brefeldin A (BioDeep_00000016488)
Chemicals and Drugs natural product
代谢物信息卡片
化学式: C16H24O4 (280.1674504)
中文名称: 布雷菲德菌素A
谱图信息:
最多检出来源 Viridiplantae(plant) 8.4%
分子结构信息
SMILES: CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O
InChI: InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3
描述信息
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.042
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.035
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.034
[Raw Data] CB245_Brefeldin-A_pos_50eV_isCID-10eV_rep000008.txt
[Raw Data] CB245_Brefeldin-A_pos_40eV_isCID-10eV_rep000008.txt
[Raw Data] CB245_Brefeldin-A_pos_30eV_isCID-10eV_rep000008.txt
[Raw Data] CB245_Brefeldin-A_pos_20eV_isCID-10eV_rep000008.txt
[Raw Data] CB245_Brefeldin-A_pos_10eV_isCID-10eV_rep000008.txt
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus[1][2]. Brefeldin A is also an autophagy and mitophagy inhibitor[3]. Brefeldin A is a CRISPR/Cas9 activator[5]. Brefeldin A inhibits HSV-1 and has anti-cancer activity[5].
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus[1][2]. Brefeldin A is also an autophagy and mitophagy inhibitor[3]. Brefeldin A is a CRISPR/Cas9 activator[5]. Brefeldin A inhibits HSV-1 and has anti-cancer activity[5].
同义名列表
6 个代谢物同义名
Brefeldin, 7-epi; brefeldin A; Brefeldin-A; BFA; Cyanein; Decumbin
数据库引用编号
29 个数据库交叉引用编号
- ChEBI: CHEBI:91555
- ChEBI: CHEBI:48080
- KEGG: C73840
- PubChem: 5477951
- PubChem: 5287620
- PubChem: 2430
- Metlin: METLIN85101
- DrugBank: DB07348
- ChEMBL: CHEMBL1882087
- ChEMBL: CHEMBL19980
- MeSH: Brefeldin A
- CAS: 20350-15-6
- CAS: 83710-00-3
- CAS: 11006-23-8
- CAS: 60132-23-2
- MoNA: BML80838
- MoNA: BML80837
- MoNA: BML80836
- MoNA: BML80835
- MoNA: FIO00534
- MoNA: FIO00533
- MoNA: FIO00532
- MoNA: FIO00531
- MoNA: FIO00530
- PMhub: MS000009372
- MetaboLights: MTBLC48080
- RefMet: Brefeldin A
- medchemexpress: HY-16592
- LOTUS: LTS0040667
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
24 个相关的物种来源信息
- 40948 - Angelica: LTS0040667
- 165353 - Angelica sinensis: 10.1365/S10337-009-1222-9
- 165353 - Angelica sinensis: LTS0040667
- 165353 - Angelica sinensis (Oliv.)Diels: -
- 4037 - Apiaceae: LTS0040667
- 4890 - Ascomycota: LTS0040667
- 1131492 - Aspergillaceae: LTS0040667
- 5503 - Curvularia lunata: 10.1039/P19820002387
- 2759 - Eukaryota: LTS0040667
- 147545 - Eurotiomycetes: LTS0040667
- 4751 - Fungi: LTS0040667
- 3398 - Magnoliopsida: LTS0040667
- 5073 - Penicillium: 10.1080/14786419.2016.1169414
- 5073 - Penicillium: LTS0040667
- 1131482 - Penicillium brefeldianum: 10.1002/HLCA.19640470603
- 1131482 - Penicillium brefeldianum: 10.1016/0306-3623(94)00189-T
- 1131482 - Penicillium brefeldianum: 10.1080/14786419.2016.1169414
- 1131482 - Penicillium brefeldianum: LTS0040667
- 5075 - Penicillium camemberti: 10.1055/S-2006-961528
- 5075 - Penicillium camemberti: LTS0040667
- 35493 - Streptophyta: LTS0040667
- 58023 - Tracheophyta: LTS0040667
- 28568 - Trichocomaceae: LTS0040667
- 33090 - Viridiplantae: LTS0040667
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Qin He, Huiliang Zhang, Xingyun Qi. Image-Based Methods to Study Membrane Trafficking Events in Stomatal Lineage Cells.
Journal of visualized experiments : JoVE.
2023 05; ?(195):. doi:
10.3791/65257
. [PMID: 37246859] - Kentaro Oh-Hashi, Hibiki Nakamura, Hirotaka Ogawa, Yoko Hirata, Kaori Sakurai. Elucidation of OSW-1-Induced Stress Responses in Neuro2a Cells.
International journal of molecular sciences.
2023 Mar; 24(6):. doi:
10.3390/ijms24065787
. [PMID: 36982858] - Sang-Jin Kim, Federica Brandizzi. Microscopy and Immunocytochemistry-Based Methods to Study Cell Wall Biosynthetic Enzymes in the Golgi.
Methods in molecular biology (Clifton, N.J.).
2023; 2557(?):39-51. doi:
10.1007/978-1-0716-2639-9_4
. [PMID: 36512208] - Sujeong Je, Yuree Lee, Yasuyo Yamaoka. Effect of common ER stress-inducing drugs on the growth and lipid phenotypes of Chlamydomonas and Arabidopsis.
Plant & cell physiology.
2022 Nov; ?(?):. doi:
10.1093/pcp/pcac154
. [PMID: 36318453] - Sang-Chul Kim, Shuaibing Yao, Qun Zhang, Xuemin Wang. Phospholipase Dδ and phosphatidic acid mediate heat-induced nuclear localization of glyceraldehyde-3-phosphate dehydrogenase in Arabidopsis.
