NCBI Taxonomy: 668

Aliivibrio fischeri (ncbi_taxid: 668)

found 25 associated metabolites at species taxonomy rank level.

Child Taxonomies: Aliivibrio fischeri SR5, Aliivibrio fischeri MJ11, Aliivibrio fischeri CB37, Aliivibrio fischeri EM17, Aliivibrio fischeri SA1G, Aliivibrio fischeri 1-C10, Aliivibrio fischeri ZF-55, Aliivibrio fischeri 9ZB36, Aliivibrio fischeri ES114, Aliivibrio fischeri ZF-211, Aliivibrio fischeri ZF-129, Aliivibrio fischeri JRM200, Aliivibrio fischeri ETJB5C, Aliivibrio fischeri ATCC 7744 = JCM 18803 = DSM 507

N-hexanoyl-L-Homoserine lactone

N-[(3S)-tetrahydro-2-oxo-3-furanyl]-hexanamide

C10H17NO3 (199.1208372)

N-Hexanoyl-L-homoserine lactone (HHSL) is a type of signaling molecule known as an autoinducer, which plays a significant role in bacterial communication and behavior, particularly in processes governed by quorum sensing (QS). Here are some of its key biological functions: Quorum Sensing Signaling: HHSL is involved in quorum sensing, a mechanism by which bacteria communicate with each other to coordinate their behavior based on population density. When the concentration of HHSL reaches a certain threshold, it triggers specific responses in the bacterial population. Regulation of Gene Expression: In many bacteria, HHSL binds to specific transcriptional regulators, leading to the activation or repression of target genes. This regulation can control a variety of biological processes, including bioluminescence, biofilm formation, virulence factor production, and sporulation. Biofilm Formation: HHSL can influence the formation and maintenance of biofilms, which are complex communities of bacteria encased in a self-produced matrix. Biofilms are often associated with increased resistance to antibiotics and host immune responses. Virulence and Pathogenicity: In pathogenic bacteria, HHSL can regulate the expression of virulence factors, contributing to the bacteria’s ability to cause disease. By modulating these factors, HHSL can affect the bacteria’s interaction with the host and its ability to evade the immune system. Symbiotic Interactions: HHSL is not only important in pathogenic bacteria but also in beneficial interactions, such as those found in nitrogen-fixing bacteria or in symbiotic relationships with plants and animals. Understanding the role of HHSL and other autoinducers in bacterial communication and behavior is crucial for developing new strategies to control bacterial infections and manage biofilm-related issues.