N6-Succinyl Adenosine (BioDeep_00000181426)
human metabolite blood metabolite natural product
代谢物信息卡片
化学式: C14H17N5O8 (383.1077)
中文名称: N6-琥珀酰腺苷
谱图信息:
最多检出来源 Homo sapiens(blood) 84.47%
Last reviewed on 2024-07-29.
Cite this Page
N6-Succinyl Adenosine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/n6-succinyl_adenosine (retrieved
2025-02-19) (BioDeep RN: BioDeep_00000181426). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: O=C(O)CC(Nc1ncnc2c1ncn2C1OC(CO)C(O)C1O)C(=O)O
InChI: InChI=1S/C14H17N5O8/c20-2-6-9(23)10(24)13(27-6)19-4-17-8-11(15-3-16-12(8)19)18-5(14(25)26)1-7(21)22/h3-6,9-10,13,20,23-24H,1-2H2,(H,21,22)(H,25,26)(H,15,16,18)
描述信息
N6-Succinyl Adenosine (Succinyl-AMP) is a nucleotide derivative that possesses a unique chemical structure and plays significant roles in various biological processes. Its chemical structure consists of adenosine, a nucleoside composed of the nitrogenous base adenine and ribose sugar, with an additional succinyl group attached to the N6 position of the adenine base. This succinyl group is derived from succinic acid, a four-carbon dicarboxylic acid.
The presence of the succinyl group at the N6 position of adenine alters the physicochemical properties of adenosine, influencing its interactions with enzymes and other molecules in the cell. This modification is biologically relevant, as N6-succinyl adenosine is involved in several metabolic pathways and regulatory mechanisms.
Biologically, N6-succinyl adenosine is known for its role in the regulation of gene expression. It can serve as a substrate for the formation of N6-threonylcarbamoyladenosine (t6A), a key modification found in the wobble position of certain tRNAs. This modification is critical for the efficiency of translation initiation and the accuracy of decoding the genetic code.
Moreover, N6-succinyl adenosine is involved in the transsulfuration pathway, a metabolic route that interconverts sulfur-containing amino acids. It acts as a precursor for the synthesis of cysteine, an essential amino acid that plays a vital role in protein structure and function, as well as in the synthesis of glutathione, a major antioxidant in the cell.
Additionally, N6-succinyl adenosine has been implicated in the process of protein succinylation, a novel post-translational modification where the succinyl group is transferred to lysine residues of proteins. This modification can affect protein function, stability, and cellular signaling pathways.
2-({9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-yl}amino)butanedioic acid belongs to the class of organic compounds known as purine nucleosides. Purine nucleosides are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety. Based on a literature review very few articles have been published on 2-({9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-yl}amino)butanedioic acid. This compound has been identified in human blood as reported by (PMID: 31557052 ). N6-succinyl adenosine is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. Technically N6-Succinyl Adenosine is part of the human exposome. The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual's exposure begins before birth and includes insults from environmental and occupational sources.
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代谢反应
0 个相关的代谢反应过程信息。
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24 个相关的物种来源信息
- 4890 - Ascomycota: LTS0031850
- 1131492 - Aspergillaceae: LTS0031850
- 2759 - Eukaryota: LTS0031850
- 147545 - Eurotiomycetes: LTS0031850
- 4751 - Fungi: LTS0031850
- 9606 - Homo sapiens: -
- 4447 - Liliopsida: LTS0031850
- 3398 - Magnoliopsida: LTS0031850
- 5140 - Neurospora: LTS0031850
- 5141 - Neurospora crassa: LTS0031850
- 5073 - Penicillium: LTS0031850
- 5076 - Penicillium chrysogenum: 10.1038/179154A0
- 5076 - Penicillium chrysogenum: LTS0031850
- 4479 - Poaceae: LTS0031850
- 5148 - Sordariaceae: LTS0031850
- 147550 - Sordariomycetes: LTS0031850
- 35493 - Streptophyta: LTS0031850
- 58023 - Tracheophyta: LTS0031850
- 28568 - Trichocomaceae: LTS0031850
- 33090 - Viridiplantae: LTS0031850
- 4575 - Zea: LTS0031850
- 4577 - Zea mays: 10.1016/0031-9422(73)80453-4
- 4577 - Zea mays: LTS0031850
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
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