The Plant journal : for cell and molecular biology.
2022 11; 112(3):786-799. doi:
10.1111/tpj.15981
. [PMID: 36111506] - Yi Yang, Fang Liu, Le Liu, Mingyue Zhu, Jinfeng Yuan, Yan-Xia Mai, Jun-Jie Zou, Jie Le, Yonghong Wang, Klaus Palme, Xugang Li, Yong Wang, Long Wang. The unconventional prefoldin RPB5 interactor mediates the gravitropic response by modulating cytoskeleton organization and auxin transport in Arabidopsis.
Journal of integrative plant biology.
2022 Oct; 64(10):1916-1934. doi:
10.1111/jipb.13341
. [PMID: 35943836] - Majid M Syed-Abdul, Priska Stahel, Lili Tian, Changting Xiao, Avital Nahmias, Gary F Lewis. Glucagon-like peptide-2 mobilization of intestinal lipid does not require canonical enterocyte chylomicron synthetic machinery.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2022 09; 1867(9):159194. doi:
10.1016/j.bbalip.2022.159194
. [PMID: 35680083] - Jingjing Xing, Dongchao Ji, Zhikun Duan, Tong Chen, Xiaomin Luo. Spatiotemporal dynamics of FERONIA reveal alternative endocytic pathways in response to flg22 elicitor stimuli.
The New phytologist.
2022 07; 235(2):518-532. doi:
10.1111/nph.18127
. [PMID: 35358335] - Peter T A Linders, Melina Ioannidis, Martin Ter Beest, Geert van den Bogaart. Fluorescence Lifetime Imaging of pH along the Secretory Pathway.
ACS chemical biology.
2022 01; 17(1):240-251. doi:
10.1021/acschembio.1c00907
. [PMID: 35000377] - Kensei Taguchi, Sho Sugahara, Bertha C Elias, Craig R Brooks. Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection.
Journal of visualized experiments : JoVE.
2021 11; ?(177):. doi:
10.3791/63178
. [PMID: 34842234] - Liang Zhang, Jingwen Ma, Huan Liu, Qian Yi, Yanan Wang, Jingjing Xing, Peipei Zhang, Shengdong Ji, Mingjun Li, Jingyuan Li, Jinbo Shen, Jinxing Lin. SNARE proteins VAMP721 and VAMP722 mediate the post-Golgi trafficking required for auxin-mediated development in Arabidopsis.
The Plant journal : for cell and molecular biology.
2021 10; 108(2):426-440. doi:
10.1111/tpj.15450
. [PMID: 34343378] - Monica De Caroli, Elisa Manno, Gabriella Piro, Marcello S Lenucci. Ride to cell wall: Arabidopsis XTH11, XTH29 and XTH33 exhibit different secretion pathways and responses to heat and drought stress.
The Plant journal : for cell and molecular biology.
2021 07; 107(2):448-466. doi:
10.1111/tpj.15301
. [PMID: 33932060] - Akira Yoshinari, Yosuke Toda, Junpei Takano. GNOM-dependent endocytosis maintains polar localisation of the borate exporter BOR1 in Arabidopsis.
Biology of the cell.
2021 May; 113(5):264-269. doi:
10.1111/boc.202000106
. [PMID: 33443774] - Hideki Uedono, Katsuhito Mori, Akinobu Ochi, Shinya Nakatani, Yuya Miki, Akihiro Tsuda, Tomoaki Morioka, Yuki Nagata, Yasuo Imanishi, Tetsuo Shoji, Masaaki Inaba, Masanori Emoto. Effects of fetuin-A-containing calciprotein particles on posttranslational modifications of fetuin-A in HepG2 cells.
Scientific reports.
2021 04; 11(1):7486. doi:
10.1038/s41598-021-86881-0
. [PMID: 33820929] - Monica Scali, Alessandra Moscatelli, Luca Bini, Elisabetta Onelli, Rita Vignani, Wei Wang. Protein Analysis of Pollen Tubes after the Treatments of Membrane Trafficking Inhibitors Gains Insights on Molecular Mechanism Underlying Pollen Tube Polar Growth.
The protein journal.
2021 04; 40(2):205-222. doi:
10.1007/s10930-021-09972-x
. [PMID: 33751342] - Ely Oliveira-Garcia, Barbara Valent. Characterizing the Secretion Systems of Magnaporthe oryzae.
Methods in molecular biology (Clifton, N.J.).
2021; 2356(?):69-77. doi:
10.1007/978-1-0716-1613-0_5
. [PMID: 34236677] - Ilse Foissner, Margit Hoeftberger, Marion C Hoepflinger, Aniela Sommer, Alexander A Bulychev. Brefeldin A inhibits clathrin-dependent endocytosis and ion transport in Chara internodal cells.
Biology of the cell.
2020 Nov; 112(11):317-334. doi:
10.1111/boc.202000031
. [PMID: 32648585] - V Vieira, C Pain, S Wojcik, T Spatola Rossi, J Denecke, A Osterrieder, C Hawes, V Kriechbaumer. Living on the edge: the role of Atgolgin-84A at the plant ER-Golgi interface.
Journal of microscopy.
2020 11; 280(2):158-173. doi:
10.1111/jmi.12946
. [PMID: 32700322] - Karolina Kubiasová, Juan Carlos Montesinos, Olga Šamajová, Jaroslav Nisler, Václav Mik, Hana Semerádová, Lucie Plíhalová, Ondřej Novák, Peter Marhavý, Nicola Cavallari, David Zalabák, Karel Berka, Karel Doležal, Petr Galuszka, Jozef Šamaj, Miroslav Strnad, Eva Benková, Ondřej Plíhal, Lukáš Spíchal. Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum.
