Scoparone (BioDeep_00000000140)

Secondary id: BioDeep_00000398492, BioDeep_00000861045

human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs

代谢物信息卡片

6,7-dimethoxychromen-2-one

化学式: C11H10O4 (206.057906)
中文名称: 滨蒿内酯, 滨蒿內酯, 6,7-二甲氧基香豆素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.09%

Reviewed

Last reviewed on 2024-09-04.

Cite this Page

Scoparone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/scoparone (retrieved 2024-09-18) (BioDeep RN: BioDeep_00000000140). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(c(cc2c(c1)ccc(=O)o2)OC)OC
InChI: InChI=1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3

描述信息

Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as a plant metabolite, an anti-inflammatory agent, an antilipemic drug, an immunosuppressive agent, an antihypertensive agent and an anti-allergic agent. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin.
Scoparone is a natural product found in Haplophyllum ramosissimum, Haplophyllum thesioides, and other organisms with data available.
A member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities.
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
Scoparone is found in anise. Scoparone is found in several citrus oil
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Found in several citrus oils
Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities[1].
Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities[1].

同义名列表

41 个代谢物同义名

5-18-03-00204 (Beilstein Handbook Reference); 6,7-Dimethylesculetin, 6,7-Dimethoxycoumarin; 6,7-Dimethoxycoumarin pound>>Escoparone; Benzopyran-2-one, 6,7-dimethoxy- (9CI); 2H-1-Benzopyran-2-one, 6,7-dimethoxy-; 6,7-Dimethoxy-2H-1-benzopyran-2-one; Benzopyran-2-one, 6,7-dimethoxy-; 6,7-Dimethoxy-2H-chromen-2-one #; 6,7-Dimethoxy-2H-chromen-2-one; 6,7-Dimethoxy-Benzopyran-2-one; 6,7-Dimethoxybenzopyran-2-one; Esculetin 6,7-dimethyl ether; 6,7-Dimethoxy-chromen-2-one; 6,7-Dimethoxy-2-benzopyrone; 6,7-Dimethoxycoumarin, 98\\%; GUAFOGOEJLSQBT-UHFFFAOYSA-N; 6,7-dimethoxychromen-2-one; Aesculetin dimethyl ether; Esculetin dimethyl ether; Coumarin, 6,7-dimethoxy-; Scopoletin methyl ether; 6,7-dimethoxy-coumarin; 6,7-dimethoxycoumarin; 6,7-Dimethylcoumarine; o-Methylisoscopoletin; 6,7-dimethylesculetin; o,o-Dimethylesculetin; Dimethyl esculetin; Dimethylaesculetin; o-Methylscopoletin; Maybridge4_003009; SCOPARONE [INCI]; SCOPARONE [MI]; Scoparone,(S); MEGxp0_001422; ACon1_002079; Escoparone; Scoparin?; Scoparone; 1ST164127; Scoparon

数据库引用编号

20 个数据库交叉引用编号

ChEBI: CHEBI:9055
KEGG: C09311
PubChem: 8417
HMDB: HMDB0030818
Metlin: METLIN67595
ChEMBL: CHEMBL325864
Wikipedia: Scoparone
MeSH: scoparone
ChemIDplus: 0000120081
MetaCyc: CPD-14452
KNApSAcK: C00002498
foodb: FDB002774
chemspider: 8110
CAS: 120-08-1
medchemexpress: HY-N0228
PMhub: MS000004771
MetaboLights: MTBLC9055
3DMET: B02851
NIKKAJI: J5.319H
RefMet: Scoparone

分类词条

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

esculetin modification: SAM + esculetin ⟶ H⁺ + SAH + scopoletin

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(4)

esculetin modification: H₂O + esculin ⟶ D-glucopyranose + esculetin
esculetin modification: SAM + esculetin ⟶ H⁺ + SAH + scopoletin
esculetin modification: H₂O + esculin ⟶ D-glucopyranose + esculetin
esculetin modification: H₂O + esculin ⟶ D-glucopyranose + esculetin

