Aconitic acid (BioDeep_00000175708)

   

human metabolite blood metabolite natural product


代谢物信息卡片


prop-1-ene-1,2,3-tricarboxylic acid

化学式: C6H6O6 (174.0164)
中文名称: 乌头酸
谱图信息: 最多检出来源 Homo sapiens(blood) 14.6%

分子结构信息

SMILES: C(C(=CC(=O)O)C(=O)O)C(=O)O
InChI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

53 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Alyssa C Baugh, Justin B Defalco, Chantel V Duscent-Maitland, Melissa P Tumen-Velasquez, Nicole S Laniohan, Kayla Figatner, Timothy R Hoover, Anna C Karls, Kathryn T Elliott, Ellen L Neidle. Regulation of tricarboxylate transport and metabolism in Acinetobacter baylyi ADP1. Applied and environmental microbiology. 2024 Jan; ?(?):e0211123. doi: 10.1128/aem.02111-23. [PMID: 38289138]
  • Zhaojun Nie, Linglu Wang, Peng Zhao, Zhenbo Wang, Qiuzhe Shi, Hongen Liu. Metabolomics reveals the impact of nitrogen combined with the zinc supply on zinc availability in calcareous soil via root exudates of winter wheat (Triticum aestivum). Plant physiology and biochemistry : PPB. 2023 Nov; 204(?):108069. doi: 10.1016/j.plaphy.2023.108069. [PMID: 37852066]
  • Ce Geng, Zhigang Jin, Meng Gu, Jibin Li, Shen Tang, Qiang Guo, Yunpeng Zhang, Wei Zhang, Yuezhong Li, Xuenian Huang, Xuefeng Lu. Microbial production of trans-aconitic acid. Metabolic engineering. 2023 Jun; ?(?):. doi: 10.1016/j.ymben.2023.06.007. [PMID: 37315711]
  • Waeil Al Youssef, Regina Feil, Maureen Saint-Sorny, Xenie Johnson, John E Lunn, Bernhard Grimm, Pawel Brzezowski. Singlet oxygen-induced signalling depends on the metabolic status of the Chlamydomonas reinhardtii cell. Communications biology. 2023 May; 6(1):529. doi: 10.1038/s42003-023-04872-5. [PMID: 37193883]
  • Congcong Chen, Junshen Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou. An integrated strategy to study the combination mechanisms of Bupleurum chinense DC and Paeonia lactiflora Pall for treating depression based on correlation analysis between serum chemical components profiles and endogenous metabolites profiles. Journal of ethnopharmacology. 2023 Apr; 305(?):116068. doi: 10.1016/j.jep.2022.116068. [PMID: 36574791]
  • Somruthai Chaowongdee, Srihunsa Malichan, Pornkanok Pongpamorn, Atchara Paemanee, Wanwisa Siriwan. Metabolic profiles of Sri Lankan cassava mosaic virus-infected and healthy cassava (Manihot esculenta Crantz) cultivars with tolerance and susceptibility phenotypes. BMC plant biology. 2023 Apr; 23(1):178. doi: 10.1186/s12870-023-04181-3. [PMID: 37020181]
  • Sandeep Kumar, Anmol, Upendra Sharma, Sg Eswara Reddy. Insecticidal potential of extracts, fractions, and molecules of Aconitum heterophyllum Wall ex. Royle against aphid Aphis craccivora Koch (Hemiptera: Aphididae). Pest management science. 2022 Dec; ?(?):. doi: 10.1002/ps.7324. [PMID: 36519419]
  • Diego Pinto de Oliveira, Eliana de Faria Garcia, Mariana Assíria de Oliveira, Luiza C M Candido, Fernanda M Coelho, Vivian Vasconcelos Costa, Nathália Vieira Batista, Celso Martins Queiroz-Junior, Larissa Froede Brito, Lirlândia Pires Sousa, Daniele G Souza, Flávio Almeida Amaral, Rodrigo Maia de Pádua, Mauro Martins Teixeira, Fernão Castro Braga. cis-Aconitic Acid, a Constituent of Echinodorus grandiflorus Leaves, Inhibits Antigen-Induced Arthritis and Gout in Mice. Planta medica. 2022 Oct; 88(13):1123-1131. doi: 10.1055/a-1676-4371. [PMID: 34763354]
  • Ru-Ping Hong, Yue-Ying Hou, Xin-Jie Xu, Ji-Dong Lang, Yun-Feng Jin, Xiao-Feng Zeng, Xuan Zhang, Geng Tian, Xin You. The Difference of Gut Microbiota and Their Correlations With Urinary Organic Acids Between Autistic Children With and Without Atopic Dermatitis. Frontiers in cellular and infection microbiology. 2022; 12(?):886196. doi: 10.3389/fcimb.2022.886196. [PMID: 35800387]
  • Mònica Bulló, Christopher Papandreou, Jesus García-Gavilán, Miguel Ruiz-Canela, Jun Li, Marta Guasch-Ferré, Estefanía Toledo, Clary Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Chih-Hao Lee, Kerry Pierce, Cristina Razquin, Fernando Arós, Lluís Serra-Majem, Liming Liang, Miguel A Martínez-González, Frank B Hu, Jordi Salas-Salvadó. Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure. Metabolism: clinical and experimental. 2021 12; 125(?):154915. doi: 10.1016/j.metabol.2021.154915. [PMID: 34678258]
