Vidarabine (BioDeep_00000033205)

 

Secondary id: BioDeep_00000593218

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


(2R,3S,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

化学式: C10H13N5O4 (267.09674980000005)
中文名称: 阿糖腺苷
谱图信息: 最多检出来源 Mus musculus(plant) 7.03%

分子结构信息

SMILES: C([C@@H]1[C@H]([C@@H]([C@H](n2cnc3c(N)ncnc23)O1)O)O)O
InChI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7+,10-/m1/s1

描述信息

A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccinia VIRUS and varicella zoster virus. [PubChem]
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AB - Nucleosides and nucleotides excl. reverse transcriptase inhibitors
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AD - Antivirals
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C471 - Enzyme Inhibitor > C29575 - DNA Polymerase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
D009676 - Noxae > D000963 - Antimetabolites
Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses[1][2]. Vidarabine has IC50s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2[2]. Vidarabine also has anti-orthopoxvirus activity[3].
Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses[1][2]. Vidarabine has IC50s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2[2]. Vidarabine also has anti-orthopoxvirus activity[3].
Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses[1][2]. Vidarabine has IC50s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2[2]. Vidarabine also has anti-orthopoxvirus activity[3].

同义名列表

40 个代谢物同义名

(2R,3S,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 2-(6-AMINO-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol; 9-beta-D-Arabinofuranosyl-9H-purin-6-amine; 9-Β-D-arabinofuranosyl-9H-purin-6-amine; 9-b-D-Arabinofuranosyl-9H-purin-6-amine; 9-beta-D-Arabinofuranosyl-adenine; 9 beta D Arabinofuranosyladenine; 9-beta-D-Arabinofuranosyladenine; Parke davis brand OF vidarabine; alpha D Arabinofuranosyladenine; alpha-D-Arabinofuranosyladenine; 9-beta-Arabinofuranosyladenine; 9 beta Arabinofuranosyladenine; 9-b-D-Arabinofuranosyladenine; 9-Β-D-arabinofuranosyladenine; Monarch brand OF vidarabine; Arabinofuranosyladenine; Arabinoside, adenine; Vidarabine anhydrous; Adenine arabinoside; Arabinoside adenine; Arabinosyl adenine; Arabinosyladenine; Spongoadenosine; a, alpha-Ara; Araadenosine; alpha Ara a; a, beta-Ara; alpha-Ara a; Vidarabine; beta-Ara a; beta Ara a; Ara-ATP; a, Ara; Vira-a; Vira a; Ara a; Armes; ARA-a; ViraA