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

275 个相关的物种来源信息

33090 滨蒿: -
68554 Phellodendron amurense:
60419 Castanea mollissima: 10.1080/10286020903451757
2099548 Zanthoxylum zanthoxyloides: 10.1021/NP50046A035
171251 Citrus medica:
265783 Artemisia capillaris:
354527 Zanthoxylum avicennae:
1056465 Zanthoxylum beecheyanum: 10.1002/JCCS.200400159
1898877 Hibiscus taiwanensis:
183267 Talipariti tiliaceum: 10.1248/CPB.53.56
1089418 Microtropis japonica:
4047 Coriandrum sativum: 10.1016/0031-9422(95)00930-2
318062 Euphorbia hirta: 10.1016/S1875-5364(12)60009-0
199751 Bupleurum salicifolium:
176559 Pericome caudata: 10.1016/S0031-9422(00)82480-2
72349 Artemisia nova: 10.1016/S0021-9673(01)97678-2
142615 Dendrobium officinale: 10.1021/JF040017R
906689 Dendrobium catenatum: 10.1021/JF040017R
142614 Dendrobium moniliforme: 10.1021/JF040017R
183483 Dendrobium tosaense: 10.1021/JF040017R
401875 Artemisia adamsii: 10.1016/S0031-9422(00)83171-4
469930 Garcinia kola: 10.1021/NP8006364
469925 Garcinia conrauana: 10.1021/NP8006364
1009474 Garcinia multiflora: 10.1021/NP8006364
159071 Zanthoxylum ailanthoides:
1006079 Haplophyllum ramosissimum:
992815 Zanthoxylum leprieurii: 10.1021/NP50048A057
23278 Vahlia capensis: 10.1016/0031-9422(94)00710-B
85854 Magnolia coco:
1487095 Melicope borbonica: 10.1016/S0378-8741(98)00137-8
72351 Artemisia scoparia:
756622 Euphorbia iberica: 10.1055/S-2006-960819
271244 Keetia multiflora: 10.1055/S-2008-1034372
123498 Aleurites moluccanus: 10.1016/S0367-326X(00)00314-2
205371 Artemisia marschalliana: 10.1016/S0031-9422(00)88402-2
76966 Citrus japonica: 10.1248/CPB.49.1356
408488 Citrus kinokuni: 10.1248/CPB.49.1356
85571 Citrus reticulata:
558547 Citrus deliciosa:
1811969 Artemisia vestita: 10.1055/S-1999-13965
403096 Allamanda schottii: 10.1021/NP50056A018
136894 Catunaregam spinosa: 10.1002/CHIN.200844208
137934 Aralia bipinnata:
169606 Tagetes lucida: 10.1021/JF053071W
401909 Artemisia laciniata: 10.1002/JLAC.198619861208
68527 Aegle marmelos: 10.1016/J.PHYTOCHEM.2011.11.018
282633 Phebalium squamulosum: 10.1016/0031-9422(92)83450-D
1905583 Rubia wallichiana:
298346 Dictamnus albus: 10.1016/S0031-9422(98)00519-6
1475378 Calea ternifolia: 10.3390/MOLECULES22020289
271192 Pimpinella anisum: 10.1007/BF00993733
4045 Apium graveolens: 10.1007/BF00993733
117978 Dendrobium thyrsiflorum:
354518 Skimmia laureola: 10.1016/S0031-9422(00)81759-8
354528 Zanthoxylum nitidum:
72350 Artemisia reptans: 10.1016/S0031-9422(00)89536-9
1735025 Suaeda nudiflora: 10.1002/JPS.3030350906
126913 Suaeda maritima: 10.1002/JPS.3030350906
127995 Gonospermum ferulaceum: 10.1016/0031-9422(90)83068-C
1008928 Pittosporum illicioides: 10.1021/NP8004503
38874 Fraxinus ornus:
127982 Gonospermum fruticosum:
371362 Ferula linkii: 10.1016/0031-9422(93)85291-X
161866 Dendrobium densiflorum:
126552 Olea capensis:
127983 Gonospermum gomerae: 10.1021/NP800474V
1006083 Haplophyllum thesioides: 10.1080/10575639308050059
237573 Citrus sulcata: 10.1248/CPB.39.2509
489439 Deverra tortuosa: 10.1590/S0103-50532003000100008
114476 Gardenia jasminoides: 10.1021/NP800002Z
2805000 Aldama robusta: 10.1016/0305-1978(96)00057-9
864332 Cedrelopsis grevei:
665671 Anisotome pilifera: 10.1016/S0305-1978(02)00047-9
28525 Menyanthes trifoliata: 10.1086/325638
3406 Magnolia grandiflora: 10.1016/S0031-9422(00)80557-9
2805006 Aldama tukumanensis: 10.1016/0031-9422(95)00584-6
587579 Khaya senegalensis: 10.1016/0031-9422(95)00093-3
282723 Achillea biserrata: 10.1007/BF00579679
282761 Achillea ptarmicifolia: 10.1007/BF00579978
282741 Achillea impatiens: 10.1007/BF00579978
354530 Zanthoxylum schinifolium:
145490 Centaurea collina: 10.1016/S0031-9422(00)97993-7
145515 Centaurea salonitana: 10.1016/S0031-9422(00)97993-7
167917 Duranta erecta: 10.1248/CPB.50.515
328402 Zanthoxylum simulans: 10.1016/S0031-9422(97)00280-X
262982 Artemisia apiacea: 10.1016/S0367-326X(02)00070-9
496566 Artemisia carvifolia: 10.1016/S0367-326X(02)00070-9
1873686 Espeletia spectabilis: 10.1016/0031-9422(80)83072-X
105886 Eleutherococcus sessiliflorus: 10.1055/S-2002-34925
180498 Jatropha curcas: 10.1002/HLCA.201000313
55611 Artemisia tridentata: 10.1016/0305-1978(92)90072-L
376251 Ranunculus sieboldii: 10.1055/S-2005-873169
147635 Ranunculus sceleratus: 10.1055/S-2005-873169
231460 Afraegle paniculata: 10.1016/0031-9422(73)85149-0
557631 Chiliadenus candicans: 10.3109/13880208809053916
119185 Pulicaria arabica: 10.3109/13880208809053916
549422 Hortia longifolia: 10.1021/JO00829A053
68535 Casimiroa edulis: 10.1021/NP50037A032
329772 Solanum dasyphyllum: 10.1021/NP50037A033
2589437 Erythroxylum barbatum: 10.1016/S0305-1978(02)00249-1
3411 Magnolia salicifolia: 10.1248/CPB.39.3265
1177126 Artemisia turanica: 10.1021/NP50031A025
72341 Artemisia dracunculus:
452789 Ruta angustifolia: 10.1016/S0031-9422(00)84991-2
2839964 Zanthoxylum dimorphophyllum: 10.1515/ZNC-2001-7-802
55188 Citrus unshiu: 10.1007/BF00630620
378924 Empleurum unicapsulare: 10.1016/0031-9422(86)88018-9
2486848 Agathosma martiana: 10.1016/0031-9422(86)88018-9
430971 Agathosma capensis: 10.1016/0031-9422(86)88018-9
2486847 Agathosma lanceolata: 10.1016/0031-9422(86)88018-9
2486844 Agathosma ciliaris: 10.1016/0031-9422(86)88018-9
2894177 Empleurum unicapsularis: 10.1016/0031-9422(86)88018-9
1641042 Agathosma imbricata: 10.1016/0031-9422(86)88018-9
205364 Artemisia dracunculoides: 10.1016/S0031-9422(00)85199-7
72337 Artemisia campestris: 10.1016/0031-9422(91)83491-3
1048565 Metalasia cephalotes: 10.1016/0031-9422(90)83033-W
1048568 Metalasia capitata: 10.1016/0031-9422(90)83033-W
416184 Aeglopsis chevalieri: 10.1021/JO01273A076
286923 Ranunculus laetus: 10.1007/S10600-009-9408-9
48103 Bupleurum fruticosum: 10.1016/0031-9422(95)00749-0
155640 Melia azedarach: 10.1016/S0367-326X(99)00051-9
238933 Saussurea brunneopilosa: 10.3109/13880209409083006
378320 Saussurea eopygmaea: 10.3109/13880209409083006
