brefeldin A (BioDeep_00000016488)

   

Chemicals and Drugs natural product


代谢物信息卡片


Brefeldin, 7-epi

化学式: C16H24O4 (280.1674504)
中文名称: 布雷菲德菌素A
谱图信息: 最多检出来源 Viridiplantae(plant) 8.4%

分子结构信息

SMILES: CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O
InChI: InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3

描述信息

D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.042
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.035
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.034
[Raw Data] CB245_Brefeldin-A_pos_50eV_isCID-10eV_rep000008.txt
[Raw Data] CB245_Brefeldin-A_pos_40eV_isCID-10eV_rep000008.txt
[Raw Data] CB245_Brefeldin-A_pos_30eV_isCID-10eV_rep000008.txt
[Raw Data] CB245_Brefeldin-A_pos_20eV_isCID-10eV_rep000008.txt
[Raw Data] CB245_Brefeldin-A_pos_10eV_isCID-10eV_rep000008.txt
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus[1][2]. Brefeldin A is also an autophagy and mitophagy inhibitor[3]. Brefeldin A is a CRISPR/Cas9 activator[5]. Brefeldin A inhibits HSV-1 and has anti-cancer activity[5].
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus[1][2]. Brefeldin A is also an autophagy and mitophagy inhibitor[3]. Brefeldin A is a CRISPR/Cas9 activator[5]. Brefeldin A inhibits HSV-1 and has anti-cancer activity[5].