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

36 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jade L Kutzke, Julianna A Merten, Amanda G Pawlenty, Erin F Barreto, Gabe T Bartoo, Kristin C Mara, Mark R Litzow, William J Hogan, Mithun V Shah, Abhishek A Mangaonkar, Nelson Leung, Hassan B Alkhateeb. Relationship of iothalamate clearance and NRM in patients receiving fludarabine and melphalan reduced-intensity conditioning. Blood advances. 2022 07; 6(13):3844-3849. doi: 10.1182/bloodadvances.2021006395. [PMID: 35522968]
  • Jianyuan Zhao, Qian Liu, Dongrong Yi, Quanjie Li, SaiSai Guo, Ling Ma, Yongxin Zhang, Dongxin Dong, Fei Guo, Zhenlong Liu, Tao Wei, Xiaoyu Li, Shan Cen. 5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis. Antiviral research. 2022 02; 198(?):105254. doi: 10.1016/j.antiviral.2022.105254. [PMID: 35101534]
  • Guoxing Zhao, Runhong Wei, Lei Feng, Yi Wu, Feng He, Mingxing Xiao, Zhi Cheng. Lenalidomide enhances the efficacy of anti-BCMA CAR-T treatment in relapsed/refractory multiple myeloma: a case report and revies of the literature. Cancer immunology, immunotherapy : CII. 2022 Jan; 71(1):39-44. doi: 10.1007/s00262-021-02959-8. [PMID: 34003300]
  • Anne Laure Gagez, Franciane Paul, Elina Alaterre, Valérie Gouilleux-Gruart, Edouard Tuaillon, Stéphane Lepretre, David Ternant, Rémi Letestu, Jérôme Moreaux, Guillaume Cartron. Angiogenic factors could help us to define patients obtaining complete response with undetectable minimal residual disease in untreated CLL patients treated by FCR: results from the CLL2010FMP, a FILO study. Leukemia & lymphoma. 2021 12; 62(13):3160-3169. doi: 10.1080/10428194.2021.1955879. [PMID: 34806520]
  • Ibrahim H Eissa, Mohamed M Khalifa, Eslam B Elkaeed, Elsayed E Hafez, Aisha A Alsfouk, Ahmed M Metwaly. In Silico Exploration of Potential Natural Inhibitors against SARS-Cov-2 nsp10. Molecules (Basel, Switzerland). 2021 Oct; 26(20):. doi: 10.3390/molecules26206151. [PMID: 34684735]
  • Huiqing Xiu, Jiali Gong, Tiancha Huang, Yanmei Peng, Songjie Bai, Guirun Xiong, Shufang Zhang, Huaqiong Huang, Zhijian Cai, Gensheng Zhang. Fludarabine inhibits type I interferon-induced expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2. Cellular & molecular immunology. 2021 07; 18(7):1829-1831. doi: 10.1038/s41423-021-00698-5. [PMID: 34059790]
  • Abraham Nissani, Shaked Lev-Ari, Tomer Meirson, Elad Jacoby, Nethanel Asher, Guy Ben-Betzalel, Orit Itzhaki, Ronnie Shapira-Frommer, Jacob Schachter, Gal Markel, Michal J Besser. Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy. Journal for immunotherapy of cancer. 2021 05; 9(5):. doi: 10.1136/jitc-2020-001743. [PMID: 33990415]
  • Raheel Iftikhar, Qamar Un Nisa Chaudhry, Faiz Anwer, Karun Neupane, Abdul Rafae, Syed Kamran Mahmood, Tariq Ghafoor, Nighat Shahbaz, Mehreen Ali Khan, Tariq Azam Khattak, Ghassan Umair Shamshad, Jahanzeb Rehman, Muhammad Farhan, Maryam Khan, Iqraa Ansar, Rabia Ashraf, Judith Marsh, Tariq Mehmood Satti, Parvez Ahmed. Allogeneic hematopoietic stem cell transplantation in aplastic anemia: current indications and transplant strategies. Blood reviews. 2021 05; 47(?):100772. doi: 10.1016/j.blre.2020.100772. [PMID: 33187812]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Qin Yang, Handong Ding, Wei Wei, Jie Liu, Jiajia Wang, Jie Ren, Weicheng Chan, Min Wang, Liang Hao, Jinle Li, Yuan Yue. Periodontitis aggravates kidney injury by upregulating STAT1 expression in a mouse model of hypertension. FEBS open bio. 2021 03; 11(3):880-889. doi: 10.1002/2211-5463.13081. [PMID: 33448153]
