Candoxatrilat (BioDeep_00000176972)
human metabolite blood metabolite
代谢物信息卡片
4-{[(1-{2-carboxy-2-[(2-methoxyethoxy)methyl]ethyl}cyclopentyl)(hydroxy)methylidene]amino}cyclohexane-1-carboxylate
化学式: C20H33NO7 (399.22569080000005)
中文名称: 坎沙曲拉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COCCOCC(CC1(CCCC1)C(=O)NC1CCC(CC1)C(O)=O)C(O)=O
InChI: InChI=1S/C20H33NO7/c1-27-10-11-28-13-15(18(24)25)12-20(8-2-3-9-20)19(26)21-16-6-4-14(5-7-16)17(22)23/h14-16H,2-13H2,1H3,(H,21,26)(H,22,23)(H,24,25)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
同义名列表
5 个代谢物同义名
4-{[(1-{2-carboxy-2-[(2-methoxyethoxy)methyl]ethyl}cyclopentyl)(hydroxy)methylidene]amino}cyclohexane-1-carboxylate; 4-((2-Carboxy-3-(2-methoxyethoxy)propyl)-1-cyclopentanecarbonylamino)-1-cyclohexanecarboxylic acid; 4-(1-{2-carboxy-2-[(2-methoxyethoxy)methyl]ethyl}cyclopentaneamido)cyclohexane-1-carboxylic acid; Candoxatrilat, 4(S)-cis isomer; candoxatrilat
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- G Sansoè, M Aragno, R Mastrocola, J C Cutrin, S Silvano, G Mengozzi, A Smedile, F Rosina, O Danni, M Rizzetto. Overexpression of kidney neutral endopeptidase (EC 3.4.24.11) and renal function in experimental cirrhosis.
American journal of physiology. Renal physiology.
2006 Jun; 290(6):F1337-43. doi:
10.1152/ajprenal.00435.2005. [PMID: 16449355] - Giovanni Sansoè, Manuela Aragno, Raffaella Mastrocola, Francesca Restivo, Giulio Mengozzi, Antonina Smedile, Floriano Rosina, Oliviero Danni, Maurizio Parola, Mario Rizzetto. Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?.
Journal of hepatology.
2005 Nov; 43(5):791-8. doi:
10.1016/j.jhep.2005.04.017. [PMID: 16085334] - Thomas Walther, Holger Stepan, Kristin Pankow, Matthias Becker, Heinz-Peter Schultheiss, Wolf-Eberhard Siems. Biochemical analysis of neutral endopeptidase activity reveals independent catabolism of atrial and brain natriuretic peptide.
Biological chemistry.
2004 Feb; 385(2):179-84. doi:
10.1515/bc.2004.036. [PMID: 15101560] - O Lisy, M Jougasaki, J A Schirger, H H Chen, P T Barclay, J C Burnett. Neutral endopeptidase inhibition potentiates the natriuretic actions of adrenomedullin.
The American journal of physiology.
1998 09; 275(3):F410-4. doi:
10.1152/ajprenal.1998.275.3.f410. [PMID: 9729514] - G W Lipkin, R Thuraisingham, A B Dawnay, S M Harwood, A E Raine. Acute reversal of cyclosporine nephrotoxicity by neutral endopeptidase inhibition in stable renal transplant recipients.
Transplantation.
1997 Oct; 64(7):1007-17. doi:
10.1097/00007890-199710150-00013. [PMID: 9381523] - B Kaye, C J Brearley, N J Cussans, M Herron, M J Humphrey, A R Mollatt. Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril.
Xenobiotica; the fate of foreign compounds in biological systems.
1997 Oct; 27(10):1091-102. doi:
10.1080/004982597240046. [PMID: 9364744] - G W Lipkin, A B Dawnay, S M Harwood, W R Cattell, A E Raine. Enhanced natriuretic response to neutral endopeptidase inhibition in patients with moderate chronic renal failure.
Kidney international.
1997 Sep; 52(3):792-801. doi:
10.1038/ki.1997.396. [PMID: 9291201] - N Nomura, K Shimamoto, N Ura, M Iwata, T Aoyama, Y Takagawa, O Iimura. The role of kinins and atrial natriuretic peptide on the renal effects of neutral endopeptidase inhibitor in normotensive and hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1995 Nov; 17(8):1219-31. doi:
10.3109/10641969509037405. [PMID: 8563698] - N Ura, K Shimamoto, N Nomura, T Aoyama, M Iwata, Y Takagawa, O Iimura. The mechanisms of the renal effects of neutral endopeptidase inhibitor in rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1995 Nov; 17(8):1183-96. doi:
10.3109/10641969509037403. [PMID: 8563696] - J M Good, M Peters, M Wilkins, N Jackson, C M Oakley, J G Cleland. Renal response to candoxatrilat in patients with heart failure.
Journal of the American College of Cardiology.
1995 May; 25(6):1273-81. doi:
10.1016/0735-1097(94)00561-4. [PMID: 7722120] - J G Motwani, C C Lang, G Cramb, A D Struthers. Natriuretic response to neutral endopeptidase inhibition is blunted by enalapril in healthy men.
Hypertension (Dallas, Tex. : 1979).
1995 Apr; 25(4 Pt 1):637-42. doi:
10.1161/01.hyp.25.4.637. [PMID: 7721409] - R D Ghai, S De Lombaert, G M Ksander, C Berry, Y Sakane, A J Trapani. A rapid indirect method to determine the plasma concentrations of neutral endopeptidase inhibitors.
