Sylvatesmin (BioDeep_00000229742)
Secondary id: BioDeep_00000231913
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C21H24O6 (372.1572804)
中文名称: 连翘苷元, 连翘脂素, 连翘甙元
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC(=C(C=C4)O)OC)OC
InChI: InChI=1S/C21H24O6/c1-23-17-7-5-13(9-19(17)25-3)21-15-11-26-20(14(15)10-27-21)12-4-6-16(22)18(8-12)24-2/h4-9,14-15,20-22H,10-11H2,1-3H3/t14-,15-,20+,21-/m0/s1
描述信息
Sylvatesmin is a natural product found in Forsythia suspensa, Lindera praecox, and other organisms with data available.
Phillygenin (Phillygenol) is an active ingredient from Forsythia with many medicinal properties, such as antioxidant, reducing blood lipid, inhibition of low density lipoprotein oxidation.
Phillygenin (Phillygenol) is an active ingredient from Forsythia with many medicinal properties, such as antioxidant, reducing blood lipid, inhibition of low density lipoprotein oxidation.
同义名列表
16 个代谢物同义名
Phenol, 4-(4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo(3,4-c)furan-1-yl)-2-methoxy-, (1S-(1alpha,3aalpha,4beta,6aalpha))-; 4-[(3S,3aR,6R,6aR)-6-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol; PHENOL, 4-((1S,3AR,4R,6AR)-4-(3,4-DIMETHOXYPHENYL)TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1-YL)-2-METHOXY-; 4-((1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl)-2-methoxyphenol; Phillygenol; Epipinoresinol methyl ether; (+)-Phillygenin; Epipinoresinol methyl ether; (+)-MONOMETHYLPINORESINOL; PHILLYRIN AGLYCONE; (+)-Phillygenin; (+)-SYLVATESMIN; Forsythigenol; MEGxp0_000876; ACon1_001142; Sylvatesmin; Phillygenol; Phillygenin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiahui Zhang, Tao Jiang, Yuxin Zhang, Kai Yang, Yichen Zhao, Qi Zhou, Zhuo Yang, Renhao Yang, Ruonan Ning, Tao Liu, Lianfu Deng, Xiaobing Xi, Xing Xu, Min Jiang. Phillygenin prevents osteoclast differentiation and bone loss by targeting RhoA.
Phytotherapy research : PTR.
2024 Apr; 38(4):1863-1881. doi:
10.1002/ptr.8074. [PMID: 38358766] - Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, Peihong Zhang, Hong Chang. Phillygenin Alleviates Arthritis through the Inhibition of the NLRP3 Inflammasome and Ferroptosis by AMPK.
Critical reviews in immunology.
2024; 44(5):59-70. doi:
10.1615/critrevimmunol.2024051467. [PMID: 38618729] - Haipeng Feng, Jingyan Zhang, Kang Zhang, Xuezhi Wang, Zhiting Guo, Lei Wang, Jianxi Li. Synergistic anti-infectious bronchitis virus activity of Phillygenin combined Baicalin by modulating respiratory microbiota and improving metabolic disorders.
Poultry science.
2023 Dec; 103(2):103371. doi:
10.1016/j.psj.2023.103371. [PMID: 38150830] - Cheng Wang, Rui Wu, Shenglin Zhang, Lihong Gong, Ke Fu, Chenhao Yao, Cheng Peng, Yunxia Li. A comprehensive review on pharmacological, toxicity, and pharmacokinetic properties of phillygenin: Current landscape and future perspectives.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Oct; 166(?):115410. doi:
10.1016/j.biopha.2023.115410. [PMID: 37659207] - Cheng Wang, Yanfang Liu, Lihong Gong, Xinyan Xue, Ke Fu, Cheng Ma, Yunxia Li. Phillygenin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis: Suppression of Inflammation and Wnt/β-Catenin Signaling Pathway.
Inflammation.
