Galantamine (BioDeep_00000000236)
Secondary id: BioDeep_00000398667
human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C17H21NO3 (287.1521356)
中文名称: 雪花莲胺, 加兰他敏, 加兰他明, 雪花胺
谱图信息:
最多检出来源 Viridiplantae(plant) 0.13%
Last reviewed on 2024-09-04.
Cite this Page
Galantamine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/galantamine (retrieved
2024-11-03) (BioDeep RN: BioDeep_00000000236). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O
InChI: InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
描述信息
Galanthamine is a benzazepine alkaloid isolated from certain species of daffodils. It has a role as an antidote to curare poisoning, an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a cholinergic drug, an EC 3.1.1.8 (cholinesterase) inhibitor and a plant metabolite. It is an organic heterotetracyclic compound, a tertiary amino compound, a benzazepine alkaloid and a benzazepine alkaloid fundamental parent. It is a conjugate base of a galanthamine(1+).
Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimers disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sources, such as Galanthus nivalis. Galantamine was first studied in paralytic and neuropathic conditions, such as myopathies and postpolio paralytic conditions, and for reversal of neuromuscular blockade. Following the discovery of its AChE-inhibiting properties, the cognitive effects of galantamine were studied in a wide variety of psychiatric disorders such as mild cognitive impairment, cognitive impairment in schizophrenia and bipolar disorder, and autism; however, re-development of the drug for Alzheimer’s disease did not commence until the early 1990s due to difficulties in extraction and synthesis. Galantamine blocks the breakdown of acetylcholine in the synaptic cleft, thereby increasing acetylcholine neurotransmission. It also acts as an allosteric modulator of the nicotinic receptor, giving its dual mechanism of action clinical significance. The drug was approved by the FDA in 2001 for the treatment of mild to moderate dementia of the Alzheimers type. As Alzheimers disease is a progressive neurodegenerative disorder, galantamine is not known to alter the course of the underlying dementing process. Galantamine works to block the enzyme responsible for the breakdown of acetylcholine in the synaptic cleft, thereby enhancing cholinergic neuron function and signalling. Under this hypothesized mechanism of action, the therapeutic effects of galantamine may decrease as the disease progression advances and fewer cholinergic neurons remain functionally intact. It is therefore not considered to be a disease-modifying drug. Galantamine is marketed under the brand name Razadyne, and is available as oral immediate- and extended-release tablets and solution.
Galantamine is a Cholinesterase Inhibitor. The mechanism of action of galantamine is as a Cholinesterase Inhibitor.
Galantamine is an oral acetylcholinesterase inhibitor used for therapy of Alzheimer disease. Galantamine is associated with a minimal rate of serum enzyme elevations during therapy and has not been implicated as a cause of clinically apparent liver injury.
Galantamine is a natural product found in Pancratium trianthum, Lycoris sanguinea, and other organisms with data available.
A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.
See also: Galantamine Hydrobromide (active moiety of).
A benzazepine derived from norbelladine. It is found in galanthus and other amaryllidaceae. Galantamine is a cholinesterase inhibitor that has been used to reverse the muscular effects of gallamine triethiodide and tubocurarine, and has been studied as a treatment for Alzheimers disease and other central nervous system disorders. [PubChem]
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
N - Nervous system > N06 - Psychoanaleptics > N06D - Anti-dementia drugs > N06DA - Anticholinesterases
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
A benzazepine alkaloid isolated from certain species of daffodils.