  • Alexander T Eprintsev, Dmitry N Fedorin, Maria A Dobychina, Abir U Igamberdiev. Aconitate isomerase from maize leaves: Light-dependent expression and kinetic properties. Journal of plant physiology. 2021 Feb; 257(?):153350. doi: 10.1016/j.jplph.2020.153350. [PMID: 33360493]
  • Wen-Fa Zhang, Ze-Hao Gong, Meng-Bo Wu, Helen Chan, Yu-Jin Yuan, Ning Tang, Qiang Zhang, Ming-Jun Miao, Wei Chang, Zhi Li, Zheng-Guo Li, Liang Jin, Wei Deng. Integrative comparative analyses of metabolite and transcript profiles uncovers complex regulatory network in tomato (Solanum lycopersicum L.) fruit undergoing chilling injury. Scientific reports. 2019 03; 9(1):4470. doi: 10.1038/s41598-019-41065-9. [PMID: 30872788]
  • Tiara da Silva Coelho Bortolo, Rogério Marchiosi, Joselaine Viganó, Rita de Cássia Siqueira-Soares, Ana Paula Ferro, Gabriela Elen Barreto, Graciene de Souza Bido, Josielle Abrahão, Wanderley Dantas Dos Santos, Osvaldo Ferrarese-Filho. Trans-aconitic acid inhibits the growth and photosynthesis of Glycine max. Plant physiology and biochemistry : PPB. 2018 Nov; 132(?):490-496. doi: 10.1016/j.plaphy.2018.09.036. [PMID: 30292981]
  • Diego Pinto de Oliveira, Gabriela Guimarães Augusto, Nathália Vieira Batista, Vivian Louise S de Oliveira, Diêgo Santos Ferreira, Mateus Araújo Castro E Souza, Christian Fernandes, Flávio Almeida Amaral, Mauro Martins Teixeira, Rodrigo Maia de Pádua, Mônica Cristina Oliveira, Fernão Castro Braga. Encapsulation of trans-aconitic acid in mucoadhesive microspheres prolongs the anti-inflammatory effect in LPS-induced acute arthritis. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Jul; 119(?):112-120. doi: 10.1016/j.ejps.2018.04.010. [PMID: 29627623]
  • Ana M Gil, Daniela Duarte, Joana Pinto, António S Barros. Assessing Exposome Effects on Pregnancy through Urine Metabolomics of a Portuguese (Estarreja) Cohort. Journal of proteome research. 2018 03; 17(3):1278-1289. doi: 10.1021/acs.jproteome.7b00878. [PMID: 29424227]
  • Diego Pinto de Oliveira, Thales do Valle Moreira, Nathália Vieira Batista, José Dias de Souza Filho, Flávio Almeida Amaral, Mauro Martins Teixeira, Rodrigo Maia de Pádua, Fernão Castro Braga. Esterification of trans-aconitic acid improves its anti-inflammatory activity in LPS-induced acute arthritis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Mar; 99(?):87-95. doi: 10.1016/j.biopha.2018.01.009. [PMID: 29329035]
  • Stein Hallan, Maryam Afkarian, Leila R Zelnick, Bryan Kestenbaum, Shoba Sharma, Rintaro Saito, Manjula Darshi, Gregory Barding, Daniel Raftery, Wenjun Ju, Matthias Kretzler, Kumar Sharma, Ian H de Boer. Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients. EBioMedicine. 2017 Dec; 26(?):68-77. doi: 10.1016/j.ebiom.2017.10.027. [PMID: 29128444]
  • Ammar Hassanzadeh Keshteli, Floris F van den Brand, Karen L Madsen, Rupasri Mandal, Rosica Valcheva, Karen I Kroeker, Beomsoo Han, Rhonda C Bell, Janis Cole, Thomas Hoevers, David S Wishart, Richard N Fedorak, Levinus A Dieleman. Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study. World journal of gastroenterology. 2017 Jun; 23(21):3890-3899. doi: 10.3748/wjg.v23.i21.3890. [PMID: 28638229]
  • Cuiying Du, Shiyun Cao, Xiangyu Shi, Xiangtao Nie, Jinshui Zheng, Yun Deng, Lifang Ruan, Donghai Peng, Ming Sun. Genetic and Biochemical Characterization of a Gene Operon for trans-Aconitic Acid, a Novel Nematicide from Bacillus thuringiensis. The Journal of biological chemistry. 2017 02; 292(8):3517-3530. doi: 10.1074/jbc.m116.762666. [PMID: 28087696]
  • Lucia Abela, Ronen Spiegel, Lisa M Crowther, Andrea Klein, Katharina Steindl, Sorina Mihaela Papuc, Pascal Joset, Yoav Zehavi, Anita Rauch, Barbara Plecko, Thomas Luke Simmons. Plasma metabolomics reveals a diagnostic metabolic fingerprint for mitochondrial aconitase (ACO2) deficiency. PloS one. 2017; 12(5):e0176363. doi: 10.1371/journal.pone.0176363. [PMID: 28463998]
  • Chun Zhang, Cheng-Li Ling, Liang Pang, Qi Wang, Jing-Xin Liu, Bing-Shan Wang, Jian-Ming Liang, Yi-Zhen Guo, Jing Qin, Jian-Xin Wang. Direct Macromolecular Drug Delivery to Cerebral Ischemia Area using Neutrophil-Mediated Nanoparticles. Theranostics. 2017; 7(13):3260-3275. doi: 10.7150/thno.19979. [PMID: 28900508]