2023 May; ?(?):. doi:
10.1007/s10753-023-01826-1. [PMID: 37219693] - Cheng Ma, Cheng Wang, Yafang Zhang, Yanzhi Li, Ke Fu, Lihong Gong, Honglin Zhou, Yunxia Li. Phillygenin inhibited M1 macrophage polarization and reduced hepatic stellate cell activation by inhibiting macrophage exosomal miR-125b-5p.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Mar; 159(?):114264. doi:
10.1016/j.biopha.2023.114264. [PMID: 36652738] - Huan-Huan Xue, Jing-Jing Li, Shi-Fei Li, Jing Guo, Rui-Ping Yan, Ting-Gui Chen, Xiang-Hua Shi, Jin-Dong Wang, Li-Wei Zhang. Phillygenin Attenuated Colon Inflammation and Improved Intestinal Mucosal Barrier in DSS-induced Colitis Mice via TLR4/Src Mediated MAPK and NF-κB Signaling Pathways.
International journal of molecular sciences.
2023 Jan; 24(3):. doi:
10.3390/ijms24032238. [PMID: 36768559] - Jing Guo, Jian-Kai Tang, Bai-Fang Wang, Wen-Rui Yan, Ting Li, Xue-Jian Guo, Lei Zhang, Tao Wang, Qian-Yun Sun, Li-Wei Zhang. Phillygenin from Forsythia suspensa leaves exhibits analgesic potential and anti-inflammatory activity in carrageenan-induced paw edema in mice.
Journal of food biochemistry.
2022 12; 46(12):e14460. doi:
10.1111/jfbc.14460. [PMID: 36200742] - Cheng Wang, Cheng Ma, Ke Fu, Yanfang Liu, Lihong Gong, Cheng Peng, Yunxia Li. Hepatoprotective effect of phillygenin on carbon tetrachloride-induced liver fibrosis and its effects on short chain fatty acid and bile acid metabolism.
Journal of ethnopharmacology.
2022 Oct; 296(?):115478. doi:
10.1016/j.jep.2022.115478. [PMID: 35716920] - Wenling Zhou, Xu Yan, Yuanyuan Zhai, Hao Liu, Lingling Guan, Yuan Qiao, Jizhi Jiang, Liang Peng. Phillygenin ameliorates nonalcoholic fatty liver disease via TFEB-mediated lysosome biogenesis and lipophagy.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Aug; 103(?):154235. doi:
10.1016/j.phymed.2022.154235. [PMID: 35716542] - Haipeng Feng, Jingyan Zhang, Kang Zhang, Xuezhi Wang, Kai Zhang, Zhiting Guo, Songwei Han, Lei Wang, Zhengying Qiu, Guibo Wang, Jianxi Li. Phillygenin activates PKR/eIF2α pathway and induces stress granule to exert anti-avian infectious bronchitis virus.
International immunopharmacology.
2022 Jul; 108(?):108764. doi:
10.1016/j.intimp.2022.108764. [PMID: 35421804] - Jing Guo, Wen-Rui Yan, Jian-Kai Tang, Xiang Jin, Huan-Huan Xue, Tao Wang, Li-Wei Zhang, Qian-Yun Sun, Zhan-Xue Liang. Dietary phillygenin supplementation ameliorates aflatoxin B1-induced oxidative stress, inflammation, and apoptosis in chicken liver.
Ecotoxicology and environmental safety.
2022 May; 236(?):113481. doi:
10.1016/j.ecoenv.2022.113481. [PMID: 35405527] - Mengting Zhou, Yunqiu Tang, Li Liao, Meichen Liu, Ying Deng, Xingtao Zhao, Yunxia Li. Phillygenin inhibited LPS-induced RAW 264.7 cell inflammation by NF-κB pathway.
European journal of pharmacology.
2021 May; 899(?):174043. doi:
10.1016/j.ejphar.2021.174043. [PMID: 33745957] - Xiaomin Ding, Danqing Lu, Jianbo Fan. A natural product phillygenin suppresses osteosarcoma growth and metastasis by regulating the SHP-1/JAK2/STAT3 signaling.
Bioscience, biotechnology, and biochemistry.
2021 Feb; 85(2):307-314. doi:
10.1093/bbb/zbaa007. [PMID: 33604629] - Naihua Hu, Cheng Wang, Xuyang Dai, Mengting Zhou, Lihong Gong, Lingyuan Yu, Cheng Peng, Yunxia Li. Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-κB signaling pathway.
