Jesica Gonçalves Ribeiro, Alexander Junges, Wesley Formentin Monteiro, Fernando Mendonça Diz, Rosane Angélica Ligabue, Fernanda Bueno Morrone, Patrícia Severino, Alini Tinoco Fricks. Chitosan and chitosan/PEG nanoparticles loaded with indole-3-carbinol: Characterization, computational study and potential effect on human bladder cancer cells. Materials science & engineering. C, Materials for biological applications. 2021 May; 124(?):112089. doi: 10.1016/j.msec.2021.112089. [PMID: 33947529]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Giuseppe Novelli, Jing Liu, Michela Biancolella, Tonino Alonzi, Antonio Novelli, J J Patten, Dario Cocciadiferro, Emanuele Agolini, Vito Luigi Colona, Barbara Rizzacasa, Rosalinda Giannini, Benedetta Bigio, Delia Goletti, Maria Rosaria Capobianchi, Sandro Grelli, Justin Mann, Trevor D McKee, Ke Cheng, Fatima Amanat, Florian Krammer, Andrea Guarracino, Gerardo Pepe, Carlo Tomino, Yacine Tandjaoui-Lambiotte, Yurdagul Uzunhan, Sarah Tubiana, Jade Ghosn, Luigi D Notarangelo, Helen C Su, Laurent Abel, Aurélie Cobat, Gai Elhanan, Joseph J Grzymski, Andrea Latini, Sachdev S Sidhu, Suresh Jain, Robert A Davey, Jean-Laurent Casanova, Wenyi Wei, Pier Paolo Pandolfi. Inhibition of HECT E3 ligases as potential therapy for COVID-19. Cell death & disease. 2021 03; 12(4):310. doi: 10.1038/s41419-021-03513-1. [PMID: 33762578]
  • Alin Finkelshtein, Hala Khamesa, Luu Anh Tuan, Manely Rabanim, Daniel A Chamovitz. Overexpression of the ribosomal S30 subunit leads to indole-3-carbinol tolerance in Arabidopsis thaliana. The Plant journal : for cell and molecular biology. 2021 02; 105(3):668-677. doi: 10.1111/tpj.15062. [PMID: 33128319]
  • Wen-Chung Liu, Pei-Hsuan Chen, Lee-Wei Chen. Supplementation of endogenous Ahr ligands reverses insulin resistance and associated inflammation in an insulin-dependent diabetic mouse model. The Journal of nutritional biochemistry. 2020 09; 83(?):108384. doi: 10.1016/j.jnutbio.2020.108384. [PMID: 32512500]
  • Xu Yu, Fei Ma, Liangxiao Zhang, Peiwu Li. Extraction and Quantification of Sulforaphane and Indole-3-Carbinol from Rapeseed Tissues Using QuEChERS Coupled with UHPLC-MS/MS. Molecules (Basel, Switzerland). 2020 May; 25(9):. doi: 10.3390/molecules25092149. [PMID: 32375365]
  • Suvesh Munakarmi, Lokendra Chand, Hyun Beak Shin, Kyu Yun Jang, Yeon Jun Jeong. Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress. International journal of molecular sciences. 2020 Mar; 21(6):. doi: 10.3390/ijms21062048. [PMID: 32192079]
  • Quan V Vo, Adam Mechler. In Silico Study of the Radical Scavenging Activities of Natural Indole-3-Carbinols. Journal of chemical information and modeling. 2020 01; 60(1):316-321. doi: 10.1021/acs.jcim.9b00917. [PMID: 31841629]
  • Philip B Busbee, Lorenzo Menzel, Haider Rasheed Alrafas, Nicholas Dopkins, William Becker, Kathryn Miranda, Chaunbing Tang, Saurabh Chatterjee, Udai Singh, Mitzi Nagarkatti, Prakash S Nagarkatti. Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22-dependent manner. JCI insight. 2020 01; 5(1):. doi: 10.1172/jci.insight.127551. [PMID: 31941837]
  • El-Sayed H Bakr, Mona A El-Yamany. Chemical and Nutraceutical Studies on Infertility of Albino Rats Induced by Cadmium Chloride. Pakistan journal of biological sciences : PJBS. 2020 Jan; 23(10):1245-1252. doi: 10.3923/pjbs.2020.1245.1252. [PMID: 32981257]