Nature communications.
2020 08; 11(1):4285. doi:
10.1038/s41467-020-17949-0
. [PMID: 32855390] - Kirán R Jiménez-Vázquez, Elizabeth García-Cárdenas, Salvador Barrera-Ortiz, Randy Ortiz-Castro, León F Ruiz-Herrera, Blanca P Ramos-Acosta, Jessica L Coria-Arellano, Jorge Sáenz-Mata, José López-Bucio. The plant beneficial rhizobacterium Achromobacter sp. 5B1 influences root development through auxin signaling and redistribution.
The Plant journal : for cell and molecular biology.
2020 08; 103(5):1639-1654. doi:
10.1111/tpj.14853
. [PMID: 32445404] - Gleb Grebnev, Mislav Cvitkovic, Carolin Fritz, Giampiero Cai, Ana-Suncana Smith, Benedikt Kost. Quantitative Structural Organization of Bulk Apical Membrane Traffic in Pollen Tubes.
Plant physiology.
2020 08; 183(4):1559-1585. doi:
10.1104/pp.20.00380
. [PMID: 32482906] - L Renna, F Brandizzi. The mysterious life of the plant trans-Golgi network: advances and tools to understand it better.
Journal of microscopy.
2020 06; 278(3):154-163. doi:
10.1111/jmi.12881
. [PMID: 32115699] - Xixi Zhang, Maciek Adamowski, Petra Marhava, Shutang Tan, Yuzhou Zhang, Lesia Rodriguez, Marta Zwiewka, Vendula Pukyšová, Adrià Sans Sánchez, Vivek Kumar Raxwal, Christian S Hardtke, Tomasz Nodzyński, Jiří Friml. Arabidopsis Flippases Cooperate with ARF GTPase Exchange Factors to Regulate the Trafficking and Polarity of PIN Auxin Transporters.
The Plant cell.
2020 05; 32(5):1644-1664. doi:
10.1105/tpc.19.00869
. [PMID: 32193204] - Alexander A Bulychev, Ilse Foissner. Inhibition of endosomal trafficking by brefeldin A interferes with long-distance interaction between chloroplasts and plasma membrane transporters.
Physiologia plantarum.
2020 May; 169(1):122-134. doi:
10.1111/ppl.13058
. [PMID: 31816092] - Lei Huang, Chunhua Zhang. Perturbation and imaging of exocytosis in plant cells.
Methods in cell biology.
2020; 160(?):3-20. doi:
10.1016/bs.mcb.2020.06.006
. [PMID: 32896324] - Astrid Fabri, Khalil Kandara, Rémy Coudereau, Morgane Gossez, Paul Abraham, Céline Monard, Martin Cour, Thomas Rimmelé, Laurent Argaud, Guillaume Monneret, Fabienne Venet. Characterization of Circulating IL-10-Producing Cells in Septic Shock Patients: A Proof of Concept Study.
Frontiers in immunology.
2020; 11(?):615009. doi:
10.3389/fimmu.2020.615009
. [PMID: 33613540] - Selma Yilmaz Dejgaard, John F Presley. Rab18 regulates lipolysis via Arf/GBF1 and adipose triglyceride lipase.
Biochemical and biophysical research communications.
2019 12; 520(3):526-531. doi:
10.1016/j.bbrc.2019.10.069
. [PMID: 31610914] - Beatrice M Girard, Susan E Campbell, Megan Perkins, Harrison Hsiang, Katharine Tooke, Carolyn Drescher, Grant W Hennig, Thomas J Heppner, Mark T Nelson, Margaret A Vizzard. TRPV4 blockade reduces voiding frequency, ATP release, and pelvic sensitivity in mice with chronic urothelial overexpression of NGF.
American journal of physiology. Renal physiology.
2019 12; 317(6):F1695-F1706. doi:
10.1152/ajprenal.00147.2019
. [PMID: 31630542] - Jingjing Xing, Xiaojuan Li, Xiaohua Wang, Xueqin Lv, Li Wang, Liang Zhang, Yingfang Zhu, Qianhua Shen, František Baluška, Jozef Šamaj, Jinxing Lin. Secretion of Phospholipase Dδ Functions as a Regulatory Mechanism in Plant Innate Immunity.
The Plant cell.
2019 12; 31(12):3015-3032. doi:
10.1105/tpc.19.00534
. [PMID: 31597687] - Hui-Di Zhang, Jian-Ni Huang, Yun-Zi Liu, Hong Ren, Jing-Yuan Xie, Nan Chen. Endoplasmic reticulum stress and proteasome pathway involvement in human podocyte injury with a truncated COL4A3 mutation.
Chinese medical journal.
2019 Aug; 132(15):1823-1832. doi:
10.1097/cm9.0000000000000294
. [PMID: 31306228] - Yuyan Chen, Sarah Frost, Matloob Khushi, Laurence C Cantrill, Hong Yu, Jonathan W Arthur, Robert K Bright, Guy E Groblewski, Jennifer A Byrne. Delayed recruiting of TPD52 to lipid droplets - evidence for a "second wave" of lipid droplet-associated proteins that respond to altered lipid storage induced by Brefeldin A treatment.
Scientific reports.
2019 07; 9(1):9790. doi:
10.1038/s41598-019-46156-1
. [PMID: 31278300] - Valentina G Tabbasum, Dermot M F Cooper. Structural and Functional Determinants of AC8 Trafficking, Targeting and Responsiveness in Lipid Raft Microdomains.
The Journal of membrane biology.
2019 06; 252(2-3):159-172. doi:
10.1007/s00232-019-00060-x
. [PMID: 30746562] - Aleksandra Słupianek, Anna Kasprowicz-Maluśki, Elżbieta Myśkow, Magdalena Turzańska, Katarzyna Sokołowska. Endocytosis acts as transport pathway in wood.