Journal of ethnopharmacology.
2020 Feb; 248(?):112361. doi:
10.1016/j.jep.2019.112361. [PMID: 31683033] - Qinghua Cui, Ruikun Du, Miaomiao Liu, Lijun Rong. Lignans and Their Derivatives from Plants as Antivirals.
Molecules (Basel, Switzerland).
2020 Jan; 25(1):. doi:
10.3390/molecules25010183. [PMID: 31906391] - Bingyuan Du, Li Zhang, Ying Sun, Guimin Zhang, Jingchun Yao, Mingmin Jiang, Lihong Pan, Chenghong Sun. Phillygenin exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes.
Immunopharmacology and immunotoxicology.
2019 Feb; 41(1):76-85. doi:
10.1080/08923973.2018.1547742. [PMID: 30721636] - Jiantao He, Wei Wei, Qingbo Yang, Yiling Wang. Phillygenin Exerts In Vitro and In Vivo Antitumor Effects in Drug-Resistant Human Esophageal Cancer Cells by Inducing Mitochondrial-Mediated Apoptosis, ROS Generation, and Inhibition of the Nuclear Factor kappa B NF-κB Signalling Pathway.
Medical science monitor : international medical journal of experimental and clinical research.
2019 01; 25(?):739-745. doi:
10.12659/msm.913138. [PMID: 30681987] - Wei Song, Junjun Wu, Longjiang Yu, Zhihong Peng. Evaluation of the Pharmacokinetics and Hepatoprotective Effects of Phillygenin in Mouse.
BioMed research international.
2018; 2018(?):7964318. doi:
10.1155/2018/7964318. [PMID: 30211228] - Liang-hong Ye, Yun-xia Li, Cheng Peng, Xiao-hong Gong, Xin-guang Zheng. Determination of phillygenin in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies.
European journal of drug metabolism and pharmacokinetics.
2013 Sep; 38(3):201-7. doi:
10.1007/s13318-013-0128-y. [PMID: 23564502] - W Song, M Z Ao, Y Shi, L F Yuan, X X Yuan, L J Yu. Interaction between phillygenin and human serum albumin based on spectroscopic and molecular docking.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2012 Jan; 85(1):120-6. doi:
10.1016/j.saa.2011.09.044. [PMID: 22000638] - Yang Cui, Qiao Wang, Xiaowei Shi, Xiaowei Zhang, Xiaona Sheng, Lantong Zhang. Simultaneous quantification of 14 bioactive constituents in Forsythia suspensa by liquid chromatography-electrospray ionisation-mass spectrometry.
Phytochemical analysis : PCA.
2010 May; 21(3):253-60. doi:
10.1002/pca.1194. [PMID: 20151400] - Yun Zhao, Jin-lan Ruan, Jin-hui Wang, Yue Cong, Shuang Song. [Studies on the chemical constituents from Radix Ranunculi Ternate].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2010 May; 33(5):722-3. doi:
". [PMID: 20873554] - T Lu, X L Piao, Q Zhang, D Wang, X S Piao, S W Kim. Protective effects of Forsythia suspensa extract against oxidative stress induced by diquat in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Feb; 48(2):764-70. doi:
10.1016/j.fct.2009.12.018. [PMID: 20036301] - Yonggang Xia, Bingyou Yang, Qiuhong Wang, Jun Liang, Youhe Wei, Hedan Yu, Qingbo Zhang, Haixue Kuang. Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Forsythia suspensa extract by HPLC coupled with photodiode array detector.
Journal of separation science.
2009 Dec; 32(23-24):4113-25. doi:
10.1002/jssc.200900488. [PMID: 19950349] - Xiang Lan Piao, Eun Jung Cho, Eun June Cho, Moon Hee Jang, Jian Cui. Cytoprotective effect of lignans from Forsythia suspensa against peroxynitrite-induced LLC-PK1 cell damage.
Phytotherapy research : PTR.
2009 Jul; 23(7):938-42. doi:
10.1002/ptr.2834. [PMID: 19367664]