3-Hydroxybenzoicacid (BioDeep_00000265120)

Main id: BioDeep_00000001248

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


3-Hydroxybenzoic acid

化学式: C7H6O3 (138.03169259999999)
中文名称: 3-羟基苯甲酸, 间羟基苯甲酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC(=C1)O)C(=O)O
InChI: InChI=1S/C7H6O3/c8-6-3-1-2-5(4-6)7(9)10/h1-4,8H,(H,9,10)

描述信息

A monohydroxybenzoic acid that is benzoic acid substituted by a hydroxy group at position 3. It has been isolated from Taxus baccata. It is used as an intermediate in the synthesis of plasticisers, resins, pharmaceuticals, etc.
3-Hydroxybenzoic acid is an endogenous metabolite.
3-Hydroxybenzoic acid is an endogenous metabolite.

同义名列表

4 个代谢物同义名

3-Hydroxybenzoic acid; 3-Hydroxybenzoicacid; m-Hydroxybenzoic acid; 3-Hydroxybenzoate



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

76 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xue-Qiang Cao, Xing-Yu Ouyang, Bo Chen, Kai Song, Lian Zhou, Bo-Le Jiang, Ji-Liang Tang, Guanghai Ji, Alan R Poplawsky, Ya-Wen He. Genetic Interference Analysis Reveals that Both 3-Hydroxybenzoic Acid and 4-Hydroxybenzoic Acid Are Involved in Xanthomonadin Biosynthesis in the Phytopathogen Xanthomonas campestris pv. campestris. Phytopathology. 2020 Feb; 110(2):278-286. doi: 10.1094/phyto-08-19-0299-r. [PMID: 31613175]
  • Songül Bayrak, Cansu Öztürk, Yeliz Demir, Zuhal Alım, Ömer İrfan Küfrevioglu. Purification of Polyphenol Oxidase from Potato and Investigation of the Inhibitory Effects of Phenolic Acids on Enzyme Activity. Protein and peptide letters. 2020; 27(3):187-192. doi: 10.2174/0929866526666191002142301. [PMID: 31577197]
  • Anna M Amini, Karolin Muzs, Jeremy Pe Spencer, Parveen Yaqoob. Pelargonidin-3-O-glucoside and its metabolites have modest anti-inflammatory effects in human whole blood cultures. Nutrition research (New York, N.Y.). 2017 Oct; 46(?):88-95. doi: 10.1016/j.nutres.2017.09.006. [PMID: 29132841]
  • Xin Zhong, Chongwei Cui, Shuili Yu. Seasonal evaluation of disinfection by-products throughout two full-scale drinking water treatment plants. Chemosphere. 2017 Jul; 179(?):290-297. doi: 10.1016/j.chemosphere.2017.03.103. [PMID: 28371712]
  • Yanna C F Teles, Jaime Ribeiro-Filho, Patrícia T Bozza, Maria de Fátima Agra, Weam Siheri, John O Igoli, Alexander I Gray, Maria de Fátima V de Souza. Phenolic constituents from Wissadula periplocifolia (L.) C. Presl. and anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein. Natural product research. 2016 Aug; 30(16):1880-4. doi: 10.1080/14786419.2015.1081196. [PMID: 27498833]
  • Claudia Vetrani, Angela A Rivellese, Giovanni Annuzzi, Martin Adiels, Jan Borén, Ismo Mattila, Matej Orešič, Anna-Marja Aura. Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites. The Journal of nutritional biochemistry. 2016 07; 33(?):111-8. doi: 10.1016/j.jnutbio.2016.03.007. [PMID: 27155917]
  • Elizabeth L Cordonier, Riem Adjam, Daniel Camara Teixeira, Simone Onur, Richard Zbasnik, Paul E Read, Frank Döring, Vicki L Schlegel, Janos Zempleni. Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster. The Journal of nutritional biochemistry. 2015 Nov; 26(11):1379-84. doi: 10.1016/j.jnutbio.2015.07.004. [PMID: 26303405]
  • Dongjie Wang, Lap Ho, Jeremiah Faith, Kenjiro Ono, Elsa M Janle, Pamela J Lachcik, Bruce R Cooper, Amber H Jannasch, Bruce R D'Arcy, Barbara A Williams, Mario G Ferruzzi, Samara Levine, Wei Zhao, Lauren Dubner, Giulio M Pasinetti. Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization. Molecular nutrition & food research. 2015 Jun; 59(6):1025-40. doi: 10.1002/mnfr.201400544. [PMID: 25689033]