同义名列表

6 个代谢物同义名

Brefeldin, 7-epi; brefeldin A; Brefeldin-A; BFA; Cyanein; Decumbin



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qin He, Huiliang Zhang, Xingyun Qi. Image-Based Methods to Study Membrane Trafficking Events in Stomatal Lineage Cells. Journal of visualized experiments : JoVE. 2023 05; ?(195):. doi: 10.3791/65257. [PMID: 37246859]
  • Kentaro Oh-Hashi, Hibiki Nakamura, Hirotaka Ogawa, Yoko Hirata, Kaori Sakurai. Elucidation of OSW-1-Induced Stress Responses in Neuro2a Cells. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065787. [PMID: 36982858]
  • Sang-Jin Kim, Federica Brandizzi. Microscopy and Immunocytochemistry-Based Methods to Study Cell Wall Biosynthetic Enzymes in the Golgi. Methods in molecular biology (Clifton, N.J.). 2023; 2557(?):39-51. doi: 10.1007/978-1-0716-2639-9_4. [PMID: 36512208]
  • Sujeong Je, Yuree Lee, Yasuyo Yamaoka. Effect of common ER stress-inducing drugs on the growth and lipid phenotypes of Chlamydomonas and Arabidopsis. Plant & cell physiology. 2022 Nov; ?(?):. doi: 10.1093/pcp/pcac154. [PMID: 36318453]
  • Sang-Chul Kim, Shuaibing Yao, Qun Zhang, Xuemin Wang. Phospholipase Dδ and phosphatidic acid mediate heat-induced nuclear localization of glyceraldehyde-3-phosphate dehydrogenase in Arabidopsis. The Plant journal : for cell and molecular biology. 2022 11; 112(3):786-799. doi: 10.1111/tpj.15981. [PMID: 36111506]
  • Yi Yang, Fang Liu, Le Liu, Mingyue Zhu, Jinfeng Yuan, Yan-Xia Mai, Jun-Jie Zou, Jie Le, Yonghong Wang, Klaus Palme, Xugang Li, Yong Wang, Long Wang. The unconventional prefoldin RPB5 interactor mediates the gravitropic response by modulating cytoskeleton organization and auxin transport in Arabidopsis. Journal of integrative plant biology. 2022 Oct; 64(10):1916-1934. doi: 10.1111/jipb.13341. [PMID: 35943836]
  • Majid M Syed-Abdul, Priska Stahel, Lili Tian, Changting Xiao, Avital Nahmias, Gary F Lewis. Glucagon-like peptide-2 mobilization of intestinal lipid does not require canonical enterocyte chylomicron synthetic machinery. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2022 09; 1867(9):159194. doi: 10.1016/j.bbalip.2022.159194. [PMID: 35680083]
  • Jingjing Xing, Dongchao Ji, Zhikun Duan, Tong Chen, Xiaomin Luo. Spatiotemporal dynamics of FERONIA reveal alternative endocytic pathways in response to flg22 elicitor stimuli. The New phytologist. 2022 07; 235(2):518-532. doi: 10.1111/nph.18127. [PMID: 35358335]
  • Peter T A Linders, Melina Ioannidis, Martin Ter Beest, Geert van den Bogaart. Fluorescence Lifetime Imaging of pH along the Secretory Pathway. ACS chemical biology. 2022 01; 17(1):240-251. doi: 10.1021/acschembio.1c00907. [PMID: 35000377]
  • Kensei Taguchi, Sho Sugahara, Bertha C Elias, Craig R Brooks. Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection. Journal of visualized experiments : JoVE. 2021 11; ?(177):. doi: 10.3791/63178. [PMID: 34842234]
  • Liang Zhang, Jingwen Ma, Huan Liu, Qian Yi, Yanan Wang, Jingjing Xing, Peipei Zhang, Shengdong Ji, Mingjun Li, Jingyuan Li, Jinbo Shen, Jinxing Lin. SNARE proteins VAMP721 and VAMP722 mediate the post-Golgi trafficking required for auxin-mediated development in Arabidopsis. The Plant journal : for cell and molecular biology. 2021 10; 108(2):426-440. doi: 10.1111/tpj.15450. [PMID: 34343378]
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  • Hideki Uedono, Katsuhito Mori, Akinobu Ochi, Shinya Nakatani, Yuya Miki, Akihiro Tsuda, Tomoaki Morioka, Yuki Nagata, Yasuo Imanishi, Tetsuo Shoji, Masaaki Inaba, Masanori Emoto. Effects of fetuin-A-containing calciprotein particles on posttranslational modifications of fetuin-A in HepG2 cells. Scientific reports. 2021 04; 11(1):7486. doi: 10.1038/s41598-021-86881-0. [PMID: 33820929]
  • Monica Scali, Alessandra Moscatelli, Luca Bini, Elisabetta Onelli, Rita Vignani, Wei Wang. Protein Analysis of Pollen Tubes after the Treatments of Membrane Trafficking Inhibitors Gains Insights on Molecular Mechanism Underlying Pollen Tube Polar Growth. The protein journal. 2021 04; 40(2):205-222. doi: 10.1007/s10930-021-09972-x. [PMID: 33751342]
  • Ely Oliveira-Garcia, Barbara Valent. Characterizing the Secretion Systems of Magnaporthe oryzae. Methods in molecular biology (Clifton, N.J.). 2021; 2356(?):69-77. doi: 10.1007/978-1-0716-1613-0_5. [PMID: 34236677]
  • Ilse Foissner, Margit Hoeftberger, Marion C Hoepflinger, Aniela Sommer, Alexander A Bulychev. Brefeldin A inhibits clathrin-dependent endocytosis and ion transport in Chara internodal cells. Biology of the cell. 2020 Nov; 112(11):317-334. doi: 10.1111/boc.202000031. [PMID: 32648585]
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  • Kirán R Jiménez-Vázquez, Elizabeth García-Cárdenas, Salvador Barrera-Ortiz, Randy Ortiz-Castro, León F Ruiz-Herrera, Blanca P Ramos-Acosta, Jessica L Coria-Arellano, Jorge Sáenz-Mata, José López-Bucio. The plant beneficial rhizobacterium Achromobacter sp. 5B1 influences root development through auxin signaling and redistribution. The Plant journal : for cell and molecular biology. 2020 08; 103(5):1639-1654. doi: 10.1111/tpj.14853. [PMID: 32445404]