557757 Platymiscium yucatanum: 10.1515/HFSG.1998.52.5.459
37690 Citrus trifoliata:
307630 Citrus macrophylla:
64884 Citrus jambhiri: 10.1094/PHYTO-78-1678
4129 Cuscuta reflexa: 10.1248/CPB.50.112
475932 Citrus wilsonii: 10.1016/S0031-9422(98)00247-7
488172 Citrus tamurana: 10.1016/S0031-9422(98)00247-7
81514 Pterocaulon sphacelatum: 10.1071/CH9683079
63806 Gomortega keule: 10.1016/0031-9422(91)83506-G
371331 Ferula badhysi: 10.1007/BF00567821
371375 Ferula oopoda: 10.1007/BF00567821
68554 Phellodendron amurense:
60419 Castanea mollissima: 10.1080/10286020903451757
2099548 Zanthoxylum zanthoxyloides: 10.1021/NP50046A035
171251 Citrus medica:
265783 Artemisia capillaris:
354527 Zanthoxylum avicennae:
1056465 Zanthoxylum beecheyanum: 10.1002/JCCS.200400159
1898877 Hibiscus taiwanensis:
183267 Talipariti tiliaceum: 10.1248/CPB.53.56
1089418 Microtropis japonica:
4047 Coriandrum sativum: 10.1016/0031-9422(95)00930-2
318062 Euphorbia hirta: 10.1016/S1875-5364(12)60009-0
199751 Bupleurum salicifolium:
176559 Pericome caudata: 10.1016/S0031-9422(00)82480-2
72349 Artemisia nova: 10.1016/S0021-9673(01)97678-2
142615 Dendrobium officinale: 10.1021/JF040017R
906689 Dendrobium catenatum: 10.1021/JF040017R
142614 Dendrobium moniliforme: 10.1021/JF040017R
183483 Dendrobium tosaense: 10.1021/JF040017R
401875 Artemisia adamsii: 10.1016/S0031-9422(00)83171-4
469930 Garcinia kola: 10.1021/NP8006364
469925 Garcinia conrauana: 10.1021/NP8006364
1009474 Garcinia multiflora: 10.1021/NP8006364
159071 Zanthoxylum ailanthoides:
1006079 Haplophyllum ramosissimum:
992815 Zanthoxylum leprieurii: 10.1021/NP50048A057
23278 Vahlia capensis: 10.1016/0031-9422(94)00710-B
85854 Magnolia coco:
1487095 Melicope borbonica: 10.1016/S0378-8741(98)00137-8
72351 Artemisia scoparia:
756622 Euphorbia iberica: 10.1055/S-2006-960819
271244 Keetia multiflora: 10.1055/S-2008-1034372
123498 Aleurites moluccanus: 10.1016/S0367-326X(00)00314-2
205371 Artemisia marschalliana: 10.1016/S0031-9422(00)88402-2
76966 Citrus japonica: 10.1248/CPB.49.1356
408488 Citrus kinokuni: 10.1248/CPB.49.1356
85571 Citrus reticulata:
558547 Citrus deliciosa:
1811969 Artemisia vestita: 10.1055/S-1999-13965
403096 Allamanda schottii: 10.1021/NP50056A018
136894 Catunaregam spinosa: 10.1002/CHIN.200844208
137934 Aralia bipinnata:
169606 Tagetes lucida: 10.1021/JF053071W
401909 Artemisia laciniata: 10.1002/JLAC.198619861208
68527 Aegle marmelos: 10.1016/J.PHYTOCHEM.2011.11.018
282633 Phebalium squamulosum: 10.1016/0031-9422(92)83450-D
1905583 Rubia wallichiana:
298346 Dictamnus albus: 10.1016/S0031-9422(98)00519-6
1475378 Calea ternifolia: 10.3390/MOLECULES22020289
271192 Pimpinella anisum: 10.1007/BF00993733
4045 Apium graveolens: 10.1007/BF00993733
117978 Dendrobium thyrsiflorum:
354518 Skimmia laureola: 10.1016/S0031-9422(00)81759-8
354528 Zanthoxylum nitidum:
72350 Artemisia reptans: 10.1016/S0031-9422(00)89536-9
1735025 Suaeda nudiflora: 10.1002/JPS.3030350906
126913 Suaeda maritima: 10.1002/JPS.3030350906
127995 Gonospermum ferulaceum: 10.1016/0031-9422(90)83068-C
1008928 Pittosporum illicioides: 10.1021/NP8004503
38874 Fraxinus ornus:
127982 Gonospermum fruticosum:
371362 Ferula linkii: 10.1016/0031-9422(93)85291-X
161866 Dendrobium densiflorum:
126552 Olea capensis:
127983 Gonospermum gomerae: 10.1021/NP800474V
1006083 Haplophyllum thesioides: 10.1080/10575639308050059
237573 Citrus sulcata: 10.1248/CPB.39.2509
489439 Deverra tortuosa: 10.1590/S0103-50532003000100008
114476 Gardenia jasminoides: 10.1021/NP800002Z
2805000 Aldama robusta: 10.1016/0305-1978(96)00057-9
864332 Cedrelopsis grevei:
665671 Anisotome pilifera: 10.1016/S0305-1978(02)00047-9
28525 Menyanthes trifoliata: 10.1086/325638
3406 Magnolia grandiflora: 10.1016/S0031-9422(00)80557-9
2805006 Aldama tukumanensis: 10.1016/0031-9422(95)00584-6
587579 Khaya senegalensis: 10.1016/0031-9422(95)00093-3
282723 Achillea biserrata: 10.1007/BF00579679
282761 Achillea ptarmicifolia: 10.1007/BF00579978
282741 Achillea impatiens: 10.1007/BF00579978
354530 Zanthoxylum schinifolium:
145490 Centaurea collina: 10.1016/S0031-9422(00)97993-7
145515 Centaurea salonitana: 10.1016/S0031-9422(00)97993-7
167917 Duranta erecta: 10.1248/CPB.50.515
328402 Zanthoxylum simulans: 10.1016/S0031-9422(97)00280-X
262982 Artemisia apiacea: 10.1016/S0367-326X(02)00070-9
496566 Artemisia carvifolia: 10.1016/S0367-326X(02)00070-9
1873686 Espeletia spectabilis: 10.1016/0031-9422(80)83072-X
105886 Eleutherococcus sessiliflorus: 10.1055/S-2002-34925
180498 Jatropha curcas: 10.1002/HLCA.201000313
55611 Artemisia tridentata: 10.1016/0305-1978(92)90072-L
376251 Ranunculus sieboldii: 10.1055/S-2005-873169
147635 Ranunculus sceleratus: 10.1055/S-2005-873169
231460 Afraegle paniculata: 10.1016/0031-9422(73)85149-0
557631 Chiliadenus candicans: 10.3109/13880208809053916
119185 Pulicaria arabica: 10.3109/13880208809053916
549422 Hortia longifolia: 10.1021/JO00829A053
68535 Casimiroa edulis: 10.1021/NP50037A032
329772 Solanum dasyphyllum: 10.1021/NP50037A033
2589437 Erythroxylum barbatum: 10.1016/S0305-1978(02)00249-1
3411 Magnolia salicifolia: 10.1248/CPB.39.3265
1177126 Artemisia turanica: 10.1021/NP50031A025
72341 Artemisia dracunculus:
452789 Ruta angustifolia: 10.1016/S0031-9422(00)84991-2
2839964 Zanthoxylum dimorphophyllum: 10.1515/ZNC-2001-7-802
55188 Citrus unshiu: 10.1007/BF00630620
378924 Empleurum unicapsulare: 10.1016/0031-9422(86)88018-9
2486848 Agathosma martiana: 10.1016/0031-9422(86)88018-9
430971 Agathosma capensis: 10.1016/0031-9422(86)88018-9
2486847 Agathosma lanceolata: 10.1016/0031-9422(86)88018-9
2486844 Agathosma ciliaris: 10.1016/0031-9422(86)88018-9
2894177 Empleurum unicapsularis: 10.1016/0031-9422(86)88018-9
1641042 Agathosma imbricata: 10.1016/0031-9422(86)88018-9
205364 Artemisia dracunculoides: 10.1016/S0031-9422(00)85199-7
72337 Artemisia campestris: 10.1016/0031-9422(91)83491-3
1048565 Metalasia cephalotes: 10.1016/0031-9422(90)83033-W