  • Jing Xu, Lian Zhou, Vittorio Venturi, Ya-Wen He, Mikiko Kojima, Hitoshi Sakakibari, Monica Höfte, David De Vleesschauwer. Phytohormone-mediated interkingdom signaling shapes the outcome of rice-Xanthomonas oryzae pv. oryzae interactions. BMC plant biology. 2015 Jan; 15(?):10. doi: 10.1186/s12870-014-0411-3. [PMID: 25605284]
  • Laura Baselga-Escudero, Cinta Blade, Aleix Ribas-Latre, Ester Casanova, Manuel Suárez, Josep Lluís Torres, M Josepa Salvadó, Lluis Arola, Anna Arola-Arnal. Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells. Nucleic acids research. 2014 Jan; 42(2):882-92. doi: 10.1093/nar/gkt1011. [PMID: 24165878]
  • Lian Zhou, Tin-Wei Huang, Jia-Yuan Wang, Shuang Sun, Gongyou Chen, Alan Poplawsky, Ya-Wen He. The rice bacterial pathogen Xanthomonas oryzae pv. oryzae produces 3-hydroxybenzoic acid and 4-hydroxybenzoic acid via XanB2 for use in xanthomonadin, ubiquinone, and exopolysaccharide biosynthesis. Molecular plant-microbe interactions : MPMI. 2013 Oct; 26(10):1239-48. doi: 10.1094/mpmi-04-13-0112-r. [PMID: 23718125]
  • Stefania Montersino, Roberto Orru, Arjan Barendregt, Adrie H Westphal, Esther van Duijn, Andrea Mattevi, Willem J H van Berkel. Crystal structure of 3-hydroxybenzoate 6-hydroxylase uncovers lipid-assisted flavoprotein strategy for regioselective aromatic hydroxylation. The Journal of biological chemistry. 2013 Sep; 288(36):26235-26245. doi: 10.1074/jbc.m113.479303. [PMID: 23864660]
  • Sarina M Duckstein, Peter Lorenz, Florian C Stintzing. Conversion of phenolic constituents in aqueous Hamamelis virginiana leaf extracts during fermentation. Phytochemical analysis : PCA. 2012 Nov; 23(6):588-97. doi: 10.1002/pca.2359. [PMID: 22434718]
  • Ljerka Lah, Barbara Podobnik, Metka Novak, Branka Korošec, Sabina Berne, Matjaž Vogelsang, Nada Kraševec, Neja Zupanec, Jure Stojan, Joerg Bohlmann, Radovan Komel. The versatility of the fungal cytochrome P450 monooxygenase system is instrumental in xenobiotic detoxification. Molecular microbiology. 2011 Sep; 81(5):1374-89. doi: 10.1111/j.1365-2958.2011.07772.x. [PMID: 21810122]
  • Ya-Wen He, Ji'en Wu, Lian Zhou, Fan Yang, Yong-Qiang He, Bo-Le Jiang, Linquan Bai, Yuquan Xu, Zixin Deng, Ji-Liang Tang, Lian-Hui Zhang. Xanthomonas campestris diffusible factor is 3-hydroxybenzoic acid and is associated with xanthomonadin biosynthesis, cell viability, antioxidant activity, and systemic invasion. Molecular plant-microbe interactions : MPMI. 2011 Aug; 24(8):948-57. doi: 10.1094/mpmi-02-11-0031. [PMID: 21539432]
  • Anete Keisa, Krista Kanberga-Silina, Ilva Nakurte, Laura Kunga, Nils Rostoks. Differential disease resistance response in the barley necrotic mutant nec1. BMC plant biology. 2011 Apr; 11(?):66. doi: 10.1186/1471-2229-11-66. [PMID: 21496226]
  • Zhijuan Gao, Bo Sang, Yangjing Liang, Shixiang Wang, Jie Yu, Xiaohui Zheng. [Pharmacokinetics of three phenolic acids of xiangdan injection in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Apr; 36(7):922-5. doi: 10.4268/cjcmm20110722. [PMID: 21761736]
  • Zhenggang Yue, Jiachen Zi, Chenggen Zhu, Sheng Lin, Yongchun Yang, Jiangong Shi. [Constituents of Gymnadenia conopsea]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Nov; 35(21):2852-61. doi: . [PMID: 21322946]
  • Susana Tárraga, Purificación Lisón, María Pilar López-Gresa, Cristina Torres, Ismael Rodrigo, José María Bellés, Vicente Conejero. Molecular cloning and characterization of a novel tomato xylosyltransferase specific for gentisic acid. Journal of experimental botany. 2010 Oct; 61(15):4325-38. doi: 10.1093/jxb/erq234. [PMID: 20729481]
  • Kennan Kellaris Salinero, Keith Keller, William S Feil, Helene Feil, Stephan Trong, Genevieve Di Bartolo, Alla Lapidus. Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation. BMC genomics. 2009 Aug; 10(?):351. doi: 10.1186/1471-2164-10-351. [PMID: 19650930]