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D004791 - Enzyme Inhibitors
Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
同义名列表
86 个代谢物同义名
InChI=1/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1; 6H-BENZOFURO(3A,3,2-EF)(2)BENZAZEPIN-6-OL, 4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-, (4A.ALPHA.,6.BETA.,8AR*)-; (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.0^{1,12}.0^{6,17}]heptadeca-6,8,10(17),15-tetraen-14-ol; (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.0^{1,12}.0^{6,17}]heptadeca-6(17),7,9,15-tetraen-14-ol; 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aalpha,6beta,8ar*)-; (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.0¹,¹².0⁶,¹⁷]heptadeca-6(17),7,9,15-tetraen-14-ol; (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol; 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aR,6S,8aR)-rel-; 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-; 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-; (4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-(1)benzofuro(3a,3,2-ef)(2)benzazepin-6-ol; 6H-BENZOFURO(3A,3,2-EF)(2)BENZAZEPIN-6-OL, 4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-, (4AS,6R,8AS); (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofurol[3a,3,2,-ef][2]benzazepin-6-ol; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro(3a,3,2-ef)(2)benzazepin-6-ol; (4aS,6R,8aS)-3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol; (4aS,6R,8aS)-3-Methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol; 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-; Ortho mcneil neurologics brand OF galantamine; Ortho-mcneil neurologics brand OF galantamine; 4-27-00-02184 (Beilstein Handbook Reference); Galanthamine-O-(methyl-d3)-N-(methyl-d3); ASUTZQLVASHGKV-JDFRZJQESA-N; ASUTZQLVASHGKV-JDFRZJQESA-; Galantamine [USAN:INN:BAN]; Galanthamine hydrobromide; Galantamina (INN-Spanish); Galantamina [INN-Spanish]; Galantaminum (INN-Latin); Galantaminum [INN-Latin]; Galantamine (USAN/INN); Galanthamine, (+/-)-; GALANTAMINE [WHO-DD]; GALANTAMINE [VANDF]; Galantamine, (+/-)-; GALANTAMINE [HSDB]; (+/-)-Galanthamine; GALANTAMINE [USAN]; Prestwick1_000588; (+/-)-Galantamine; GALANTAMINE [INN]; Prestwick3_000588; Prestwick0_000588; Prestwick2_000588; Galanthamine, 12; Spectrum3_001738; Spectrum5_001673; (-)-Galanthamine; GALANTAMINE [MI]; Spectrum4_000839; (-)-Galantamine; UNII-1T835Z585R; UNII-0D3Q044KCA; Probes1_000055; Probes2_000395; DivK1c_000590; BPBio1_000480; Galanthaminum; KBio3_002636; Reminyl (TN); KBio2_004319; KBio2_006887; Galanthamine; Galantaminum; KBio2_001751; KBio1_000590; Galantamine; IDI1_000590; Razadyne ER; Galantamina; SMP1_000131; Galantamin; 0D3Q044KCA; Lycoremine; 1T835Z585R; Lycoremin; Razadyne; Bodamine; Nivaline; Reminyl; Nivalin; N06DA04; Jilkon; 1qti; 1dx6; GNT
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:42944
- KEGG: C08526
- KEGGdrug: D04292
- PubChem: 9651
- PubChem: 3449
- HMDB: HMDB0014812
- Metlin: METLIN43505
- DrugBank: DB00674
- ChEMBL: CHEMBL659
- Wikipedia: Galantamine
- MeSH: Galantamine
- ChemIDplus: 0000357700
- MetaCyc: CPD-19430
- KNApSAcK: C00001570
- KNApSAcK: C00024389
- chemspider: 9272
- CAS: 357-70-0
- medchemexpress: HY-76299
- PMhub: MS000001606
- MetaboLights: MTBLC42944
- PDB-CCD: GNT
- 3DMET: B02196
- NIKKAJI: J11.407C
分类词条
相关代谢途径
Reactome(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(1)
