1-Methylguanosine (BioDeep_00000018433)

 

Secondary id: BioDeep_00000405644

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-6,9-dihydro-1H-purin-6-one

化学式: C11H15N5O5 (297.10731400000003)
中文名称: 1-甲基鸟酐
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.49%

分子结构信息

SMILES: Cn1c(=N)[nH]c2c(ncn2C2OC(CO)C(O)C2O)c1=O
InChI: InChI=1S/C11H15N5O5/c1-15-9(20)5-8(14-11(15)12)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14)/t4-,6-,7-,10-/m1/s1

描述信息

1-Methylguanosine is a methylated nucleoside. It is known that some modified, especially methylated, nucleosides originating from RNA degradation are excreted in abnormal levels in the urine of patients with malignant tumours. These nucleosides have been proposed as tumour markers. Their measurement could provide a non-invasive diagnostic method, help identify different cancers, and monitor any therapeutic effects (PMID:9129323).
1-Methylguanosine is a methylated nucleoside. It is known that some modified, especially methylated, nucleosides originating from RNA degradation are excreted in abnormal levels in the urine of patients with malignant tumours and they have been proposed as tumour markers. Their
1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker[1].
1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker[1].

同义名列表

8 个代谢物同义名

2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-6,9-dihydro-1H-purin-6-one; 1-Methyl-guanosine; N1-Methylguanosine; N-Methylguanosine; 1-methylguanosine; Methylguanosine; TRMD Protein; m1g