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  • Jeannine S McCune, Jožefa S McKiernan, Erik van Maarseveen, Alwin D R Huitema, Timothy W Randolph, H Joachim Deeg, Ryotaro Nakamura, K Scott Baker. Prediction of Acute Graft versus Host Disease and Relapse by Endogenous Metabolomic Compounds in Patients Receiving Personalized Busulfan-Based Conditioning. Journal of proteome research. 2021 01; 20(1):684-694. doi: 10.1021/acs.jproteome.0c00599. [PMID: 33064008]
  • Taku Kikuchi, Takehiko Mori, Chikako Ohwada, Masahiro Onoda, Hiroaki Shimizu, Hiroki Yokoyama, Makoto Onizuka, Yuya Koda, Jun Kato, Yusuke Takeda, Yutaro Hino, Tatsuzo Mishina, Emiko Sakaida, Katsuhiro Shono, Yuhei Nagao, Akira Yokota, Kana Matsumoto, Kunihiko Morita, Shinichiro Okamoto. Pharmacokinetics of intravenous busulfan as condition for hematopoietic stem cell transplantation: comparison between combinations with cyclophosphamide and fludarabine. International journal of hematology. 2021 Jan; 113(1):128-133. doi: 10.1007/s12185-020-02990-y. [PMID: 32886279]
  • Rhys Williams, Dima El-Sharkawi, Andrew Stewart. Systemic capillary leak syndrome: a rare but potentially life-threatening cause of protein loss and oedema in B cell prolymphocytic leukaemia. BMJ case reports. 2020 Dec; 13(12):. doi: 10.1136/bcr-2020-237939. [PMID: 33370989]
  • Osman Mutluhan Ugurel, Ozal Mutlu, Emrah Sariyer, Sinem Kocer, Erennur Ugurel, Tugba Gul Inci, Oguz Ata, Dilek Turgut-Balik. Evaluation of the potency of FDA-approved drugs on wild type and mutant SARS-CoV-2 helicase (Nsp13). International journal of biological macromolecules. 2020 Nov; 163(?):1687-1696. doi: 10.1016/j.ijbiomac.2020.09.138. [PMID: 32980406]
  • Alison Leiper, Maite Houwing, E Graham Davies, Kanchan Rao, Siobhan Burns, Emma Morris, Joop Laven, Anne-Lotte van der Kooi, Marry van den Heuvel Eibrink, Stephen Nussey. Anti-Müllerian hormone and Inhibin B after stem cell transplant in childhood: a comparison of myeloablative, reduced intensity and treosulfan-based chemotherapy regimens. Bone marrow transplantation. 2020 10; 55(10):1985-1995. doi: 10.1038/s41409-020-0866-9. [PMID: 32231250]
  • Sung-Eun Lee, Gi June Min, Sung-Soo Park, Silvia Park, Jae-Ho Yoon, Seung Hwan Shin, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Chang-Ki Min, Hee-Je Kim, Seok-Goo Cho, Jong Wook Lee. Outcomes of Haploidentical Stem Cell Transplantation using Total Body Irradiation (600 cGy) and Fludarabine with Antithymocyte Globulin in Adult Patients with Severe Aplastic Anemia: A Prospective Phase II Study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2020 10; 26(10):1906-1914. doi: 10.1016/j.bbmt.2020.06.024. [PMID: 32634577]
  • Lei Cao, Fei Wang, Xin-Yi Du, Hua-Yuan Zhu, Li Wang, Wei Xu, Jian-Yong Li, Lei Fan. Chronic lymphocytic leukemia-associated paraneoplastic pemphigus: potential cause and therapeutic strategies. Scientific reports. 2020 10; 10(1):16357. doi: 10.1038/s41598-020-73131-y. [PMID: 33004832]