The New phytologist.
2019 06; 222(4):1846-1861. doi:
10.1111/nph.15637
. [PMID: 30548617] - Mohammad A Ashraf, Abidur Rahman. Cold stress response in Arabidopsis thaliana is mediated by GNOM ARF-GEF.
The Plant journal : for cell and molecular biology.
2019 02; 97(3):500-516. doi:
10.1111/tpj.14137
. [PMID: 30362633] - Daniel Garcia Cabanillas, Jun Jiang, Nooshin Movahed, Hugo Germain, Yasuyuki Yamaji, Huanquan Zheng, Jean-François Laliberté. Turnip Mosaic Virus Uses the SNARE Protein VTI11 in an Unconventional Route for Replication Vesicle Trafficking.
The Plant cell.
2018 10; 30(10):2594-2615. doi:
10.1105/tpc.18.00281
. [PMID: 30150314] - Kiril Mishev, Qing Lu, Bram Denoo, François Peurois, Wim Dejonghe, Jan Hullaert, Riet De Rycke, Sjef Boeren, Marine Bretou, Steven De Munck, Isha Sharma, Kaija Goodman, Kamila Kalinowska, Veronique Storme, Le Son Long Nguyen, Andrzej Drozdzecki, Sara Martins, Wim Nerinckx, Dominique Audenaert, Grégory Vert, Annemieke Madder, Marisa S Otegui, Erika Isono, Savvas N Savvides, Wim Annaert, Sacco De Vries, Jacqueline Cherfils, Johan Winne, Eugenia Russinova. Nonselective Chemical Inhibition of Sec7 Domain-Containing ARF GTPase Exchange Factors.
The Plant cell.
2018 10; 30(10):2573-2593. doi:
10.1105/tpc.18.00145
. [PMID: 30018157] - Urszula Kania, Tomasz Nodzyński, Qing Lu, Glenn R Hicks, Wim Nerinckx, Kiril Mishev, François Peurois, Jacqueline Cherfils, Riet De Rycke, Peter Grones, Stéphanie Robert, Eugenia Russinova, Jiří Friml. The Inhibitor Endosidin 4 Targets SEC7 Domain-Type ARF GTPase Exchange Factors and Interferes with Subcellular Trafficking in Eukaryotes.
The Plant cell.
2018 10; 30(10):2553-2572. doi:
10.1105/tpc.18.00127
. [PMID: 30018156] - Yuan Ruan, Laryssa S Halat, Deirdre Khan, Sylwia Jancowski, Chris Ambrose, Mark F Belmonte, Geoffrey O Wasteneys. The Microtubule-Associated Protein CLASP Sustains Cell Proliferation through a Brassinosteroid Signaling Negative Feedback Loop.
Current biology : CB.
2018 09; 28(17):2718-2729.e5. doi:
10.1016/j.cub.2018.06.048
. [PMID: 30146155] - Shumei Wang, Lydia Welsh, Peter Thorpe, Stephen C Whisson, Petra C Boevink, Paul R J Birch. The Phytophthora infestans Haustorium Is a Site for Secretion of Diverse Classes of Infection-Associated Proteins.
mBio.
2018 08; 9(4):. doi:
10.1128/mbio.01216-18
. [PMID: 30154258] - Sravani Banerjee, David Aponte-Diaz, Calvin Yeager, Suresh D Sharma, Gang Ning, Hyung S Oh, Qingxia Han, Masato Umeda, Yuji Hara, Robert Y L Wang, Craig E Cameron. Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein.
PLoS pathogens.
2018 05; 14(5):e1007086. doi:
10.1371/journal.ppat.1007086
. [PMID: 29782554] - Kazuki Motomura, Tomokazu Kawashima, Frédéric Berger, Tetsu Kinoshita, Tetsuya Higashiyama, Daisuke Maruyama. A pharmacological study of Arabidopsis cell fusion between the persistent synergid and endosperm.
Journal of cell science.
2018 01; 131(2):. doi:
10.1242/jcs.204123
. [PMID: 28808086] - Yoko Ito, Tomohiro Uemura, Akihiko Nakano. The Golgi entry core compartment functions as a COPII-independent scaffold for ER-to-Golgi transport in plant cells.
Journal of cell science.
2018 01; 131(2):. doi:
10.1242/jcs.203893
. [PMID: 28839076] - Hongpo Wu, Mark Kwaaitaal, Roxana Strugala, Ulrich Schaffrath, Paweł Bednarek, Ralph Panstruga. Chemical suppressors of mlo-mediated powdery mildew resistance.
Bioscience reports.
2017 Dec; 37(6):. doi:
10.1042/bsr20171389
. [PMID: 29127104] - Shumei Wang, Petra C Boevink, Lydia Welsh, Ruofang Zhang, Stephen C Whisson, Paul R J Birch. Delivery of cytoplasmic and apoplastic effectors from Phytophthora infestans haustoria by distinct secretion pathways.
The New phytologist.
2017 Oct; 216(1):205-215. doi:
10.1111/nph.14696
. [PMID: 28758684] - Saeko Kitakura, Maciek Adamowski, Yuki Matsuura, Luca Santuari, Hirotaka Kouno, Kohei Arima, Christian S Hardtke, Jirí Friml, Tatsuo Kakimoto, Hirokazu Tanaka. BEN3/BIG2 ARF GEF is Involved in Brefeldin A-Sensitive Trafficking at the trans-Golgi Network/Early Endosome in Arabidopsis thaliana.
Plant & cell physiology.
