Vitamin K1 (BioDeep_00000017491)

 

Secondary id: BioDeep_00000004129, BioDeep_00000398744

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


MIXTURE OF THE TRANS (E) AND CIS (Z) ISOMERS CONTAINING NOT LESS THAN 75\\% OF TRANS-PHYTOMENADIONE

化学式: C31H46O2 (450.34976159999997)
中文名称: 维生素 K1, 维生素K-1, 维生素K1, 叶绿醌, 维生素 K1
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 4.67%

分子结构信息

SMILES: C12C=CC=CC=1C(C(=C(C)C2=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=O
InChI: InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1

描述信息

Phylloquinone is a member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones. It has a role as a cofactor, a plant metabolite and a human metabolite. It is a vitamin K and a member of phylloquinones.
Vitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin. Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates precursors to coagulation factors II, VII, IX, and X. It is indicated in the treatment of coagulation disorders due to faulty formation of coagulation factors II, VII, IX, and X caused by deficiency or interference in the activity of vitamin K. Phylloquinone has been synthesized since at least 1939, and was approved by the FDA prior to 1955.
Vitamin K1 is a natural product found in Coffea arabica, Stachys annua, and other organisms with data available.
Phytonadione is an analogue of the naphthoquinone vitamin K found in plants. The vitamins K are essential for blood coagulation as it is necessary for the hepatic synthesis of the coagulation factors II, VII, IX, and X; deficiency results in a bleeding diathesis. These vitamins are lipo-soluble; absorption via intestinal lymphatics requires the presence of bile salts. (NCI04)
Phylloquinone is often called vitamin K1. It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation.
A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.
See also: Broccoli (part of); Kale, cooked (part of); Cholecalciferol; phytonadione (component of) ... View More ...
Vitamin K1, also known as phylloquinone or phytonadione, is a polycyclic aromatic ketone, based on 1,4-naphthoquinone, with 2-methyl and 3-phytyl substituents. Vitamin K is a family of phylloquinones that contain a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Several forms of vitamin K have been identified: vitamin K1 derived from plants, vitamin K2 (menaquinone) from bacteria and synthetic naphthoquinone provitamins, and vitamin K3 (menadione). Vitamin K1 has only one double bond on the proximal isoprene unit. Vitamin K1 possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X). Rich sources of vitamin K1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity. Vitamin K1 is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. Vitamin K1 is an antidote for coumatetralyl.
A member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones.
B - Blood and blood forming organs > B02 - Antihemorrhagics > B02B - Vitamin k and other hemostatics > B02BA - Vitamin k
D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
D050299 - Fibrin Modulating Agents > D000933 - Antifibrinolytic Agents
D018977 - Micronutrients > D014815 - Vitamins
Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