  • William Piang-Siong, Pascale de Caro, Arnaud Marvilliers, Xavier Chasseray, Bertrand Payet, Alain Shum Cheong Sing, Bertrand Illien. Contribution of trans-aconitic acid to DPPH scavenging ability in different media. Food chemistry. 2017 Jan; 214(?):447-452. doi: 10.1016/j.foodchem.2016.07.083. [PMID: 27507497]
  • Gantumur Battogtokh, Young Tag Ko. Graphene oxide-incorporated pH-responsive folate-albumin-photosensitizer nanocomplex as image-guided dual therapeutics. Journal of controlled release : official journal of the Controlled Release Society. 2016 07; 234(?):10-20. doi: 10.1016/j.jconrel.2016.05.007. [PMID: 27164545]
  • Chen Yuan, Clary B Clish, Chen Wu, Jared R Mayers, Peter Kraft, Mary K Townsend, Mingfeng Zhang, Shelley S Tworoger, Ying Bao, Zhi Rong Qian, Douglas A Rubinson, Kimmie Ng, Edward L Giovannucci, Shuji Ogino, Meir J Stampfer, John Michael Gaziano, Jing Ma, Howard D Sesso, Garnet L Anderson, Barbara B Cochrane, JoAnn E Manson, Margaret E Torrence, Alec C Kimmelman, Laufey T Amundadottir, Matthew G Vander Heiden, Charles S Fuchs, Brian M Wolpin. Circulating Metabolites and Survival Among Patients With Pancreatic Cancer. Journal of the National Cancer Institute. 2016 Jun; 108(6):djv409. doi: 10.1093/jnci/djv409. [PMID: 26755275]
  • Tingting Wei, Liangcai Zhao, Jianmin Jia, Huanhuan Xia, Yao Du, Qiuting Lin, Xiaodong Lin, Xinjian Ye, Zhihan Yan, Hongchang Gao. Metabonomic analysis of potential biomarkers and drug targets involved in diabetic nephropathy mice. Scientific reports. 2015 Jul; 5(?):11998. doi: 10.1038/srep11998. [PMID: 26149603]
  • Donald F Stec, Suwan Wang, Cody Stothers, Josh Avance, Deon Denson, Raymond Harris, Paul Voziyan. Alterations of urinary metabolite profile in model diabetic nephropathy. Biochemical and biophysical research communications. 2015 Jan; 456(2):610-4. doi: 10.1016/j.bbrc.2014.12.003. [PMID: 25499815]
  • Haldis H Lillefosse, Morten R Clausen, Christian C Yde, Ditte B Ditlev, Xumin Zhang, Zhen-Yu Du, Hanne C Bertram, Lise Madsen, Karsten Kristiansen, Bjørn Liaset. Urinary loss of tricarboxylic acid cycle intermediates as revealed by metabolomics studies: an underlying mechanism to reduce lipid accretion by whey protein ingestion?. Journal of proteome research. 2014 May; 13(5):2560-70. doi: 10.1021/pr500039t. [PMID: 24702026]
  • Ming Wang, Kyle Alberti, Shuo Sun, Carlos Luis Arellano, Qiaobing Xu. Combinatorially designed lipid-like nanoparticles for intracellular delivery of cytotoxic protein for cancer therapy. Angewandte Chemie (International ed. in English). 2014 Mar; 53(11):2893-8. doi: 10.1002/anie.201311245. [PMID: 24519972]
  • Doris M Jacobs, Laura Spiesser, Maxime Garnier, Niels de Roo, Ferdi van Dorsten, Boudewijn Hollebrands, Ewoud van Velzen, Richard Draijer, John van Duynhoven. SPE-NMR metabolite sub-profiling of urine. Analytical and bioanalytical chemistry. 2012 Nov; 404(8):2349-61. doi: 10.1007/s00216-012-6339-2. [PMID: 22932811]
  • Guozhu Ye, Bin Zhu, Zhenzhen Yao, Peiyuan Yin, Xin Lu, Hongwei Kong, Fei Fan, Binghua Jiao, Guowang Xu. Analysis of urinary metabolic signatures of early hepatocellular carcinoma recurrence after surgical removal using gas chromatography-mass spectrometry. Journal of proteome research. 2012 Aug; 11(8):4361-72. doi: 10.1021/pr300502v. [PMID: 22768978]
  • Kazuki Akira, Hiroyuki Hichiya, Maki Shuden, Mayu Morita, Hidemichi Mitome. Sample preparation method to minimize chemical shift variability for NMR-based urinary metabonomics of genetically hypertensive rats. Journal of pharmaceutical and biomedical analysis. 2012 Jul; 66(?):339-44. doi: 10.1016/j.jpba.2012.02.020. [PMID: 22445826]
  • Richard C Sicher, Jinyoung Y Barnaby. Impact of carbon dioxide enrichment on the responses of maize leaf transcripts and metabolites to water stress. Physiologia plantarum. 2012 Mar; 144(3):238-53. doi: 10.1111/j.1399-3054.2011.01555.x. [PMID: 22150442]
  • Peter Kämpfer, Stefanie Wellner, Kerstin Lohse, Karin Martin, Nicole Lodders. Duganella phyllosphaerae sp. nov., isolated from the leaf surface of Trifolium repens and proposal to reclassify Duganella violaceinigra into a novel genus as Pseudoduganella violceinigra gen. nov., comb. nov. Systematic and applied microbiology. 2012 Feb; 35(1):19-23. doi: 10.1016/j.syapm.2011.10.003. [PMID: 22169565]
