Ombuin (BioDeep_00000266239)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


4H-1-Benzopyran-4-one, 3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-

化学式: C17H14O7 (330.0739)
中文名称: 商陆黄素, 商陆素
谱图信息: 最多检出来源 Viridiplantae(plant) 72.28%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(c(c2=O)O)c1ccc(c(c1)O)OC)O)OC
InChI: InChI=1S/C17H14O7/c1-22-9-6-11(19)14-13(7-9)24-17(16(21)15(14)20)8-3-4-12(23-2)10(18)5-8/h3-7,18-19,21H,1-2H3

描述信息

Ombuin is a dimethoxyflavone that is quercetin in which the hydroxy groups at positions 7 and 4 are replaced by methoxy groups. Isolated from Cyperus teneriffae, it exhibits anti-inflammatory activity. It has a role as an anti-inflammatory agent and a plant metabolite. It is a trihydroxyflavone, a member of flavonols and a dimethoxyflavone. It is functionally related to a quercetin. It is a conjugate acid of a 7,4-O-dimethylquercetin 3-olate.
Ombuin is a natural product found in Chromolaena odorata, Clausena dunniana, and other organisms with data available.
A dimethoxyflavone that is quercetin in which the hydroxy groups at positions 7 and 4 are replaced by methoxy groups. Isolated from Cyperus teneriffae, it exhibits anti-inflammatory activity.
Ombuin, isolated from Zanthoxylum armatum, displays broad spectrum antibacterial effect with MIC ranges from 125 to 500 μg/mL[1].
Ombuin, isolated from Zanthoxylum armatum, displays broad spectrum antibacterial effect with MIC ranges from 125 to 500 μg/mL[1].

同义名列表

31 个代谢物同义名

4H-1-Benzopyran-4-one, 3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-; 3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one; 3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-chromen-4-one; 3,5-Dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-methoxy-chromen-4-one; 3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxychromen-4-one; 5-18-05-00498 (Beilstein Handbook Reference); FLAVONE, 4,7-DIMETHOXY-3,3,5-TRIHYDROXY-; 3,5,3-Trihydroxy-7,4-dimethoxyflavone; 4,7-Dimethoxy-3,3,5-trihydroxyflavone; Quercetin 4,7-dimethyl ether; quercetin-7,4-dimethyl ether; quercetin 7,4-dimethyl ether; kaempferol-7,4-dimethylether; Quercetin-7,4-Dimethyl Ether; DI-O-METHYLQUERCETIN, 7,4-; 7,4-Di-O-methylquercetin; 4,7-Dimethylquercetin; 7,4-dimethylquercetin; 4,7-dimethylquercetin; UNII-Z3K3F0YR3W; Z3K3F0YR3W; ombuine; Ombuin; 3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4-chromenone; 3,5-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-methoxy-chromone; BRN 0338215; AIDS-071739; AIDS071739; NSC675952; 529-40-8; 3,5-Dihydroxy-2- (3-hydroxy-4-methoxyphenyl) -7-methoxy-4H-1-benzopyran-4-one



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

12 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(11)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

60 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Elke H Heiss, Thi Van Anh Tran, Kristin Zimmermann, Stefan Schwaiger, Corina Vouk, Barbara Mayerhofer, Clemens Malainer, Atanas G Atanasov, Hermann Stuppner, Verena M Dirsch. Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata. Journal of natural products. 2014 Mar; 77(3):503-8. doi: 10.1021/np400778m. [PMID: 24476568]
  • Mastura Abd Malek, Minh-Hien Hoang, Yaoyao Jia, Ji Hae Lee, Hee Jin Jun, Dong-Ho Lee, Hak Ju Lee, Chul Lee, Myung Koo Lee, Bang Yeon Hwang, Sung-Joon Lee. Ombuin-3-O-β-D-glucopyranoside from Gynostemma pentaphyllum is a dual agonistic ligand of peroxisome proliferator-activated receptors α and δ/β. Biochemical and biophysical research communications. 2013 Jan; 430(4):1322-8. doi: 10.1016/j.bbrc.2012.12.020. [PMID: 23247028]
  • Catheleeya Mekjaruskul, Michael Jay, Bungorn Sripanidkulchai. Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2342-53. doi: 10.1124/dmd.112.047142. [PMID: 22961680]
  • K Hoa Nguyen, T Nhan Ta, T Hong Minh Pham, Q Tien Nguyen, H Dien Pham, Suresh Mishra, B L Grégoire Nyomba. Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide. Journal of ethnopharmacology. 2012 Jul; 142(2):488-95. doi: 10.1016/j.jep.2012.05.024. [PMID: 22633982]
  • Patrick Grabher, Emilie Durieu, Eirini Kouloura, Maria Halabalaki, Leandros A Skaltsounis, Laurent Meijer, Matthias Hamburger, Olivier Potterat. Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts. Planta medica. 2012 Jun; 78(10):951-6. doi: 10.1055/s-0031-1298625. [PMID: 22673832]
  • Yerra Koteswara Rao, Shih-Hua Fang, Yew-Min Tzeng. Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from Bauhinia variegata. Phytotherapy research : PTR. 2008 Jul; 22(7):957-62. doi: 10.1002/ptr.2448. [PMID: 18384188]
  • R K Cimanga, K Kambu, L Tona, N Hermans, S Apers, J Totté, L Pieters, A J Vlietinck. Cytotoxicity and in vitro susceptibility of Entamoeba histolytica to Morinda morindoides leaf extracts and its isolated constituents. Journal of ethnopharmacology. 2006 Aug; 107(1):83-90. doi: 10.1016/j.jep.2006.02.010. [PMID: 16603327]
  • Jian Zhang, Qing-hai Guo, Ling-yi Kong. [Flavonoids from rhizome of Alpinia tonkinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2003 Jan; 28(1):41-3. doi: ". [PMID: 15015265]
  • K Cimanga, T De Bruyne, A Lasure, B Van Poel, L Pieters, D Vanden Berghe, A Vlietinck, K Kambu, L Tona. In vitro anticomplementary activity of constituents from Morinda morindoides. Journal of natural products. 1995 Mar; 58(3):372-8. doi: 10.1021/np50117a005. [PMID: 7775983]
  • . . . . doi: . [PMID: 21343428]