同义名列表

125 个代谢物同义名

MIXTURE OF THE TRANS (E) AND CIS (Z) ISOMERS CONTAINING NOT LESS THAN 75\\% OF TRANS-PHYTOMENADIONE; 2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1,4-dihydronaphthalene-1,4-dione; 1,4-NAPHTHALENEDIONE, 2-METHYL-3-((2E,7R,11R)-3,7,11,15-TETRAMETHYL-2-HEXADECEN-1-YL)-, REL-; 2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione;Vitamin K1; 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, (R-(R*,R*-(E)))-; 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, [R-[R*,R*-(E)]]-; rel-2-Methyl-3-((7R,11R,E)-3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione; 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl)-; [r-[r*,R*-(E)]]-2-Methyl-3-(3-7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; 1,4-Naphthalenedione,2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl]-; 2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalene-1,4-dione; 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione; [r-[r*,R*-(E)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-napthalenedione; (R*,R*-(E))-(1)-2-Methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)-1,4-naphthoquinone; 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-; 2-Methyl-3-((7R,11R,E)-3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione; 2-Methyl-3-((2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl)-1,4-naphthoquinone; 2-METHYL-3-((2E,7R,11R)-3,7,11,15-TETRAMETHYL-2-HEXADECENYL)-1,4-NAPHTHALENEDIONE; 2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione; 2-methyl-3-((7R,11R,E)-3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione; Phytonadione, Pharmaceutical Secondary Standard; Certified Reference Material; Vitamin K1, BioXtra, >=99.0\\% (sum of isomers, HPLC), mixtur of isomers; 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-; 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalened- ione; 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; 2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone #; 2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone; 2-Methyl-3-((2E)-3,7,11,15-tetramethyl-2-hexadecenyl)naphthoquinone; Phytonadione, United States Pharmacopeia (USP) Reference Standard; Phytomenadione, European Pharmacopoeia (EP) Reference Standard; 2-methyl-3-((7R,11R,E)-3,7,11,15-tetramethylhexadec; phylloquinone;2-METHYL-3-PHYTYL-1,4-NAPHTHOQUINONE; VITAMIN K1; 2-METHYL-3-PHYTYL-1,4-NAPHTHOQUINONE; C31H46O2 (2-methyl-3-phytyl-1,4-naphthoquinone); 2-Methyl-3-phytyl-1,4-naphthochinon [German]; Phylloquinone (K1), analytical standard; Vitamin K hydroquinone (phylloquinone); 1,4-Naphthoquinone, 2-methyl-3-phytyl-; 2-Methyl-3-phythyl-1,4-naphthochinon; 2-Methyl-3-phytyl-1,4-naphthoquinone; 84C51B31-3CE2-476B-BE66-A84BDD46A513; 2-Methyl-3-phytyl-1,4-napthoquinone; 2-Methyl-3-phytyl-1,4-naphthochinon; -2-enyl)naphthalene-1,4-dione; PHYTOMENADIONE (EP IMPURITY); PHYTONADIONE (USP MONOGRAPH); Phylloquinone;Phytomenadione; Phytomenadionum [INN-Latin]; Fitomenadiona [INN-Spanish]; Vitamin K1 (Phylloquinone); Vitamin K1, viscous liquid; PHYLLOQUINONE E-FORM [MI]; PHYTONADIONEPHYTONADIONE; Phytonadione, (E)-(+/-)-; Antihemorrhagic vitamin; 2,3-trans-phylloquinone; Phytonadione [USP:JAN]; PHYTOMENADIONE (MART.); 2’,3’-trans-vitamin K1; PHYTONADIONE (USP-RS); Phyllochinon [German]; Phylloquinone e-form; Vitamin K1 (generic); Fitomenadione [DCIT]; PHYTOMENADIONE, (E)-; 2,3-trans-Vitamin K1; trans-Phylloquinone; alpha-Phylloquinone; PHYLLOQUINONE, (E)-; PHYTONADIONE [JAN]; Phyllohydroquinone; PHYTONADIONE, (E)-; 3-Phytylmenadione; (E)-phytonadione; Konakion mm paed; Phythyl-menadion; Phytonadione, K1; 5VET002 Veta K-1; Vitamin K1 (VAN); a-Phylloquinone; Phytylmenadione; Vitamin K1 ,(S); Α-phylloquinone; Phytomenadionum; UNII-S5Z3U87QHF; UNII-MLF3D1712D; Phyllochinonum; Phytomenadione; vitamin K1, 11; Tox21_111655_1; Phytonadionum; Fitomenadiona; Aqua mephyton; Phylloquinone; Aqua-Mephytin; Fitomenadione; Aquamephyton; Tox21_111655; Phytonadione; Phyllochinon; vitaminum k1; Combinal K1; Konakion mm; Vitamin K 1; CAS-84-80-0; S5Z3U87QHF; Vitamin K1; MLF3D1712D; Synthex P; VitaminK1; Vitamin K; Mephyton; Mono-Kay; Monodion; Kinadion; Konakion; Kephton; VEDA-K1; Kativ N; VETA-K1; Kanavit; B02BA01; Neokay; K-Ject; Orakay



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

34 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(3)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(30)

PharmGKB(0)