  • Ilka Haferkamp, Stephan Schmitz-Esser. The plant mitochondrial carrier family: functional and evolutionary aspects. Frontiers in plant science. 2012; 3(?):2. doi: 10.3389/fpls.2012.00002. [PMID: 22639632]
  • Ehud Katz, Kyung Hwan Boo, Ho Youn Kim, Richard A Eigenheer, Brett S Phinney, Vladimir Shulaev, Florence Negre-Zakharov, Avi Sadka, Eduardo Blumwald. Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. Journal of experimental botany. 2011 Nov; 62(15):5367-84. doi: 10.1093/jxb/err197. [PMID: 21841177]
  • Takafumi Toyohara, Takehiro Suzuki, Yasutoshi Akiyama, Daisuke Yoshihara, Yoichi Takeuchi, Eikan Mishima, Koichi Kikuchi, Chitose Suzuki, Masayuki Tanemoto, Sadayoshi Ito, Shizuko Nagao, Tomoyoshi Soga, Takaaki Abe. Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model. Clinical and experimental nephrology. 2011 Oct; 15(5):676-687. doi: 10.1007/s10157-011-0467-4. [PMID: 21695416]
  • Elena Lissina, Brian Young, Malene L Urbanus, Xue Li Guan, Jonathan Lowenson, Shawn Hoon, Anastasia Baryshnikova, Isabelle Riezman, Magali Michaut, Howard Riezman, Leah E Cowen, Markus R Wenk, Steven G Clarke, Guri Giaever, Corey Nislow. A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis. PLoS genetics. 2011 Oct; 7(10):e1002332. doi: 10.1371/journal.pgen.1002332. [PMID: 22028670]
  • Timo Mühlhaus, Julia Weiss, Dorothea Hemme, Frederik Sommer, Michael Schroda. Quantitative shotgun proteomics using a uniform ¹⁵N-labeled standard to monitor proteome dynamics in time course experiments reveals new insights into the heat stress response of Chlamydomonas reinhardtii. Molecular & cellular proteomics : MCP. 2011 Sep; 10(9):M110.004739. doi: 10.1074/mcp.m110.004739. [PMID: 21610104]
  • Sílvia O Diaz, Joana Pinto, Gonçalo Graça, Iola F Duarte, António S Barros, Eulália Galhano, Cristina Pita, Maria do Céu Almeida, Brian J Goodfellow, Isabel M Carreira, Ana M Gil. Metabolic biomarkers of prenatal disorders: an exploratory NMR metabonomics study of second trimester maternal urine and blood plasma. Journal of proteome research. 2011 Aug; 10(8):3732-42. doi: 10.1021/pr200352m. [PMID: 21649438]
  • Takeshi Izawa, Motohiro Mihara, Yuji Suzuki, Meenu Gupta, Hironori Itoh, Atsushi J Nagano, Ritsuko Motoyama, Yuji Sawada, Masahiro Yano, Masami Yokota Hirai, Amane Makino, Yoshiaki Nagamura. Os-GIGANTEA confers robust diurnal rhythms on the global transcriptome of rice in the field. The Plant cell. 2011 May; 23(5):1741-55. doi: 10.1105/tpc.111.083238. [PMID: 21571948]
  • Claire L Gavaghan, Jia V Li, Stephen T Hadfield, Stephen Hole, Jeremy K Nicholson, Ian D Wilson, Peter W A Howe, Paul D Stanley, Elaine Holmes. Application of NMR-based metabolomics to the investigation of salt stress in maize (Zea mays). Phytochemical analysis : PCA. 2011 May; 22(3):214-24. doi: 10.1002/pca.1268. [PMID: 21204151]
  • Takafumi Toyohara, Takaaki Abe. [Analysis of transporter function and development to clinical application]. Seikagaku. The Journal of Japanese Biochemical Society. 2011 Apr; 83(4):323-8. doi: NULL. [PMID: 21626887]
  • Jeeyoun Jung, Minhwa Park, Hye Jin Park, Sun Bo Shim, Yang Ha Cho, Jinho Kim, Ho-Sub Lee, Do Hyun Ryu, Donwoong Choi, Geum-Sook Hwang. ¹H NMR-based metabolic profiling of naproxen-induced toxicity in rats. Toxicology letters. 2011 Jan; 200(1-2):1-7. doi: 10.1016/j.toxlet.2010.09.020. [PMID: 20932884]
  • Nico Marr, Nita R Shah, Rose Lee, Emma J Kim, Rachel C Fernandez. Bordetella pertussis autotransporter Vag8 binds human C1 esterase inhibitor and confers serum resistance. PloS one. 2011; 6(6):e20585. doi: 10.1371/journal.pone.0020585. [PMID: 21695123]
  • Jennifer C Ewald, Sabrina Reich, Stephan Baumann, Wolf B Frommer, Nicola Zamboni. Engineering genetically encoded nanosensors for real-time in vivo measurements of citrate concentrations. PloS one. 2011; 6(12):e28245. doi: 10.1371/journal.pone.0028245. [PMID: 22164251]
  • Takayuki Tohge, Tabea Mettler, Stéphanie Arrivault, Adam James Carroll, Mark Stitt, Alisdair R Fernie. From models to crop species: caveats and solutions for translational metabolomics. Frontiers in plant science. 2011; 2(?):61. doi: 10.3389/fpls.2011.00061. [PMID: 22639601]