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  • Xixi Zhang, Maciek Adamowski, Petra Marhava, Shutang Tan, Yuzhou Zhang, Lesia Rodriguez, Marta Zwiewka, Vendula Pukyšová, Adrià Sans Sánchez, Vivek Kumar Raxwal, Christian S Hardtke, Tomasz Nodzyński, Jiří Friml. Arabidopsis Flippases Cooperate with ARF GTPase Exchange Factors to Regulate the Trafficking and Polarity of PIN Auxin Transporters. The Plant cell. 2020 05; 32(5):1644-1664. doi: 10.1105/tpc.19.00869. [PMID: 32193204]
  • Alexander A Bulychev, Ilse Foissner. Inhibition of endosomal trafficking by brefeldin A interferes with long-distance interaction between chloroplasts and plasma membrane transporters. Physiologia plantarum. 2020 May; 169(1):122-134. doi: 10.1111/ppl.13058. [PMID: 31816092]
  • Lei Huang, Chunhua Zhang. Perturbation and imaging of exocytosis in plant cells. Methods in cell biology. 2020; 160(?):3-20. doi: 10.1016/bs.mcb.2020.06.006. [PMID: 32896324]
  • Astrid Fabri, Khalil Kandara, Rémy Coudereau, Morgane Gossez, Paul Abraham, Céline Monard, Martin Cour, Thomas Rimmelé, Laurent Argaud, Guillaume Monneret, Fabienne Venet. Characterization of Circulating IL-10-Producing Cells in Septic Shock Patients: A Proof of Concept Study. Frontiers in immunology. 2020; 11(?):615009. doi: 10.3389/fimmu.2020.615009. [PMID: 33613540]
  • Selma Yilmaz Dejgaard, John F Presley. Rab18 regulates lipolysis via Arf/GBF1 and adipose triglyceride lipase. Biochemical and biophysical research communications. 2019 12; 520(3):526-531. doi: 10.1016/j.bbrc.2019.10.069. [PMID: 31610914]
  • Beatrice M Girard, Susan E Campbell, Megan Perkins, Harrison Hsiang, Katharine Tooke, Carolyn Drescher, Grant W Hennig, Thomas J Heppner, Mark T Nelson, Margaret A Vizzard. TRPV4 blockade reduces voiding frequency, ATP release, and pelvic sensitivity in mice with chronic urothelial overexpression of NGF. American journal of physiology. Renal physiology. 2019 12; 317(6):F1695-F1706. doi: 10.1152/ajprenal.00147.2019. [PMID: 31630542]
  • Jingjing Xing, Xiaojuan Li, Xiaohua Wang, Xueqin Lv, Li Wang, Liang Zhang, Yingfang Zhu, Qianhua Shen, František Baluška, Jozef Šamaj, Jinxing Lin. Secretion of Phospholipase Dδ Functions as a Regulatory Mechanism in Plant Innate Immunity. The Plant cell. 2019 12; 31(12):3015-3032. doi: 10.1105/tpc.19.00534. [PMID: 31597687]
  • Hui-Di Zhang, Jian-Ni Huang, Yun-Zi Liu, Hong Ren, Jing-Yuan Xie, Nan Chen. Endoplasmic reticulum stress and proteasome pathway involvement in human podocyte injury with a truncated COL4A3 mutation. Chinese medical journal. 2019 Aug; 132(15):1823-1832. doi: 10.1097/cm9.0000000000000294. [PMID: 31306228]
  • Yuyan Chen, Sarah Frost, Matloob Khushi, Laurence C Cantrill, Hong Yu, Jonathan W Arthur, Robert K Bright, Guy E Groblewski, Jennifer A Byrne. Delayed recruiting of TPD52 to lipid droplets - evidence for a "second wave" of lipid droplet-associated proteins that respond to altered lipid storage induced by Brefeldin A treatment. Scientific reports. 2019 07; 9(1):9790. doi: 10.1038/s41598-019-46156-1. [PMID: 31278300]
  • Valentina G Tabbasum, Dermot M F Cooper. Structural and Functional Determinants of AC8 Trafficking, Targeting and Responsiveness in Lipid Raft Microdomains. The Journal of membrane biology. 2019 06; 252(2-3):159-172. doi: 10.1007/s00232-019-00060-x. [PMID: 30746562]
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  • Mohammad A Ashraf, Abidur Rahman. Cold stress response in Arabidopsis thaliana is mediated by GNOM ARF-GEF. The Plant journal : for cell and molecular biology. 2019 02; 97(3):500-516. doi: 10.1111/tpj.14137. [PMID: 30362633]
  • Daniel Garcia Cabanillas, Jun Jiang, Nooshin Movahed, Hugo Germain, Yasuyuki Yamaji, Huanquan Zheng, Jean-François Laliberté. Turnip Mosaic Virus Uses the SNARE Protein VTI11 in an Unconventional Route for Replication Vesicle Trafficking. The Plant cell. 2018 10; 30(10):2594-2615. doi: 10.1105/tpc.18.00281. [PMID: 30150314]
  • Kiril Mishev, Qing Lu, Bram Denoo, François Peurois, Wim Dejonghe, Jan Hullaert, Riet De Rycke, Sjef Boeren, Marine Bretou, Steven De Munck, Isha Sharma, Kaija Goodman, Kamila Kalinowska, Veronique Storme, Le Son Long Nguyen, Andrzej Drozdzecki, Sara Martins, Wim Nerinckx, Dominique Audenaert, Grégory Vert, Annemieke Madder, Marisa S Otegui, Erika Isono, Savvas N Savvides, Wim Annaert, Sacco De Vries, Jacqueline Cherfils, Johan Winne, Eugenia Russinova. Nonselective Chemical Inhibition of Sec7 Domain-Containing ARF GTPase Exchange Factors. The Plant cell. 2018 10; 30(10):2573-2593. doi: 10.1105/tpc.18.00145. [PMID: 30018157]
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  • Yuan Ruan, Laryssa S Halat, Deirdre Khan, Sylwia Jancowski, Chris Ambrose, Mark F Belmonte, Geoffrey O Wasteneys. The Microtubule-Associated Protein CLASP Sustains Cell Proliferation through a Brassinosteroid Signaling Negative Feedback Loop. Current biology : CB. 2018 09; 28(17):2718-2729.e5. doi: 10.1016/j.cub.2018.06.048. [PMID: 30146155]
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