35 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Natália Gonçalves Silva, Marco Preto, Vitor Vasconcelos, Ralph Urbatzka. Reduction of neutral lipid reservoirs, bioconversion and untargeted metabolomics reveal distinct roles for vitamin K isoforms on lipid metabolism. Food & function. 2024 Feb; 15(4):2170-2180. doi: 10.1039/d3fo02915h. [PMID: 38312068]
  • Qian-Kun He, Yuan-Hua Wu, Xiao-Ying Lu, Ming-Wei Liu. Rodenticide poisoning leading to cerebral hemorrhage: A case report. Medicine. 2024 Feb; 103(7):e36971. doi: 10.1097/md.0000000000036971. [PMID: 38363928]
  • Ateequr Rehman, Van Pham, Nicole Seifert, Nathalie Richard, Wilbert Sybesma, Robert E Steinert. The Polyunsaturated Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid, and Vitamin K1 Modulate the Gut Microbiome: A Study Using an In Vitro Shime Model. Journal of dietary supplements. 2024; 21(2):135-153. doi: 10.1080/19390211.2023.2198007. [PMID: 37078491]
  • Jill Romer, Katharina Gutbrod, Antonia Schuppener, Michael Melzer, Stefanie J Müller-Schüssele, Andreas J Meyer, Peter Dörmann. Tocopherol and phylloquinone biosynthesis in chloroplasts requires the phytol kinase VTE5 and the farnesol kinase FOLK. The Plant cell. 2023 Dec; ?(?):. doi: 10.1093/plcell/koad316. [PMID: 38124486]
  • Xupeng Shao, Yuanyuan Ren, Na Xie, Kailiang Fan, Haiyan Sun, Jiamin Lu, Jiuxiang Wei, Xincheng Tian. Effect of Cefoperazone/Sulbactam on Blood Coagulation Function in Infected Emergency Department Patients and the Necessity of Vitamin K1 (VK1) Preventive Intervention: A Single-Center, Retrospective Analysis. Medical science monitor : international medical journal of experimental and clinical research. 2023 Jun; 29(?):e939203. doi: 10.12659/msm.939203. [PMID: 37271979]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • David Card, Ella Freke, Dominic Harrington. Characterization and traceability of two generations of standard reference material for the measurement of vitamin K1 (phylloquinone) at endogenous concentrations in human plasma and serum. Biomedical chromatography : BMC. 2022 Jul; 36(7):e5378. doi: 10.1002/bmc.5378. [PMID: 35368089]
  • Benedikt Kolbrink, Friedrich Alexander von Samson-Himmelstjerna, Maja Lucia Messtorff, Theresa Riebeling, Raphael Nische, Jessica Schmitz, Jan Hinrich Bräsen, Ulrich Kunzendorf, Stefan Krautwald. Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injury. Cellular and molecular life sciences : CMLS. 2022 Jun; 79(7):387. doi: 10.1007/s00018-022-04416-w. [PMID: 35763128]
  • Andreas Meinitzer, Dietmar Enko, Sieglinde Zelzer, Florian Prüller, Nerea Alonso, Eva Fritz-Petrin, Markus Herrmann. Development of a liquid chromatography mass spectrometry method for the determination of vitamin K1, menaquinone-4, menaquinone-7 and vitamin K1-2,3 epoxide in serum of individuals without vitamin K supplements. Clinical chemistry and laboratory medicine. 2022 06; 60(7):1011-1019. doi: 10.1515/cclm-2022-0192. [PMID: 35427444]
  • Cheng Xu, Yang Cunqing, Gu Chun, Wu Min, Li Jun, Hou Xueyun, Fei Jiaxin, Sun Li, An Cheng, Liu Guijian, Shi Fengxiang, Pang Bo. The relationship between serum vitamin K concentration and coronary artery calcification in middle-aged and elderly people. Clinica chimica acta; international journal of clinical chemistry. 2022 Jun; 531(?):325-330. doi: 10.1016/j.cca.2022.04.1001. [PMID: 35504322]