  • Carolynn Cairns, Bryan Conway. Modeling Human Diabetic Kidney Disease by Combining Hyperglycemia and Hypertension in a Transgenic Rodent Model. Methods in molecular biology (Clifton, N.J.). 2020; 2067(?):41-52. doi: 10.1007/978-1-4939-9841-8_4. [PMID: 31701444]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jing-Ru Weng, Tse-Hung Huang, Zih-Chan Lin, Ahmed Alalaiwe, Jia-You Fang. Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, mitigates psoriasiform lesion by blocking MAPK/NF-κB/AP-1 activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Nov; 119(?):109398. doi: 10.1016/j.biopha.2019.109398. [PMID: 31493747]
  • Kyle M Brawner, Venkata A Yeramilli, Lennard W Duck, William Van Der Pol, Lesley E Smythies, Casey D Morrow, Charles O Elson, Colin A Martin. Depletion of dietary aryl hydrocarbon receptor ligands alters microbiota composition and function. Scientific reports. 2019 10; 9(1):14724. doi: 10.1038/s41598-019-51194-w. [PMID: 31604984]
  • Yonghong Jiang, Gang Yang, Qingyao Liao, Yanke Zou, Yun Du, Jing Huang. Indole-3-carbinol inhibits lipid deposition and promotes autophagy in hyperlipidemia zebrafish larvae. Environmental toxicology and pharmacology. 2019 Aug; 70(?):103205. doi: 10.1016/j.etap.2019.103205. [PMID: 31195360]
  • Yu-Ru Lee, Ming Chen, Jonathan D Lee, Jinfang Zhang, Shu-Yu Lin, Tian-Min Fu, Hao Chen, Tomoki Ishikawa, Shang-Yin Chiang, Jesse Katon, Yang Zhang, Yulia V Shulga, Assaf C Bester, Jacqueline Fung, Emanuele Monteleone, Lixin Wan, Chen Shen, Chih-Hung Hsu, Antonella Papa, John G Clohessy, Julie Teruya-Feldstein, Suresh Jain, Hao Wu, Lydia Matesic, Ruey-Hwa Chen, Wenyi Wei, Pier Paolo Pandolfi. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science (New York, N.Y.). 2019 05; 364(6441):. doi: 10.1126/science.aau0159. [PMID: 31097636]
  • Mari N Willeman, Monica K Chawla, Marc A Zempare, Lauren A Biwer, Lan T Hoang, Ajay R Uprety, Megan C Fitzhugh, Matthew De Both, Paul D Coleman, Theodore P Trouard, Gene E Alexander, Kenneth D Mitchell, Carol A Barnes, Taben M Hale, Matthew Huentelman. Gradual hypertension induction in middle-aged Cyp1a1-Ren2 transgenic rats produces significant impairments in spatial learning. Physiological reports. 2019 03; 7(6):e14010. doi: 10.14814/phy2.14010. [PMID: 30916484]
  • Yanbei Wu, Robert W Li, Haiqiu Huang, Arnetta Fletcher, Lu Yu, Quynhchi Pham, Liangli Yu, Qiang He, Thomas T Y Wang. Inhibition of Tumor Growth by Dietary Indole-3-Carbinol in a Prostate Cancer Xenograft Model May Be Associated with Disrupted Gut Microbial Interactions. Nutrients. 2019 Feb; 11(2):. doi: 10.3390/nu11020467. [PMID: 30813350]
  • Hiba Hasan, Hanan Ismail, Youmna El-Orfali, Ghada Khawaja. Therapeutic benefits of Indole-3-Carbinol in adjuvant-induced arthritis and its protective effect against methotrexate induced-hepatic toxicity. BMC complementary and alternative medicine. 2018 Dec; 18(1):337. doi: 10.1186/s12906-018-2408-1. [PMID: 30567538]
  • Lenka Sedláková, Soňa Kikerlová, Zuzana Husková, Lenka Červenková, Věra Čertíková Chábová, Josef Zicha, John R Falck, John D Imig, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Vojtěch Krátký, Luděk Červenka, Libor Kopkan. 20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats. Bioscience reports. 2018 10; 38(5):. doi: 10.1042/bsr20171496. [PMID: 30054426]
  • Catherine J Leader, Barbara J Clark, Amber R Hannah, Ivan A Sammut, Gerard T Wilkins, Robert J Walker. Breeding Characteristics and Dose-dependent Blood Pressure Responses of Transgenic Cyp1a1-Ren2 Rats. Comparative medicine. 2018 10; 68(5):360-366. doi: 10.30802/aalas-cm-17-18000026. [PMID: 30185285]
  • Subhadip Hajra, Arup Ranjan Patra, Abhishek Basu, Prosenjit Saha, Sudin Bhattacharya. Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway. Chemico-biological interactions. 2018 Jun; 290(?):19-36. doi: 10.1016/j.cbi.2018.05.005. [PMID: 29775573]