1048568 Metalasia capitata: 10.1016/0031-9422(90)83033-W
416184 Aeglopsis chevalieri: 10.1021/JO01273A076
286923 Ranunculus laetus: 10.1007/S10600-009-9408-9
48103 Bupleurum fruticosum: 10.1016/0031-9422(95)00749-0
155640 Melia azedarach: 10.1016/S0367-326X(99)00051-9
238933 Saussurea brunneopilosa: 10.3109/13880209409083006
378320 Saussurea eopygmaea: 10.3109/13880209409083006
557757 Platymiscium yucatanum: 10.1515/HFSG.1998.52.5.459
37690 Citrus trifoliata:
307630 Citrus macrophylla:
64884 Citrus jambhiri: 10.1094/PHYTO-78-1678
4129 Cuscuta reflexa: 10.1248/CPB.50.112
475932 Citrus wilsonii: 10.1016/S0031-9422(98)00247-7
488172 Citrus tamurana: 10.1016/S0031-9422(98)00247-7
81514 Pterocaulon sphacelatum: 10.1071/CH9683079
63806 Gomortega keule: 10.1016/0031-9422(91)83506-G
371331 Ferula badhysi: 10.1007/BF00567821
371375 Ferula oopoda: 10.1007/BF00567821
9606 Homo sapiens: -
35608 Artemisia Annua L.: -
259893 Artemisia argyi Lévl.et Vant.: -
126418 Forsythia suspensa (Thunb.) Vahl: -
72351 Artemisia scoparia Waldst.et Kit.: -
265783 Artemisia capillaris Thunb.: -
4129 Cuscuta reflexa: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Tianyi Zhao, Shiyi Lun, Maoying Yan, JongPil Park, Shumin Wang, Changbao Chen. 6,7-Dimethoxycoumarin, Gardenoside and Rhein combination improves non-alcoholic fatty liver disease in rats. Journal of ethnopharmacology. 2024 Mar; 322(?):117646. doi: 10.1016/j.jep.2023.117646. [PMID: 38135236]
Jinxiang Luo, Huijun Xie, Wei Ding, Yongqiang Zhang. Photodegradation of the pure and formulated scoparone in liquid solutions: kinetics and mechanism. Environmental technology. 2024 Jan; 45(1):87-98. doi: 10.1080/09593330.2022.2099312. [PMID: 35796037]
Sha Huang, Luping Lin, Yifei Ma, Qing Zhu, Ningna Weng. Scoparone induces autophagic cell death via the PAK1/AKT axis in colorectal cancer. European journal of pharmacology. 2023 Oct; 959(?):176091. doi: 10.1016/j.ejphar.2023.176091. [PMID: 37805132]
Miaoqing Ye, Chunyan Liu, Jiaojiao Liu, Fenping Lu, Jingdong Xue, Fenping Li, Yinghui Tang. Scoparone inhibits the development of hepatocellular carcinoma by modulating the p38 MAPK/Akt/NF-κB signaling in nonalcoholic fatty liver disease mice. Environmental toxicology. 2023 Jul; ?(?):. doi: 10.1002/tox.23851. [PMID: 37436232]
Hongping Shen, Yiting Wei, Qunying Yang, Yili Cai, Keqi Zhu, Xueqin Chen. Scoparone induces both apoptosis and ferroptosis via multiple mechanisms in non-small-cell lung cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. 2023 Jun; 91(?):105627. doi: 10.1016/j.tiv.2023.105627. [PMID: 37315743]
Juan Zou, Yuanyuan Li, Jingyi Cai, Xiaotian Peng, Lincong Zhang, Tian Tian, Tianming Wang, Rong Shi, Jiasheng Wu, Yueming Ma. Identification of Yinchenwuling fang's active components and hepatoprotective effects against cholestatic liver damage induced by alpha-naphthyl isothiocyanate in mice. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2023 Jan; 1215(?):123570. doi: 10.1016/j.jchromb.2022.123570. [PMID: 36542898]
Min Wei, Ting Li, Houkang Cao, Haiyan He, Chaoyue Yang, Yifan Yin, Huijie Lu, Petr Novák, Kefeng Zhang, Ya Gao. The effects of scoparone on alcohol and high-fat diet-induced liver injury revealed by RNA sequencing. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113770. doi: 10.1016/j.biopha.2022.113770. [PMID: 36182737]
Kyung-Ran Park, Bomi Kim, Joon Yeop Lee, Ho-Jin Moon, Il Keun Kwon, Hyung-Mun Yun. Effects of Scoparone on differentiation, adhesion, migration, autophagy and mineralization through the osteogenic signalling pathways. Journal of cellular and molecular medicine. 2022 08; 26(16):4520-4529. doi: 10.1111/jcmm.17476. [PMID: 35796406]
Hong Zhou, Fenglin Wan, Fuyou Guo, Jinlin Liu, Wei Ding. High value-added application of a renewable bioresource as acaricide: Investigation the mechanism of action of scoparone against Tetranychus cinnabarinus. Journal of advanced research. 2022 05; 38(?):29-39. doi: 10.1016/j.jare.2021.08.013. [PMID: 35572395]
Joanna Kowalczyk, Barbara Budzyńska, Łukasz Kurach, Daniele Pellegata, Nesrine S El Sayed, Jürg Gertsch, Krystyna Skalicka-Woźniak. Neuropsychopharmacological profiling of scoparone in mice. Scientific reports. 2022 01; 12(1):822. doi: 10.1038/s41598-021-04741-3. [PMID: 35039558]
Xiaoyan Huang, Ya Gao, Houkang Cao, Jun Li, Siyi Mo, Ting Li, Jianzhao Wu, Kai Guo, Riming Wei, Kefeng Zhang. Effects of scoparone on non-alcoholic fatty liver disease revealed by RNA sequencing. Frontiers in endocrinology. 2022; 13(?):1004284. doi: 10.3389/fendo.2022.1004284. [PMID: 36157436]
Hong Zhou, Jinlin Liu, Fenglin Wan, Fuyou Guo, Yeshuang Ning, Sisi Liu, Wei Ding. Insight into the mechanism of action of scoparone inhibiting egg development of Tetranychus cinnabarinus Boisduval. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2021 Aug; 246(?):109055. doi: 10.1016/j.cbpc.2021.109055. [PMID: 33894369]
Linmao Lyu, Jiazheng Chen, Wei Wang, Tao Yan, Jiamao Lin, Hongmei Gao, Hui Li, Ruijuan Lv, Feng Xu, Lijun Fang, Yuguo Chen. Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress. Journal of cellular and molecular medicine. 2021 03; 25(6):3136-3148. doi: 10.1111/jcmm.16304. [PMID: 33560596]
Yang-Liu Xia, Jing-Jing Wang, Shi-Yang Li, Yong Liu, Frank J Gonzalez, Ping Wang, Guang-Bo Ge. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorganic & medicinal chemistry. 2021 01; 29(?):115851. doi: 10.1016/j.bmc.2020.115851. [PMID: 33218896]
Monterrosas-Brisson Nayeli, Herrera-Ruiz Maribel, Jiménez-Ferrer Enrique, Bahena-Pérez Rafael, Avilés-Flores Margarita, Fuentes-Mata Macrina, Martínez-Duncker Ivan, González-Cortazar Manasés. Anti-inflammatory activity of coumarins isolated from Tagetes lucida Cav. Natural product research. 2020 Nov; 34(22):3244-3248. doi: 10.1080/14786419.2018.1553172. [PMID: 30618303]