  • Federica Bellone, Maria Cinquegrani, Ramona Nicotera, Nazareno Carullo, Alessandro Casarella, Pierangela Presta, Michele Andreucci, Giovanni Squadrito, Giuseppe Mandraffino, Marcello Prunestì, Cristina Vocca, Giovambattista De Sarro, Davide Bolignano, Giuseppe Coppolino. Role of Vitamin K in Chronic Kidney Disease: A Focus on Bone and Cardiovascular Health. International journal of molecular sciences. 2022 May; 23(9):. doi: 10.3390/ijms23095282. [PMID: 35563672]
  • Jessie L Ellis, Xueyan Fu, J Philip Karl, Christopher J Hernandez, Joel B Mason, Russell A DeBose-Boyd, Sarah L Booth. Multiple Dietary Vitamin K Forms Are Converted to Tissue Menaquinone-4 in Mice. The Journal of nutrition. 2022 04; 152(4):981-993. doi: 10.1093/jn/nxab332. [PMID: 34550377]
  • Aegida Neradova, Grzegorz Wasilewski, Selene Prisco, Peter Leenders, Marjolein Caron, Tim Welting, Bert van Rietbergen, Rafael Kramann, Jürgen Floege, Marc G Vervloet, Leon J Schurgers. Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2022 03; 37(4):652-662. doi: 10.1093/ndt/gfab314. [PMID: 34718756]
  • Přemysl Mladěnka, Kateřina Macáková, Lenka Kujovská Krčmová, Lenka Javorská, Kristýna Mrštná, Alejandro Carazo, Michele Protti, Fernando Remião, Lucie Nováková. Vitamin K - sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity. Nutrition reviews. 2022 03; 80(4):677-698. doi: 10.1093/nutrit/nuab061. [PMID: 34472618]
  • Maria K Sobczyk, Tom R Gaunt. Reply to Janssen et al. Comment on 'Sobczyk, M.K.; Gaunt, T.R. The Effect of Circulating Zinc, Selenium, Copper and Vitamin K1 on COVID-19 Outcomes: A Mendelian Randomization Study. Nutrients 2022, 14, 233'. Nutrients. 2022 Mar; 14(5):. doi: 10.3390/nu14051113. [PMID: 35268088]
  • Rob Janssen, Cees Vermeer, Jona Walk, Allan Linneberg. Comment on Sobczyk, M.K.; Gaunt, T.R. The Effect of Circulating Zinc, Selenium, Copper and Vitamin K1 on COVID-19 Outcomes: A Mendelian Randomization Study. Nutrients 2022, 14, 233. Nutrients. 2022 Mar; 14(5):. doi: 10.3390/nu14051112. [PMID: 35268087]
  • M Kyla Shea, Kathryn Barger, Sarah L Booth, Jifan Wang, Harold I Feldman, Raymond R Townsend, Jing Chen, John Flack, Jiang He, Bernard G Jaar, Mayank Kansal, Sylvia E Rosas, Daniel E Weiner. Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the Chronic Renal Insufficiency Cohort. The American journal of clinical nutrition. 2022 03; 115(3):941-948. doi: 10.1093/ajcn/nqab375. [PMID: 34788785]
  • Rama Vaidya, Ashok D B Vaidya, Jayesh Sheth, Shashank Jadhav, Umakant Mahale, Dilip Mehta, Janusz Popko, Vladimir Badmaev, Sidney J Stohs. Vitamin K Insufficiency in the Indian Population: Pilot Observational Epidemiology Study. JMIR public health and surveillance. 2022 02; 8(2):e31941. doi: 10.2196/31941. [PMID: 35113033]
  • Nadine Kaesler, Felix Schreibing, Thimoteus Speer, Sofia de la Puente-Secades, Nikolas Rapp, Christiane Drechsler, Nazanin Kabgani, Christoph Kuppe, Peter Boor, Vera Jankowski, Leon Schurgers, Rafael Kramann, Jürgen Floege. Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease. Kidney international. 2022 02; 101(2):338-348. doi: 10.1016/j.kint.2021.10.029. [PMID: 34774554]