Research communications in molecular pathology and pharmacology.
1995 Feb; 87(2):211-20. doi:
NULL. [PMID: 7749658] - N Ura, K Shimamoto, S Kuroda, N Nomura, M Iwata, T Aoyama, O Iimura. The role of kinins and atrial natriuretic peptide on the renal effects of neutral endopeptidase inhibitor in rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1994 Nov; 16(6):799-808. doi:
10.3109/10641969409078026. [PMID: 7858560] - K Shimamoto, N Ura, O Iimura. The natriuretic mechanisms of neutral endopeptidase inhibitor in rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
1994 Aug; 27(8):1965-73. doi:
NULL. [PMID: 7749388] - J M Scott, P L Barclay, N B Shepperson. Renal effects of neutral endopeptidase inhibition in euvolemic and hypervolemic rats.
European journal of pharmacology.
1993 Sep; 242(1):91-7. doi:
10.1016/0014-2999(93)90014-9. [PMID: 8223941] - J E Kirk, M R Wilkins. Effect of endopeptidase-24.11 inhibition and of atrial natriuretic peptide clearance receptor ligand on the response to rat brain natriuretic peptide in the conscious rat.
British journal of pharmacology.
1993 Sep; 110(1):350-4. doi:
10.1111/j.1476-5381.1993.tb13816.x. [PMID: 8220896] - G W Lipkin, I C Macdougall, A E Raine. Prolonged elevation of plasma atrial natriuretic factor does not increase erythropoietin levels in patients with chronic renal failure.
Nephron.
1993; 65(4):640-1. doi:
10.1159/000187580. [PMID: 8302426] - T Münzel, S Kurz, J Holtz, R Busse, H Steinhauer, H Just, H Drexler. Neurohormonal inhibition and hemodynamic unloading during prolonged inhibition of ANF degradation in patients with severe chronic heart failure.
Circulation.
1992 Oct; 86(4):1089-98. doi:
10.1161/01.cir.86.4.1089. [PMID: 1394917] - D B Northridge, A Jardine, E Henderson, S G Dilly, H J Dargie. Increased circulating atrial natriuretic factor concentrations in patients with chronic heart failure after inhibition of neutral endopeptidase: effects on diastolic function.
British heart journal.
1992 Oct; 68(4):387-91. doi:
10.1136/hrt.68.10.387. [PMID: 1449922] - P L Barclay, J A Bennett, P M Greengrass, A Griffin, G M Samuels, N B Shepperson. The pharmacokinetics of 125I-atrial natriuretic factor in anaesthetized rats. Effects of neutral endopeptidase inhibition with candoxatrilat and of ANF-C receptor blockade.
Biochemical pharmacology.
1992 Sep; 44(6):1013-22. doi:
10.1016/0006-2952(92)90362-m. [PMID: 1417928] - M R Wilkins, S L Settle, J E Kirk, S A Taylor, K P Moore, R J Unwin. Response to atrial natriuretic peptide, endopeptidase 24.11 inhibitor and C-ANP receptor ligand in the rat.
British journal of pharmacology.
1992 Sep; 107(1):50-7. doi:
10.1111/j.1476-5381.1992.tb14462.x. [PMID: 1330165] - R J Winter, L Zhao, T Krausz, J M Hughes. Neutral endopeptidase 24.11 inhibition reduces pulmonary vascular remodeling in rats exposed to chronic hypoxia.
The American review of respiratory disease.
1991 Dec; 144(6):1342-6. doi:
10.1164/ajrccm/144.6.1342. [PMID: 1835825] - N B Shepperson, P L Barclay, J A Bennett, G M Samuels. Inhibition of neutral endopeptidase (EC 3.4.24.11) leads to an atrial natriuretic factor-mediated natriuretic, diuretic and antihypertensive response in rodents.
Clinical science (London, England : 1979).
1991 Mar; 80(3):265-9. doi:
10.1042/cs0800265. [PMID: 1850687] - P L Barclay, J A Bennett, G M Samuels, N B Shepperson. The atriopeptidase inhibitor (+/-) candoxatrilat reduces the clearance of atrial natriuretic factor in both intact and nephrectomized rats: evidence for an extrarenal site of action.
Biochemical pharmacology.
1991 Mar; 41(5):841-4. doi:
10.1016/0006-2952(91)90091-i. [PMID: 1847819] - A G Jardine, J M Connell, D Northridge, S G Dilly, N J Cussans, G Davidson, J Doyle, B L Leckie, A F Lever. The atriopeptidase inhibitor UK 69,578 increases atrial natriuretic factor and causes a natriuresis in normal humans.
American journal of hypertension.
1990 Sep; 3(9):661-7. doi:
10.1093/ajh/3.9.661. [PMID: 2145871] - D B Northridge, A G Jardine, I N Findlay, M Archibald, S G Dilly, H J Dargie. Inhibition of the metabolism of atrial natriuretic factor causes diuresis and natriuresis in chronic heart failure.
American journal of hypertension.
1990 Sep; 3(9):682-7. doi:
10.1093/ajh/3.9.682. [PMID: 2145874] - J C Danilewicz, P L Barclay, I T Barnish, D Brown, S F Campbell, K James, G M Samuels, N K Terrett, M J Wythes. UK-69,578, a novel inhibitor of EC 3.4.24.11 which increases endogenous ANF levels and is natriuretic and diuretic.
Biochemical and biophysical research communications.
1989 Oct; 164(1):58-65. doi:
10.1016/0006-291x(89)91682-3. [PMID: 2529858]