Moracin C (BioDeep_00000017566)

 

Secondary id: BioDeep_00000618360

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-butenyl)- (9CI); 5-(6-Hydroxy-2-benzofuranyl)-2-(3-methyl-2-buten-1-yl)-1,3-benzenediol

化学式: C19H18O4 (310.1205028)
中文名称: 5-(6-羟基-2-苯并呋喃基)-2-(3-甲基-2-丁烯基)-1,3-苯二醇
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 27.78%

分子结构信息

SMILES: c1(ccc2c(c1)oc(c2)c1cc(c(c(c1)O)CC=C(C)C)O)O
InChI: InChI=1S/C19H18O4/c1-11(2)3-6-15-16(21)7-13(8-17(15)22)18-9-12-4-5-14(20)10-19(12)23-18/h3-5,7-10,20-22H,6H2,1-2H3

描述信息

Moracin C is a member of benzofurans.
Moracin C is a natural product found in Morus mesozygia, Morus alba var. multicaulis, and other organisms with data available.
Isolated from Morus alba (white mulberry) infected with Fusarium solani. Moracin C is found in mulberry and fruits.
Moracin C is found in fruits. Moracin C is isolated from Morus alba (white mulberry) infected with Fusarium solani.
Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells[1].
Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells[1].

同义名列表

19 个代谢物同义名

1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-butenyl)- (9CI); 5-(6-Hydroxy-2-benzofuranyl)-2-(3-methyl-2-buten-1-yl)-1,3-benzenediol; 5-(6-hydroxy-1-benzofuran-2-yl)-2-(3-methylbut-2-en-1-yl)benzene-1,3-diol; 1,3-BENZENEDIOL, 5-(6-HYDROXY-2-BENZOFURANYL)-2-(3-METHYL-2-BUTEN-1-YL)-; 5-(6-Hydroxy-2-benzofuranyl)-2-(3-methyl-2-butenyl)-1,3-benzenediol, 9CI; 2-(3-METHYLBUT-2-ENYL)-5-(6-OXIDANYL-1-BENZOFURAN-2-YL)BENZENE-1,3-DIOL; 5-(6-hydroxy-1-benzofuran-2-yl)-2-(3-methylbut-2-enyl)benzene-1,3-diol; 5-(6-Hydroxy-benzofuran-2-yl)-2-(3-methyl-but-2-enyl)-benzene-1,3-diol; 5-(6-HYDROXY-2-BENZOFURANYL)-2-(3-METHYL-2-BUTEN-1-YL)-1,3-BENZENEDIOL; 5-(6-hydroxy-1-benzouran-2-yl)-2-(3-methylbut-2-enyl)benzene-1,3-diol; 1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-butenyl)-; 5-(6-hydroxybenzofuran-2-yl)-2-(3-methylbut-2-enyl)benzene-1,3-diol; 5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol; 2-(3,5-Dihydroxy-4-prenylphenyl)-6-hydroxybenzofuran; UNII-TGZ4GH2N64; TGZ4GH2N64; Moracin C; moracin N; MORACIN-C; MoracinC