  • Jamie W Bellinge, Roslyn J Francis, Sing C Lee, Nicola P Bondonno, Marc Sim, Joshua R Lewis, Gerald F Watts, Carl J Schultz. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial. The American journal of clinical nutrition. 2022 01; 115(1):45-52. doi: 10.1093/ajcn/nqab306. [PMID: 34637494]
  • Anna Stępień, Małgorzata Koziarska-Rościszewska, Jacek Rysz, Mariusz Stępień. Biological Role of Vitamin K-With Particular Emphasis on Cardiovascular and Renal Aspects. Nutrients. 2022 Jan; 14(2):. doi: 10.3390/nu14020262. [PMID: 35057443]
  • Maria K Sobczyk, Tom R Gaunt. The Effect of Circulating Zinc, Selenium, Copper and Vitamin K1 on COVID-19 Outcomes: A Mendelian Randomization Study. Nutrients. 2022 Jan; 14(2):. doi: 10.3390/nu14020233. [PMID: 35057415]
  • Hanako Bai, Hikoji Arai, Kentarou Ikuta, Sho Ishikawa, Yoshihisa Ohtani, Kunihiro Iwashita, Nao Okada, Hitoshi Shirakawa, Michio Komai, Fuminori Terada, Yoshiaki Obara. Effects of dietary vitamin K3 supplementation on vitamin K1 and K2 (menaquinone) dynamics in dairy cows. Animal science journal = Nihon chikusan Gakkaiho. 2022 Jan; 93(1):e13680. doi: 10.1111/asj.13680. [PMID: 35029011]
  • Anton S M Dofferhoff, Ianthe Piscaer, Leon J Schurgers, Margot P J Visser, Jody M W van den Ouweland, Pim A de Jong, Reinoud Gosens, Tilman M Hackeng, Henny van Daal, Petra Lux, Cecile Maassen, Esther G A Karssemeijer, Cees Vermeer, Emiel F M Wouters, Loes E M Kistemaker, Jona Walk, Rob Janssen. Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 12; 73(11):e4039-e4046. doi: 10.1093/cid/ciaa1258. [PMID: 32852539]
  • Markus Ketteler, Moritz Schanz, Severin Schricker. Vitamin K: should we supplement to protect the kidneys and the heart?. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2021 12; 36(12):2196-2198. doi: 10.1093/ndt/gfz291. [PMID: 31943083]
  • Ulf Schött, Cecilia Augustsson, Luukas Lilover, Caroline Ulfsdotter Nilsson, Louise Walther-Sturesson, Thomas Kander. Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study. Nutrients. 2021 Nov; 13(11):. doi: 10.3390/nu13114101. [PMID: 34836355]
  • Xi Gu, Ing-Gin Chen, Chung-Jui Tsai. How do holoparasitic plants exploit vitamin K1?. Plant signaling & behavior. 2021 11; 16(11):1976546. doi: 10.1080/15592324.2021.1976546. [PMID: 34514932]
  • Nadine Kaesler, Leon J Schurgers, Jürgen Floege. Vitamin K and cardiovascular complications in chronic kidney disease patients. Kidney international. 2021 11; 100(5):1023-1036. doi: 10.1016/j.kint.2021.06.037. [PMID: 34310988]
  • Dion Groothof, Adrian Post, Reinold O B Gans, Stephan J L Bakker. Reduced Vitamin K Status and Coronavirus Disease 2019: An Epiphenomenon of Impaired Kidney Function?. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 10; 73(7):1324-1325. doi: 10.1093/cid/ciab164. [PMID: 33630997]
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  • Jamie W Bellinge, Frederik Dalgaard, Kevin Murray, Emma Connolly, Lauren C Blekkenhorst, Catherine P Bondonno, Joshua R Lewis, Marc Sim, Kevin D Croft, Gunnar Gislason, Christian Torp-Pedersen, Anne Tjønneland, Kim Overvad, Jonathan M Hodgson, Carl Schultz, Nicola P Bondonno. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study. Journal of the American Heart Association. 2021 08; 10(16):e020551. doi: 10.1161/jaha.120.020551. [PMID: 34369182]
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