  • Asunción Martín-Ruiz, Laura Peña, Alfredo González-Gil, Lucía Teresa Díez-Córdova, Sara Cáceres, Juan Carlos Illera. Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer. BMC cancer. 2018 Jun; 18(1):626. doi: 10.1186/s12885-018-4518-z. [PMID: 29866056]
  • Subhadip Hajra, Arup Ranjan Patra, Abhishek Basu, Sudin Bhattacharya. Prevention of doxorubicin (DOX)-induced genotoxicity and cardiotoxicity: Effect of plant derived small molecule indole-3-carbinol (I3C) on oxidative stress and inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 May; 101(?):228-243. doi: 10.1016/j.biopha.2018.02.088. [PMID: 29494960]
  • Youngshim Choi, Mohamed A Abdelmegeed, Byoung-Joon Song. Preventive effects of indole-3-carbinol against alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms: Role of gut-liver-adipose tissue axis. The Journal of nutritional biochemistry. 2018 05; 55(?):12-25. doi: 10.1016/j.jnutbio.2017.11.011. [PMID: 29331880]
  • Nelci A de Moura, Brunno F R Caetano, Leonardo N de Moraes, Robson F Carvalho, Maria A M Rodrigues, Luis F Barbisan. Enhancement of colon carcinogenesis by the combination of indole-3 carbinol and synbiotics in hemin-fed rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Feb; 112(?):11-18. doi: 10.1016/j.fct.2017.12.029. [PMID: 29269057]
  • Ada Popolo, Aldo Pinto, Maria Daglia, Seyed Fazel Nabavi, Ammad Ahmad Farooqi, Luca Rastrelli. Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor. Seminars in cancer biology. 2017 10; 46(?):132-137. doi: 10.1016/j.semcancer.2017.06.002. [PMID: 28596013]
  • Ella Katz, Daniel A Chamovitz. Wounding of Arabidopsis leaves induces indole-3-carbinol-dependent autophagy in roots of Arabidopsis thaliana. The Plant journal : for cell and molecular biology. 2017 Sep; 91(5):779-787. doi: 10.1111/tpj.13610. [PMID: 28621915]
  • Ahmed M Kabel, Aisha H Al-Shehri, Rehab A Al-Talhi, Maaly A Abd Elmaaboud. The promising effect of linagliptin and/or indole-3-carbinol on experimentally-induced polycystic ovarian syndrome. Chemico-biological interactions. 2017 Aug; 273(?):190-199. doi: 10.1016/j.cbi.2017.06.009. [PMID: 28619389]
  • Christiane Hammerschmidt-Kamper, Daniel Biljes, Katja Merches, Irina Steiner, Thomas Daldrup, Marianne Bol-Schoenmakers, Raymond H H Pieters, Charlotte Esser. Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice. PloS one. 2017; 12(6):e0180321. doi: 10.1371/journal.pone.0180321. [PMID: 28666018]
  • Šárka Jíchová, Šárka Doleželová, Libor Kopkan, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Luděk Červenka. Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats. The American journal of the medical sciences. 2016 Dec; 352(6):618-630. doi: 10.1016/j.amjms.2016.09.008. [PMID: 27916218]
  • Albert S Chang, Ruriko Grant, Hirofumi Tomita, Hyung-Suk Kim, Oliver Smithies, Masao Kakoki. Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 2016 11; 113(44):12538-12543. doi: 10.1073/pnas.1615051113. [PMID: 27791173]
  • Šárka Jíchová, Libor Kopkan, Zuzana Husková, Šárka Doleželová, Jan Neckář, Petr Kujal, Zdenka Vernerová, Herbert J Kramer, Janusz Sadowski, Elzbieta Kompanowska-Jezierska, Rami N Reddy, John R Falck, John D Imig, Luděk Červenka. Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats. Journal of hypertension. 2016 10; 34(10):2008-25. doi: 10.1097/hjh.0000000000001029. [PMID: 27428043]
  • Jae Kyeom Kim, Daniel D Gallaher, Chi Chen, Cynthia M Gallaher, Dan Yao, Sabrina P Trudo. Phenethyl isothiocyanate and indole-3-carbinol from cruciferous vegetables, but not furanocoumarins from apiaceous vegetables, reduced PhIP-induced DNA adducts in Wistar rats. Molecular nutrition & food research. 2016 09; 60(9):1956-66. doi: 10.1002/mnfr.201500790. [PMID: 27133590]