  • Linkun Wu, Haibin Wang, Zhixing Zhang, Rui Lin, Zhongyi Zhang, Wenxiong Lin. Comparative metaproteomic analysis on consecutively Rehmannia glutinosa-monocultured rhizosphere soil. PloS one. 2011; 6(5):e20611. doi: 10.1371/journal.pone.0020611. [PMID: 21655235]
  • So-Hyun Kim, Somi K Cho, Sun-Hee Hyun, Hae-Eun Park, Young-Suk Kim, Hyung-Kyoon Choi. Metabolic profiling and predicting the free radical scavenging activity of guava (Psidium guajava L.) leaves according to harvest time by 1H-nuclear magnetic resonance spectroscopy. Bioscience, biotechnology, and biochemistry. 2011; 75(6):1090-7. doi: 10.1271/bbb.100908. [PMID: 21670527]
  • Harin Kanani, Bhaskar Dutta, Maria I Klapa. Individual vs. combinatorial effect of elevated CO2 conditions and salinity stress on Arabidopsis thaliana liquid cultures: comparing the early molecular response using time-series transcriptomic and metabolomic analyses. BMC systems biology. 2010 Dec; 4(?):177. doi: 10.1186/1752-0509-4-177. [PMID: 21190570]
  • Il Yong Kim, Jeeyoun Jung, Mi Jang, Yun Gyong Ahn, Jae Hoon Shin, Ji Won Choi, Mi Ra Sohn, Sun Mee Shin, Dae-Gil Kang, Ho-Sub Lee, Yun Soo Bae, Do Hyun Ryu, Je Kyung Seong, Geum-Sook Hwang. 1H NMR-based metabolomic study on resistance to diet-induced obesity in AHNAK knock-out mice. Biochemical and biophysical research communications. 2010 Dec; 403(3-4):428-34. doi: 10.1016/j.bbrc.2010.11.048. [PMID: 21094140]
  • Eliana de Faria Garcia, Mariana Assíria de Oliveira, Adriana Martins Godin, Wallace Carvalho Ferreira, Leandro Francisco Silva Bastos, Márcio de Matos Coelho, Fernão Castro Braga. Antiedematogenic activity and phytochemical composition of preparations from Echinodorus grandiflorus leaves. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Dec; 18(1):80-6. doi: 10.1016/j.phymed.2010.05.008. [PMID: 20637578]
  • Oliver Fiehn, W Timothy Garvey, John W Newman, Kerry H Lok, Charles L Hoppel, Sean H Adams. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PloS one. 2010 Dec; 5(12):e15234. doi: 10.1371/journal.pone.0015234. [PMID: 21170321]
  • Ivan K S Yap, Ian J Brown, Queenie Chan, Anisha Wijeyesekera, Isabel Garcia-Perez, Magda Bictash, Ruey Leng Loo, Marc Chadeau-Hyam, Timothy Ebbels, Maria De Iorio, Elaine Maibaum, Liancheng Zhao, Hugo Kesteloot, Martha L Daviglus, Jeremiah Stamler, Jeremy K Nicholson, Paul Elliott, Elaine Holmes. Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study. Journal of proteome research. 2010 Dec; 9(12):6647-54. doi: 10.1021/pr100798r. [PMID: 20853909]
  • Muniasamy Neerathilingam, David E Volk, Swapna Sarkar, Todd M Alam, M Kathleen Alam, G A Shakeel Ansari, Bruce A Luxon. 1H NMR-based metabonomic investigation of tributyl phosphate exposure in rats. Toxicology letters. 2010 Nov; 199(1):10-6. doi: 10.1016/j.toxlet.2010.07.013. [PMID: 20688139]
  • A Almodares, M Ranjbar, M R Hadi. Effects of nitrogen treatments and harvesting stages on the aconitic acid, invert sugar and fiber in sweet sorghum cultivars. Journal of environmental biology. 2010 Nov; 31(6):1001-5. doi: . [PMID: 21506489]
  • Zeming Wu, Min Li, Chunxia Zhao, Jia Zhou, Yuwei Chang, Xiang Li, Peng Gao, Xin Lu, Yousheng Li, Guowang Xu. Urinary metabonomics study in a rat model in response to protein-energy malnutrition by using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. Molecular bioSystems. 2010 Nov; 6(11):2157-63. doi: 10.1039/c005291d. [PMID: 20717558]
  • Javier Terol, Guillermo Soler, Manuel Talon, Manuel Cercos. The aconitate hydratase family from Citrus. BMC plant biology. 2010 Oct; 10(?):222. doi: 10.1186/1471-2229-10-222. [PMID: 20958971]
  • Karin Radrich, Yoshimasa Tsuruoka, Paul Dobson, Albert Gevorgyan, Neil Swainston, Gino Baart, Jean-Marc Schwartz. Integration of metabolic databases for the reconstruction of genome-scale metabolic networks. BMC systems biology. 2010 Aug; 4(?):114. doi: 10.1186/1752-0509-4-114. [PMID: 20712863]
  • Dennis Janz, Katja Behnke, Jörg-Peter Schnitzler, Basem Kanawati, Philippe Schmitt-Kopplin, Andrea Polle. Pathway analysis of the transcriptome and metabolome of salt sensitive and tolerant poplar species reveals evolutionary adaption of stress tolerance mechanisms. BMC plant biology. 2010 Jul; 10(?):150. doi: 10.1186/1471-2229-10-150. [PMID: 20637123]