Yangyang Hui, Xiaoyu Wang, Zihan Yu, Xiaofei Fan, Binxin Cui, Tianming Zhao, Lihong Mao, Hongjuan Feng, Lin Lin, Qingxiang Yu, Jie Zhang, Bangmao Wang, Xin Chen, Xingliang Zhao, Chao Sun. Scoparone as a therapeutic drug in liver diseases: Pharmacology, pharmacokinetics and molecular mechanisms of action. Pharmacological research. 2020 10; 160(?):105170. doi: 10.1016/j.phrs.2020.105170. [PMID: 32877694]
Beibei Liu, Xiaoling Deng, Qianqian Jiang, Guixin Li, Junli Zhang, Ning Zhang, Shengliang Xin, Keshu Xu. Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 May; 125(?):109895. doi: 10.1016/j.biopha.2020.109895. [PMID: 32000066]
Yijun Yao, Feiran Xu, Xingrong Ju, Zhifang Li, Lifeng Wang. Lipid-Lowering Effects and Intestinal Transport of Polyphenol Extract from Digested Buckwheat in Caco-2/HepG2 Coculture Models. Journal of agricultural and food chemistry. 2020 Apr; 68(14):4205-4214. doi: 10.1021/acs.jafc.0c00321. [PMID: 32141744]
Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer. Bioorganic & medicinal chemistry. 2020 01; 28(1):115180. doi: 10.1016/j.bmc.2019.115180. [PMID: 31784199]
Seung Hyo Jung, Gyoung Beom Lee, Yunkyoung Ryu, Long Cui, Hwan Myung Lee, Junghwan Kim, Bokyung Kim, Kyung Jong Won. Inhibitory effects of scoparone from chestnut inner shell on platelet-derived growth factor-BB-induced vascular smooth muscle cell migration and vascular neointima hyperplasia. Journal of the science of food and agriculture. 2019 Jul; 99(9):4397-4406. doi: 10.1002/jsfa.9674. [PMID: 30861122]
Risto O Juvonen, Filip Novák, Eleni Emmanouilidou, Seppo Auriola, Juri Timonen, Aki T Heikkinen, Jenni Küblbeck, Moshe Finel, Hannu Raunio. Metabolism of Scoparone in Experimental Animals and Humans. Planta medica. 2019 Apr; 85(6):453-464. doi: 10.1055/a-0835-2301. [PMID: 30736072]
Chang Liu, Shuang Li, Qingkai Zhang, Fangyue Guo, Mengying Tong, Maria Francesca Ysabelle M Martinez, Heather H Wang, Yutong Zhao, Dong Shang. Emerging Role of Chinese Herbal Medicines in the Treatment of Pancreatic Fibrosis. The American journal of Chinese medicine. 2019; 47(4):709-726. doi: 10.1142/s0192415x1950037x. [PMID: 31091974]
Tun-Pin Hsueh, Tung-Hu Tsai. Preclinical Pharmacokinetics of Scoparone, Geniposide and Rhein in an Herbal Medicine Using a Validated LC-MS/MS Method. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102716. [PMID: 30360359]
Anam Fayyaz, Seddy Makwinja, Seppo Auriola, Hannu Raunio, Risto O Juvonen. Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals. Planta medica. 2018 Mar; 84(5):320-328. doi: 10.1055/s-0043-119886. [PMID: 28950382]
Yu-Yi Chan, Tsong-Long Hwang, Ping-Chung Kuo, Hsin-Yi Hung, Tian-Shung Wu. Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release. Molecules (Basel, Switzerland). 2017 Sep; 22(9):. doi: 10.3390/molecules22091454. [PMID: 28862688]
Tasmia Tahsin, Jean Duplex Wansi, Afaf Al-Groshi, Andrew Evans, Lutfun Nahar, Claire Martin, Satyajit Dey Sarker. Cytotoxic Properties of the Stem Bark of Citrus reticulata Blanco (Rutaceae). Phytotherapy research : PTR. 2017 Aug; 31(8):1215-1219. doi: 10.1002/ptr.5842. [PMID: 28568378]
Ruijie He, Shengping Deng, Hui Nie, Yan Huang, Buming Liu, Ruiyun Yang, Shuai Huang, Dexiong Zhou, Huangcan Chen, Jun Li, Yanjun Zhang. Two new coumarins from the bark of Streblus indicus (Bur.) Corner. Natural product research. 2017 May; 31(9):1052-1058. doi: 10.1080/14786419.2016.1269098. [PMID: 28013566]
Jian-Yuan Li, Hong-Yan Cao, Lin Sun, Run-Fei Sun, Chao Wu, Yan-Qin Bian, Shu Dong, Ping Liu, Ming-Yu Sun. Therapeutic mechanism of Yīn-Chén-Hāo decoction in hepatic diseases. World journal of gastroenterology. 2017 Feb; 23(7):1125-1138. doi: 10.3748/wjg.v23.i7.1125. [PMID: 28275293]
Sang-Hyun Lee, Jung-Yun Lee, Young-In Kwon, Hae-Dong Jang. Anti-Osteoclastic Activity of Artemisia capillaris Thunb. Extract Depends upon Attenuation of Osteoclast Differentiation and Bone Resorption-Associated Acidification Due to Chlorogenic Acid, Hyperoside, and Scoparone. International journal of molecular sciences. 2017 Feb; 18(2):. doi: 10.3390/ijms18020322. [PMID: 28165389]
Duk-Yeon Cho, Hyun Myung Ko, Joonsoo Kim, Byung-Wook Kim, Yo-Sep Yun, Jeong-In Park, Palanivel Ganesan, Jin-Tae Lee, Dong-Kug Choi. Scoparone Inhibits LPS-Simulated Inflammatory Response by Suppressing IRF3 and ERK in BV-2 Microglial Cells. Molecules (Basel, Switzerland). 2016 Dec; 21(12):. doi: 10.3390/molecules21121718. [PMID: 27983636]
Tun-Pin Hsueh, Wan-Ling Lin, Tung-Hu Tsai. Using Light Microscopy and Liquid Chromatography Tandem Mass Spectrometry for Qualitative and Quantitative Control of a Combined Three-Herb Formulation in Different Preparations. Molecules (Basel, Switzerland). 2016 Dec; 21(12):. doi: 10.3390/molecules21121673. [PMID: 27929444]
Heng Fang, Aihua Zhang, Jingbo Yu, Liang Wang, Chang Liu, Xiaohang Zhou, Hui Sun, Qi Song, Xijun Wang. Insight into the metabolic mechanism of scoparone on biomarkers for inhibiting Yanghuang syndrome. Scientific reports. 2016 11; 6(?):37519. doi: 10.1038/srep37519. [PMID: 27869223]
Kiranmayee Rao, Bhuvaneswari Chodisetti, Suryakala Gandi, Archana Giri, P B Kavi Kishor. Regeneration-Based Quantification of Coumarins (Scopoletin and Scoparone) in Abutilon indicum In Vitro Cultures. Applied biochemistry and biotechnology. 2016 Oct; 180(4):766-779. doi: 10.1007/s12010-016-2131-7. [PMID: 27188970]
B Zhou, S-Z Liu, M-J Li, Z-H Chen, P Wang, D Cheng. Study on quality standards for Chimonanthus nitens. Genetics and molecular research : GMR. 2016 Aug; 15(3):. doi: 10.4238/gmr.15038984. [PMID: 27706658]
Aihua Zhang, Shi Qiu, Hui Sun, Tianlei Zhang, Yu Guan, Ying Han, Guangli Yan, Xijun Wang. Scoparone affects lipid metabolism in primary hepatocytes using lipidomics. Scientific reports. 2016 06; 6(?):28031. doi: 10.1038/srep28031. [PMID: 27306123]
Marie Fomani, Emmanuel Ngeufa Happi, Achille Nouga Bisoue, Jean Claude Ndom, Alain François Kamdem Waffo, Norbert Sewald, Jean Duplex Wansi. Oxidative burst inhibition, cytotoxicity and antibacterial acriquinoline alkaloids from Citrus reticulate (Blanco). Bioorganic & medicinal chemistry letters. 2016 Jan; 26(2):306-309. doi: 10.1016/j.bmcl.2015.12.028. [PMID: 26711890]