2017 Oct; 58(10):1801-1811. doi:
10.1093/pcp/pcx118
. [PMID: 29016942] - Chan Mao, Jiang Gu, Hai-Guang Wang, Yao Fang, Ping Yang, Bin Tang, Na Li, Ting-Ting Wang, Quan-Ming Zou, Qian Li. Translocation of enterohemorrhagic Escherichia coli effector Tir to the plasma membrane via host Golgi apparatus.
Molecular medicine reports.
2017 Aug; 16(2):1544-1550. doi:
10.3892/mmr.2017.6763
. [PMID: 28627613] - Neema Prabhakaran Mariyamma, Hongwei Hou, Francine M Carland, Timothy Nelson, Elizabeth A Schultz. Localization of Arabidopsis FORKED1 to a RABA-positive compartment suggests a role in secretion.
Journal of experimental botany.
2017 06; 68(13):3375-3390. doi:
10.1093/jxb/erx180
. [PMID: 28575401] - Masroor Qadri, Yedukondalu Nalli, Shreyans K Jain, Asha Chaubey, Asif Ali, Gary A Strobel, Ram A Vishwakarma, Syed Riyaz-Ul-Hassan. An Insight into the Secondary Metabolism of Muscodor yucatanensis: Small-Molecule Epigenetic Modifiers Induce Expression of Secondary Metabolism-Related Genes and Production of New Metabolites in the Endophyte.
Microbial ecology.
2017 05; 73(4):954-965. doi:
10.1007/s00248-016-0901-y
. [PMID: 27924400] - Hana Mahmutefendić, Gordana Blagojević Zagorac, Kristina Grabušić, Ljerka Karleuša, Senka Maćešić, Frank Momburg, Pero Lučin. Late Endosomal Recycling of Open MHC-I Conformers.
Journal of cellular physiology.
2017 Apr; 232(4):872-887. doi:
10.1002/jcp.25495
. [PMID: 27438986] - Tsutomu Nakagawa, Chiharu Suzuki-Nakagawa, Akiko Watanabe, Eriko Asami, Mizuki Matsumoto, Mami Nakano, Akio Ebihara, Mohammad Nasir Uddin, Fumiaki Suzuki. Site-1 protease is required for the generation of soluble (pro)renin receptor.
Journal of biochemistry.
2017 Apr; 161(4):369-379. doi:
10.1093/jb/mvw080
. [PMID: 28013223] - Yoko Ito, Kiminori Toyooka, Masaru Fujimoto, Takashi Ueda, Tomohiro Uemura, Akihiko Nakano. The trans-Golgi Network and the Golgi Stacks Behave Independently During Regeneration After Brefeldin A Treatment in Tobacco BY-2 Cells.
Plant & cell physiology.
2017 04; 58(4):811-821. doi:
10.1093/pcp/pcx028
. [PMID: 28339924] - Qinghua Yang, Xiaoyang Li, Haitao Tu, Shen Q Pan. Agrobacterium-delivered virulence protein VirE2 is trafficked inside host cells via a myosin XI-K-powered ER/actin network.
Proceedings of the National Academy of Sciences of the United States of America.
2017 03; 114(11):2982-2987. doi:
10.1073/pnas.1612098114
. [PMID: 28242680] - Benjamin Weller, Melina Zourelidou, Lena Frank, Inês C R Barbosa, Astrid Fastner, Sandra Richter, Gerd Jürgens, Ulrich Z Hammes, Claus Schwechheimer. Dynamic PIN-FORMED auxin efflux carrier phosphorylation at the plasma membrane controls auxin efflux-dependent growth.
Proceedings of the National Academy of Sciences of the United States of America.
2017 01; 114(5):E887-E896. doi:
10.1073/pnas.1614380114
. [PMID: 28096328] - Wenjin Shen, Zhidan Xiao, Jinbo Shen, Caiji Gao. Analysis of Golgi-Mediated Protein Traffic in Plant Cells.
Methods in molecular biology (Clifton, N.J.).
2017; 1662(?):75-86. doi:
10.1007/978-1-4939-7262-3_6
. [PMID: 28861818] - Brian D Rutter, Roger W Innes. Extracellular Vesicles Isolated from the Leaf Apoplast Carry Stress-Response Proteins.
Plant physiology.
2017 01; 173(1):728-741. doi:
10.1104/pp.16.01253
. [PMID: 27837092] - Chao Wang, Xu Yan, Tingting Meng, Tianwei Hu, Jianwei Pan. Immunofluorescence Analysis of Membrane-Associated Proteins for Clathrin-Mediated Endocytosis in Plant Root Cells.
Methods in molecular biology (Clifton, N.J.).
2017; 1662(?):151-157. doi:
10.1007/978-1-4939-7262-3_13
. [PMID: 28861825] - Yu Luo, Eugenia Russinova. Quantitative Microscopic Analysis of Plasma Membrane Receptor Dynamics in Living Plant Cells.
Methods in molecular biology (Clifton, N.J.).
2017; 1564(?):121-132. doi:
10.1007/978-1-4939-6813-8_10
. [PMID: 28124250] - Riko Tanaka, Makoto Amijima, Yuji Iwata, Nozomu Koizumi, Kei-Ichiro Mishiba. Effect of light and auxin transport inhibitors on endoreduplication in hypocotyl and cotyledon.
Plant cell reports.
2016 Dec; 35(12):2539-2547. doi:
10.1007/s00299-016-2054-3
. [PMID: 27637202] - Toshiyuki Yamaji, Aya Horie, Yuriko Tachida, Chisato Sakuma, Yusuke Suzuki, Yasunori Kushi, Kentaro Hanada. Role of Intracellular Lipid Logistics in the Preferential Usage of Very Long Chain-Ceramides in Glucosylceramide.
