Demethylnobiletin (BioDeep_00000270090)

PANOMIX_OTCML-2023 natural product

代谢物信息卡片

2- (3,4-Dimethoxyphenyl) -5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one

化学式: C20H20O8 (388.115812)
中文名称: 去甲基川陈皮素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c(c1)c(OC)c(cc1C(O3)=CC(c(c32)c(c(c(c(OC)2)OC)OC)O)=O)OC
InChI: InChI=1S/C20H20O8/c1-23-12-7-6-10(8-14(12)24-2)13-9-11(21)15-16(22)18(25-3)20(27-5)19(26-4)17(15)28-13/h6-9,22H,1-5H3

描述信息

5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].
5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].
5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].

同义名列表

6 个代谢物同义名

5-hydroxy-6,7,8,3,4-pentamethoxyflavone; Demethylnobiletin; 2- (3,4-Dimethoxyphenyl) -5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one; 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one; 5-O-Demethylnobiletin; 5-Demethylnobiletin

数据库引用编号

6 个数据库交叉引用编号

Metlin: METLIN49901
KNApSAcK: C00003936
CAS: 2174-59-6
Flavonoid: FL3FGCNS0012
medchemexpress: HY-N1942
LOTUS: LTS0209649

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

79 个相关的物种来源信息

4210 - Asteraceae: LTS0209649
41487 - Baccharis: LTS0209649
2707836 - Baccharis thymifolia: 10.1016/S0031-9422(00)84587-2
2707836 - Baccharis thymifolia: LTS0209649
2706 - Citrus: 10.1016/S0040-4020(01)93331-9
2706 - Citrus: LTS0209649
43166 - Citrus aurantium: 10.1016/S0040-4020(01)93331-9
43166 - Citrus aurantium: 10.1248/CPB.41.714
697036 - Citrus depressa: 10.1248/CPB.35.3025
697036 - Citrus depressa: LTS0209649
76966 - Citrus japonica: 10.1016/J.BMC.2008.11.039
76966 - Citrus japonica: 10.1021/JF000100O
76966 - Citrus japonica: 10.1248/CPB.49.1356
76966 - Citrus japonica: LTS0209649
408488 - Citrus kinokuni: 10.1016/J.BMC.2008.11.039
408488 - Citrus kinokuni: 10.1248/CPB.49.1356
408488 - Citrus kinokuni: LTS0209649
171249 - Citrus limonia: LTS0209649
1603710 - Citrus madurensis: 10.1021/JF000100O
1603710 - Citrus madurensis: LTS0209649
85571 - Citrus reticulata: 10.1007/BF00599010
85571 - Citrus reticulata: 10.1007/BF02975340
85571 - Citrus reticulata: 10.1016/J.BSE.2016.02.031
85571 - Citrus reticulata: 10.1021/JF970606F
85571 - Citrus reticulata: 10.1248/CPB.28.717
85571 - Citrus reticulata: 10.1248/CPB.35.3025
85571 - Citrus reticulata: 10.1248/CPB.41.714
85571 - Citrus reticulata: 10.1248/YAKUSHI1947.111.3_193
85571 - Citrus reticulata: 10.1515/ZNC-2000-11-1230
85571 - Citrus reticulata: LTS0209649
2711 - Citrus sinensis: 10.1016/S0278-6915(01)00058-8
2711 - Citrus sinensis: LTS0209649
237575 - Citrus tangerina: 10.1021/JF960110I
237575 - Citrus tangerina: LTS0209649
55188 - Citrus unshiu: 10.1007/BF00599010
55188 - Citrus unshiu: 10.1007/BF02975340
55188 - Citrus unshiu: 10.1248/YAKUSHI1947.111.3_193
55188 - Citrus unshiu: LTS0209649
182371 - Clinopodium: LTS0209649
2759 - Eukaryota: LTS0209649
616993 - Heteropappus: LTS0209649
4136 - Lamiaceae: LTS0209649
3398 - Magnoliopsida: LTS0209649
21819 - Mentha: LTS0209649
294739 - Mentha pulegium: 10.1016/0305-1978(91)90088-H
294739 - Mentha pulegium: LTS0209649
29719 - Mentha spicata: 10.1016/S0031-9422(97)01112-6
29719 - Mentha spicata: 10.1016/S0031-9422(98)00672-4
29719 - Mentha spicata: LTS0209649
34256 - Mentha × piperita: 10.1016/0031-9422(84)83060-5
34256 - Mentha × piperita: 10.1016/0031-9422(92)83268-4
34256 - Mentha × piperita: 10.1016/0305-1978(94)90119-8
43710 - Murraya: LTS0209649
43711 - Murraya paniculata: 10.1016/0031-9422(96)00058-1
43711 - Murraya paniculata: LTS0209649
39173 - Ocimum: LTS0209649
204141 - Ocimum americanum: 10.1016/S0031-9422(00)00439-8
204141 - Ocimum americanum: LTS0209649
112378 - Oedera: LTS0209649
4033 - Oxalidaceae: LTS0209649
4034 - Oxalis: LTS0209649
53809 - Oxalis pes-caprae: 10.1002/CBDV.200800179
53809 - Oxalis pes-caprae: LTS0209649
33090 - Plants: -
112392 - Relhania: LTS0209649
1973297 - Relhania corymbosa: 10.1016/0031-9422(90)80181-F
1973297 - Relhania corymbosa: LTS0209649
23513 - Rutaceae: LTS0209649
155231 - Sideritis: LTS0209649
155267 - Sideritis tragoriganum: 10.1016/0031-9422(88)80607-1
155267 - Sideritis tragoriganum: 10.1055/S-2007-969399
155267 - Sideritis tragoriganum: LTS0209649
53171 - Stachys: LTS0209649
1391947 - Stachys aegyptiaca: 10.1016/S0031-9422(00)95197-5
1391947 - Stachys aegyptiaca: LTS0209649
35493 - Streptophyta: LTS0209649
99105 - Tanacetum: LTS0209649
58023 - Tracheophyta: LTS0209649
33090 - Viridiplantae: LTS0209649

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。