- Amaryllidacea alkaloids biosynthesis:
4'-O-methylnorbelladine + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ (4aS,10bR)-noroxomaritidine + H2O + an oxidized [NADPH-hemoprotein reductase]
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(1)
- Amaryllidacea alkaloids biosynthesis:
SAM + norbelladine ⟶ 4'-O-methylnorbelladine + H+ + SAH
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
86 个相关的物种来源信息
- 82206 - Agave amica: 10.1055/S-2006-959728
- 39547 - Agave neopringlei: 10.1055/S-2006-959728
- 198669 - Alstroemeria angustifolia: 10.1055/S-2006-959728
- 4668 - Amaryllidaceae:
- 180132 - Ammocharis coranica: 10.1055/S-2006-960889
- 112542 - Ammocharis longifolia: 10.1055/S-2006-960889
- 488914 - Bomarea salsilla: 10.1055/S-2006-959728
- 112533 - Boophone disticha: 10.1055/S-2006-960889
- 180134 - Boophone haemanthoides: 10.1055/S-2006-960889
- 180135 - Brunsvigia bosmaniae: 10.1055/S-2006-960889
- 112534 - Brunsvigia comptonii: 10.1055/S-2006-960889
- 527043 - Brunsvigia gregaria: 10.1055/S-2006-960889
- 379211 - Brunsvigia orientalis: 10.1055/S-2006-960889
- 527044 - Brunsvigia radulosa: 10.1055/S-2006-960889
- 146419 - Caliphruria subedentata: 10.1055/S-2006-959728
- 82220 - Calostemma luteum: 10.1055/S-2006-959728
- 1142947 - Conanthera bifolia: 10.1055/S-2006-959728
- 59084 - Conanthera campanulata: 10.1055/S-2006-959728
- 205937 - Crinum asiaticum:
- 223245 - Crinum asiaticum var. sinicum:
- 209086 - Crinum bulbispermum: 10.1055/S-2006-960889
- 28480 - Crinum jagus: 10.1007/BF00579844
- 180140 - Crinum macowanii: 10.1055/S-2006-960889
- 82223 - Crinum moorei: 10.1007/S10600-006-0237-9
- 180141 - Crinum variabile: 10.1055/S-2006-960889
- 1259857 - Cyanella alba: 10.1055/S-2006-959728
- 232727 - Cyrtanthus brachyscyphus: 10.1055/S-2006-960889
- 112543 - Cyrtanthus elatus: 10.1016/S0367-326X(00)00313-0
- 527294 - Cyrtanthus falcatus: 10.1055/S-2006-960889
- 261535 - Cyrtanthus herrei:
- 527297 - Cyrtanthus montanus: 10.1055/S-2006-960889
- 527976 - Cyrtanthus obrienii: 10.1055/S-2006-960889
- 146421 - Eucharis amazonica: 10.1002/CHIN.200334195
- 1157045 - Galanthus alpinus var. alpinus:
- 82232 - Galanthus elwesii:
- 82232 - Galanthus elwesii: 10.1007/BF00567346
- 4670 - Galanthus nivalis:
- 197699 - Galanthus woronowii:
- 240633 - Gethyllis verticillata: 10.1055/S-2006-960889
- 152472 - Haemanthus coccineus:
- 527305 - Haemanthus crispus: 10.1055/S-2006-960889
- 527307 - Haemanthus montanus: 10.1055/S-2006-960889
- 180144 - Hessea breviflora: 10.1055/S-2006-960889
- 112556 - Hessea zeyheri: 10.1055/S-2006-960889
- 112595 - Hippeastrum papilio: 10.3390/MOLECULES16087097
- 1234392 - Hippeastrum puniceum: 10.1007/BF00579672
- 9606 - Homo sapiens: -
- 59040 - Hymenocallis littoralis:
- 1234395 - Hymenocallis rotata: 10.1248/CPB.35.1070
- 54835 - Leucojum aestivum:
- 54835 - Leucojum aestivum: 10.1248/CPB.43.318
- 197685 - Leucojum vernum: 10.1007/BF00563649
- 152838 - Lycoris aurea: 10.1002/HLCA.200590193
- 317644 - Lycoris incarnata: 10.1248/CPB.42.289
- 228395 - Lycoris radiata:
- 228395 - Lycoris radiata [Syn. Amaryllis radiata]: -
- 108053 - Lycoris sanguinea:
- 108053 - Lycoris sanguinea: 10.1016/S0031-9422(00)89030-5
- 112568 - Lycoris squamigera: 10.3987/COM-08-S(F)92
- 82237 - Lycoris traubii: 10.1016/J.BMC.2008.10.061
- 4697 - Narcissus:
- 1695117 - Narcissus confusus:
- 1290242 - Narcissus obesus: 10.1021/NP50084A016
- 54860 - Narcissus tazetta:
- 54860 - Narcissus tazetta: 10.1016/0031-9422(94)00827-G
- 180151 - Nerine alta: 10.1055/S-2006-960889
- 59042 - Nerine bowdenii:
- 1234398 - Nerine humilis: 10.1055/S-2006-960889
- 1234399 - Nerine huttoniae: 10.1055/S-2006-960889
- 527310 - Nerine laticoma: 10.1055/S-2006-960889
- 1234400 - Nerine masonorum: 10.1055/S-2006-960889
- 180152 - Nerine sarniensis: 10.1055/S-2006-960889
- 1234402 - Nerine undulata: 10.1055/S-2006-960889
- 644807 - Pancratium maritimum:
- 1055008 - Pancratium trianthum:
- 82243 - Phaedranassa dubia: 10.1016/J.PHYTOL.2010.06.004
- 33090 - Plants: -
- 146452 - Rauhia multiflora: 10.1055/S-2006-959728
- 59076 - Rhodohypoxis milloides: 10.1055/S-2006-959728
- 180155 - Strumaria chaplinii: 10.1055/S-2006-960889
- 527311 - Strumaria salteri: 10.1055/S-2006-960889
- 180158 - Strumaria tenella:
- 112578 - Strumaria truncata: 10.1055/S-2006-960889
- 95968 - Tribonanthes uniflora: 10.1055/S-2006-959728
- 1263242 - Zephyranthes chlorosolen: 10.1055/S-2006-959728
- 33090 - 石蒜: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Gabriela Haist, Boriana Sidjimova, Elina Yankova-Tsvetkova, Milena Nikolova, Rumen Denev, Ivanka Semerdjieva, Jaume Bastida, Strahil Berkov. Metabolite profiling and histochemical localization of alkaloids in Hippeastrum papilio (Ravena) van Scheepen.
Journal of plant physiology.
2024 May; 296(?):154223. doi:
10.1016/j.jplph.2024.154223
. [PMID: 38507926] - M A Aldubayan, A S Alsharidah, S K Alenezi, A H Alhowail. Galantamine mitigates neurotoxicity caused by doxorubicin via reduced neuroinflammation, oxidative stress, and apoptosis in rat model.
European review for medical and pharmacological sciences.
2024 Jan; 28(2):805-813. doi:
10.26355/eurrev_202401_35081
. [PMID: 38305623] - Ayca Cimen, Yavuz Baba, Arzu Birinci Yildirim, Arzu Ucar Turker. Do Vermicompost Applications Improve Growth Performance, Pharmaceutically Important Alkaloids, Phenolic Content, Free Radical Scavenging Potency and Defense Enzyme Activities in Summer Snowflake (Leucojum aestivum L.)?.
Chemistry & biodiversity.
2023 Oct; ?(?):e202301074. doi:
10.1002/cbdv.202301074
. [PMID: 37779102] - Wenli Shi, Wenxin Han, Yijing Liao, Jiaqi Wen, Guowen Zhang. Inhibition mechanism of fisetin on acetylcholinesterase and its synergistic effect with galantamine.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2023 Sep; 305(?):123452. doi:
10.1016/j.saa.2023.123452
. [PMID: 37769468] - Kouadio Kra Norbert Bini, Koffi Christophe Kobenan, Malanno Kouakou, Ibrahime Sinan Kouadio, Gokhan Zengin, József Jekő, Zoltán Cziáky, Mathias Danho, Ochou Germain Ochou. Phytochemical profiling, antioxidant activities, enzymatic activities and insecticidal potential of aqueous extracts of four plants on the larvae of Helicoverpa armigera (Lepidoptera: Noctuidae), the main pest of cotton plant in Ivory Coast.
Archives of insect biochemistry and physiology.
2023 Apr; ?(?):e22017. doi:
10.1002/arch.22017
. [PMID: 37185885] - Rupa Sanyal, Manokari M, Sharmila Pandey, Saheli Nandi, Protha Biswas, Saikat Dewanjee, Abilash Valsala Gopalakrishnan, Niraj Kumar Jha, Saurabh Kumar Jha, Nirmal Joshee, Devendra Kumar Pandey, Abhijit Dey, Mahipal S Shekhawat. Biotechnological interventions and production of galanthamine in Crinum spp.