International journal of molecular sciences.
2016 Oct; 17(10):. doi:
10.3390/ijms17101761
. [PMID: 27775668] - Zhi-Fei Hu, Le-Le Qin, Wan-Jing Ding, Yu Liu, Zhong-Jun Ma. New analogues of brefeldin A from sediment-derived fungus Penicillium sp. DT-F29.
Natural product research.
2016 Oct; 30(20):2311-5. doi:
10.1080/14786419.2016.1169414
. [PMID: 27067647] - Joohyun Park, Oh Yeon Cho, Jung Ah Kim, Sunghoe Chang. Endosome-mediated endocytic mechanism replenishes the majority of synaptic vesicles at mature CNS synapses in an activity-dependent manner.
Scientific reports.
2016 08; 6(?):31807. doi:
10.1038/srep31807
. [PMID: 27534442] - Ahmad Massarweh, Michaël Bosco, Soria Iatmanen-Harbi, Clarice Tessier, Laura Amana, Patricia Busca, Isabelle Chantret, Christine Gravier-Pelletier, Stuart E H Moore. Brefeldin A promotes the appearance of oligosaccharyl phosphates derived from Glc3Man9GlcNAc2-PP-dolichol within the endomembrane system of HepG2 cells.
Journal of lipid research.
2016 08; 57(8):1477-91. doi:
10.1194/jlr.m068551
. [PMID: 27281477] - Kentaro Kaneko, Takeshi Takamatsu, Takuya Inomata, Kazusato Oikawa, Kimiko Itoh, Kazuko Hirose, Maho Amano, Shin-Ichiro Nishimura, Kiminori Toyooka, Ken Matsuoka, Javier Pozueta-Romero, Toshiaki Mitsui. N-Glycomic and Microscopic Subcellular Localization Analyses of NPP1, 2 and 6 Strongly Indicate that trans-Golgi Compartments Participate in the Golgi to Plastid Traffic of Nucleotide Pyrophosphatase/Phosphodiesterases in Rice.
Plant & cell physiology.
2016 Aug; 57(8):1610-28. doi:
10.1093/pcp/pcw089
. [PMID: 27335351] - Tomofumi Nakayama, Noriko Saitoh, Keiko Morotomi-Yano, Ken-Ichi Yano, Mitsuyoshi Nakao, Hisato Saitoh. Nuclear extrusion precedes discharge of genomic DNA fibers during tunicamycin-induced neutrophil extracellular trap-osis (NETosis)-like cell death in cultured human leukemia cells.
Cell biology international.
2016 May; 40(5):597-602. doi:
10.1002/cbin.10594
. [PMID: 26888435] - Kaoutar El-Mounadi, Kazi T Islam, Patricia Hernández-Ortiz, Nick D Read, Dilip M Shah. Antifungal mechanisms of a plant defensin MtDef4 are not conserved between the ascomycete fungi Neurospora crassa and Fusarium graminearum.
Molecular microbiology.
2016 05; 100(3):542-59. doi:
10.1111/mmi.13333
. [PMID: 26801962] - Mark Windheim, Stefan Höning, Keith N Leppard, Larissa Butler, Christina Seed, Sreenivasan Ponnambalam, Hans-Gerhard Burgert. Sorting Motifs in the Cytoplasmic Tail of the Immunomodulatory E3/49K Protein of Species D Adenoviruses Modulate Cell Surface Expression and Ectodomain Shedding.
The Journal of biological chemistry.
2016 Mar; 291(13):6796-812. doi:
10.1074/jbc.m115.684787
. [PMID: 26841862] - Haiyan Zhang, Jinjin Li. From Cytosol to the Apoplast: The Hygromycin Phosphotransferase (HYG(R)) Model in Arabidopsis.
Methods in molecular biology (Clifton, N.J.).
2016; 1459(?):81-90. doi:
10.1007/978-1-4939-3804-9_5
. [PMID: 27665552] - Sonika Gupta, Vijay Wardhan, Amit Kumar, Divya Rathi, Aarti Pandey, Subhra Chakraborty, Niranjan Chakraborty. Secretome analysis of chickpea reveals dynamic extracellular remodeling and identifies a Bet v1-like protein, CaRRP1 that participates in stress response.
Scientific reports.
2015 Dec; 5(?):18427. doi:
10.1038/srep18427
. [PMID: 26678784] - Efrat Dvash, Michal Har-Tal, Sara Barak, Ofir Meir, Menachem Rubinstein. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage.
Nature communications.
2015 Dec; 6(?):10112. doi:
10.1038/ncomms10112
. [PMID: 26656251] - Natsuko Macabuag, Annette C Dolphin. Alternative Splicing in Ca(V)2.2 Regulates Neuronal Trafficking via Adaptor Protein Complex-1 Adaptor Protein Motifs.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 Oct; 35(43):14636-52. doi:
10.1523/jneurosci.3034-15.2015
. [PMID: 26511252] - Cătălin Voiniciuc, Maximilian Heinrich-Wilhelm Schmidt, Adeline Berger, Bo Yang, Berit Ebert, Henrik V Scheller, Helen M North, Björn Usadel, Markus Günl. MUCILAGE-RELATED10 Produces Galactoglucomannan That Maintains Pectin and Cellulose Architecture in Arabidopsis Seed Mucilage.
Plant physiology.
2015 Sep; 169(1):403-20. doi:
10.1104/pp.15.00851
. [PMID: 26220953] - Derek R Drost, Swati Puranik, Evandro Novaes, Carolina R D B Novaes, Christopher Dervinis, Oliver Gailing, Matias Kirst. Genetical genomics of Populus leaf shape variation.