  • Carmen D Herling, Florence Cymbalista, Carolin Groß-Ophoff-Müller, Jasmin Bahlo, Sandra Robrecht, Petra Langerbeins, Anna-Maria Fink, Othman Al-Sawaf, Raymonde Busch, Raphael Porcher, Bruno Cazin, Brigitte Dreyfus, Stefan Ibach, Stéphane Leprêtre, Kirsten Fischer, Florian Kaiser, Barbara Eichhorst, Clemens-Martin Wentner, Manuela A Hoechstetter, Hartmut Döhner, Veronique Leblond, Michael Kneba, Remi Letestu, Sebastian Böttcher, Stephan Stilgenbauer, Michael Hallek, Vincent Levy. Early treatment with FCR versus watch and wait in patients with stage Binet A high-risk chronic lymphocytic leukemia (CLL): a randomized phase 3 trial. Leukemia. 2020 08; 34(8):2038-2050. doi: 10.1038/s41375-020-0747-7. [PMID: 32071431]
  • Sigbjørn Berentsen, Wilma Barcellini, Shirley D'Sa, Ulla Randen, Tor Henrik Anderson Tvedt, Bruno Fattizzo, Einar Haukås, Megan Kell, Robert Brudevold, Anders E A Dahm, Jakob Dalgaard, Hege Frøen, Randi Fykse Hallstensen, Pernille H Jæger, Henrik Hjorth-Hansen, Agnieszka Małecka, Markku Oksman, Jürgen Rolke, Mallika Sekhar, Jon Hjalmar Sørbø, Eirik Tjønnfjord, Galina Tsykunova, Geir E Tjønnfjord. Cold agglutinin disease revisited: a multinational, observational study of 232 patients. Blood. 2020 07; 136(4):480-488. doi: 10.1182/blood.2020005674. [PMID: 32374875]
  • Eric P Allain, Michèle Rouleau, Katrina Vanura, Sophie Tremblay, Joanie Vaillancourt, Vincent Bat, Patrick Caron, Lyne Villeneuve, Adrien Labriet, Véronique Turcotte, Trang Le, Medhat Shehata, Susanne Schnabl, Dita Demirtas, Rainer Hubmann, Charles Joly-Beauparlant, Arnaud Droit, Ulrich Jäger, Philipp B Staber, Eric Lévesque, Chantal Guillemette. UGT2B17 modifies drug response in chronic lymphocytic leukaemia. British journal of cancer. 2020 07; 123(2):240-251. doi: 10.1038/s41416-020-0887-6. [PMID: 32418995]
  • XiaoLe Han, Hao Hao, QingYu Li, ChenYin Liu, JiaWen Lei, Fan Yu, Ke Chen, Yi Liu, Tao Huang. The interaction mechanism between fludarabine and human serum albumin researched by comprehensive spectroscopic methods and molecular docking technique. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Jun; 233(?):118170. doi: 10.1016/j.saa.2020.118170. [PMID: 32143170]
  • Aleksandar Radujkovic, Ute Hegenbart, Carsten Müller-Tidow, Klaus Herfarth, Peter Dreger, Thomas Luft. High leukemia-free survival after TBI-based conditioning and mycophenolate mofetil-containing immunosuppression in patients allografted for chronic myelomonocytic leukemia: a single-center experience. Annals of hematology. 2020 Apr; 99(4):855-866. doi: 10.1007/s00277-020-03952-4. [PMID: 32036420]
  • Shinichi Kako, Yoshinobu Kanda, Makoto Onizuka, Nobuyuki Aotsuka, Kensuke Usuki, Takayoshi Tachibana, Takeshi Kobayashi, Jun Kato, Shingo Yano, Hiroaki Shimizu, Katsuhiro Shono, Masatsugu Tanaka, Shokichi Tsukamoto, Takehiko Mori, Etsuko Yamazaki, Yuho Najima, Akira Hangaishi, Takumi Hoshino, Reiko Watanabe, Kenji Matsumoto, Shinichiro Okamoto. Allogeneic hematopoietic stem cell transplantation for aplastic anemia with pre-transplant conditioning using fludarabine, reduced-dose cyclophosphamide, and low-dose thymoglobulin: A KSGCT prospective study. American journal of hematology. 2020 03; 95(3):251-257. doi: 10.1002/ajh.25693. [PMID: 31804748]
  • Adrian Martuszewski, Patrycja Paluszkiewicz, Katarzyna Sierżęga-Staykov, Elżbieta Wawrzyniak-Dzierżek, Małgorzata Salamonowicz-Bodzioch, Jowita Frączkiewicz, Małgorzata Janeczko-Czarnecka, Monika Mielcarek-Siedziuk, Mateusz Nowak, Nel Dąbrowska-Leonik, Beata Wolska-Kuśnierz, Katarzyna Gul, Katarzyna Bąbol-Pokora, Wojciech Młynarski, Krzysztof Kałwak, Marek Ussowicz. Successful Allogeneic Stem Cell Transplantation in Nuclear Factor-Kappa B Essential Modulator Deficiency Syndrome After Treosulfan-Based Conditioning: A Case Report. Transplantation proceedings. 2020 Mar; 52(2):647-652. doi: 10.1016/j.transproceed.2019.11.033. [PMID: 32035679]