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Byoung Hoon You, Melanayakanakatte Kuberappa BasavanaGowda, Jae Un Lee, Young-Won Chin, Won Jun Choi, Young Hee Choi. Pharmacokinetic Properties of Moracin C in Mice. Planta medica. 2021 Jul; 87(8):642-651. doi: 10.1055/a-1321-1519. [PMID: 33498088]
  • Jagadeesh Nagarajappa Masagalli, Melanayakanakatte Kuberappa BasavanaGowda, Hee-Sung Chae, Won Jun Choi. Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells. Molecules (Basel, Switzerland). 2021 Mar; 26(5):. doi: 10.3390/molecules26051327. [PMID: 33801308]
  • Luce M Mattio, Giorgia Catinella, Andrea Pinto, Sabrina Dallavalle. Natural and nature-inspired stilbenoids as antiviral agents. European journal of medicinal chemistry. 2020 Sep; 202(?):112541. doi: 10.1016/j.ejmech.2020.112541. [PMID: 32652408]
  • Jiaming Tu, Dingding Shi, Lingrong Wen, Yueming Jiang, Yupeng Zhao, Jiali Yang, Huiling Liu, Guangrong Liu, Bao Yang. Identification of moracin N in mulberry leaf and evaluation of antioxidant activity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Oct; 132(?):110730. doi: 10.1016/j.fct.2019.110730. [PMID: 31369850]
  • Su Hui Seong, Manh Tuan Ha, Byung Sun Min, Hyun Ah Jung, Jae Sue Choi. Moracin derivatives from Morus Radix as dual BACE1 and cholinesterase inhibitors with antioxidant and anti-glycation capacities. Life sciences. 2018 Oct; 210(?):20-28. doi: 10.1016/j.lfs.2018.08.060. [PMID: 30170070]
  • Ming Li, Xuewei Wu, Xiaoning Wang, Tao Shen, Dongmei Ren. Two novel compounds from the root bark of Morus alba L. Natural product research. 2018 Jan; 32(1):36-42. doi: 10.1080/14786419.2017.1327862. [PMID: 28521570]
  • Jin Hu, Wei Zhu, Yaohan Li, Qijie Guan, Haijian Yan, Jiaojiao Yu, Zhirong Fu, Xingmeng Lu, Jingkui Tian. SWATH-based quantitative proteomics reveals the mechanism of enhanced Bombyx mori nucleopolyhedrovirus-resistance in silkworm reared on UV-B treated mulberry leaves. Proteomics. 2017 Jul; 17(13-14):. doi: 10.1002/pmic.201600383. [PMID: 28556443]
  • Ji Yeon Jeong, Yang Hee Jo, Seon Beom Kim, Qing Liu, Jin Woo Lee, Eun Jin Mo, Ki Yong Lee, Bang Yeon Hwang, Mi Kyeong Lee. Pancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions. Bioorganic & medicinal chemistry letters. 2015 Jun; 25(11):2269-74. doi: 10.1016/j.bmcl.2015.04.045. [PMID: 25935644]
  • Hana Zelová, Zuzana Hanáková, Zuzana Čermáková, Karel Šmejkal, Stefano Dalĺ Acqua, Petr Babula, Josef Cvačka, Jan Hošek. Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra. Journal of natural products. 2014 Jun; 77(6):1297-303. doi: 10.1021/np401025f. [PMID: 24901948]
  • Shang-Ke Chen, Peng Zhao, Yong-Xian Shao, Zhe Li, Cuixian Zhang, Peiqing Liu, Xixin He, Hai-Bin Luo, Xiaopeng Hu. Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor. Bioorganic & medicinal chemistry letters. 2012 May; 22(9):3261-4. doi: 10.1016/j.bmcl.2012.03.026. [PMID: 22483586]
  • Yu Jin Kim, Mi-Jin Sohn, Won-Gon Kim. Chalcomoracin and moracin C, new inhibitors of Staphylococcus aureus enoyl-acyl carrier protein reductase from Morus alba. Biological & pharmaceutical bulletin. 2012; 35(5):791-5. doi: 10.1248/bpb.35.791. [PMID: 22687419]
  • Mariana Royer, Gaëtan Herbette, Véronique Eparvier, Jacques Beauchêne, Bernard Thibaut, Didier Stien. Secondary metabolites of Bagassa guianensis Aubl. wood: a study of the chemotaxonomy of the Moraceae family. Phytochemistry. 2010 Oct; 71(14-15):1708-13. doi: 10.1016/j.phytochem.2010.06.020. [PMID: 20655556]
  • Yong-Xia Tan, Chao Liu, Ruo-Yun Chen. [2-Arylbenzofuran derivatives from Morus wittiorum]. Yao xue xue bao = Acta pharmaceutica Sinica. 2008 Nov; 43(11):1119-22. doi: ". [PMID: 19239031]