BMC plant biology.
2015 Jun; 15(?):166. doi:
10.1186/s12870-015-0557-7
. [PMID: 26122556] - Minetaro Arita, Stefan Philipov, Angel S Galabov. Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A.
Microbiology and immunology.
2015 Jun; 59(6):338-47. doi:
10.1111/1348-0421.12261
. [PMID: 25891300] - Aurélie Mercier, Romain Clément, Thomas Harnois, Nicolas Bourmeyster, Patrick Bois, Aurélien Chatelier. Nav1.5 channels can reach the plasma membrane through distinct N-glycosylation states.
Biochimica et biophysica acta.
2015 Jun; 1850(6):1215-23. doi:
10.1016/j.bbagen.2015.02.009
. [PMID: 25721215] - Edgar B Cepeda, Tatjana Dediulia, Joan Fernando, Esther Bertran, Gustavo Egea, Estanislao Navarro, Isabel Fabregat. Mechanisms regulating cell membrane localization of the chemokine receptor CXCR4 in human hepatocarcinoma cells.
Biochimica et biophysica acta.
2015 May; 1853(5):1205-18. doi:
10.1016/j.bbamcr.2015.02.012
. [PMID: 25704914] - Miaomiao Tian, Lijuan Lou, Lijing Liu, Feifei Yu, Qingzhen Zhao, Huawei Zhang, Yaorong Wu, Sanyuan Tang, Ran Xia, Baoge Zhu, Giovanna Serino, Qi Xie. The RING finger E3 ligase STRF1 is involved in membrane trafficking and modulates salt-stress response in Arabidopsis thaliana.
The Plant journal : for cell and molecular biology.
2015 Apr; 82(1):81-92. doi:
10.1111/tpj.12797
. [PMID: 25704231] - Chao Geng, Qian-Qian Cong, Xiang-Dong Li, An-Li Mou, Rui Gao, Jin-Liang Liu, Yan-Ping Tian. DEVELOPMENTALLY REGULATED PLASMA MEMBRANE PROTEIN of Nicotiana benthamiana contributes to potyvirus movement and transports to plasmodesmata via the early secretory pathway and the actomyosin system.
Plant physiology.
2015 Feb; 167(2):394-410. doi:
10.1104/pp.114.252734
. [PMID: 25540331] - Jianping Liu, Kyoko Hayashi, Ken Matsuoka. Membrane topology of Golgi-localized probable S-adenosylmethionine-dependent methyltransferase in tobacco (Nicotiana tabacum) BY-2 cells.
Bioscience, biotechnology, and biochemistry.
2015; 79(12):2007-13. doi:
10.1080/09168451.2015.1069700
. [PMID: 26222189] - Lian-Jun Zhang, Bo Chen, Xin-Lei Feng, Hua-Gang Ma, Li-Lan Sun, Yan-Min Feng, Gui-Jin Liang, Shun-Feng Cheng, Lan Li, Wei Shen. Exposure to Brefeldin A promotes initiation of meiosis in murine female germ cells.
Reproduction, fertility, and development.
2015 Jan; 27(2):294-303. doi:
10.1071/rd13281
. [PMID: 24209976] - Kathryn M Wright, Katrin M MacKenzie. Probing protein targeting to plasmodesmata using fluorescence recovery after photo-bleaching.
Methods in molecular biology (Clifton, N.J.).
2015; 1217(?):259-74. doi:
10.1007/978-1-4939-1523-1_17
. [PMID: 25287209] - Matthias T F Wolf, Sung-Wan An, Mingzhu Nie, Manjot S Bal, Chou-Long Huang. Klotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms.
The Journal of biological chemistry.
2014 Dec; 289(52):35849-57. doi:
10.1074/jbc.m114.616649
. [PMID: 25378396] - Chao-Neng Tseng, Yi-Ren Hong, Hsueh-Wei Chang, Tsai-Jung Yu, Ting-Wei Hung, Ming-Feng Hou, Shyng-Shiou F Yuan, Chung-Lung Cho, Chien-Tsung Liu, Chien-Chih Chiu, Chih-Jen Huang. Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells.
Molecules (Basel, Switzerland).
2014 Oct; 19(11):17464-77. doi:
10.3390/molecules191117464
. [PMID: 25356567] - Ján Jásik, Elmon Schmelzer. Internalized and newly synthesized Arabidopsis PIN-FORMED2 pass through brefeldin A compartments: a new insight into intracellular dynamics of the protein by using the photoconvertible fluorescence protein Dendra2 as a tag.
Molecular plant.
2014 Oct; 7(10):1578-81. doi:
10.1093/mp/ssu052
. [PMID: 24777990] - Yue Cai, Yuhong Wang, Jia Xu, Xu Zuo, Yanfang Xu. Down-regulation of ether-a-go-go-related gene potassium channel protein through sustained stimulation of AT1 receptor by angiotensin II.
Biochemical and biophysical research communications.
2014 Sep; 452(3):852-7. doi:
10.1016/j.bbrc.2014.09.014
. [PMID: 25218469] - Kaitlin C Lenhart, Abby L Becherer, Jianbin Li, Xiao Xiao, Elizabeth M McNally, Christopher P Mack, Joan M Taylor. GRAF1 promotes ferlin-dependent myoblast fusion.
Developmental biology.
2014 Sep; 393(2):298-311. doi:
10.1016/j.ydbio.2014.06.025
. [PMID: 25019370] - Caleb M Rounds, Peter K Hepler, Lawrence J Winship. The apical actin fringe contributes to localized cell wall deposition and polarized growth in the lily pollen tube.
Plant physiology.
