Flavomycin (BioDeep_00000171880)
human metabolite blood metabolite
代谢物信息卡片
化学式: C69H107N4O35P (1582.6453)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1OC(OC2C(O)C(NC(C)=O)C(OC3C(OP(O)(=O)OCC(OCC=C(C)CCC=CC(C)(C)CCC(=C)CC=C(C)CCC=C(C)C)C(O)=O)OC(C(O)=O)C(C)(O)C3OC(N)=O)OC2COC2OC(CO)C(O)C(O)C2O)C(NC(C)=O)C(O)C1OC1OC(C(O)C(O)C1O)C(=O)NC1=C(O)CCC1=O
InChI: InChI=1S/C69H107N4O35P/c1-30(2)15-14-17-31(3)18-19-33(5)22-25-68(9,10)24-13-12-16-32(4)23-26-96-41(60(88)89)29-98-109(94,95)108-66-56(57(107-67(70)92)69(11,93)58(106-66)61(90)91)105-63-44(72-36(8)76)47(81)54(40(101-63)28-97-64-51(85)48(82)45(79)39(27-74)100-64)103-62-43(71-35(7)75)46(80)53(34(6)99-62)102-65-52(86)49(83)50(84)55(104-65)59(87)73-42-37(77)20-21-38(42)78/h13,15,18,23-24,34,39-41,43-58,62-66,74,77,79-86,93H,5,12,14,16-17,19-22,25-29H2,1-4,6-11H3,(H2,70,92)(H,71,75)(H,72,76)(H,73,87)(H,88,89)(H,90,91)(H,94,95)
描述信息
同义名列表
10 个代谢物同义名
4-(carbamoyloxy)-6-[({2-carboxy-2-[(3,8,8,14,18-pentamethyl-11-methylidenenonadeca-2,6,13,17-tetraen-1-yl)oxy]ethoxy}(hydroxy)phosphoryl)oxy]-5-[(3-acetamido-5-{[3-acetamido-4-hydroxy-6-methyl-5-({3,4,5-trihydroxy-6-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)carbamoyl]oxan-2-yl}oxy)oxan-2-yl]oxy}-4-hydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-2-yl)oxy]-3-hydroxy-3-methyloxane-2-carboxylic acid; 4-(carbamoyloxy)-6-({2-carboxy-2-[(3,8,8,14,18-pentamethyl-11-methylidenenonadeca-2,6,13,17-tetraen-1-yl)oxy]ethoxy(hydroxy)phosphoryl}oxy)-5-[(3-acetamido-5-{[3-acetamido-4-hydroxy-6-methyl-5-({3,4,5-trihydroxy-6-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)carbamoyl]oxan-2-yl}oxy)oxan-2-yl]oxy}-4-hydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-2-yl)oxy]-3-hydroxy-3-methyloxane-2-carboxylic acid; Flavophospholipols; Flavophospholipol; Bambermycins; Bambermycin; Moenomycins; Flavomycins; Flavomycin; Menomycin
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Venkateswarlu Yarlagadda, Vishwas N Rao, Manpreet Kaur, Allison K Guitor, Gerard D Wright. A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent.
ACS infectious diseases.
2021 06; 7(6):1569-1577. doi:
10.1021/acsinfecdis.1c00040. [PMID: 33826296] - Jiajun Yang, Minhong Zhang, Ying Zhou. Effects of selenium-enriched Bacillus sp. compounds on growth performance, antioxidant status, and lipid parameters breast meat quality of Chinese Huainan partridge chicks in winter cold stress.
Lipids in health and disease.
2019 Mar; 18(1):63. doi:
10.1186/s12944-019-1015-6. [PMID: 30871550] - Shuangshuang Guo, Qiang Cheng, Yehan Li, Rui Duan, Yongqing Hou, Dan Yi, Binying Ding. Effects of dietary coated-oleum cinnamomi supplementation on the immunity and intestinal integrity of broiler chickens.
Animal science journal = Nihon chikusan Gakkaiho.
2018 Nov; 89(11):1581-1590. doi:
10.1111/asj.13094. [PMID: 30175428] - Ismahene Dahmane, Caroline Montagner, André Matagne, Shrinivas Dumbre, Piet Herdewijn, Mohammed Terrak. Peptidoglycan glycosyltransferase-ligand binding assay based on tryptophan fluorescence quenching.
Biochimie.
2018 Sep; 152(?):1-5. doi:
10.1016/j.biochi.2018.06.010. [PMID: 29909047] - Daniel Bury, Ismahene Dahmane, Adeline Derouaux, Shrinivas Dumbre, Piet Herdewijn, André Matagne, Eefjan Breukink, Erika Mueller-Seitz, Michael Petz, Mohammed Terrak. Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.
Biochemical pharmacology.
2015 Jan; 93(2):141-50. doi:
10.1016/j.bcp.2014.11.003. [PMID: 25462814] - Valeria A Torok, Gwen E Allison, Nigel J Percy, Kathy Ophel-Keller, Robert J Hughes. Influence of antimicrobial feed additives on broiler commensal posthatch gut microbiota development and performance.
Applied and environmental microbiology.