Licinio Díaz, José Antonio Del Río, Manuela Pérez-Gilabert, Ana Ortuño. Involvement of an extracellular fungus laccase in the flavonoid metabolism in Citrus fruits inoculated with Alternaria alternata. Plant physiology and biochemistry : PPB. 2015 Apr; 89(?):11-7. doi: 10.1016/j.plaphy.2015.02.006. [PMID: 25686700]
Dong Ju Son, Gyung Rak Lee, Sungil Oh, Sung Eun Lee, Won Sik Choi. Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents. Nutrients. 2015 Mar; 7(3):1945-64. doi: 10.3390/nu7031945. [PMID: 25781220]
Aihua Zhang, Hui Sun, Xijun Wang. Urinary metabolic profiling of rat models revealed protective function of scoparone against alcohol induced hepatotoxicity. Scientific reports. 2014 Oct; 4(?):6768. doi: 10.1038/srep06768. [PMID: 25341677]
Simona M Sanzani, Leonardo Schena, Antonio Ippolito. Effectiveness of phenolic compounds against citrus green mould. Molecules (Basel, Switzerland). 2014 Aug; 19(8):12500-8. doi: 10.3390/molecules190812500. [PMID: 25153867]
Aline Witaicenis, Leonardo Noboru Seito, Alexandre da Silveira Chagas, Luiz Domingues de Almeida, Ana Carolina Luchini, Patrícia Rodrigues-Orsi, Silvia Helena Cestari, Luiz Claudio Di Stasi. Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Feb; 21(3):240-6. doi: 10.1016/j.phymed.2013.09.001. [PMID: 24176844]
Jamal Kasaian, Milad Iranshahy, Milena Masullo, Sonia Piacente, Fatemeh Ebrahimi, Mehrdad Iranshahi. Sesquiterpene lactones from Ferula oopoda and their cytotoxic properties. Journal of Asian natural products research. 2014; 16(3):248-53. doi: 10.1080/10286020.2013.866099. [PMID: 24320993]
Lilan Cheng, Zhen Wang, Cuiju Jiang, Shifu Zhang. [Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. 2013 Dec; 27(23):1310-2. doi: . [PMID: 24620662]
Jung-Ran Noh, Yong-Hoon Kim, Jung Hwan Hwang, Gil-Tae Gang, Seung-Hoon Yeo, Kyoung-Shim Kim, Won-Keun Oh, Sun-Yung Ly, In-Kyu Lee, Chul-Ho Lee. Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes. Food chemistry. 2013 Nov; 141(2):723-30. doi: 10.1016/j.foodchem.2013.04.036. [PMID: 23790840]
Michal Kielbus, Krystyna Skalicka-Wozniak, Aneta Grabarska, Witold Jeleniewicz, Magdalena Dmoszynska-Graniczka, Andrew Marston, Krzysztof Polberg, Piotr Gawda, Janusz Klatka, Andrzej Stepulak. 7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro. Anticancer research. 2013 Oct; 33(10):4347-56. doi: . [PMID: 24123002]
Bin Zhou, Meng-Jie Li, Ping Wang, Dan Cheng, Jie Li, Xiao-Di Cui. [Study on quality standard of Chimonanthus nitens leaf]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Sep; 36(9):1434-6. doi: . [PMID: 24620687]
Jung-Woo Kang, Dong-Wook Kim, Jae Sue Choi, Yeong Shik Kim, Sun-Mee Lee. Scoparone attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Jul; 57(?):132-9. doi: 10.1016/j.fct.2013.03.016. [PMID: 23535186]
Aihua Zhang, Hui Sun, Gelin Wu, Wenjun Sun, Ye Yuan, Xijun Wang. Proteomics analysis of hepatoprotective effects for scoparone using MALDI-TOF/TOF mass spectrometry with bioinformatics. Omics : a journal of integrative biology. 2013 Apr; 17(4):224-9. doi: 10.1089/omi.2012.0064. [PMID: 23514563]
Nadja Soares Vila-Nova, Selene Maia de Morais, Maria José Cajazeiras Falcão, Terezinha Thaize Negreiros Alcantara, Pablito Augusto Travassos Ferreira, Eveline Solon Barreira Cavalcanti, Icaro Gusmão Pinto Vieira, Cláudio Cabral Campello, Mary Wilson. Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone. Experimental parasitology. 2013 Mar; 133(3):334-8. doi: 10.1016/j.exppara.2012.11.025. [PMID: 23232251]
Aihua Zhang, Hui Sun, Shengshan Dou, Wenjun Sun, Xiuhong Wu, Ping Wang, Xijun Wang. Metabolomics study on the hepatoprotective effect of scoparone using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. The Analyst. 2013 Jan; 138(1):353-61. doi: 10.1039/c2an36382h. [PMID: 23152956]
Ana-Rosa Ballester, M Teresa Lafuente, Luis González-Candelas. Citrus phenylpropanoids and defence against pathogens. Part II: gene expression and metabolite accumulation in the response of fruits to Penicillium digitatum infection. Food chemistry. 2013 Jan; 136(1):285-91. doi: 10.1016/j.foodchem.2012.08.006. [PMID: 23017425]
Jun-Lan Lv, Rui-Sheng Li, Shi-Ying Jin, Hai-Long Yuan, Shan-Shan Fu, Jin Han, Shi-Xiao Jin, Xiao-He Xiao. Changes of pharmacokinetics of 6,7-dimethoxycoumarin in a rat model of alpha-naphthylisothiocyanate-induced experimental hepatic injury after Yinchenhao Decoction () treatment. Chinese journal of integrative medicine. 2012 Nov; 18(11):831-6. doi: 10.1007/s11655-012-1272-8. [PMID: 23086487]
Aihong Zhao, Xiuwei Yang, Xinbao Yang, Jianxun Liu, Qiuling Wang, Wenquan Wang. [A new natural product from root of Angelica dahurica cv. Qibaizhi]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Aug; 37(16):2400-7. doi: . [PMID: 23234138]
Aihua Zhang, Hui Sun, Xijun Wang, Guozheng Jiao, Ye Yuan, Wenjun Sun. Simultaneous in vivo RP-HPLC-DAD quantification of multiple-component and drug-drug interaction by pharmacokinetics, using 6,7-dimethylesculetin, geniposide and rhein as examples. Biomedical chromatography : BMC. 2012 Jul; 26(7):844-50. doi: 10.1002/bmc.1739. [PMID: 22068685]
Quanwei Yin, Hui Sun, Aihua Zhang, Xijun Wang. Pharmacokinetics and tissue distribution study of scoparone in rats by ultraperformance liquid-chromatography with tandem high-definition mass spectrometry. Fitoterapia. 2012 Jun; 83(4):795-800. doi: 10.1016/j.fitote.2012.03.010. [PMID: 22465507]
Hyun Ah Jung, Jin Ju Park, Md Nurul Islam, Seung Eun Jin, Byung-Sun Min, Je-Hyun Lee, Hee Sook Sohn, Jae Sue Choi. Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation. Archives of pharmacal research. 2012 Jun; 35(6):1021-35. doi: 10.1007/s12272-012-0610-0. [PMID: 22870812]
Kai He, Xiaoli Ye, Xuegang Li, Hongying Chen, Lujiang Yuan, Yafei Deng, Xin Chen, Xiaoduo Li. Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jan; 881-882(?):49-54. doi: 10.1016/j.jchromb.2011.11.040. [PMID: 22197606]