2014 Sep; 166(1):139-51. doi:
10.1104/pp.114.242974
. [PMID: 25037212] - Pablo F Céspedes, Susan M Bueno, Bruno A Ramírez, Roberto S Gomez, Sebastián A Riquelme, Christian E Palavecino, Juan Pablo Mackern-Oberti, Jorge E Mora, David Depoil, Catarina Sacristán, Michael Cammer, Alison Creneguy, Tuan H Nguyen, Claudia A Riedel, Michael L Dustin, Alexis M Kalergis. Surface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells.
Proceedings of the National Academy of Sciences of the United States of America.
2014 Aug; 111(31):E3214-23. doi:
10.1073/pnas.1400760111
. [PMID: 25056968] - Stéphanie Le Corre, David Eyre, Iain A Drummond. Modulation of the secretory pathway rescues zebrafish polycystic kidney disease pathology.
Journal of the American Society of Nephrology : JASN.
2014 Aug; 25(8):1749-59. doi:
10.1681/asn.2013101060
. [PMID: 24627348] - Satoshi Naramoto, Marisa S Otegui, Natsumaro Kutsuna, Riet de Rycke, Tomoko Dainobu, Michael Karampelias, Masaru Fujimoto, Elena Feraru, Daisuke Miki, Hiroo Fukuda, Akihiko Nakano, Jiří Friml. Insights into the localization and function of the membrane trafficking regulator GNOM ARF-GEF at the Golgi apparatus in Arabidopsis.
The Plant cell.
2014 Jul; 26(7):3062-76. doi:
10.1105/tpc.114.125880
. [PMID: 25012191] - Haruki Hasegawa, Carla Forte, Irene Barber, Shanon Turnbaugh, Janelle Stoops, Min Shen, Ai Ching Lim. Modulation of in vivo IgG crystallization in the secretory pathway by heavy chain isotype class switching and N-linked glycosylation.
Biochimica et biophysica acta.
2014 Jul; 1843(7):1325-38. doi:
10.1016/j.bbamcr.2014.03.024
. [PMID: 24703881] - Mie Ichikawa, Tomoko Hirano, Kazuhiko Enami, Taylor Fuselier, Naohiro Kato, Chian Kwon, Boris Voigt, Paul Schulze-Lefert, František Baluška, Masa H Sato. Syntaxin of plant proteins SYP123 and SYP132 mediate root hair tip growth in Arabidopsis thaliana.
Plant & cell physiology.
2014 Apr; 55(4):790-800. doi:
10.1093/pcp/pcu048
. [PMID: 24642714] - Hirokazu Tanaka, Tomasz Nodzyłski, Saeko Kitakura, Mugurel I Feraru, Michiko Sasabe, Tomomi Ishikawa, Jürgen Kleine-Vehn, Tatsuo Kakimoto, Jiři Friml. BEX1/ARF1A1C is required for BFA-sensitive recycling of PIN auxin transporters and auxin-mediated development in Arabidopsis.
Plant & cell physiology.
2014 Apr; 55(4):737-49. doi:
10.1093/pcp/pct196
. [PMID: 24369434] - Tomohiro Uemura, Yasuyuki Suda, Takashi Ueda, Akihiko Nakano. Dynamic behavior of the trans-golgi network in root tissues of Arabidopsis revealed by super-resolution live imaging.
Plant & cell physiology.
2014 Apr; 55(4):694-703. doi:
10.1093/pcp/pcu010
. [PMID: 24443496] - Anthi Katsiarimpa, Alfonso Muñoz, Kamila Kalinowska, Tomohiro Uemura, Enrique Rojo, Erika Isono. The ESCRT-III-interacting deubiquitinating enzyme AMSH3 is essential for degradation of ubiquitinated membrane proteins in Arabidopsis thaliana.
Plant & cell physiology.
2014 Apr; 55(4):727-36. doi:
10.1093/pcp/pcu019
. [PMID: 24486765] - Anna Vittoria Carluccio, Stefania Zicca, Livia Stavolone. Hitching a ride on vesicles: cauliflower mosaic virus movement protein trafficking in the endomembrane system.
Plant physiology.
2014 Mar; 164(3):1261-70. doi:
10.1104/pp.113.234534
. [PMID: 24477592] - Ngoc-Nam Trinh, Tsai-Lien Huang, Wen-Chang Chi, Shih-Feng Fu, Chi-Chien Chen, Hao-Jen Huang. Chromium stress response effect on signal transduction and expression of signaling genes in rice.
Physiologia plantarum.
2014 Feb; 150(2):205-24. doi:
10.1111/ppl.12088
. [PMID: 24033343] - Carlos Munoz, Tatsiana Pakladok, Ahmad Almilaji, Bernat Elvira, Niels Decher, Ekaterina Shumilina, Florian Lang. Up-regulation of Kir2.1 (KCNJ2) by the serum & glucocorticoid inducible SGK3.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2014; 33(2):491-500. doi:
10.1159/000358629
. [PMID: 24556932] - Anna Vittoria Carluccio, Livia Stavolone. Interference of Brefeldin A in viral movement protein tubules assembly.
Plant signaling & behavior.
2014; 9(7):e29121. doi:
10.4161/psb.29121
. [PMID: 25763491] - Ana Claudia Batista Possidonio, Carolina Pontes Soares, Débora Morueco Portilho, Victor Midlej, Marlene Benchimol, Gillian Butler-Browne, Manoel Luis Costa, Claudia Mermelstein. Differences in the expression and distribution of flotillin-2 in chick, mice and human muscle cells.
PloS one.
2014; 9(8):e103990. doi:
10.1371/journal.pone.0103990
. [PMID: 25105415]