  • Nathalie Gonzalez, Stefanie De Bodt, Ronan Sulpice, Yusuke Jikumaru, Eunyoung Chae, Stijn Dhondt, Twiggy Van Daele, Liesbeth De Milde, Detlef Weigel, Yuji Kamiya, Mark Stitt, Gerrit T S Beemster, Dirk Inzé. Increased leaf size: different means to an end. Plant physiology. 2010 Jul; 153(3):1261-79. doi: 10.1104/pp.110.156018. [PMID: 20460583]
  • Marie-Caroline Steinhauser, Dirk Steinhauser, Karin Koehl, Fernando Carrari, Yves Gibon, Alisdair R Fernie, Mark Stitt. Enzyme activity profiles during fruit development in tomato cultivars and Solanum pennellii. Plant physiology. 2010 May; 153(1):80-98. doi: 10.1104/pp.110.154336. [PMID: 20335402]
  • Aleksej Zelezniak, Tune H Pers, Simão Soares, Mary Elizabeth Patti, Kiran Raosaheb Patil. Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes. PLoS computational biology. 2010 Apr; 6(4):e1000729. doi: 10.1371/journal.pcbi.1000729. [PMID: 20369014]
  • Margaretha J van der Merwe, Jan-Hendrik Groenewald, Mark Stitt, Jens Kossmann, Frederik C Botha. Downregulation of pyrophosphate: D-fructose-6-phosphate 1-phosphotransferase activity in sugarcane culms enhances sucrose accumulation due to elevated hexose-phosphate levels. Planta. 2010 Feb; 231(3):595-608. doi: 10.1007/s00425-009-1069-1. [PMID: 19957089]
  • Anibh M Das, Ulrike Steuerwald, Sabine Illsinger. Inborn errors of energy metabolism associated with myopathies. Journal of biomedicine & biotechnology. 2010; 2010(?):340849. doi: 10.1155/2010/340849. [PMID: 20589068]
  • Takafumi Toyohara, Takehiro Suzuki, Ryo Morimoto, Yasutoshi Akiyama, Tomokazu Souma, Hiromi O Shiwaku, Yoichi Takeuchi, Eikan Mishima, Michiaki Abe, Masayuki Tanemoto, Satohiro Masuda, Hiroaki Kawano, Koji Maemura, Masaaki Nakayama, Hiroshi Sato, Tsuyoshi Mikkaichi, Hiroaki Yamaguchi, Shigefumi Fukui, Yoshihiro Fukumoto, Hiroaki Shimokawa, Ken-ichi Inui, Tetsuya Terasaki, Junichi Goto, Sadayoshi Ito, Takanori Hishinuma, Isabelle Rubera, Michel Tauc, Yoshiaki Fujii-Kuriyama, Hikaru Yabuuchi, Yoshinori Moriyama, Tomoyoshi Soga, Takaaki Abe. SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. Journal of the American Society of Nephrology : JASN. 2009 Dec; 20(12):2546-55. doi: 10.1681/asn.2009070696. [PMID: 19875811]
  • Francois-Pierre J Martin, Serge Rezzi, Emma Peré-Trepat, Beate Kamlage, Sebastiano Collino, Edgar Leibold, Jürgen Kastler, Dietrich Rein, Laurent B Fay, Sunil Kochhar. Metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress-related metabolism in free-living subjects. Journal of proteome research. 2009 Dec; 8(12):5568-79. doi: 10.1021/pr900607v. [PMID: 19810704]
  • Qing Huang, Yi-Hong Lu, Guang-Ji Wang, Xin-Wen Wang, Nan Meng, Jie Gao, Di Lu, Xin Yan, Ying Zhang, Lin-Sheng Liu, Gang Hao, Bei Yan, Sheng-Hua Gu, Ji-Ye A. [Metabonomic profiling of plasma metabolites in Wistar rats to study the effect of aging by means of GC/TOFMS-based techniques]. Yao xue xue bao = Acta pharmaceutica Sinica. 2009 Oct; 44(10):1095-101. doi: NULL. [PMID: 20055130]
  • Wilfried Rémus-Borel, James G Menzies, Richard R Bélanger. Aconitate and methyl aconitate are modulated by silicon in powdery mildew-infected wheat plants. Journal of plant physiology. 2009 Sep; 166(13):1413-22. doi: 10.1016/j.jplph.2009.02.011. [PMID: 19345440]
  • William R Wikoff, Ewa Kalisak, Sunia Trauger, Marianne Manchester, Gary Siuzdak. Response and recovery in the plasma metabolome tracks the acute LCMV-induced immune response. Journal of proteome research. 2009 Jul; 8(7):3578-87. doi: 10.1021/pr900275p. [PMID: 19496611]
  • Widodo, John H Patterson, Ed Newbigin, Mark Tester, Antony Bacic, Ute Roessner. Metabolic responses to salt stress of barley (Hordeum vulgare L.) cultivars, Sahara and Clipper, which differ in salinity tolerance. Journal of experimental botany. 2009; 60(14):4089-103. doi: 10.1093/jxb/erp243. [PMID: 19666960]
  • Chul-Sa Kim, Kabir M Alamgir, Sachi Matsumoto, Shin-ichi Tebayashi, Hen-Sik Koh. Antifeedants of Indian barnyard millet, Echinochloa frumentacea link, against brown planthopper, Nilaparvata lugens (Stål). Zeitschrift fur Naturforschung. C, Journal of biosciences. 2008 Sep; 63(9-10):755-60. doi: 10.1515/znc-2008-9-1022. [PMID: 19040117]