2011 May; 77(10):3380-90. doi:
10.1128/aem.02300-10. [PMID: 21441326] - Shinichiro Fuse, Hirokazu Tsukamoto, Yanqiu Yuan, Tsung-Shing Andrew Wang, Yi Zhang, Megan Bolla, Suzanne Walker, Piotr Sliz, Daniel Kahne. Functional and structural analysis of a key region of the cell wall inhibitor moenomycin.
ACS chemical biology.
2010 Jul; 5(7):701-11. doi:
10.1021/cb100048q. [PMID: 20496948] - Chen-Yu Liu, Chih-Wei Guo, Yi-Fan Chang, Jen-Tsung Wang, Hao-Wei Shih, Yu-Fang Hsu, Chia-Wei Chen, Shao-Kang Chen, Yen-Chih Wang, Ting-Jen R Cheng, Che Ma, Chi-Huey Wong, Jim-Min Fang, Wei-Chieh Cheng. Synthesis and evaluation of a new fluorescent transglycosylase substrate: lipid II-based molecule possessing a dansyl-C20 polyprenyl moiety.
Organic letters.
2010 Apr; 12(7):1608-11. doi:
10.1021/ol100338v. [PMID: 20187630] - Masaatsu Adachi, Yi Zhang, Catherine Leimkuhler, Binyuan Sun, John V LaTour, Daniel E Kahne. Degradation and reconstruction of moenomycin A and derivatives: dissecting the function of the isoprenoid chain.
Journal of the American Chemical Society.
2006 Nov; 128(43):14012-3. doi:
10.1021/ja065905c. [PMID: 17061868] - Sylvie Garneau, Lei Qiao, Lan Chen, Suzanne Walker, John C Vederas. Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b.
Bioorganic & medicinal chemistry.
2004 Dec; 12(24):6473-94. doi:
10.1016/j.bmc.2004.09.019. [PMID: 15556765] - Heike Betat, Stefan Vogel, Marc Struhalla, Hans-Heinrich Förster, Michael Famulok, Peter Welzel, Ulrich Hahn. Aptamers that recognize the lipid moiety of the antibiotic moenomycin A.
Biological chemistry.
2003 Oct; 384(10-11):1497-500. doi:
10.1515/bc.2003.165. [PMID: 14669992] - Haitian Liu, Thomas K Ritter, Reiko Sadamoto, Pamela S Sears, Min Wu, Chi-Huey Wong. Acceptor specificity and inhibition of the bacterial cell-wall glycosyltransferase MurG.
Chembiochem : a European journal of chemical biology.
2003 Jul; 4(7):603-9. doi:
10.1002/cbic.200300557. [PMID: 12851929] - Eugene R Baizman, Arthur A Branstrom, Clifford B Longley, Nigel Allanson, Michael J Sofia, David Gange, Robert C Goldman. Antibacterial activity of synthetic analogues based on the disaccharide structure of moenomycin, an inhibitor of bacterial transglycosylase.
Microbiology (Reading, England).
2000 Dec; 146 Pt 12(?):3129-3140. doi:
10.1099/00221287-146-12-3129. [PMID: 11101671] - A A Branstrom, S Midha, R C Goldman. In situ assay for identifying inhibitors of bacterial transglycosylase.
FEMS microbiology letters.
2000 Oct; 191(2):187-90. doi:
10.1111/j.1574-6968.2000.tb09338.x. [PMID: 11024262] - R C Goldman, D Gange. Inhibition of transglycosylation involved in bacterial peptidoglycan synthesis.
Current medicinal chemistry.
2000 Aug; 7(8):801-20. doi:
10.2174/0929867003374651. [PMID: 10828288] - K Graves-Woodward, R F Pratt. Interactions of soluble penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus with moenomycin.
Biochemistry.
1999 Aug; 38(32):10533-42. doi:
10.1021/bi982309p. [PMID: 10441150] - M Kurz, W Guba, L Vértesy. Three-dimensional structure of moenomycin A--a potent inhibitor of penicillin-binding protein 1b.
European journal of biochemistry.
1998 Mar; 252(3):500-7. doi:
10.1046/j.1432-1327.1998.2520500.x. [PMID: 9546666] - B Subramaniam-Niehaus, T Schneider, J W Metzger, W Wohlleben. Isolation and analysis of moenomycin and its biosynthetic intermediates from Streptomyces ghanaensis (ATCC 14672) wildtype and selected mutants.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
1997 Mar; 52(3-4):217-26. doi:
10.1515/znc-1997-3-413. [PMID: 9167274] - Y T Pan, A D Elbein. Inhibition of the trehalose-P synthase of mycobacteria by various antibiotics.
Archives of biochemistry and biophysics.
1996 Nov; 335(2):258-66. doi:
10.1006/abbi.1996.0506. [PMID: 8914922] - U Kohlrausch, J V Höltje. Analysis of murein and murein precursors during antibiotic-induced lysis of Escherichia coli.
Journal of bacteriology.
1991 Jun; 173(11):3425-31. doi:
10.1128/jb.173.11.3425-3431.1991. [PMID: 2045364] - E Bause, G Legler. The effect of flavomycin on the synthesis and transfer of lipid-linked saccharides in pig brain.
The Biochemical journal.
1982 Mar; 201(3):481-7. doi:
10.1042/bj2010481. [PMID: 6178396]