Mukadder Atmaca, Hakkı Murat Bilgin, Basra Deniz Obay, Hüda Diken, Mustafa Kelle, Ebru Kale. The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats. Journal of physiology and biochemistry. 2011 Dec; 67(4):569-76. doi: 10.1007/s13105-011-0103-5. [PMID: 21656273]
Jarinporn Phongmaykin, Takuya Kumamoto, Tsutomu Ishikawa, Ekarin Saifah, Rutt Suttisri. Biologically active constituents of Aglaia erythrosperma. Natural product research. 2011 Oct; 25(17):1621-8. doi: 10.1080/14786419.2010.508038. [PMID: 22011221]
Yifang Sun, Lili Du, Le Zhou, Wugang Zhang, Fang Miao, Xinjuan Yang, Huiling Geng. [Study on antibacterial active components from Viola yedoensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Oct; 36(19):2666-71. doi: 10.4268/cjcmm20111913. [PMID: 22242426]
Oh Song Kwon, Jae Sue Choi, Md Nurul Islam, Yeong Shik Kim, Hyun Pyo Kim. Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents. Archives of pharmacal research. 2011 Sep; 34(9):1561-9. doi: 10.1007/s12272-011-0919-0. [PMID: 21975819]
Jung-Ran Noh, Yong-Hoon Kim, Gil-Tae Gang, Jung Hwan Hwang, Hyun-Sun Lee, Sun-Yung Ly, Won-Keun Oh, Kyung-Sik Song, Chul-Ho Lee. Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Jul; 49(7):1537-43. doi: 10.1016/j.fct.2011.03.045. [PMID: 21457746]
Hakkı Murat Bilgin, Mukadder Atmaca, Basra Deniz Obay, Selver Ozekinci, Ezel Taşdemir, Aydın Ketani. Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2011 May; 63(4):325-30. doi: 10.1016/j.etp.2010.02.006. [PMID: 20207117]
Hyun Ah Jung, M D Nurul Islam, Yong Soo Kwon, Seong Eun Jin, You Kyung Son, Jin Ju Park, Hee Sook Sohn, Jae Sue Choi. Extraction and identification of three major aldose reductase inhibitors from Artemisia montana. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Feb; 49(2):376-84. doi: 10.1016/j.fct.2010.11.012. [PMID: 21092751]
Yuan-Chang Chang, Tung-Yuan Lai, Chun-Shu Yu, Hung-Yi Chen, Jai-Sing Yang, Fu-Shin Chueh, Chi-Cheng Lu, Jo-Hua Chiang, Wen-Wen Huang, Chia-Yu Ma, Jing-Gung Chung. Emodin Induces Apoptotic Death in Murine Myelomonocytic Leukemia WEHI-3 Cells In Vitro and Enhances Phagocytosis in Leukemia Mice In Vivo. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):523596. doi: 10.1155/2011/523596. [PMID: 21660305]
Jung-Ran Noh, Gil-Tae Gang, Yong-Hoon Kim, Keum-Jin Yang, Jung-Hwan Hwang, Hyun-Sun Lee, Won-Keun Oh, Kyung-Sik Song, Chul-Ho Lee. Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Nov; 48(11):3177-83. doi: 10.1016/j.fct.2010.08.018. [PMID: 20732376]
Jian-Xin Chen, Shen-Hui Huang, Ying Wang, Meng Shao, Wen-Cai Ye. [Studies on the chemical constituents from Lobelia chinensis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Nov; 33(11):1721-4. doi: ". [PMID: 21434431]
Luis González-Candelas, Santiago Alamar, Paloma Sánchez-Torres, Lorenzo Zacarías, Jose F Marcos. A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection. BMC plant biology. 2010 Aug; 10(?):194. doi: 10.1186/1471-2229-10-194. [PMID: 20807411]
Biao Yang, Guangying Chen, Xiaoping Song, Zhong Chen, Xinming Song, Jing Wang. Chemical constituents and antimicrobial activities of Canthium horridum. Natural product communications. 2010 Jun; 5(6):913-4. doi: . [PMID: 20614823]
Rostand M Ngoumfo, Jean-Bosco Jouda, Ferdinand T Mouafo, Justin Komguem, Céline D Mbazoa, Tze Chieh Shiao, Mohammed I Choudhary, Hartmut Laatsch, Jean Legault, André Pichette, René Roy. In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr. Bioorganic & medicinal chemistry. 2010 May; 18(10):3601-5. doi: 10.1016/j.bmc.2010.03.040. [PMID: 20413315]
Ruben F Tchokouaha, Xanthippi Alexi, Elizabeth Chosson, Thierry Besson, Alexios-Leandros Skaltsounis, Elisabeth Seguin, Michael N Alexis, Jean Wandji. Erymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells. Journal of enzyme inhibition and medicinal chemistry. 2010 Apr; 25(2):228-33. doi: 10.3109/14756360903169972. [PMID: 19874114]
You-Bo Zhang, Xiu-Wei Yang. A simple RP-HPLC method for quantification of columbianadin in rat plasma and its application to pharmacokinetic study. Biomedical chromatography : BMC. 2010 Apr; 24(4):433-7. doi: 10.1002/bmc.1310. [PMID: 19662622]
Y H Choi, G H Yan. Anti-allergic effects of scoparone on mast cell-mediated allergy model. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2009 Dec; 16(12):1089-94. doi: 10.1016/j.phymed.2009.05.003. [PMID: 19524421]
Soumaya Kilani-Jaziri, Aicha Neffati, Ilef Limem, Jihed Boubaker, Ines Skandrani, Mohamed Ben Sghair, Ines Bouhlel, Wissem Bhouri, Anne Marie Mariotte, Kamel Ghedira, Marie-Genviève Dijoux Franca, Leila Chekir-Ghedira. Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells. Chemico-biological interactions. 2009 Sep; 181(1):85-94. doi: 10.1016/j.cbi.2009.04.014. [PMID: 19446539]
Lina Xu, Xu Han, Yan Qi, Youwei Xu, Lianhong Yin, Jinyong Peng, Kexin Liu, Changkai Sun. Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. Analytica chimica acta. 2009 Feb; 633(1):136-48. doi: 10.1016/j.aca.2008.11.043. [PMID: 19110127]
Fumio Matsuda, Keiko Yonekura-Sakakibara, Rie Niida, Takashi Kuromori, Kazuo Shinozaki, Kazuki Saito. MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites. The Plant journal : for cell and molecular biology. 2009 Feb; 57(3):555-77. doi: 10.1111/j.1365-313x.2008.03705.x. [PMID: 18939963]
Jih-Jung Chen, Ching-Yi Chung, Tsong-Long Hwang, Jinn-Fen Chen. Amides and benzenoids from Zanthoxylum ailanthoides with inhibitory activity on superoxide generation and elastase release by neutrophils. Journal of natural products. 2009 Jan; 72(1):107-11. doi: 10.1021/np800689b. [PMID: 19128011]
G D'Hallewin, G M Molinu, A Dore, T Venditti, V Rodov. Abiotic stresses sequentially applied enhance natural resistance and reduce postharvest decay. Communications in agricultural and applied biological sciences. 2009; 74(3):659-65. doi: ". [PMID: 20222548]