  • Xiao-Ming Tian, Shi-Zhong Chen, Peng-Fei Tu, Lian-Di Lei. [Studies on chemical constituents of aerial parts of Ammopiptanthus mongolicus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Oct; 33(19):2204-6. doi: . [PMID: 19166007]
  • Wendy R Russell, Lorraine Scobbie, Garry G Duthie, Andrew Chesson. Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids. Bioorganic & medicinal chemistry. 2008 Apr; 16(8):4589-93. doi: 10.1016/j.bmc.2008.02.041. [PMID: 18314336]
  • Zhen Xie, Zhong-Lin Zhang, Shane Hanzlik, Everett Cook, Qingxi J Shen. Salicylic acid inhibits gibberellin-induced alpha-amylase expression and seed germination via a pathway involving an abscisic-acid-inducible WRKY gene. Plant molecular biology. 2007 Jun; 64(3):293-303. doi: 10.1007/s11103-007-9152-0. [PMID: 17390108]
  • Chao-Bin Xue, Li Zhang, Wan-Chun Luo, Xian-Ye Xie, Lin Jiang, Ting Xiao. 3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors. Bioorganic & medicinal chemistry. 2007 Mar; 15(5):2006-15. doi: 10.1016/j.bmc.2006.12.038. [PMID: 17258462]
  • Ahsan Sharif, Ejaz Ahmed, Abdul Malik, Naheed Riaz, Nighat Afza, Sarfraz Ahmad Nawaz, Muhammad Arshad, Muhammad Raza Shah, Muhammad Iqbal Choudhary. Lipoxygenase inhibitory constituents from Indigofera oblongifolia. Archives of pharmacal research. 2005 Jul; 28(7):761-4. doi: 10.1007/bf02977339. [PMID: 16114488]
  • Yong Ok Kim, Jon D Johnson, Eun Ju Lee. Phytotoxic effects and chemical analysis of leaf extracts from three Phytolaccaceae species in South Korea. Journal of chemical ecology. 2005 May; 31(5):1175-86. doi: 10.1007/s10886-005-4255-z. [PMID: 16124240]
  • I Sperlingová, L Dabrowská, V Stránský, M Tichý. A rapid HPLC method for the determination of carboxylic acids in human urine using a monolithic column. Analytical and bioanalytical chemistry. 2004 Jan; 378(2):536-43. doi: 10.1007/s00216-003-2289-z. [PMID: 14598013]
  • Naheed Riaz, Itrat Anis, Pir Muhammad Khan, Raza Shah, Abdul Malik. Alysinol--a new triterpene from Alysicarpus monolifer. Natural product letters. 2002 Dec; 16(6):415-8. doi: 10.1080/10575630290034258. [PMID: 12462347]
  • Pirjo Mattila, Jorma Kumpulainen. Determination of free and total phenolic acids in plant-derived foods by HPLC with diode-array detection. Journal of agricultural and food chemistry. 2002 Jun; 50(13):3660-7. doi: 10.1021/jf020028p. [PMID: 12059140]
  • M A Saunders, L Sansores-Garcia, D W Gilroy, K K Wu. Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. The Journal of biological chemistry. 2001 Jun; 276(22):18897-904. doi: 10.1074/jbc.m011147200. [PMID: 11278846]
  • A P Femia, G Caderni, C Buzzigoli, E Cocca, M Salvadori, P Dolara. Effect of simple phenolic compounds on azoxymethane-induced aberrant crypt foci in rat colon. Nutrition and cancer. 2001; 41(1-2):107-10. doi: 10.1080/01635581.2001.9680620. [PMID: 12094612]
  • W Barillas, L Beerhues. 3-Hydroxybenzoate:coenzyme A ligase from cell cultures of Centaurium erythraea: isolation and characterization. Biological chemistry. 2000 Feb; 381(2):155-60. doi: 10.1515/bc.2000.021. [PMID: 10746747]
  • G Gronow, M Moussavian, M Mályusz. Effect of hydroxyl radical scavengers in renal cortical cells. Advances in experimental medicine and biology. 1999; 471(?):345-51. doi: 10.1007/978-1-4615-4717-4_41. [PMID: 10659165]
  • M H Akhtar, S Mahadevan. Diphenyl ether cleavage of 3-phenoxybenzoic acid by chicken kidney microsomal preparations. Drug metabolism and disposition: the biological fate of chemicals. 1992 May; 20(3):356-9. doi: NULL. [PMID: 1355708]
  • R A Scherrer, S M Howard. Use of distribution coefficients in quantitative structure-activity relationships. Journal of medicinal chemistry. 1977 Jan; 20(1):53-8. doi: 10.1021/jm00211a010. [PMID: 13215]