  • C G Mao, L J Wan, X C Zhou, H T Lu, Y D Jiang, Z Z Tao. [Study on Indole-3-carbinol inhibits nasopharyngeal carcinoma cells growth in vitra and in vivo]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. 2016 Aug; 30(15):1215-1218. doi: 10.13201/j.issn.1001-1781.2016.15.009. [PMID: 29798332]
  • Mei-Lin Wang, Shyh-Hsiang Lin, Yuan-Yu Hou, Yue-Hwa Chen. Suppression of Lipid Accumulation by Indole-3-Carbinol Is Associated with Increased Expression of the Aryl Hydrocarbon Receptor and CYP1B1 Proteins in Adipocytes and with Decreased Adipocyte-Stimulated Endothelial Tube Formation. International journal of molecular sciences. 2016 Aug; 17(8):. doi: 10.3390/ijms17081256. [PMID: 27527145]
  • Reem N El-Naga, Yasmen F Mahran. Indole-3-carbinol protects against cisplatin-induced acute nephrotoxicity: role of calcitonin gene-related peptide and insulin-like growth factor-1. Scientific reports. 2016 07; 6(?):29857. doi: 10.1038/srep29857. [PMID: 27417335]
  • Naomi Fujioka, Vincent Fritz, Pramod Upadhyaya, Fekadu Kassie, Stephen S Hecht. Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg. Molecular nutrition & food research. 2016 06; 60(6):1228-38. doi: 10.1002/mnfr.201500889. [PMID: 26840393]
  • Kris G Hargraves, Lin He, Gary L Firestone. Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells. Molecular carcinogenesis. 2016 May; 55(5):486-98. doi: 10.1002/mc.22296. [PMID: 25789847]
  • Almokhtar A Adwas, Abeer A Elkhoely, Ahmed M Kabel, Mohamed Nabih Abdel-Rahman, Amany A Eissa. Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2016 Jan; 22(1):36-43. doi: 10.1016/j.jiac.2015.10.001. [PMID: 26603425]
  • Ella Katz, Sophia Nisani, Brijesh S Yadav, Melkamu G Woldemariam, Ben Shai, Uri Obolski, Marcelo Ehrlich, Eilon Shani, Georg Jander, Daniel A Chamovitz. The glucosinolate breakdown product indole-3-carbinol acts as an auxin antagonist in roots of Arabidopsis thaliana. The Plant journal : for cell and molecular biology. 2015 May; 82(4):547-55. doi: 10.1111/tpj.12824. [PMID: 25758811]
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  • Ella Katz, Sophia Nisani, Mor Sela, Hila Behar, Daniel A Chamovitz. The effect of indole-3-carbinol on PIN1 and PIN2 in Arabidopsis roots. Plant signaling & behavior. 2015; 10(9):e1062200. doi: 10.1080/15592324.2015.1062200. [PMID: 26252364]
  • Alexandra Sporková, Sárka Jíchová, Zuzana Husková, Libor Kopkan, Akira Nishiyama, Sung H Hwang, Bruce D Hammock, John D Imig, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Herbert J Kramer, Luděk Cervenka. Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. Clinical and experimental pharmacology & physiology. 2014 Dec; 41(12):1003-13. doi: 10.1111/1440-1681.12310. [PMID: 25224811]
  • Bryan R Conway, Boris Betz, Tara A Sheldrake, Jonathan R Manning, Donald R Dunbar, Abigail Dobyns, Jeremy Hughes, John J Mullins. Tight blood glycaemic and blood pressure control in experimental diabetic nephropathy reduces extracellular matrix production without regression of fibrosis. Nephrology (Carlton, Vic.). 2014 Dec; 19(12):802-13. doi: 10.1111/nep.12335. [PMID: 25196678]
  • Hyeon-Son Choi, Hui-Jeon Jeon, Ok-Hwan Lee, Boo-Yong Lee. Indole-3-carbinol, a vegetable phytochemical, inhibits adipogenesis by regulating cell cycle and AMPKα signaling. Biochimie. 2014 Sep; 104(?):127-36. doi: 10.1016/j.biochi.2014.06.010. [PMID: 24952351]
  • Reem N El-Naga, Hebatalla I Ahmed, Ekram N Abd Al Haleem. Effects of indole-3-carbinol on clonidine-induced neurotoxicity in rats: Impact on oxidative stress, inflammation, apoptosis and monoamine levels. Neurotoxicology. 2014 Sep; 44(?):48-57. doi: 10.1016/j.neuro.2014.05.004. [PMID: 24877722]
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