  • Xing X Gao, Hui M Ge, Wei F Zheng, Ren X Tan. NMR-based metabonomics for detection of Helicobacter pylori infection in gerbils: which is more descriptive. Helicobacter. 2008 Apr; 13(2):103-11. doi: 10.1111/j.1523-5378.2008.00590.x. [PMID: 18321300]
  • Sandeep Tripathi, B S Somashekar, Abbas Ali Mahdi, Ashish Gupta, Farzana Mahdi, Mahdi Hasan, Raja Roy, C L Khetrapal. Aluminum-mediated metabolic changes in rat serum and urine: a proton nuclear magnetic resonance study. Journal of biochemical and molecular toxicology. 2008 Mar; 22(2):119-27. doi: 10.1002/jbt.20219. [PMID: 18418893]
  • Laura K Schnackenberg, Jinchun Sun, Parvaneh Espandiari, Ricky D Holland, Joseph Hanig, Richard D Beger. Metabonomics evaluations of age-related changes in the urinary compositions of male Sprague Dawley rats and effects of data normalization methods on statistical and quantitative analysis. BMC bioinformatics. 2007 Nov; 8 Suppl 7(?):S3. doi: 10.1186/1471-2105-8-s7-s3. [PMID: 18047726]
  • Roy A Browne, Kevin M Brindle. H NMR-based metabolite profiling as a potential selection tool for breeding passive resistance against Fusarium head blight (FHB) in wheat. Molecular plant pathology. 2007 Jul; 8(4):401-10. doi: 10.1111/j.1364-3703.2007.00400.x. [PMID: 20507509]
  • Matthew D Denton, Erik J Veneklaas, Hans Lambers. Does phenotypic plasticity in carboxylate exudation differ among rare and widespread Banksia species (Proteaceae)?. The New phytologist. 2007; 173(3):592-599. doi: 10.1111/j.1469-8137.2006.01956.x. [PMID: 17244054]
  • Bertrand Perroud, Jinoo Lee, Nelly Valkova, Amy Dhirapong, Pei-Yin Lin, Oliver Fiehn, Dietmar Kültz, Robert H Weiss. Pathway analysis of kidney cancer using proteomics and metabolic profiling. Molecular cancer. 2006 Nov; 5(?):64. doi: 10.1186/1476-4598-5-64. [PMID: 17123452]
  • Hideyuki Takahashi, Mitsunori Hayashi, Fumiyuki Goto, Shigeru Sato, Tomoyoshi Soga, Takaaki Nishioka, Masaru Tomita, Maki Kawai-Yamada, Hirofumi Uchimiya. Evaluation of metabolic alteration in transgenic rice overexpressing dihydroflavonol-4-reductase. Annals of botany. 2006 Oct; 98(4):819-25. doi: 10.1093/aob/mcl162. [PMID: 16849376]
  • Wilfried Rémus-Borel, Nancy Shallow, David J McNally, Caroline Labbé, Richard R Bélanger. High-speed counter-current chromatography for the study of defense metabolites in wheat. Characterization of 5,6-O-methyl trans-aconitic acid. Journal of chromatography. A. 2006 Jul; 1121(2):200-8. doi: 10.1016/j.chroma.2006.04.004. [PMID: 16650851]
  • Anna Spagnoletta, Aurelio De Santis, Elisabetta Tampieri, Elena Baraldi, Angela Bachi, Giuseppe Genchi. Identification and kinetic characterization of HtDTC, the mitochondrial dicarboxylate-tricarboxylate carrier of Jerusalem artichoke tubers. Journal of bioenergetics and biomembranes. 2006 Feb; 38(1):57-65. doi: 10.1007/s10863-006-9006-5. [PMID: 16786427]
  • Lui G Forni, William McKinnon, Philip J Hilton. Unmeasured anions in metabolic acidosis: unravelling the mystery. Critical care (London, England). 2006; 10(4):220. doi: 10.1186/cc4954. [PMID: 16879718]
  • Lee Tarpley, Anthony L Duran, Tesfamichael H Kebrom, Lloyd W Sumner. Biomarker metabolites capturing the metabolite variance present in a rice plant developmental period. BMC plant biology. 2005 May; 5(?):8. doi: 10.1186/1471-2229-5-8. [PMID: 15927065]
  • Carine Fillebeen, Annie Caltagirone, Alain Martelli, Jean-Marc Moulis, Kostas Pantopoulos. IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities. The Biochemical journal. 2005 May; 388(Pt 1):143-50. doi: 10.1042/bj20041623. [PMID: 15636585]
  • Elemar Voll, Cristiano Elemar Voll, Ricardo Victória Filho. Allelopathic effects of aconitic acid on wild poinsettia (Euphorbia heterophylla) and morningglory (Ipomoea grandifolia). Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2005; 40(1):69-75. doi: 10.1081/pfc-200034226. [PMID: 15656164]
  • Markus Engstler, Michael Boshart. Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei. Genes & development. 2004 Nov; 18(22):2798-811. doi: 10.1101/gad.323404. [PMID: 15545633]
  • Elemar Voll, Júlio Cezar Franchini, Roberto Tomazoni Da Cruz, Dionízio Luis Pisa Gazziero, Alexandre Magno Brighenti, Fernando Storniolo Adegas. Chemical interactions of Brachiaria plantaginea with Commelina bengalensis and Acanthospermum hispidum in soybean cropping systems. Journal of chemical ecology. 2004 Jul; 30(7):1467-75. doi: 10.1023/b:joec.0000037752.57907.fb. [PMID: 15503532]