Applied microbiology and biotechnology.
2023 Apr; 107(7-8):2155-2167. doi:
10.1007/s00253-023-12444-0
. [PMID: 36922438] - Meng Tang, Chaohan Li, Cheng Zhang, Youming Cai, Yongchun Zhang, Liuyan Yang, Moxian Chen, Fuyuan Zhu, Qingzhu Li, Kehu Li. SWATH-MS-Based Proteomics Reveals the Regulatory Metabolism of Amaryllidaceae Alkaloids in Three Lycoris Species.
International journal of molecular sciences.
2023 Feb; 24(5):. doi:
10.3390/ijms24054495
. [PMID: 36901927] - Gabriela Haist, Boriana Sidjimova, Vladimir Vladimirov, Liliya Georgieva, Milena Nikolova, Jaume Bastida, Strahil Berkov. Morphological, cariological, and phytochemical studies of diploid and autotetraploid Hippeastrum papilio plants.
Planta.
2023 Feb; 257(3):51. doi:
10.1007/s00425-023-04084-5
. [PMID: 36757512] - Meenakshee Shrivas, Dignesh Khunt, Meera Shrivas, Manju Misra. Studies on pomegranate seed oil enriched galantamine hydrobromide microemulsion: formulation, in vitro antioxidant and neuroprotective potential.
Pharmaceutical development and technology.
2023 Feb; 28(2):153-163. doi:
10.1080/10837450.2023.2171433
. [PMID: 36662596] - Luciane B Silva, Elenilze F B Ferreira, Maryam, José M Espejo-Román, Glauber V Costa, Josiane V Cruz, Njogu M Kimani, Josivan S Costa, José A H M Bittencourt, Jorddy N Cruz, Joaquín M Campos, Cleydson B R Santos. Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach.
Molecules (Basel, Switzerland).
2023 Jan; 28(3):. doi:
10.3390/molecules28031035
. [PMID: 36770702] - Rumyana Simeonova, Mariyana Atanasova, Georgi Stavrakov, Irena Philipova, Irini Doytchinova. Ex Vivo Antioxidant and Cholinesterase Inhibiting Effects of a Novel Galantamine-Curcumin Hybrid on Scopolamine-Induced Neurotoxicity in Mice.
International journal of molecular sciences.
2022 Nov; 23(23):. doi:
10.3390/ijms232314843
. [PMID: 36499171] - María Pilar de Torre, Rita Yolanda Cavero, María Isabel Calvo. Anticholinesterase Activity of Selected Medicinal Plants from Navarra Region of Spain and a Detailed Phytochemical Investigation of Origanum vulgare L. ssp. vulgare.
Molecules (Basel, Switzerland).
2022 Oct; 27(20):. doi:
10.3390/molecules27207100
. [PMID: 36296692] - Cheng Liu, Li-Ning Wang, Yu-Ming Liu. Novel Morpholine-Bearing Quinoline Derivatives as Potential Cholinesterase Inhibitors: The Influence of Amine, Carbon Linkers and Phenylamino Groups.
International journal of molecular sciences.
2022 Sep; 23(19):. doi:
10.3390/ijms231911231
. [PMID: 36232533] - Ion Brinza, Mohamed A El Raey, Walaa El-Kashak, Omayma A Eldahshan, Lucian Hritcu. Sweroside Ameliorated Memory Deficits in Scopolamine-Induced Zebrafish (Danio rerio) Model: Involvement of Cholinergic System and Brain Oxidative Stress.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185901
. [PMID: 36144637] - Agata Ptak, Emilia Morańska, Marzena Warchoł, Artur Gurgul, Edyta Skrzypek, Michał Dziurka, Dominique Laurain-Mattar, Rosella Spina, Anita Jaglarz, Magdalena Simlat. Endophytic bacteria from in vitro culture of Leucojum aestivum L. a new source of galanthamine and elicitor of alkaloid biosynthesis.
Scientific reports.
2022 08; 12(1):13700. doi:
10.1038/s41598-022-17992-5
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