  • Jagdeep T Podichetty, Bryan J Brinda, Robert P Nelson, Alissa H Karr, Nagendra K Prasad, Sara Quinney, Susanna Foxworthy Scott, Patrick J Kiel. Pharmacokinetics of Basiliximab for the Prevention of Graft-versus-Host Disease in Patients Undergoing Hematopoietic Cell Transplantation with Minimal-Intensity Cyclophosphamide and Fludarabine. Pharmacotherapy. 2020 01; 40(1):26-32. doi: 10.1002/phar.2347. [PMID: 31742732]
  • D Amicizia, R T Micale, B M Pennati, F Zangrillo, M Iovine, E Lecini, F Marchini, P L Lai, D Panatto. Burden of typhoid fever and cholera: similarities and differences. Prevention strategies for European travelers to endemic/epidemic areas. Journal of preventive medicine and hygiene. 2019 Dec; 60(4):E271-E285. doi: 10.15167/2421-4248/jpmh2019.60.4.1333. [PMID: 31967084]
  • Philip A Thompson, Jaya Srivastava, Christine Peterson, Paolo Strati, Jeffrey L Jorgensen, Tyler Hether, Michael J Keating, Susan M O'Brien, Alessandra Ferrajoli, Jan A Burger, Zeev Estrov, Nitin Jain, William G Wierda. Minimal residual disease undetectable by next-generation sequencing predicts improved outcome in CLL after chemoimmunotherapy. Blood. 2019 11; 134(22):1951-1959. doi: 10.1182/blood.2019001077. [PMID: 31537528]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Zheng-Ping Yu, Jia-Hua Ding, Ai-Ning Sun, Bao-An Chen, Zheng Ge, De-Pei Wu. A New Conditioning Regimen Can Significantly Promote Post-Transplant Immune Reconstitution and Improve the Outcome of Umbilical Cord Blood Transplantation for Patients. Stem cells and development. 2019 10; 28(20):1376-1383. doi: 10.1089/scd.2019.0139. [PMID: 31464164]
  • Lan Sun, Na Wang, Yi Chen, Liyuan Tang, Chongyun Xing, Nina Lu, Yifen Shi, Yongyong Ma, Fengyang Lin, Kang Yu, Jianhua Feng. Unrelated Donor Peripheral Blood Stem Cell Transplantation for Patients with β-Thalassemia Major Based on a Novel Conditioning Regimen. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2019 08; 25(8):1592-1596. doi: 10.1016/j.bbmt.2019.03.028. [PMID: 30951841]
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  • Daniel Wegener, Peter Lang, Frank Paulsen, Nicola Weidner, Daniel Zips, Martin Ebinger, Ursula Holzer, Michaela Döring, Oliver Basu, Bernd Gruhn, Andrea Wittig, Heiko-Manuel Teltschik, Rupert Handgretinger, Frank Heinzelmann. Immunosuppressive Total Nodal Irradiation-Based Reconditioning Regimens After Graft Rejection or Graft Failure in Pediatric Patients Treated With Myeloablative Allogeneic Hematopoietic Cell Transplantation. International journal of radiation oncology, biology, physics. 2019 05; 104(1):137-143. doi: 10.1016/j.ijrobp.2018.12.031. [PMID: 30593907]
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  • Mohamad Fekredeen Ayas, Amal Al-Seraihi, Amal Al-Agil, Ali Al-Ahmari, Ibrahim Ghemlas, Mouhab Ayas. Successful hematopoietic cell transplantation in Fanconi anemia patients with renal impairment using ultra-reduced doses of cyclophosphamide and fludarabine. Pediatric blood & cancer. 2018 12; 65(12):e27371. doi: 10.1002/pbc.27371. [PMID: 30070008]
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