  • Hartmut Hentschel, Birgitta C Burckhardt, Beate Schölermann, Lars Kühne, Gerhard Burckhardt, Jürgen Steffgen. Basolateral localization of flounder Na+-dicarboxylate cotransporter (fNaDC-3) in the kidney of Pleuronectes americanus. Pflugers Archiv : European journal of physiology. 2003 Aug; 446(5):578-84. doi: 10.1007/s00424-003-1081-4. [PMID: 12759753]
  • Yasuomi Yamasaki, Jin Hisazumi, Kiyoshi Yamaoka, Yoshinobu Takakura. Efficient scavenger receptor-mediated hepatic targeting of proteins by introduction of negative charges on the proteins by aconitylation: the influence of charge density and size of the proteins molecules. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2003 Apr; 18(5):305-12. doi: 10.1016/s0928-0987(03)00021-6. [PMID: 12694882]
  • Nathalie Picault, Luigi Palmieri, Isabella Pisano, Michael Hodges, Ferdinando Palmieri. Identification of a novel transporter for dicarboxylates and tricarboxylates in plant mitochondria. Bacterial expression, reconstitution, functional characterization, and tissue distribution. The Journal of biological chemistry. 2002 Jul; 277(27):24204-11. doi: 10.1074/jbc.m202702200. [PMID: 11978797]
  • Leonie Beljaars, René Floris, Ben Berkhout, Catharina Smit, Dirk K F Meijer, Grietje Molema. The influence of charge clustering on the anti-HIV-1 activity and in vivo distribution of negatively charged albumins. Biochemical pharmacology. 2002 May; 63(9):1663-73. doi: 10.1016/s0006-2952(02)00912-7. [PMID: 12007569]
  • Martin Bartsch, Alida H Weeke-Klimp, Dirk K F Meijer, Gerrit L Scherphof, Jan A A M Kamps. Massive and selective delivery of lipid-coated cationic lipoplexes of oligonucleotides targeted in vivo to hepatic endothelial cells. Pharmaceutical research. 2002 May; 19(5):676-80. doi: 10.1023/a:1015318415705. [PMID: 12069172]
  • Q Lin, Y Chen, H Chen, C Zheng. [Effect of organic acids on soil chemical behavior of lead and cadmium and their toxicity to plants]. Ying yong sheng tai xue bao = The journal of applied ecology. 2001 Aug; 12(4):619-22. doi: ". [PMID: 11758397]
  • O V Popova, T N Popova, S F Izmaĭlov. [Characteristics of NADP-dependent isocitrate dehydrogenase functioning in pea leaves during salt stress]. Izvestiia Akademii nauk. Seriia biologicheskaia. 2001 Mar; ?(2):174-9. doi: ". [PMID: 11357381]
  • P Olinga, I H Hof, M T Merema, M Smit, M H de Jager, P J Swart, M J Slooff, D K Meijer, G M Groothuis. The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake. Journal of pharmacological and toxicological methods. 2001 Jan; 45(1):55-63. doi: 10.1016/s1056-8719(01)00127-7. [PMID: 11489665]
  • C Cabrera, M Witvrouw, A Gutiérrez, B Clotet, M E Kuipers, P J Swart, D K Meijer, J Desmyter, E De Clercq, J A Esté. Resistance of the human immunodeficiency virus to the inhibitory action of negatively charged albumins on virus binding to CD4. AIDS research and human retroviruses. 1999 Nov; 15(17):1535-43. doi: 10.1089/088922299309829. [PMID: 10580404]
  • M E Kuipers, P J Swart, M Witvrouw, J A Esté, D Reymen, E De Clercq, D K Meijer. Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged human serum albumins (NCAs) and AZT. Journal of drug targeting. 1999; 6(5):323-35. doi: 10.3109/10611869908996840. [PMID: 10342381]
  • Y Bousquet, P J Swart, N Schmitt-Colin, F Velge-Roussel, M E Kuipers, D K Meijer, N Bru, J Hoebeke, P Breton. Molecular mechanisms of the adsorption of a model protein (human serum albumin) on poly(methylidene malonate 2.1.2) nanoparticles. Pharmaceutical research. 1999 Jan; 16(1):141-7. doi: 10.1023/a:1018843401077. [PMID: 9950293]
  • J A Kamps, H W Morselt, P J Swart, D K Meijer, G L Scherphof. Massive targeting of liposomes, surface-modified with anionized albumins, to hepatic endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 1997 Oct; 94(21):11681-5. doi: 10.1073/pnas.94.21.11681. [PMID: 9326670]
  • K Watanabe, M Katsuhara, H Nakao, M Sato. Detection and molecular analysis of plant- and insect-associated bacteria harboring aconitate isomerase involved in biosynthesis of trans-aconitic acid as antifeedant in brown planthoppers. Current microbiology. 1997 Aug; 35(2):97-102. doi: 10.1007/s002849900219. [PMID: 9216883]