Acetamidopropanal (BioDeep_00000012123)

 

Secondary id: BioDeep_00001869221

human metabolite Endogenous


代谢物信息卡片


N-(3-Oxopropyl)acetamide

化学式: C5H9NO2 (115.0633254)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 0.79%

分子结构信息

SMILES: CC(=O)NCCC=O
InChI: InChI=1S/C5H9NO2/c1-5(8)6-3-2-4-7/h4H,2-3H2,1H3,(H,6,8)

描述信息

Acetamidopropanal is associated with urea cycle and metabolism of arginine, proline, glutamate, aspartate and asparagine. Induction of SSAT typically gives rise to growth inhibition or apoptosis, depending upon the cell type and the extent of enzyme overexpression. In such experiments, growth inhibition has been closely linked to depletion of intracellular polyamine pools ( 12) and disturbances in polyamine metabolism ( 13), whereas apoptosis has been associated with downstream events emanating from polyamine oxidase-mediated oxidation of acetylated polyamines and the associated release of oxidatively reactive by-products such as hydrogen peroxide and the aldehyde, 3-acetamidopropanal.
Acetamidopropanal, also known as N-(3-oxopropyl)acetamide or 3aap, is a member of the class of compounds known as alpha-hydrogen aldehydes. Alpha-hydrogen aldehydes are aldehydes with the general formula HC(H)(R)C(=O)H, where R is an organyl group. Acetamidopropanal is soluble (in water) and a very weakly acidic compound (based on its pKa). Acetamidopropanal can be found in a number of food items such as passion fruit, cloves, irish moss, and calabash, which makes acetamidopropanal a potential biomarker for the consumption of these food products. Acetamidopropanal exists in all living organisms, ranging from bacteria to humans.

同义名列表

4 个代谢物同义名

N-(3-Oxopropyl)acetamide; 3-acetamidopropanal; Acetamidopropanal; 3AAP



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(8)

BioCyc(0)

PlantCyc(0)

代谢反应

137 个相关的代谢反应过程信息。

Reactome(109)

BioCyc(4)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(24)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Ikumi Ishii, Yoshihiko Ikeguchi, Hiroshi Mano, Masahiro Wada, Anthony E Pegg, Akira Shirahata. Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino acids. 2012 Feb; 42(2-3):619-26. doi: 10.1007/s00726-011-1037-5. [PMID: 21809076]
  • Kuniyasu Soda. The mechanisms by which polyamines accelerate tumor spread. Journal of experimental & clinical cancer research : CR. 2011 Oct; 30(?):95. doi: 10.1186/1756-9966-30-95. [PMID: 21988863]
  • Tianyun Wu, Victoria Yankovskaya, William S McIntire. Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase. The Journal of biological chemistry. 2003 Jun; 278(23):20514-25. doi: 10.1074/jbc.m302149200. [PMID: 12660232]
  • V Pavlov, P Kong Thoo Lin, V Rodilla. Biochemical effects and growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives. Cellular and molecular life sciences : CMLS. 2002 Apr; 59(4):715-23. doi: 10.1007/s00018-002-8460-4. [PMID: 12022477]