H Lv, H Sun, W Sun, L Liu, P Wang, X Wang, H Cao. Pharmacokinetic studies of a Chinese triple herbal drug formula. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008 Nov; 15(11):993-1001. doi: 10.1016/j.phymed.2008.01.006. [PMID: 18339526]
Tsung-Hsien Chou, Ih-Sheng Chen, Tsong-Long Hwang, Tai-Chi Wang, Tzong-Huei Lee, Lin-Yang Cheng, Ya-Chih Chang, Jui-Ying Cho, Jih-Jung Chen. Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils. Journal of natural products. 2008 Oct; 71(10):1692-5. doi: 10.1021/np8004503. [PMID: 18817445]
Xiao-jie Tan, Qing Li, Xiao-hui Chen, Zhi-wei Wang, Zheng-yuan Shi, Kai-shun Bi, Ying Jia. Simultaneous determination of 13 bioactive compounds in Herba Artemisiae Scopariae (Yin Chen) from different harvest seasons by HPLC-DAD. Journal of pharmaceutical and biomedical analysis. 2008 Aug; 47(4-5):847-53. doi: 10.1016/j.jpba.2008.04.010. [PMID: 18502075]
Guangchun Gao, Shuhua Qi, Si Zhang, Hao Yin, Zhihui Xiao, Minyi Li, Qingxin Li. Minor compounds from the stem bark of Chinese mangrove associate Catunaregam spinosa. Die Pharmazie. 2008 Jul; 63(7):542-4. doi: ". [PMID: 18717492]
Jih-Jung Chen, Chang-Syun Yang, Chien-Fang Peng, Ih-Sheng Chen, Chang-Ling Miaw. Dihydroagarofuranoid sesquiterpenes, a lignan derivative, a benzenoid, and antitubercular constituents from the stem of Microtropis japonica. Journal of natural products. 2008 Jun; 71(6):1016-21. doi: 10.1021/np800097t. [PMID: 18471021]
Ting Zhang, Daofeng Chen. Anticomplementary principles of a Chinese multiherb remedy for the treatment and prevention of SARS. Journal of ethnopharmacology. 2008 May; 117(2):351-61. doi: 10.1016/j.jep.2008.02.012. [PMID: 18400428]
Xu-Dong Xu, Xiao-Ru Hu, Jing-Quan Yuan, Jun-Shan Yang. [Studies on chemical constituents of Sarcandra glabra]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Apr; 33(8):900-2. doi: . [PMID: 18619347]
Maminata Traoré, Jerzy W Jaroszewski, Carl Erik Olsen, Jean Bosco Ouédraogo, Guissou I Pierre, Odile G Nacoulma, T Robert Guiguemdé, S Brøgger Christensen. A new oxygenated ursane derivative from Canthium multiflorum. Planta medica. 2008 Apr; 74(5):560-2. doi: 10.1055/s-2008-1034372. [PMID: 18543152]
Shimshon Ben-Yehoshua, Victor Rodov, Beatrice Nafussi, Xuqiao Feng, Jin Yen, Tomer Koltai, Uri Nelkenbaum. Involvement of limonene hydroperoxides formed after oil gland injury in the induction of defense response against Penicillium digitatum in lemon fruit. Journal of agricultural and food chemistry. 2008 Mar; 56(6):1889-95. doi: 10.1021/jf072825z. [PMID: 18298064]
Haitao Lv, Hui Sun, Xijun Wang, Wenjun Sun, Guozheng Jiao, Dixin Zhou, Li Zhao, Hongxin Cao, Guangmei Zhang. Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine after oral administration of Yin Chen Hao Tang preparation. Journal of separation science. 2008 Mar; 31(4):659-66. doi: 10.1002/jssc.200700596. [PMID: 18264991]
Jih-Jung Chen, Tzu-Ying Wang, Tsong-Long Hwang. Neolignans, a coumarinolignan, lignan derivatives, and a chromene: anti-inflammatory constituents from Zanthoxylum avicennae. Journal of natural products. 2008 Feb; 71(2):212-7. doi: 10.1021/np070594k. [PMID: 18211005]
Jarinporn Phongmaykin, Takuya Kumamoto, Tsutomu Ishikawa, Rutt Suttisri, Ekarin Saifah. A new sesquiterpene and other terpenoid constituents of Chisocheton penduliflorus. Archives of pharmacal research. 2008 Jan; 31(1):21-7. doi: 10.1007/s12272-008-1115-8. [PMID: 18277603]
Xijun Wang, Haitao Lv, Hui Sun, Wenjun Sun, Lian Liu, Ping Wang, Hongxin Cao. Simultaneous determination of 6,7-dimethylesculetin and geniposide in rat plasma and its application to pharmacokinetic studies of Yin Chen Hao Tang preparation. Arzneimittel-Forschung. 2008; 58(7):336-41. doi: 10.1055/s-0031-1296516. [PMID: 18751499]
Zhi-guo Yu, Qian Wang, Ke Li, Ying-qi Li, Xiao-xia Gao. Determination and pharmacokinetics of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of yinchenhao tang. Journal of chromatographic science. 2007 Sep; 45(8):544-8. doi: 10.1093/chromsci/45.8.544. [PMID: 18019567]
Susana Johann, Vetúria Lopes de Oliveira, Moacir G Pizzolatti, Jan Schripsema, Raimundo Braz-Filho, Alexsandro Branco, Artur Smânia. Antimicrobial activity of wax and hexane extracts from Citrus spp. peels. Memorias do Instituto Oswaldo Cruz. 2007 09; 102(6):681-5. doi: 10.1590/s0074-02762007005000087. [PMID: 17923995]
Mario Figueroa, Isabel Rivero-Cruz, Blanca Rivero-Cruz, Robert Bye, Andrés Navarrete, Rachel Mata. Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida. Journal of ethnopharmacology. 2007 Aug; 113(1):125-31. doi: 10.1016/j.jep.2007.05.015. [PMID: 17582715]
Xiu-wei Yang, Bo Xu, Fu-xiang Ran, Rui-qing Wang, Jun Wu, Jing-rong Cui. [Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2007 Jan; 5(1):56-60. doi: 10.3736/jcim20070111. [PMID: 17214937]
Paul Sourivong, Kristina Schronerová, Melánia Babincová. Scoparone inhibits ultraviolet radiation-induced lipid peroxidation. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2007 Jan; 62(1-2):61-4. doi: 10.1515/znc-2007-1-211. [PMID: 17425107]
Viresh Mohanlall, Bharti Odhav. Biocontrol of aflatoxins B1, B2, G1, G2, and fumonisin B1 with 6,7-dimethoxycoumarin, a phytoalexin from Citrus sinensis. Journal of food protection. 2006 Sep; 69(9):2224-9. doi: 10.4315/0362-028x-69.9.2224. [PMID: 16995528]
Guangnong Zhang, Fang Zhang, Li Yang, Enyuan Zhu, Zhengtao Wang, Luoshan Xu, Zhibi Hu. Simultaneous analysis of trans- and cis-isomers of 2-glucosyloxycinnamic acids and coumarin derivatives in Dendrobium thyrsiflorum by high-performance liquid chromatography (HPLC)-photodiode array detection (DAD)-electrospray ionization (ESI)-tandem mass spectrometry (MS). Analytica chimica acta. 2006 Jun; 571(1):17-24. doi: 10.1016/j.aca.2006.04.062. [PMID: 17723413]
Wei Zheng, Chang-xin Zhou, Shui-li Zhang, Lin-jia Weng, Yu Zhao. [Studies on the chemical constituents in herb of Ranunculus japonicus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Jun; 31(11):892-4. doi: ". [PMID: 17048626]