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaohuan Jin, Zhengyi Lv, Junbao Gao, Rui Zhang, Ting Zheng, Ping Yin, Dongqin Li, Liangcai Peng, Xintao Cao, Yan Qin, Staffan Persson, Bo Zheng, Peng Chen. AtTrm5a catalyses 1-methylguanosine and 1-methylinosine formation on tRNAs and is important for vegetative and reproductive growth in Arabidopsis thaliana. Nucleic acids research. 2019 01; 47(2):883-898. doi: 10.1093/nar/gky1205. [PMID: 30508117]
  • Chao-Jung Chen, Wen-Ling Liao, Chiz-Tzung Chang, Yu-Ning Lin, Fuu-Jen Tsai. Identification of Urinary Metabolite Biomarkers of Type 2 Diabetes Nephropathy Using an Untargeted Metabolomic Approach. Journal of proteome research. 2018 11; 17(11):3997-4007. doi: 10.1021/acs.jproteome.8b00644. [PMID: 30265543]
  • Daniel G Beach, Wojciech Gabryelski. Linear and nonlinear regimes of electrospray signal response in analysis of urine by electrospray ionization-high field asymmetric waveform ion mobility spectrometry-MS and implications for nontarget quantification. Analytical chemistry. 2013 Feb; 85(4):2127-34. doi: 10.1021/ac3027542. [PMID: 23297652]
  • Wiktoria Struck, Małgorzata Waszczuk-Jankowska, Roman Kaliszan, Michał J Markuszewski. The state-of-the-art determination of urinary nucleosides using chromatographic techniques 'hyphenated' with advanced bioinformatic methods. Analytical and bioanalytical chemistry. 2011 Oct; 401(7):2039-50. doi: 10.1007/s00216-011-4789-6. [PMID: 21359827]
  • Peng Chen, Gunilla Jäger, Bo Zheng. Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana. BMC plant biology. 2010 Sep; 10(?):201. doi: 10.1186/1471-2229-10-201. [PMID: 20836892]
  • Ewa Szymańska, Michał J Markuszewski, Yvan Vander Heyden, Roman Kaliszan. Efficient recovery of electrophoretic profiles of nucleoside metabolites from urine samples by multivariate curve resolution. Electrophoresis. 2009 Oct; 30(20):3573-81. doi: 10.1002/elps.200900063. [PMID: 19768701]
  • Hua-Yu Li, Shao-Min Wang, Hong-Min Liu, Shan-Shan Bu, Juan Li, Dong Han, Ming-zhi Zhang, Guang-Yin Wu. Separation and identification of purine nucleosides in the urine of patients with malignant cancer by reverse phase liquid chromatography/electrospray tandem mass spectrometry. Journal of mass spectrometry : JMS. 2009 May; 44(5):641-51. doi: 10.1002/jms.1539. [PMID: 19142897]
  • Kei Iida, Hailing Jin, Jian-Kang Zhu. Bioinformatics analysis suggests base modifications of tRNAs and miRNAs in Arabidopsis thaliana. BMC genomics. 2009 Apr; 10(?):155. doi: 10.1186/1471-2164-10-155. [PMID: 19358740]
  • Carsten Henneges, Dino Bullinger, Richard Fux, Natascha Friese, Harald Seeger, Hans Neubauer, Stefan Laufer, Christoph H Gleiter, Matthias Schwab, Andreas Zell, Bernd Kammerer. Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection. BMC cancer. 2009 Apr; 9(?):104. doi: 10.1186/1471-2407-9-104. [PMID: 19344524]
  • Maciej Szuwart, Elzbieta Starzyńska, Małgorzata Pietrowska-Borek, Andrzej Guranowski. Calcium-stimulated guanosine--inosine nucleosidase from yellow lupin (Lupinus luteus). Phytochemistry. 2006 Jul; 67(14):1476-85. doi: 10.1016/j.phytochem.2006.05.021. [PMID: 16820181]
  • A Seidel, S Brunner, P Seidel, G I Fritz, O Herbarth. Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control. British journal of cancer. 2006 Jun; 94(11):1726-33. doi: 10.1038/sj.bjc.6603164. [PMID: 16685264]
  • Bo Feng, Min-Hua Zheng, Yu-Fang Zheng, Ai-Guo Lu, Jian-Wen Li, Ming-Liang Wang, Jun-Jun Ma, Guo-Wang Xu, Bing-Ya Liu, Zheng-Gang Zhu. Normal and modified urinary nucleosides represent novel biomarkers for colorectal cancer diagnosis and surgery monitoring. Journal of gastroenterology and hepatology. 2005 Dec; 20(12):1913-9. doi: 10.1111/j.1440-1746.2005.03888.x. [PMID: 16336453]
  • Bo Feng, Min-hua Zheng, Yu-fang Zheng, Ai-guo Lu, Jian-wen Li, Ming-liang Wang, Jun-jun Ma, Guo-wang Xu, Bao-ming Yu. [Application of urinary nucleosides in the diagnosis and surgical monitoring of colorectal cancer]. Zhonghua wai ke za zhi [Chinese journal of surgery]. 2005 May; 43(9):564-8. doi: . [PMID: 15938925]
  • H M Liebich, S Müller-Hagedorn, F Klaus, K Meziane, K R Kim, A Frickenschmidt, B Kammerer. Chromatographic, capillary electrophoretic and matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis of urinary modified nucleosides as tumor markers. Journal of chromatography. A. 2005 Apr; 1071(1-2):271-5. doi: 10.1016/j.chroma.2004.12.055. [PMID: 15865203]
  • Edward Dudley, Filip Lemière, Walter Van Dongen, Robin Tuytten, Salah El-Sharkawi, A Gareth Brenton, Eddy L Esmans, Russell P Newton. Analysis of urinary nucleosides. IV. Identification of urinary purine nucleosides by liquid chromatography/electrospray mass spectrometry. Rapid communications in mass spectrometry : RCM. 2004; 18(22):2730-8. doi: 10.1002/rcm.1685. [PMID: 15499664]
  • H M Liebich, C Di Stefano, A Wixforth, H R Schmid. Quantitation of urinary nucleosides by high-performance liquid chromatography. Journal of chromatography. A. 1997 Feb; 763(1-2):193-7. doi: 10.1016/s0021-9673(96)00757-1. [PMID: 9129323]
  • K Koshida, J Harmenberg, U Stendahl, B Wahren, E Borgström, L Helström, L Andersson. Urinary modified nucleosides as tumor markers in cancer of the urinary organs or female genital tract. Urological research. 1985; 13(5):213-8. doi: 10.1007/bf00261578. [PMID: 4060364]
  • C Jayabaskaran. Antibodies specific for 1-methylguanosine as a probe of tRNA conformation. Biochemistry international. 1984 Apr; 8(4):561-71. doi: NULL. [PMID: 6477620]
  • D A Heldman, M R Grever, J S Miser, R W Trewyn. Relationship of urinary excretion of modified nucleosides to disease status in childhood acute lymphoblastic leukemia. Journal of the National Cancer Institute. 1983 Aug; 71(2):269-73. doi: . [PMID: 6576186]
  • D A Heldman, M R Grever, C E Speicher, R W Trewyn. Urinary excretion of modified nucleosides in chronic myelogenous leukemia. The Journal of laboratory and clinical medicine. 1983 May; 101(5):783-92. doi: NULL. [PMID: 6572681]
  • P Clemens, G Schöch, G Ziemer, J Altenhoff, N Erb, H Lorenz, J Müller, R Grüttner. [Excretion of methylated nucleosides in the initial therapy phase in a case of anorexia nervosa]. Padiatrie und Padologie. 1982; 17(2):157-63. doi: NULL. [PMID: 7099674]